X0306 4 2016-03-29 0 0000315545 PROVECTUS BIOPHARMACEUTICALS, INC. PVCT 0001550814 Koe Jan 1204 E. CENTRAL ROAD, SUITE 100 ARLINGTON HEIGHTS IL 60005 1 0 0 0 Common Stock 2016-03-29 4 O 0 100000 1.25 A 686300 D Common Stock 2016-03-29 4 O 0 100000 1.25 A 786300 D Common Stock 150000 I By Vekoe Partners LLC Common Stock Warrants (right to buy) 1.25 2016-03-29 4 O 0 100000 D 2012-06-28 2016-04-15 Common Stock 100000 0 D Common Stock Warrants (right to buy) 0.85 2016-03-29 4 O 0 100000 A 2016-03-29 2020-06-19 Common Stock 100000 100000 D Common Stock Warrants (right to buy) 1.25 2016-03-29 4 O 0 100000 D 2011-04-20 2016-04-20 Common Stock 100000 0 D Common Stock Warrants (right to buy) 0.85 2016-03-29 4 O 0 100000 A 2016-03-29 2020-06-19 Common Stock 100000 100000 D On March 29, 2016, the reporting person exercised an aggregate of 200,000 warrants pursuant to the Issuer's warrant exchange offer, at a discounted exercise price of $0.50 per share, which exercise consisted of: (i) an exercise of 100,000 shares pursuant to a warrant issued on June 28, 2012, with an original exercise price of $1.25 per share and (ii) an exercise of 100,000 shares pursuant to a warrant issued on September 20, 2013, with an original exercise price of $1.25 per share. Under the terms of the warrant exchange offer, holders received, in addition to the common stock acquired upon exercise of their existing warrants, an equal number of new warrants to purchase the same number of shares of the Issuer's common stock at an exercise price of $0.85 per share that will expire June 19, 2020. /s/ Jan E. Koe 2016-03-31