X0306 4 2015-12-09 0 0000315545 PROVECTUS BIOPHARMACEUTICALS, INC. PVCT 0001281041 CULPEPPER PETER R 7327 OAK RIDGE HWY. SUITE A KNOXVILLE TN 37931 0 1 0 0 CFO & COO Common Stock 2015-12-09 4 M 0 138831 0.94 A 1251163 D Common Stock 2015-12-09 4 M 0 6383 0.94 A 190503 I By 401(k) Stock Option (right to buy) 0.75 2015-12-09 4 A 0 400000 0.00 A 2015-12-09 2025-12-09 Common Stock 400000 400000 D Stock Option (right to buy) 0.94 2015-12-09 4 M 0 145214 0.00 D 2006-12-09 2015-12-09 Common Stock 145214 0.00 D The option, representing a right to purchase a total of 175,000 shares, became exercisable in three equal installments beginning on December 9, 2006, which was the first anniversary of the date on which the option was granted. /s/ Peter R. Culpepper 2015-12-10