<SEC-DOCUMENT>0000315066-14-003602-index.html : 20140710
<SEC-HEADER>0000315066-14-003602.hdr.sgml : 20140710
<ACCEPTANCE-DATETIME>20140710121242
ACCESSION NUMBER:		0000315066-14-003602
CONFORMED SUBMISSION TYPE:	SC 13G/A
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20140710
DATE AS OF CHANGE:		20140710

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Karyopharm Therapeutics Inc.
		CENTRAL INDEX KEY:			0001503802
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				263931704
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13G/A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	005-87705
		FILM NUMBER:		14968848

	BUSINESS ADDRESS:	
		STREET 1:		2 MERCER ROAD
		CITY:			NATICK
		STATE:			MA
		ZIP:			01760
		BUSINESS PHONE:		508-975-4820

	MAIL ADDRESS:	
		STREET 1:		2 MERCER ROAD
		CITY:			NATICK
		STATE:			MA
		ZIP:			01760

FILED BY:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			FMR LLC
		CENTRAL INDEX KEY:			0000315066
		STANDARD INDUSTRIAL CLASSIFICATION:	UNKNOWN SIC - 0000 [0000]
		IRS NUMBER:				061209781
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13G/A

	BUSINESS ADDRESS:	
		STREET 1:		245 SUMMER STREET
		CITY:			BOSTON
		STATE:			MA
		ZIP:			02210
		BUSINESS PHONE:		6175706339

	MAIL ADDRESS:	
		STREET 1:		245 SUMMER STREET
		CITY:			BOSTON
		STATE:			MA
		ZIP:			02210

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	FMR CORP
		DATE OF NAME CHANGE:	19920717
</SEC-HEADER>
<DOCUMENT>
<TYPE>SC 13G/A
<SEQUENCE>1
<FILENAME>filing.txt
<TEXT>
Document 1 - file: filing.txt

</DOCUMENT>
</SEC-DOCUMENT>