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      </invstOrSec>
      <invstOrSec>
        <name>REZOLUTE INC</name>
        <lei>549300T05L48T72P2G08</lei>
        <title>REZOLUTE INC</title>
        <cusip>76200L309</cusip>
        <identifiers>
          <isin value="US76200L3096"/>
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        <balance>1985100.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>6630234.00000000</valUSD>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
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      </invstOrSec>
      <invstOrSec>
        <name>ASCENDIS PHARMA A/S</name>
        <lei>549300B66JN3W3J8GH73</lei>
        <title>ASCENDIS PHARMA AS SPON ADR</title>
        <cusip>04351P101</cusip>
        <identifiers>
          <isin value="US04351P1012"/>
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        <balance>370625.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>83798312.50000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>DK</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>BIOGEN INC</name>
        <lei>W8J5WZB5IY3K0NDQT671</lei>
        <title>BIOGEN INC</title>
        <cusip>09062X103</cusip>
        <identifiers>
          <isin value="US09062X1037"/>
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        <balance>294100.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>52905649.00000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>SOLENO THERAPEUTICS INC</name>
        <lei>5493003LCY77N7FXK844</lei>
        <title>SOLENO THERAPEUTICS INC</title>
        <cusip>834203309</cusip>
        <identifiers>
          <isin value="US8342033094"/>
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        <balance>181000.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>6979360.00000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>CELLDEX THERAPEUTICS INC</name>
        <lei>529900F018DMYWH38923</lei>
        <title>CELLDEX THERAPEUTICS INC</title>
        <cusip>15117B202</cusip>
        <identifiers>
          <isin value="US15117B2025"/>
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        <balance>275652.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>6781039.20000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>AVALO THERAPEUTICS INC</name>
        <lei>549300GPK6FPJ3X8SZ39</lei>
        <title>AVALO THERAPEUTICS INC</title>
        <cusip>05338F306</cusip>
        <identifiers>
          <isin value="US05338F3064"/>
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        <balance>220300.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3328733.00000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>CYTOKINETICS INC</name>
        <lei>549300BE5DY1HW7IHA64</lei>
        <title>CYTOKINETICS INC</title>
        <cusip>23282W605</cusip>
        <identifiers>
          <isin value="US23282W6057"/>
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        <balance>283071.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>17887256.49000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>CYTOMX THERAPEUTICS INC</name>
        <lei>5493004VW2FW0QLL3345</lei>
        <title>CYTOMX THERAPEUTICS INC</title>
        <cusip>23284F105</cusip>
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          <isin value="US23284F1057"/>
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        <balance>1350251.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>7682928.19000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Fidelity Revere Street Trust</name>
        <lei>549300BDV45LJNXBZC55</lei>
        <title>Fidelity Cash Central Fund</title>
        <cusip>31635A105</cusip>
        <identifiers>
          <isin value="US31635A1051"/>
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        <balance>5792224.10500000</balance>
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        <curCd>USD</curCd>
        <valUSD>5793382.55000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>STIV</assetCat>
        <issuerCat>RF</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Fidelity Revere Street Trust</name>
        <lei>549300BDV45LJNXBZC55</lei>
        <title>Fidelity Securities Lending Cash Central Fund</title>
        <cusip>31635A303</cusip>
        <identifiers>
          <isin value="US31635A3032"/>
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        <balance>66938144.47900000</balance>
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        <curCd>USD</curCd>
        <valUSD>66944838.29000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>STIV</assetCat>
        <issuerCat>RF</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <cashCollateralCondition cashCollateralVal="66944838.29000000" isCashCollateral="Y"/>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>GILEAD SCIENCES INC</name>
        <lei>549300WTZWR07K8MNV44</lei>
        <title>GILEAD SCIENCES INC</title>
        <cusip>375558103</cusip>
        <identifiers>
          <isin value="US3755581036"/>
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        <balance>864100.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>122658995.00000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>CRESCENT BIOPHARMA INC</name>
        <lei>549300TZ84FFU2J2J459</lei>
        <title>CRESCENT BIOPHARMA INC</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="KYG2545C1042"/>
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        <balance>251090.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2407953.10000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>KY</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>INSMED INC</name>
        <lei>529900Q55QAG41CCAC11</lei>
        <title>INSMED INC</title>
        <cusip>457669307</cusip>
