Goodwill and Other Intangible Assets - Major Categories of Intangible Assets (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2017	Dec. 31, 2016	Dec. 31, 2015
Major categories of finite-lived intangible assets
Accumulated Amortization	$ (219,026)	$ (195,300)
Net Carrying Amount	420,323
Gross Carrying Amount	952,323
Impairment	(163,813)
Intangible assets, net	569,484	758,854
Impairment of intangible assets	92,613	40,519	$ 30,376
IPR&D
Major categories of indefinite-lived intangible assets
Gross Carrying Amount	173,757
Reclassifications	0
Impairment - indefinite lived intangible assets	(24,596)	(3,850)
Net Carrying Amount	149,161	173,757	186,932
Product licensing rights
Major categories of finite-lived intangible assets
Gross Carrying Amount	747,106
Accumulated Amortization	(205,549)
Reclassifications	0
Impairment	(139,217)
Net Carrying Amount	$ 402,340	564,005	653,627
Weighted Average Remaining Amortization Period (years)	9 years 10 months 25 days
Impairment of intangible assets, accumulated amortization	$ 35,700
Impairment of intangible assets	103,530	40,519
Trademarks
Major categories of finite-lived intangible assets
Gross Carrying Amount	16,000
Accumulated Amortization	(5,376)
Reclassifications	0
Impairment	0
Net Carrying Amount	$ 10,624	11,756	13,018
Weighted Average Remaining Amortization Period (years)	17 years 9 months 18 days
Impairment of intangible assets	$ 0	0
Customer relationships
Major categories of finite-lived intangible assets
Gross Carrying Amount	4,225
Accumulated Amortization	(2,058)
Reclassifications	0
Impairment	0
Net Carrying Amount	$ 2,167	2,427	2,777
Weighted Average Remaining Amortization Period (years)	8 years 3 months 19 days
Impairment of intangible assets	$ 0	0
Other intangibles
Major categories of finite-lived intangible assets
Gross Carrying Amount	11,235
Accumulated Amortization	(6,043)
Reclassifications	0
Impairment	0
Net Carrying Amount	$ 5,192	6,909	$ 8,635
Weighted Average Remaining Amortization Period (years)	5 years 8 months 12 days
Impairment of intangible assets	$ 0	$ 0