Prudential National Muni Fund, Inc.

655 Broad Street
6th Floor
Newark, New Jersey 07102

November 2, 2022

VIA EDGAR

U.S. Securities and Exchange Commission
450 Fifth Street, N.W.
Washington, D.C. 20549

Re:

497(j) Filing for Prudential National Muni Fund, Inc.

Registration numbers 002-66407 and 811-02992

Dear Sir or Madam,

Pursuant to Rule 497(j) under the Securities Act of 1933, as amended, please accept this certification that the Prospectus and Statement of Additional Information for the above-referenced Registrant do not differ from that contained in Post-Effective Amendment No. 67 to the Registrant’s Registration Statement on Form N-1A, which was electronically filed with the Commission on October 27, 2022.

Thank you for your attention to this filing. Please direct any questions regarding this filing to the undersigned at (973) 716-6422.

Very truly yours,

/s/ Patrick McGuinness
Patrick McGuinness
Director & Corporate Counsel