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          <isin value="US4576693075"/>
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        <balance>412300.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>64677501.00000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>INOVIO PHARMACEUTICALS INC</name>
        <lei>529900B9W875XDZXTM97</lei>
        <title>INOVIO PHARMACEUTICALS INC</title>
        <cusip>45773H409</cusip>
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          <isin value="US45773H4092"/>
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        <balance>883081.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1439422.03000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>NATERA INC</name>
        <lei>529900CQ3OZ0A0VYVU59</lei>
        <title>NATERA INC</title>
        <cusip>632307104</cusip>
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        <balance>89400.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>20663916.00000000</valUSD>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>UNIQURE N.V.</name>
        <lei>724500RPCTZLFYJZ3S98</lei>
        <title>UNIQURE N.V.</title>
        <cusip>N/A</cusip>
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          <isin value="NL0010696654"/>
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        <balance>991600.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>22529152.00000000</valUSD>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>NL</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>AFFERENT PHARMA</name>
        <lei>N/A</lei>
        <title>AFFERENT PHARMACEUTICALS INC SER C PC PP</title>
        <cusip>N/A</cusip>
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          <other otherDesc="Internal" value="74W995233"/>
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        <balance>1915787.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>19.16000000</valUSD>
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        <assetCat>EP</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>3</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>TRAVERE THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>TRAVERE THERAPEUTICS INC</title>
        <cusip>89422G107</cusip>
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        <balance>301200.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>WAVE LIFE SCIENCES LTD</name>
        <lei>54930070006GPKFYZ813</lei>
        <title>WAVE LIFE SCIENCES LTD</title>
        <cusip>N/A</cusip>
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          <isin value="SG9999014716"/>
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        <balance>289700.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3748718.00000000</valUSD>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>SG</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>VIRIDIAN THERAPEUTICS INC</name>
        <lei>549300C775BNYF550E70</lei>
        <title>VIRIDIAN THERAPEUTICS INC</title>
        <cusip>92790C104</cusip>
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          <isin value="US92790C1045"/>
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        <balance>1782464.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>58821312.00000000</valUSD>
        <pctVal>3.152688333566</pctVal>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>TENAX THERAPEUTICS INC</name>
        <lei>549300J03O6B1IJ2B606</lei>
        <title>TENAX THERAPEUTICS INC</title>
        <cusip>88032L605</cusip>
        <identifiers>
          <isin value="US88032L6056"/>
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        <balance>322600.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4035726.00000000</valUSD>
        <pctVal>0.216305720580</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>UCB SA</name>
        <lei>2138008J191VLSGY5A09</lei>
        <title>UCB SA</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="BE0003739530"/>
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        <balance>75800.00000000</balance>
        <units>NS</units>
        <currencyConditional curCd="EUR" exchangeRt="0.84363268"/>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>BE</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>VIKING THERAPEUTICS INC</name>
        <lei>529900IVC72YPFA25M37</lei>
        <title>VIKING THERAPEUTICS INC</title>
        <cusip>92686J106</cusip>
        <identifiers>
          <isin value="US92686J1060"/>
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        <balance>647387.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>18800118.48000000</valUSD>
        <pctVal>1.007643525557</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="12704274.00000000"/>
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      <invstOrSec>
        <name>XENON PHARMACEUTICALS INC</name>
        <lei>549300XV44Q9Z1MIPQ03</lei>
        <title>XENON PHARMACEUTICALS INC</title>
        <cusip>98420N105</cusip>
        <identifiers>
          <isin value="CA98420N1050"/>
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        <balance>710758.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>29148185.58000000</valUSD>
        <pctVal>1.562276350155</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>CA</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>SPYRE THERAPEUTICS INC</name>
        <lei>52990017AIJPRH3HQH40</lei>
        <title>SPYRE THERAPEUTICS INC</title>
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          <isin value="US00773J2024"/>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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      </invstOrSec>
      <invstOrSec>
        <name>MODERNA INC</name>
        <lei>549300EI6OKH5K5Q2G38</lei>
