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        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>PRAXIS PRECISION MEDICINES INC.</name>
        <lei>N/A</lei>
        <title>PRAXIS PRECISION MEDICINES INC</title>
        <cusip>74006W207</cusip>
        <identifiers>
          <isin value="US74006W2070"/>
        </identifiers>
        <balance>108600.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>21585336.00000000</valUSD>
        <pctVal>1.239612773790</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ABBVIE INC</name>
        <lei>FR5LCKFTG8054YNNRU85</lei>
        <title>ABBVIE INC</title>
        <cusip>00287Y109</cusip>
        <identifiers>
          <isin value="US00287Y1091"/>
        </identifiers>
        <balance>1323880.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>288658795.20000000</valUSD>
        <pctVal>16.57723233017</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>X4 PHARMACEUTICALS INC</name>
        <lei>549300R0UFVPXWP86U94</lei>
        <title>X4 PHARMACEUTICALS INC</title>
        <cusip>98420X202</cusip>
        <identifiers>
          <isin value="US98420X2027"/>
        </identifiers>
        <balance>1341800.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>5420872.00000000</valUSD>
        <pctVal>0.311312373190</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="135744.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>SONOMA BIOTHERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>SONOMA BIOTHERAPEUTICS INC SER B1 PFD PP</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="HIE261000"/>
        </identifiers>
        <balance>1049456.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3305786.40000000</valUSD>
        <pctVal>0.189846247881</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EP</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>AFFERENT PHARMA</name>
        <lei>N/A</lei>
        <title>AFFERENT PHARMACEUTICALS INC SER C PC PP</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="74W995233"/>
        </identifiers>
        <balance>1915787.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>19.16000000</valUSD>
        <pctVal>0.000001100329</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EP</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ORUKA THERAPEUTICS INC</name>
        <lei>529900TG7O4ESUDMGI54</lei>
        <title>ORUKA THERAPEUTICS INC PIPE</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="KGU471000"/>
        </identifiers>
        <balance>26600.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>749322.00000000</valUSD>
        <pctVal>0.043032414361</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ENLIVEN THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>ENLIVEN THERAPEUTICS INC CVR (NON-TRADABLE)</title>
        <cusip>N/A</cusip>
        <identifiers>
          <ticker value="2226681D"/>
        </identifiers>
        <balance>739725.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>7.40000000</valUSD>
        <pctVal>0.000000424970</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>CENTESSA PHARMACEUTICALS PLC</name>
        <lei>213800GIDAARDSKOI827</lei>
        <title>CENTESSA PHARMACEUTICALS LTD ADR</title>
        <cusip>152309100</cusip>
        <identifiers>
          <isin value="US1523091007"/>
        </identifiers>
        <balance>210600.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>5243940.00000000</valUSD>
        <pctVal>0.301151439523</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>GB</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>MEREO BIOPHARMA GROUP PLC</name>
        <lei>213800U8JQHIJOS5AS09</lei>
        <title>MEREO BIOPHARMA ADR</title>
        <cusip>589492107</cusip>
        <identifiers>
          <isin value="US5894921072"/>
        </identifiers>
        <balance>759100.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1442290.00000000</valUSD>
        <pctVal>0.082828504847</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>GB</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="985150.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>CRINETICS PHARMACEUTICALS INC</name>
        <lei>549300Q1CNFXK5P31D28</lei>
        <title>CRINETICS PHARMACEUTICALS INC</title>
        <cusip>22663K107</cusip>
        <identifiers>
          <isin value="US22663K1079"/>
        </identifiers>
        <balance>544470.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>23684445.00000000</valUSD>
        <pctVal>1.360161387441</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>SONOMA BIOTHERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>SONOMA BIOTHERAPEUTICS INC SER B PFD PP</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="HIE257000"/>
        </identifiers>
        <balance>1967762.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>5450700.74000000</valUSD>
        <pctVal>0.313025392026</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EP</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>NEWAMSTERDAM PHARMA COMPANY NV</name>
        <lei>984500B6549TF6E14D36</lei>
        <title>NEWAMSTERDAM PHARMA COMPANY NV</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="NL00150012L7"/>
        </identifiers>
        <balance>753700.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>28602915.00000000</valUSD>
        <pctVal>1.642621583543</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>NL</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="2557830.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ENDEAVOR BIOMEDICINES INC</name>
        <lei>N/A</lei>
        <title>ENDEAVOR BIOMEDICINES INC SERIES C PC PP</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="KHI911000"/>
        </identifiers>
        <balance>526643.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3265186.60000000</valUSD>
        <pctVal>0.187514663573</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EP</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>CRESCENT BIOPHARMA INC</name>
