X0306 4 2016-12-28 1 0000315545 PROVECTUS BIOPHARMACEUTICALS, INC. PVCT 0001281041 CULPEPPER PETER R P.O. BOX 32429 KNOXVILLE TN 37930 0 0 0 1 Prior Interim CEO, CFO, COO Common Stock 1411829 D Common Stock 296503 I By 401(k) plan Share Option (Right to buy) 1.00 2010-07-22 2020-07-22 Common Stock 550000 550000 D Share Option (Right to buy) 0.93 2011-09-06 2021-09-06 Common Stock 550000 550000 D Share Option (Right to buy) 0.75 2015-12-09 2025-12-09 Common Stock 400000 400000 D Warrant (Right to buy) 0.85 2016-03-29 2020-06-19 Common Stock 266666 266666 D On December 28, 2016, the reporting person, Peter Culpepper, was terminated as an officer and an interim officer of Provectus Biopharmaceuticals, Inc. (the "Issuer"). This Form 4 serves as his exit filing. No acquisitions, dispositions or other transactions involving securities of the Issuer are being reported on this Form. /s/ Peter R. Culpepper 2017-01-09