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        <curCd>USD</curCd>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>AMGEN INC</name>
        <lei>62QBXGPJ34PQ72Z12S66</lei>
        <title>AMGEN INC</title>
        <cusip>031162100</cusip>
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          <isin value="US0311621009"/>
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        <balance>207703.00000000</balance>
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        <curCd>USD</curCd>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      </invstOrSec>
      <invstOrSec>
        <name>ABBVIE INC</name>
        <lei>FR5LCKFTG8054YNNRU85</lei>
        <title>ABBVIE INC</title>
        <cusip>00287Y109</cusip>
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          <isin value="US00287Y1091"/>
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        <balance>1331980.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>SONOMA BIOTHERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>SONOMA BIOTHERAPEUTICS INC SER B1 PFD PP</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="HIE261000"/>
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        <balance>1049456.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EP</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>3</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>AFFERENT PHARMA</name>
        <lei>N/A</lei>
        <title>AFFERENT PHARMACEUTICALS INC SER C PC PP</title>
        <cusip>N/A</cusip>
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          <other otherDesc="Internal" value="74W995233"/>
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        <balance>1915787.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EP</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>3</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>ENLIVEN THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>ENLIVEN THERAPEUTICS INC CVR (NON-TRADABLE)</title>
        <cusip>N/A</cusip>
        <identifiers>
          <ticker value="2226681D"/>
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        <balance>739725.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>3</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>MEREO BIOPHARMA GROUP PLC</name>
        <lei>213800U8JQHIJOS5AS09</lei>
        <title>MEREO BIOPHARMA ADR</title>
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          <isin value="US5894921072"/>
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        <balance>759100.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>GB</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>CRINETICS PHARMACEUTICALS INC</name>
        <lei>549300Q1CNFXK5P31D28</lei>
        <title>CRINETICS PHARMACEUTICALS INC</title>
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          <isin value="US22663K1079"/>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>BICARA THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>BICARA THERAPEUTICS INC</title>
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          <isin value="US0554771032"/>
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        <assetCat>EC</assetCat>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>SONOMA BIOTHERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>SONOMA BIOTHERAPEUTICS INC SER B PFD PP</title>
        <cusip>N/A</cusip>
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          <other otherDesc="Internal" value="HIE257000"/>
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        <balance>1967762.00000000</balance>
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        <assetCat>EP</assetCat>
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        <fairValLevel>3</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>NEWAMSTERDAM PHARMA COMPANY NV</name>
        <lei>984500B6549TF6E14D36</lei>
        <title>NEWAMSTERDAM PHARMA COMPANY NV</title>
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          <isin value="NL00150012L7"/>
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        <assetCat>EC</assetCat>
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        <invCountry>NL</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>ENDEAVOR BIOMEDICINES INC</name>
        <lei>N/A</lei>
        <title>ENDEAVOR BIOMEDICINES INC SERIES C PC PP</title>
        <cusip>N/A</cusip>
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          <other otherDesc="Internal" value="KHI911000"/>
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        <assetCat>EP</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>3</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>CRESCENT BIOPHARMA INC</name>
        <lei>549300TZ84FFU2J2J459</lei>
        <title>CRESCENT BIOPHARMA INC PIPE</title>
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          <other otherDesc="Bloomberg" value="EQ0000000096770470"/>
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        <balance>251090.00000000</balance>
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        <assetCat>EC</assetCat>
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        <invCountry>KY</invCountry>

        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>DISC MEDICINE INC</name>
        <lei>N/A</lei>
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        <assetCat>EC</assetCat>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>WUGEN INC</name>
        <lei>N/A</lei>
        <title>WUGEN INC SER B PC PP</title>
        <cusip>N/A</cusip>
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          <other otherDesc="Internal" value="HHE329000"/>
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      <invstOrSec>
        <name>CARDURION PHARMACEUTICALS INC</name>
        <lei>N/A</lei>
        <title>CARDURION PHARMACEUTICALS INC SER B PC PP</title>
        <cusip>N/A</cusip>
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          <other otherDesc="Internal" value="KMC429000"/>
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        <fairValLevel>3</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>KARTOS THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>KARTOS THERAPEUTICS INC SERIES C PC PP</title>