        <lei>549300TZ84FFU2J2J459</lei>
        <title>CRESCENT BIOPHARMA INC PIPE</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Bloomberg" value="EQ0000000096770470"/>
        </identifiers>
        <balance>251090.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3201397.50000000</valUSD>
        <pctVal>0.183851353297</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>KY</invCountry>

        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>DISC MEDICINE INC</name>
        <lei>N/A</lei>
        <title>DISC MEDICINE INC</title>
        <cusip>254604101</cusip>
        <identifiers>
          <isin value="US2546041011"/>
        </identifiers>
        <balance>225022.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>19401396.84000000</valUSD>
        <pctVal>1.114192494026</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>AMYLYX PHARMACEUTICALS INC</name>
        <lei>N/A</lei>
        <title>AMYLYX PHARMACEUTICALS INC</title>
        <cusip>03237H101</cusip>
        <identifiers>
          <isin value="US03237H1014"/>
        </identifiers>
        <balance>2433200.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>33894476.00000000</valUSD>
        <pctVal>1.946507824133</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>WUGEN INC</name>
        <lei>N/A</lei>
        <title>WUGEN INC SER B PC PP</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="HHE329000"/>
        </identifiers>
        <balance>580277.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1027090.29000000</valUSD>
        <pctVal>0.058984221664</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EP</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>CARDURION PHARMACEUTICALS INC</name>
        <lei>N/A</lei>
        <title>CARDURION PHARMACEUTICALS INC SER B PC PP</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="KMC429000"/>
        </identifiers>
        <balance>331596.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1767406.68000000</valUSD>
        <pctVal>0.101499457641</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EP</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>KARTOS THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>KARTOS THERAPEUTICS INC SERIES C PC PP</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="JXD843000"/>
        </identifiers>
        <balance>530692.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3247835.04000000</valUSD>
        <pctVal>0.186518190068</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EP</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ORUKA THERAPEUTICS INC</name>
        <lei>529900TG7O4ESUDMGI54</lei>
        <title>ORUKA THERAPEUTICS INC</title>
        <cusip>687604108</cusip>
        <identifiers>
          <isin value="US6876041087"/>
        </identifiers>
        <balance>710786.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>20022841.62000000</valUSD>
        <pctVal>1.149881115574</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="3411387.00000000"/>
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      </invstOrSec>
      <invstOrSec>
        <name>SCHOLAR ROCK HOLDING CORP</name>
        <lei>549300Z1FLPGL4OWJ459</lei>
        <title>SCHOLAR ROCK HOLDING CORP</title>
        <cusip>80706P103</cusip>
        <identifiers>
          <isin value="US80706P1030"/>
        </identifiers>
        <balance>576368.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>17072020.16000000</valUSD>
        <pctVal>0.980419960326</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="3010813.76000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>LIFEMINE THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>LIFEMINE THERAPEUTICS INC SER C PP</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="IHD504000"/>
        </identifiers>
        <balance>1950028.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2301033.04000000</valUSD>
        <pctVal>0.132144801883</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EP</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>ARGENX SE</name>
        <lei>7245009C5FZE6G9ODQ71</lei>
        <title>ARGENX SE SPONSORED ADR</title>
        <cusip>04016X101</cusip>
        <identifiers>
          <isin value="US04016X1019"/>
        </identifiers>
        <balance>99700.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>81604450.00000000</valUSD>
        <pctVal>4.686418530532</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>NL</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>MIND MEDICINE MINDMED INC</name>
        <lei>529900UG3DGE202N5D44</lei>
        <title>MIND MEDICINE MINDMED INC</title>
        <cusip>60255C885</cusip>
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      <invstOrSec>
        <name>ASTRIA THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>ASTRIA THERAPEUTICS INC WT</title>
        <cusip>N/A</cusip>
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          <other otherDesc="Internal" value="KAD591000"/>
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        <balance>247630.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1632732.15000000</valUSD>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>2</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>NATERA INC</name>
        <lei>N/A</lei>
        <title>NATERA INC</title>
        <cusip>632307104</cusip>
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          <isin value="US6323071042"/>
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        <balance>48600.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>9667998.00000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>CYTOMX THERAPEUTICS INC</name>
        <lei>5493004VW2FW0QLL3345</lei>
        <title>CYTOMX THERAPEUTICS INC</title>
        <cusip>23284F105</cusip>
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          <isin value="US23284F1057"/>
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        <balance>3444351.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>12296333.07000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>CANDID THERAPEUTICS</name>