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          <isin value="US60770K1079"/>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>ANAPTYSBIO INC</name>
        <lei>529900HH4WQT03IG1A12</lei>
        <title>ANAPTYSBIO INC</title>
        <cusip>032724106</cusip>
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          <isin value="US0327241065"/>
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        <assetCat>EC</assetCat>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>ARGENX SE</name>
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        <title>ARGENX SE SPONSORED ADR</title>
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          <isin value="US04016X1019"/>
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        <curCd>USD</curCd>
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        <invCountry>NL</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>ROIVANT SCIENCES LTD</name>
        <lei>549300DL466NY5J6U724</lei>
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        <cusip>N/A</cusip>
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          <isin value="BMG762791017"/>
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        <assetCat>EC</assetCat>
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        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>RHYTHM PHARMACEUTICALS INC</name>
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          <isin value="US76243J1051"/>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>X4 PHARMACEUTICALS INC</name>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>KINIKSA PHARMACEUTICALS INTERNATIONAL PLC</name>
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        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>COGENT BIOSCIENCES INC</name>
        <lei>N/A</lei>
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        <assetCat>EC</assetCat>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>SCHOLAR ROCK HOLDING CORP</name>
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        <title>SCHOLAR ROCK HOLDING CORP</title>
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        <assetCat>EC</assetCat>
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        <fairValLevel>1</fairValLevel>
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        <name>DIANTHUS THERAPEUTICS INC</name>
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        <assetCat>EC</assetCat>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>TECTONIC THERAPEUTIC INC</name>
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        <fairValLevel>1</fairValLevel>
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        <name>CRINETICS PHARMACEUTICALS INC</name>
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        <name>STOKE THERAPEUTICS INC</name>
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        <name>ENLIVEN THERAPEUTICS INC</name>
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        <name>DEFINIUM THERAPEUTICS INC</name>
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        <name>VAXCYTE INC</name>
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        <name>ANNEXON INC</name>
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        <name>DISC MEDICINE INC</name>
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        <name>KYMERA THERAPEUTICS INC</name>
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        <name>TANGO THERAPEUTICS INC</name>
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        <name>SUMMIT THERAPEUTICS INC</name>
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        <title>SUMMIT THERAPEUTICS INC</title>
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        <name>PRAXIS PRECISION MEDICINES INC.</name>
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        <name>OLEMA PHARMACEUTICALS INC</name>
        <lei>N/A</lei>
        <title>OLEMA PHARMACEUTICALS INC</title>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>CENTESSA PHARMACEUTICALS PLC</name>
        <lei>213800GIDAARDSKOI827</lei>
        <title>CENTESSA PHARMACEUTICALS LTD ADR</title>
        <cusip>152309100</cusip>
        <identifiers>
          <isin value="US1523091007"/>
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        <balance>83600.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2054052.00000000</valUSD>
        <pctVal>0.110092508255</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>GB</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>BRIGHT PEAK THERAPEUTICS INC.</name>
        <lei>N/A</lei>
        <title>BRIGHT PEAK THERAPEUTICS SER B PC PP</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="HFH266000"/>
        </identifiers>
        <balance>1920122.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3437018.38000000</valUSD>
        <pctVal>0.184216355950</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EP</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>JADE BIOSCIENCES INC</name>
        <lei>N/A</lei>
        <title>JADE BIOSCIENCES INC</title>
        <cusip>008064206</cusip>
        <identifiers>
          <isin value="US0080642061"/>
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        <balance>894343.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>13960694.23000000</valUSD>
        <pctVal>0.748261409528</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>JANUX THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>JANUX THERAPEUTICS INC</title>
        <cusip>47103J105</cusip>
        <identifiers>
          <isin value="US47103J1051"/>
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        <balance>320385.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4392478.35000000</valUSD>
