Collaborations - Novartis AG (Details) - Collaborative Arrangement with Novartis AG [Member] - USD ($) $ in Millions	12 Months Ended
Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Potential future milestone payment	$ 100
Selling, general and administrative [Member]
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Cost recoveries	160	$ 192	$ 187
Cost of sales [Member]
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Royalties due	$ 116	$ 139	$ 115

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+ References

No definition available.

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+ References

Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef
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Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef
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-Name Accounting Standards Codification
-Topic 220
-SubTopic 10
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