        <lei>N/A</lei>
        <title>CANDID THERAPEUTICS INC SER B PC PP</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="KPC029000"/>
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        <balance>1500060.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1575063.00000000</valUSD>
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        <assetCat>EP</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>3</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>EXACT SCIENCES CORP</name>
        <lei>549300VM3X1FYD4N9Z14</lei>
        <title>EXACT SCIENCES CORP</title>
        <cusip>30063P105</cusip>
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          <isin value="US30063P1057"/>
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        <balance>338800.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>ZENAS BIOPHARMA INC</name>
        <lei>N/A</lei>
        <title>ZENAS BIOPHARMA INC PIPE</title>
        <cusip>N/A</cusip>
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          <other otherDesc="Internal" value="LSC975000"/>
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        <balance>86234.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>ARCELLX INC</name>
        <lei>N/A</lei>
        <title>ARCELLX INC</title>
        <cusip>03940C100</cusip>
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          <isin value="US03940C1009"/>
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        <balance>181600.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>STOKE THERAPEUTICS INC</name>
        <lei>549300RD25SS2DIJHJ67</lei>
        <title>STOKE THERAPEUTICS INC</title>
        <cusip>86150R107</cusip>
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          <isin value="US86150R1077"/>
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        <balance>402800.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>UCB SA</name>
        <lei>2138008J191VLSGY5A09</lei>
        <title>UCB SA</title>
        <cusip>N/A</cusip>
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          <isin value="BE0003739530"/>
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        <balance>97700.00000000</balance>
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        <currencyConditional curCd="EUR" exchangeRt="0.86756604"/>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>BE</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>RHYTHM PHARMACEUTICALS INC</name>
        <lei>529900JPNWXQ8DPLA551</lei>
        <title>RHYTHM PHARMACEUTICALS INC</title>
        <cusip>76243J105</cusip>
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          <isin value="US76243J1051"/>
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        <balance>141200.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>RAPPORT THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>RAPPORT THERAPEUTICS INC</title>
        <cusip>75383L102</cusip>
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          <isin value="US75383L1026"/>
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        <balance>206346.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>ALNYLAM PHARMACEUTICALS INC</name>
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        <title>ALNYLAM PHARMACEUTICALS INC</title>
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          <isin value="US02043Q1076"/>
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        <balance>292486.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>ZENAS BIOPHARMA INC</name>
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        <title>ZENAS BIOPHARMA INC</title>
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          <isin value="US98937L1052"/>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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        <name>Fidelity Revere Street Trust</name>
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        <title>Fidelity Securities Lending Cash Central Fund</title>
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          <isin value="US31635A3032"/>
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        <curCd>USD</curCd>
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        <assetCat>STIV</assetCat>
        <issuerCat>RF</issuerCat>
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        <fairValLevel>1</fairValLevel>
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        <name>KYMERA THERAPEUTICS INC</name>
        <lei>N/A</lei>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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        <name>XENON PHARMACEUTICALS INC</name>
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        <invCountry>CA</invCountry>
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        <fairValLevel>1</fairValLevel>
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        <name>TRAVERE THERAPEUTICS INC</name>
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        <title>TRAVERE THERAPEUTICS INC</title>
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        <fairValLevel>1</fairValLevel>
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        <name>JADE BIOSCIENCES INC</name>
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        <fairValLevel>1</fairValLevel>
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        <name>WUGEN INC</name>
        <lei>N/A</lei>
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        <fairValLevel>3</fairValLevel>
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          <isContngtConvrtbl>Y</isContngtConvrtbl>
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            <dbtSecRefInstrument>
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              <title>WUGEN INC</title>
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      <invstOrSec>
        <name>BRIGHT PEAK THERAPEUTICS INC.</name>