        <cusip>N/A</cusip>
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          <other otherDesc="Internal" value="JXD843000"/>
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        <fairValLevel>3</fairValLevel>
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      <invstOrSec>
        <name>MOONLAKE IMMUNOTHERAPEUTICS</name>
        <lei>N/A</lei>
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        <isRestrictedSec>N</isRestrictedSec>

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        <name>ORUKA THERAPEUTICS INC</name>
        <lei>529900TG7O4ESUDMGI54</lei>
        <title>ORUKA THERAPEUTICS INC</title>
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        <fairValLevel>1</fairValLevel>
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        <name>SCHOLAR ROCK HOLDING CORP</name>
        <lei>549300Z1FLPGL4OWJ459</lei>
        <title>SCHOLAR ROCK HOLDING CORP</title>
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          <isin value="US80706P1030"/>
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        <balance>576368.00000000</balance>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>NURIX THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>NURIX THERAPEUTICS INC</title>
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          <isin value="US67080M1036"/>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>MBX BIOSCIENCES INC</name>
        <lei>N/A</lei>
        <title>MBX BIOSCIENCES INC</title>
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        <fairValLevel>1</fairValLevel>
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        <name>LIFEMINE THERAPEUTICS INC</name>
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        <title>LIFEMINE THERAPEUTICS INC SER C PP</title>
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        <fairValLevel>3</fairValLevel>
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        <name>ARGENX SE</name>
        <lei>7245009C5FZE6G9ODQ71</lei>
        <title>ARGENX SE SPONSORED ADR</title>
        <cusip>04016X101</cusip>
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        <balance>109900.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>NL</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>PERSPECTIVE THERAPEUTICS INC</name>
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        <assetCat>EC</assetCat>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>JANUX THERAPEUTICS INC</name>
        <lei>N/A</lei>
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        <assetCat>EC</assetCat>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>ENLIVEN THERAPEUTICS INC</name>
        <lei>N/A</lei>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>BRIDGEBIO PHARMA INC</name>
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        <assetCat>EC</assetCat>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>VAXCYTE INC</name>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>VIRIDIAN THERAPEUTICS INC</name>
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        <fairValLevel>1</fairValLevel>
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        <name>SOLENO THERAPEUTICS INC</name>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>NEUROCRINE BIOSCIENCES INC</name>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>SPYRE THERAPEUTICS INC</name>
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        <fairValLevel>1</fairValLevel>
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        <name>REZOLUTE INC</name>
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        <fairValLevel>1</fairValLevel>
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        <name>MINERALYS THERAPEUTICS INC</name>
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        <fairValLevel>1</fairValLevel>
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        <name>STRUCTURE THERAPEUTICS INC</name>
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        <fairValLevel>1</fairValLevel>
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        <name>SUMMIT THERAPEUTICS INC</name>
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        <name>JADE BIOSCIENCES INC</name>
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        <name>PARABILIS MEDICINES INC</name>
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        <name>TREELINE BIOSCIENCES</name>
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        <name>SCHOLAR ROCK HOLDING CORP</name>
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        <name>Fidelity Revere Street Trust</name>
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        <name>AKERO THERAPEUTICS INC</name>
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        <name>ASCENDIS PHARMA A/S</name>
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        <name>ASTRIA THERAPEUTICS INC</name>
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        <title>ASTRIA THERAPEUTICS INC WT</title>
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        <name>CYTOMX THERAPEUTICS INC</name>
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        <title>CYTOMX THERAPEUTICS INC</title>
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      <invstOrSec>
        <name>CANDID THERAPEUTICS</name>
        <lei>N/A</lei>
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        <cusip>N/A</cusip>
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          <other otherDesc="Internal" value="KPC029000"/>
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        <fairValLevel>3</fairValLevel>
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      <invstOrSec>
        <name>EXACT SCIENCES CORP</name>
        <lei>549300VM3X1FYD4N9Z14</lei>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>ARCELLX INC</name>
        <lei>N/A</lei>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>STOKE THERAPEUTICS INC</name>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>DAY ONE BIOPHARMACEUTICALS INC</name>
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          <isin value="US23954D1090"/>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>UCB SA</name>