        <pctVal>0.235426833891</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>T-KNIFE THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>T-KNIFE THERAPEUTICS INC SER B PC PP</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="HHE278000"/>
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        <balance>1300097.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>897066.93000000</valUSD>
        <pctVal>0.048080744010</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EP</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>WUGEN INC</name>
        <lei>N/A</lei>
        <title>WUGEN INC SER B PC PP</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="HHE329000"/>
        </identifiers>
        <balance>580277.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>922640.43000000</valUSD>
        <pctVal>0.049451425356</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EP</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>TREELINE BIOSCIENCES</name>
        <lei>N/A</lei>
        <title>TREELINE BIOSCIENCES SERIES A PC PP</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="HIB405000"/>
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        <balance>47600.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>401744.00000000</valUSD>
        <pctVal>0.021532563263</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EP</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>NUVALENT INC</name>
        <lei>N/A</lei>
        <title>NUVALENT INC-A</title>
        <cusip>670703107</cusip>
        <identifiers>
          <isin value="US6707031075"/>
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        <balance>412264.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>42417842.96000000</valUSD>
        <pctVal>2.273499758643</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>SONOMA BIOTHERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>SONOMA BIOTHERAPEUTICS INC SER B PFD PP</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="HIE257000"/>
        </identifiers>
        <balance>1967762.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>5903286.00000000</valUSD>
        <pctVal>0.316402682447</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EP</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>SONOMA BIOTHERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>SONOMA BIOTHERAPEUTICS INC SER B1 PFD PP</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="HIE261000"/>
        </identifiers>
        <balance>1049456.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3536666.72000000</valUSD>
        <pctVal>0.189557279984</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EP</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>AMYLYX PHARMACEUTICALS INC</name>
        <lei>N/A</lei>
        <title>AMYLYX PHARMACEUTICALS INC</title>
        <cusip>03237H101</cusip>
        <identifiers>
          <isin value="US03237H1014"/>
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        <balance>2433200.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>34770428.00000000</valUSD>
        <pctVal>1.863615736907</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ARCELLX INC</name>
        <lei>N/A</lei>
        <title>ARCELLX INC</title>
        <cusip>03940C100</cusip>
        <identifiers>
          <isin value="US03940C1009"/>
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        <balance>142900.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>9761499.00000000</valUSD>
        <pctVal>0.523194110587</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="9290160.00000000"/>
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      </invstOrSec>
      <invstOrSec>
        <name>LIFEMINE THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>LIFEMINE THERAPEUTICS INC SER C PP</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="IHD504000"/>
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        <balance>1950028.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2301033.04000000</valUSD>
        <pctVal>0.123330129398</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EP</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>PARABILIS MEDICINES INC</name>
        <lei>N/A</lei>
        <title>PARABILIS MEDICINES INC SER D PC PP</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="JMR047000"/>
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        <balance>239281.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1756322.54000000</valUSD>
        <pctVal>0.094134887399</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EP</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>NEWAMSTERDAM PHARMA COMPANY NV</name>
        <lei>984500B6549TF6E14D36</lei>
        <title>NEWAMSTERDAM PHARMA COMPANY NV</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="NL00150012L7"/>
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        <balance>586400.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>18248768.00000000</valUSD>
        <pctVal>0.978092395755</pctVal>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>NL</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>STRUCTURE THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>STRUCTURE THERAPEUTICS INC ADR</title>
        <cusip>86366E106</cusip>
        <identifiers>
          <isin value="US86366E1064"/>
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        <balance>481200.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>42562140.00000000</valUSD>
        <pctVal>2.281233751291</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>KY</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>MINERALYS THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>MINERALYS THERAPEUTICS INC</title>
        <cusip>603170101</cusip>
        <identifiers>
          <isin value="US6031701013"/>
