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Business combinations (Allocation of Fair Values of Assets and Liabilities - Onyx) (Details) - USD ($)
$ in Millions
Dec. 31, 2015
Dec. 31, 2014
Dec. 31, 2013
Oct. 01, 2013
Allocation of the total consideration to the acquisition date fair values of assets acquired and liabilities assumed        
Goodwill $ 14,787 $ 14,788 $ 14,968  
Onyx [Member]        
Allocation of the total consideration to the acquisition date fair values of assets acquired and liabilities assumed        
Cash and cash equivalents       $ 319
Marketable securities       337
Inventories       170
Indefinite-lived intangible assets - IPR&D       1,180
Goodwill       2,402
Convertible debt       (742)
Assumed contingent consideration       (261)
Deferred income taxes, net       (3,011)
Other assets (liabilities), net       141
Total consideration (excluding compensation expense)       9,517
Onyx [Member] | Developed product technology rights [Member]        
Allocation of the total consideration to the acquisition date fair values of assets acquired and liabilities assumed        
Finite-lived intangible assets       6,190
Onyx [Member] | Licensing rights [Member]        
Allocation of the total consideration to the acquisition date fair values of assets acquired and liabilities assumed        
Finite-lived intangible assets       $ 2,792