Goodwill and Other Intangible Assets - Narrative (Details)	12 Months Ended
	Dec. 31, 2018 USD ($) product	Dec. 31, 2017 USD ($) product	Dec. 31, 2016 USD ($) product
Finite-Lived Intangible Assets [Line Items]
Accumulated amortization	$ 217,603,000	$ 219,000,000
Amortization of intangibles	53,472,000	61,443,000	$ 65,713,000
Impairment of intangible assets	231,086,000	128,127,000	$ 44,369,000
Impairments	$ 0	$ 0
IPR&D
Finite-Lived Intangible Assets [Line Items]
Number of IPR&D projects abandoned (in project) | product	18	3	1
Impairment of IPR&D projects	$ 139,461,000	$ 24,596,000
IPR&D | R&D expenses
Finite-Lived Intangible Assets [Line Items]
Impairment of IPR&D projects	$ 139,500,000	24,600,000	$ 3,900,000
Minimum
Finite-Lived Intangible Assets [Line Items]
Useful life	1 year
Maximum
Finite-Lived Intangible Assets [Line Items]
Useful life	30 years
Product licensing rights
Finite-Lived Intangible Assets [Line Items]
Accumulated amortization	$ 203,323,000
Amortization of intangibles	50,567,000	58,335,000
Impairment of intangible assets	$ 88,492,000	$ 103,530,000
Number of IPR&D projects abandoned (in project) | product	25	10	8
Product licensing rights | R&D expenses
Finite-Lived Intangible Assets [Line Items]
Impairment of intangible assets	$ 91,600,000	$ 103,500,000	$ 40,500,000