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        <balance>266800.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>8241452.00000000</valUSD>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>ENLIVEN THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>ENLIVEN THERAPEUTICS INC CVR (NON-TRADABLE)</title>
        <cusip>N/A</cusip>
        <identifiers>
          <ticker value="2226681D"/>
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        <balance>739725.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>3</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>APOGEE THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>APOGEE THERAPEUTICS INC</title>
        <cusip>03770N101</cusip>
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          <isin value="US03770N1019"/>
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        <balance>452639.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>RAPPORT THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>RAPPORT THERAPEUTICS INC</title>
        <cusip>75383L102</cusip>
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          <isin value="US75383L1026"/>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>KARTOS THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>KARTOS THERAPEUTICS INC SERIES C PC PP</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="JXD843000"/>
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        <balance>530692.00000000</balance>
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        <invCountry>US</invCountry>
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        <fairValLevel>3</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      </invstOrSec>
      <invstOrSec>
        <name>ASTRIA THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>ASTRIA THERAPEUTICS INC WT</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="KAD591000"/>
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        <balance>247630.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>2</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      </invstOrSec>
      <invstOrSec>
        <name>CG ONCOLOGY INC</name>
        <lei>N/A</lei>
        <title>CG ONCOLOGY INC</title>
        <cusip>156944100</cusip>
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          <isin value="US1569441009"/>
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        <balance>248900.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>12955245.00000000</valUSD>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      </invstOrSec>
      <invstOrSec>
        <name>ENLIVEN THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>ENLIVEN THERAPEUTICS INC PIPE</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="KGD809000"/>
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        <balance>73200.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>1936140.00000000</valUSD>
        <pctVal>0.103772693648</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ORUKA THERAPEUTICS INC</name>
        <lei>529900TG7O4ESUDMGI54</lei>
        <title>ORUKA THERAPEUTICS INC PIPE</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="KGU471000"/>
        </identifiers>
        <balance>26600.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>910518.00000000</valUSD>
        <pctVal>0.048801690722</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>MBX BIOSCIENCES INC</name>
        <lei>N/A</lei>
        <title>MBX BIOSCIENCES INC</title>
        <cusip>55287L101</cusip>
        <identifiers>
          <isin value="US55287L1017"/>
        </identifiers>
        <balance>111100.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4094035.00000000</valUSD>
        <pctVal>0.219430950158</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ENDEAVOR BIOMEDICINES INC</name>
        <lei>N/A</lei>
        <title>ENDEAVOR BIOMEDICINES INC SERIES C PC PP</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="KHI911000"/>
        </identifiers>
        <balance>526643.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3433712.36000000</valUSD>
        <pctVal>0.184039160809</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EP</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>BRIGHT PEAK THERAPEUTICS INC.</name>
        <lei>N/A</lei>
        <title>BRIGHT PEAK THERAPEUTICS SER C PC PP</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="KIK660000"/>
        </identifiers>
        <balance>873604.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1074532.92000000</valUSD>
        <pctVal>0.057592516823</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EP</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>WUGEN INC</name>
        <lei>N/A</lei>
        <title>WUGEN INC CONV 0% 12/31/2199 P/P</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="KKY969000"/>
        </identifiers>
        <balance>831313.00000000</balance>
        <units>PA</units>
        <curCd>USD</curCd>
        <valUSD>880526.73000000</valUSD>
        <pctVal>0.047194226967</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>DBT</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <debtSec>
          <maturityDt>2199-12-31</maturityDt>
          <couponKind>Variable</couponKind>
          <annualizedRt>0.00000000</annualizedRt>
          <isDefault>N</isDefault>
          <areIntrstPmntsInArrs>N</areIntrstPmntsInArrs>
          <isPaidKind>N</isPaidKind>
          <isMandatoryConvrtbl>Y</isMandatoryConvrtbl>
          <isContngtConvrtbl>Y</isContngtConvrtbl>
          <dbtSecRefInstruments>
            <dbtSecRefInstrument>
              <name>WUGEN INC</name>
              <title>WUGEN INC</title>
              <curCd>USD</curCd>
              <identifiers>
                <other otherDesc="Internal" value="HFD394000"/>
              </identifiers>