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        <title>BRIGHT PEAK THERAPEUTICS SER C PC PP</title>
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      <invstOrSec>
        <name>COGENT BIOSCIENCES INC</name>
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        <title>COGENT BIOSCIENCES INC</title>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>CG ONCOLOGY INC</name>
        <lei>N/A</lei>
        <title>CG ONCOLOGY INC</title>
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          <isin value="US1569441009"/>
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        <balance>317200.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>13725244.00000000</valUSD>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>AVALO THERAPEUTICS INC</name>
        <lei>549300GPK6FPJ3X8SZ39</lei>
        <title>AVALO THERAPEUTICS INC</title>
        <cusip>05338F306</cusip>
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          <isin value="US05338F3064"/>
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        <balance>220300.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>3972009.00000000</valUSD>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>INSMED INC</name>
        <lei>529900Q55QAG41CCAC11</lei>
        <title>INSMED INC</title>
        <cusip>457669307</cusip>
        <identifiers>
          <isin value="US4576693075"/>
        </identifiers>
        <balance>360500.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>68350800.00000000</valUSD>
        <pctVal>3.925281718052</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>MAZE THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>MAZE THERAPEUTICS INC</title>
        <cusip>578784100</cusip>
        <identifiers>
          <isin value="US5787841007"/>
        </identifiers>
        <balance>65900.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2168769.00000000</valUSD>
        <pctVal>0.124549080718</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>GILEAD SCIENCES INC</name>
        <lei>549300WTZWR07K8MNV44</lei>
        <title>GILEAD SCIENCES INC</title>
        <cusip>375558103</cusip>
        <identifiers>
          <isin value="US3755581036"/>
        </identifiers>
        <balance>799800.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>95808042.00000000</valUSD>
        <pctVal>5.502109056586</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>VIKING THERAPEUTICS INC</name>
        <lei>529900IVC72YPFA25M37</lei>
        <title>VIKING THERAPEUTICS INC</title>
        <cusip>92686J106</cusip>
        <identifiers>
          <isin value="US92686J1060"/>
        </identifiers>
        <balance>706987.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>26922064.96000000</valUSD>
        <pctVal>1.546092941116</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="26449911.04000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>APOGEE THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>APOGEE THERAPEUTICS INC</title>
        <cusip>03770N101</cusip>
        <identifiers>
          <isin value="US03770N1019"/>
        </identifiers>
        <balance>476539.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>26967342.01000000</valUSD>
        <pctVal>1.548693132725</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ENLIVEN THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>ENLIVEN THERAPEUTICS INC PIPE</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="KGD809000"/>
        </identifiers>
        <balance>73200.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1714344.00000000</valUSD>
        <pctVal>0.098452149230</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>CIDARA THERAPEUTICS INC</name>
        <lei>549300IHQ9Z7RI1X2D22</lei>
        <title>CIDARA THERAPEUTICS INC</title>
        <cusip>171757206</cusip>
        <identifiers>
          <isin value="US1717572069"/>
        </identifiers>
        <balance>103900.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>11350036.00000000</valUSD>
        <pctVal>0.651815177145</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>CELLDEX THERAPEUTICS INC</name>
        <lei>529900F018DMYWH38923</lei>
        <title>CELLDEX THERAPEUTICS INC</title>
        <cusip>15117B202</cusip>
        <identifiers>
          <isin value="US15117B2025"/>
        </identifiers>
        <balance>366952.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>9808626.96000000</valUSD>
        <pctVal>0.563294417699</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>BRIGHT PEAK THERAPEUTICS INC.</name>
        <lei>N/A</lei>
        <title>BRIGHT PEAK THERAPEUTICS SER B PC PP</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="HFH266000"/>
        </identifiers>
        <balance>1920122.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3110597.64000000</valUSD>
        <pctVal>0.178636856459</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EP</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>NUVALENT INC</name>
        <lei>N/A</lei>
        <title>NUVALENT INC-A</title>
        <cusip>670703107</cusip>
        <identifiers>
          <isin value="US6707031075"/>
        </identifiers>
        <balance>423009.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>42013253.88000000</valUSD>
        <pctVal>2.412756798326</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
    </invstOrSecs>
    <explntrNotes>
      <explntrNote note="As of March 2025, monthly returns presented in Item B.5.a. have been calculated without deducting any applicable sales loads or redemption fees." noteItem="B.5.a"/>
    </explntrNotes>
    <signature>
      <ncom:dateSigned>2025-11-30</ncom:dateSigned>
      <ncom:nameOfApplicant>Stacie M. Smith</ncom:nameOfApplicant>
      <ncom:signature>Stacie M. Smith</ncom:signature>
      <ncom:signerName>Stacie M. Smith</ncom:signerName>
      <ncom:title>President and Treasurer</ncom:title>
    </signature>
  </formData>
  <documents>XXXX</documents>
</edgarSubmission>
