Goodwill and Other Intangible Assets - Major Categories of Intangible Assets (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2018	Dec. 31, 2017	Dec. 31, 2016
Major categories of finite-lived intangible assets
Accumulated Amortization	$ (217,603)	$ (219,000)
Net Carrying Amount	280,576
Gross Carrying Amount	778,581
Impairment	276,002
Intangible assets, net	284,976	569,484
Impairment of intangible assets	231,086	128,127	$ 44,369
Product licensing rights
Major categories of finite-lived intangible assets
Gross Carrying Amount (2)	597,960
Accumulated Amortization	(203,323)
Reclassifications	5,300
Impairment	(131,306)
Net Carrying Amount	$ 268,631	402,340	564,005
Weighted Average Remaining Amortization Period (years)	9 years 1 month 6 days
Impairment of intangible assets	$ 88,492	103,530
Impairment of intangible assets, accumulated amortization	(42,800)
Trademarks
Major categories of finite-lived intangible assets
Gross Carrying Amount (2)	16,000
Accumulated Amortization	(6,304)
Reclassifications	0
Impairment	0
Net Carrying Amount	$ 9,696	10,624	11,756
Weighted Average Remaining Amortization Period (years)	17 years 6 months
Impairment of intangible assets	$ 0	0
Customer relationships
Major categories of finite-lived intangible assets
Gross Carrying Amount (2)	4,225
Accumulated Amortization	(2,318)
Reclassifications	0
Impairment	0
Net Carrying Amount	$ 1,907	2,167	2,427
Weighted Average Remaining Amortization Period (years)	7 years 3 months 19 days
Impairment of intangible assets	$ 0	0
Other intangibles
Major categories of finite-lived intangible assets
Gross Carrying Amount (2)	11,235
Accumulated Amortization	(5,658)
Reclassifications	0
Impairment	(5,235)
Net Carrying Amount	$ 342	5,192	6,909
Weighted Average Remaining Amortization Period (years)	3 months 19 days
Impairment of intangible assets	$ 3,133	0
Impairment of intangible assets, accumulated amortization	(2,100)
IPR&D
Major categories of indefinite-lived intangible assets
Gross Carrying Amount (2)	149,161
Reclassifications	(5,300)
Impairments	(139,461)
Net Carrying Amount	4,400	149,161	173,757
R&D expenses | Product licensing rights
Major categories of finite-lived intangible assets
Impairment of intangible assets	$ 91,600	$ 103,500	$ 40,500