Income Taxes Components of deferred tax asset/ liability (Details) - USD ($)	Dec. 31, 2015	Dec. 31, 2014
Deferred tax assets:
Net operating loss carry forwards	$ 83,522,000	$ 72,058,000
Tax credit carry forwards	18,940,000	26,571,000
Fixed and intangible assets	868,000	6,424,000
Capitalized research and development costs	58,000	58,000
Reserves and other cumulative temporary differences	3,828,000	15,535,000
Gross deferred income tax assets	107,216,000	120,646,000
Deferred tax liabilities:
Fixed and intangible assets	0	0
Gross deferred income tax liabilities	0	0
Valuation allowance	(107,216,000)	(120,646,000)
Net deferred income tax assets	$ 0	$ 0
Percentage of deferred tax assets on which valuation allowance is created		100.00%