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Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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MIC-Info: RSA-MD5,RSA,
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<SEC-DOCUMENT>0000911420-05-000458.txt : 20051019
<SEC-HEADER>0000911420-05-000458.hdr.sgml : 20051019
<ACCEPTANCE-DATETIME>20051019205843
ACCESSION NUMBER:		0000911420-05-000458
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20051017
FILED AS OF DATE:		20051019
DATE AS OF CHANGE:		20051019

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			ENZO BIOCHEM INC
		CENTRAL INDEX KEY:			0000316253
		STANDARD INDUSTRIAL CLASSIFICATION:	SERVICES-MEDICAL LABORATORIES [8071]
		IRS NUMBER:				132866202
		STATE OF INCORPORATION:			NY
		FISCAL YEAR END:			0731

	BUSINESS ADDRESS:	
		STREET 1:		60 EXECUTIVE BLVD
		CITY:			FARMINGDALE
		STATE:			NY
		ZIP:			11735
		BUSINESS PHONE:		5167555500

	MAIL ADDRESS:	
		STREET 1:		ENZO BIOCHEM INC
		STREET 2:		60 EXECUTIVE BLVD
		CITY:			FARMINGDALE
		STATE:			NY
		ZIP:			11735

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			ENGELHARDT DEAN
		CENTRAL INDEX KEY:			0001263101

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-09974
		FILM NUMBER:		051146111

	BUSINESS ADDRESS:	
		STREET 1:		C/O ENZO BIOCHEM INC
		STREET 2:		60 EXECUTIVE BOULEVARD
		CITY:			FARMINGDALE
		STATE:			NY
		ZIP:			11735
		BUSINESS PHONE:		631 755 5500

	MAIL ADDRESS:	
		STREET 1:		C/O ENZO BIOCHEM INC
		STREET 2:		60 EXECUTIVE BLVD
		CITY:			FARMINGDALE
		STATE:			NY
		ZIP:			11735
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>p1128274_ex.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0202</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2005-10-17</periodOfReport>

    <notSubjectToSection16>0</notSubjectToSection16>

    <issuer>
        <issuerCik>0000316253</issuerCik>
        <issuerName>ENZO BIOCHEM INC</issuerName>
        <issuerTradingSymbol>ENZ</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001263101</rptOwnerCik>
            <rptOwnerName>ENGELHARDT DEAN</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O ENZO BIOCHEM, INC.</rptOwnerStreet1>
            <rptOwnerStreet2>527 MADISON AVENUE</rptOwnerStreet2>
            <rptOwnerCity>NEW YORK</rptOwnerCity>
            <rptOwnerState>NY</rptOwnerState>
            <rptOwnerZipCode>10022</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>1</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle>Executive Vice President</officerTitle>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock, par value $.01 per share</value>
            </securityTitle>
            <transactionDate>
                <value>2005-10-17</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>M</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>20101</value>
                    <footnoteId id="F1"/>
                </transactionShares>
                <transactionPricePerShare>
                    <value>11.0067</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>239264</value>
                    <footnoteId id="F2"/>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock, par value $.01 per share</value>
            </securityTitle>
            <transactionDate>
                <value>2005-10-17</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>F</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>16401</value>
                    <footnoteId id="F1"/>
                </transactionShares>
                <transactionPricePerShare>
                    <value>13.49</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>D</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>239264</value>
                    <footnoteId id="F2"/>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
    </nonDerivativeTable>

    <footnotes>
        <footnote id="F1">This transaction was a cashless exercise of options to purchase 20,101 shares of Common Stock. The exercise price for the
stock options was paid in the form of 16,401 shares of Common Stock owned by the Reporting Person valued at an aggregate of
$221,250 based on the $13.49 closing price of Enzo Biochem's Common Stock on October 17, 2005, the exercise date.</footnote>
        <footnote id="F2">As of the date hereof, the Reporting Person directly beneficially owns 171,901 shares of Common Stock, 4,765 shares of Common
Stock in Enzo Biochem's 401K plan and 62,598 options to purchase Common Stock, par value $.01 per share which are currently
exercisable.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>/s/ Dean Engelhardt</signatureName>
        <signatureDate>2005-10-19</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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