            </dbtSecRefInstrument>
          </dbtSecRefInstruments>
          <currencyInfos>
            <currencyInfo convRatio="1.50696000" curCd="USD"/>
          </currencyInfos>
          <delta>XXXX</delta>
        </debtSec>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>CARDURION PHARMACEUTICALS INC</name>
        <lei>N/A</lei>
        <title>CARDURION PHARMACEUTICALS INC SER B PC PP</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="KMC429000"/>
        </identifiers>
        <balance>331596.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1767406.68000000</valUSD>
        <pctVal>0.094728972055</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EP</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>CANDID THERAPEUTICS</name>
        <lei>N/A</lei>
        <title>CANDID THERAPEUTICS INC SER B PC PP</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="KPC029000"/>
        </identifiers>
        <balance>1500060.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1815072.60000000</valUSD>
        <pctVal>0.097283756788</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EP</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ZENAS BIOPHARMA INC</name>
        <lei>N/A</lei>
        <title>ZENAS BIOPHARMA INC</title>
        <cusip>98937L105</cusip>
        <identifiers>
          <isin value="US98937L1052"/>
        </identifiers>
        <balance>629316.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>11560534.92000000</valUSD>
        <pctVal>0.619618337858</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="670505.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>UPSTREAM BIO INC</name>
        <lei>N/A</lei>
        <title>UPSTREAM BIO INC</title>
        <cusip>91678A107</cusip>
        <identifiers>
          <isin value="US91678A1079"/>
        </identifiers>
        <balance>691003.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>21476373.24000000</valUSD>
        <pctVal>1.151084684426</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="3341100.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>CRESCENT BIOPHARMA INC</name>
        <lei>549300TZ84FFU2J2J459</lei>
        <title>CRESCENT BIOPHARMA INC PIPE</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Bloomberg" value="EQ0000000096770470"/>
        </identifiers>
        <balance>98300.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>942697.00000000</valUSD>
        <pctVal>0.050526411821</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>KY</invCountry>

        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>MAZE THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>MAZE THERAPEUTICS INC</title>
        <cusip>578784100</cusip>
        <identifiers>
          <isin value="US5787841007"/>
        </identifiers>
        <balance>128000.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>5578240.00000000</valUSD>
        <pctVal>0.298980957273</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>MENTARI THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>MENTARI THERAPEUTICS INC SER A PC PP</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="LQE027000"/>
        </identifiers>
        <balance>1457407.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2011221.66000000</valUSD>
        <pctVal>0.107796899594</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EP</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ZENAS BIOPHARMA INC</name>
        <lei>N/A</lei>
        <title>ZENAS BIOPHARMA INC PIPE</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="LSC975000"/>
        </identifiers>
        <balance>86234.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1584118.58000000</valUSD>
        <pctVal>0.084905147409</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>FABIO TUB HOLDINGS LLC</name>
        <lei>N/A</lei>
        <title>FABIO TUB HOLDINGS LLC PP</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="LUL112000"/>
        </identifiers>
        <balance>6300.00000000</balance>
        <units>NS</units>
        <currencyConditional curCd="EUR" exchangeRt="0.84363268"/>
        <valUSD>2267942.01000000</valUSD>
        <pctVal>0.121556525569</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>DE</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>GALECTO INC</name>
        <lei>N/A</lei>
        <title>DAMORA THERAPEUTICS SER C PC PIPE</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="LVN332000"/>
        </identifiers>
        <balance>100.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2623500.00000000</valUSD>
        <pctVal>0.140613623904</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EP</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>

        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>PARABILIS MEDICINES INC</name>
        <lei>N/A</lei>
        <title>PARABILIS MEDICINES INC SER F PC PP</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="MBT390000"/>
        </identifiers>
        <balance>491600.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3028256.00000000</valUSD>
        <pctVal>0.162307623506</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EP</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
    </invstOrSecs>
    <explntrNotes>
      <explntrNote note="As of March 2025, monthly returns presented in Item B.5.a. have been calculated without deducting any applicable sales loads or redemption fees." noteItem="B.5.a"/>
    </explntrNotes>
    <signature>
      <ncom:dateSigned>2026-03-02</ncom:dateSigned>
      <ncom:nameOfApplicant>Stacie M. Smith</ncom:nameOfApplicant>
      <ncom:signature>Stacie M. Smith</ncom:signature>
      <ncom:signerName>Stacie M. Smith</ncom:signerName>
      <ncom:title>President and Treasurer</ncom:title>
    </signature>
  </formData>
</edgarSubmission>