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          <isin value="BE0003739530"/>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>RHYTHM PHARMACEUTICALS INC</name>
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          <isin value="US76243J1051"/>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>RAPPORT THERAPEUTICS INC</name>
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        <fairValLevel>1</fairValLevel>
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        <name>ALNYLAM PHARMACEUTICALS INC</name>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>ZENAS BIOPHARMA INC</name>
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        <fairValLevel>1</fairValLevel>
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        <name>Fidelity Revere Street Trust</name>
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          <isin value="US31635A3032"/>
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        <fairValLevel>1</fairValLevel>
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        <name>IMMUNOVANT INC</name>
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        <fairValLevel>1</fairValLevel>
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        <name>KYMERA THERAPEUTICS INC</name>
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        <fairValLevel>1</fairValLevel>
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        <name>XENON PHARMACEUTICALS INC</name>
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        <fairValLevel>1</fairValLevel>
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        <name>WUGEN INC</name>
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        <name>BRIGHT PEAK THERAPEUTICS INC.</name>
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        <name>COGENT BIOSCIENCES INC</name>
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        <name>CG ONCOLOGY INC</name>
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        <name>INSMED INC</name>
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      <invstOrSec>
        <name>MAZE THERAPEUTICS INC</name>
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        <fairValLevel>1</fairValLevel>
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        <name>GILEAD SCIENCES INC</name>
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        <title>GILEAD SCIENCES INC</title>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>VIKING THERAPEUTICS INC</name>
        <lei>529900IVC72YPFA25M37</lei>
        <title>VIKING THERAPEUTICS INC</title>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="19016515.62000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>APOGEE THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>APOGEE THERAPEUTICS INC</title>
        <cusip>03770N101</cusip>
        <identifiers>
          <isin value="US03770N1019"/>
        </identifiers>
        <balance>472339.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>18071690.14000000</valUSD>
        <pctVal>1.291805782123</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>MERUS NV</name>
        <lei>549300W8GPUWU8QNU293</lei>
        <title>MERUS B.V.</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="NL0011606264"/>
        </identifiers>
        <balance>411509.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>27258356.16000000</valUSD>
        <pctVal>1.948489699961</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>NL</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="847872.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ENLIVEN THERAPEUTICS INC</name>
        <lei>N/A</lei>
        <title>ENLIVEN THERAPEUTICS INC PIPE</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="KGD809000"/>
        </identifiers>
        <balance>73200.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1376892.00000000</valUSD>
        <pctVal>0.098423392232</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>CIDARA THERAPEUTICS INC</name>
        <lei>549300IHQ9Z7RI1X2D22</lei>
        <title>CIDARA THERAPEUTICS INC</title>
        <cusip>171757206</cusip>
        <identifiers>
          <isin value="US1717572069"/>
        </identifiers>
        <balance>103900.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>6577909.00000000</valUSD>
        <pctVal>0.470203993907</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>CELLDEX THERAPEUTICS INC</name>
        <lei>529900F018DMYWH38923</lei>
        <title>CELLDEX THERAPEUTICS INC</title>
        <cusip>15117B202</cusip>
        <identifiers>
          <isin value="US15117B2025"/>
        </identifiers>
        <balance>468752.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>10303168.96000000</valUSD>
        <pctVal>0.736494103961</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>BRIGHT PEAK THERAPEUTICS INC.</name>
        <lei>N/A</lei>
        <title>BRIGHT PEAK THERAPEUTICS SER B PC PP</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal" value="HFH266000"/>
        </identifiers>
        <balance>1920122.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2937786.66000000</valUSD>
        <pctVal>0.209999715833</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EP</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>NUVALENT INC</name>
        <lei>N/A</lei>
        <title>NUVALENT INC-A</title>
        <cusip>670703107</cusip>
        <identifiers>
          <isin value="US6707031075"/>
        </identifiers>
        <balance>409298.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>32068498.30000000</valUSD>
        <pctVal>2.292329671825</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
    </invstOrSecs>
    <explntrNotes>
      <explntrNote note="As of March 2025, monthly returns presented in Item B.5.a. have been calculated without deducting any applicable sales loads or redemption fees." noteItem="B.5.a"/>
    </explntrNotes>
    <signature>
      <ncom:dateSigned>2025-08-30</ncom:dateSigned>
      <ncom:nameOfApplicant>Stacie M. Smith</ncom:nameOfApplicant>
      <ncom:signature>Stacie M. Smith</ncom:signature>
      <ncom:signerName>Stacie M. Smith</ncom:signerName>
      <ncom:title>President and Treasurer</ncom:title>
    </signature>
  </formData>
</edgarSubmission>
