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Segment Reporting - Sales from Products (Details) - USD ($)
$ in Millions
 3 Months Ended 6 Months Ended
Jun. 30, 2023
Jun. 30, 2022
Jun. 30, 2023
Jun. 30, 2022
Segment Reporting Information [Line Items]        
Sales $ 15,035 $ 14,593 $ 29,522 $ 30,494
Increase in hedge revenue     128 277
Revenue related to the sale of the marketing rights     54 146
U.S.        
Segment Reporting Information [Line Items]        
Sales 7,018 6,238 13,676 13,577
Int’l        
Segment Reporting Information [Line Items]        
Sales 8,018 8,355 15,846 16,917
Operating Segments        
Segment Reporting Information [Line Items]        
Sales 14,913 14,223 29,126 29,812
Operating Segments | U.S.        
Segment Reporting Information [Line Items]        
Sales 7,045 6,203 13,644 13,449
Operating Segments | Int’l        
Segment Reporting Information [Line Items]        
Sales 7,869 8,020 15,482 16,362
Corporate, Non-Segment        
Segment Reporting Information [Line Items]        
Sales 122 370 396 682
Corporate, Non-Segment | U.S.        
Segment Reporting Information [Line Items]        
Sales (27) 35 32 128
Corporate, Non-Segment | Int’l        
Segment Reporting Information [Line Items]        
Sales 149 335 364 555
Pharmaceutical | Operating Segments        
Segment Reporting Information [Line Items]        
Sales 13,457 12,756 26,179 26,863
Pharmaceutical | Operating Segments | U.S.        
Segment Reporting Information [Line Items]        
Sales 6,570 5,726 12,688 12,498
Pharmaceutical | Operating Segments | Int’l        
Segment Reporting Information [Line Items]        
Sales 6,887 7,030 13,491 14,364
Pharmaceutical | Operating Segments | Keytruda        
Segment Reporting Information [Line Items]        
Sales 6,271 5,252 12,065 10,061
Pharmaceutical | Operating Segments | Keytruda | U.S.        
Segment Reporting Information [Line Items]        
Sales 3,863 3,197 7,348 5,976
Pharmaceutical | Operating Segments | Keytruda | Int’l        
Segment Reporting Information [Line Items]        
Sales 2,408 2,055 4,718 4,085
Pharmaceutical | Operating Segments | Alliance revenue - Lynparza        
Segment Reporting Information [Line Items]        
Sales 310 275 585 541
Pharmaceutical | Operating Segments | Alliance revenue - Lynparza | U.S.        
Segment Reporting Information [Line Items]        
Sales 144 143 286 283
Pharmaceutical | Operating Segments | Alliance revenue - Lynparza | Int’l        
Segment Reporting Information [Line Items]        
Sales 166 132 299 257
Pharmaceutical | Operating Segments | Alliance revenue - Lenvima        
Segment Reporting Information [Line Items]        
Sales 242 231 474 459
Pharmaceutical | Operating Segments | Alliance revenue - Lenvima | U.S.        
Segment Reporting Information [Line Items]        
Sales 163 128 316 284
Pharmaceutical | Operating Segments | Alliance revenue - Lenvima | Int’l        
Segment Reporting Information [Line Items]        
Sales 79 103 158 175
Pharmaceutical | Operating Segments | Welireg        
Segment Reporting Information [Line Items]        
Sales 50 27 92 45
Pharmaceutical | Operating Segments | Welireg | U.S.        
Segment Reporting Information [Line Items]        
Sales 49 27 90 45
Pharmaceutical | Operating Segments | Welireg | Int’l        
Segment Reporting Information [Line Items]        
Sales 2 0 3 0
Pharmaceutical | Operating Segments | Alliance Revenue - Reblozyl        
Segment Reporting Information [Line Items]        
Sales 47 33 90 86
Pharmaceutical | Operating Segments | Alliance Revenue - Reblozyl | U.S.        
Segment Reporting Information [Line Items]        
Sales 36 28 66 55
Pharmaceutical | Operating Segments | Alliance Revenue - Reblozyl | Int’l        
Segment Reporting Information [Line Items]        
Sales 11 5 24 30
Pharmaceutical | Operating Segments | Gardasil/Gardasil 9        
Segment Reporting Information [Line Items]        
Sales 2,458 1,674 4,430 3,133
Pharmaceutical | Operating Segments | Gardasil/Gardasil 9 | U.S.        
Segment Reporting Information [Line Items]        
Sales 464 428 880 846
Pharmaceutical | Operating Segments | Gardasil/Gardasil 9 | Int’l        
Segment Reporting Information [Line Items]        
Sales 1,994 1,245 3,550 2,287
Pharmaceutical | Operating Segments | ProQuad/M-M-R II/Varivax        
Segment Reporting Information [Line Items]        
Sales 582 578 1,109 1,047
Pharmaceutical | Operating Segments | ProQuad/M-M-R II/Varivax | U.S.        
Segment Reporting Information [Line Items]        
Sales 447 434 868 805
Pharmaceutical | Operating Segments | ProQuad/M-M-R II/Varivax | Int’l        
Segment Reporting Information [Line Items]        
Sales 135 143 242 243
Pharmaceutical | Operating Segments | RotaTeq        
Segment Reporting Information [Line Items]        
Sales 131 173 428 389
Pharmaceutical | Operating Segments | RotaTeq | U.S.        
Segment Reporting Information [Line Items]        
Sales 93 98 273 273
Pharmaceutical | Operating Segments | RotaTeq | Int’l        
Segment Reporting Information [Line Items]        
Sales 37 75 155 116
Pharmaceutical | Operating Segments | Vaxneuvance        
Segment Reporting Information [Line Items]        
Sales 168 12 274 16
Pharmaceutical | Operating Segments | Vaxneuvance | U.S.        
Segment Reporting Information [Line Items]        
Sales 147 11 241 16
Pharmaceutical | Operating Segments | Vaxneuvance | Int’l        
Segment Reporting Information [Line Items]        
Sales 20 0 33 1
Pharmaceutical | Operating Segments | Pneumovax 23        
Segment Reporting Information [Line Items]        
Sales 92 153 188 325
Pharmaceutical | Operating Segments | Pneumovax 23 | U.S.        
Segment Reporting Information [Line Items]        
Sales 23 94 63 212
Pharmaceutical | Operating Segments | Pneumovax 23 | Int’l        
Segment Reporting Information [Line Items]        
Sales 69 59 125 114
Pharmaceutical | Operating Segments | Vaqta        
Segment Reporting Information [Line Items]        
Sales 42 35 82 71
Pharmaceutical | Operating Segments | Vaqta | U.S.        
Segment Reporting Information [Line Items]        
Sales 29 16 59 45
Pharmaceutical | Operating Segments | Vaqta | Int’l        
Segment Reporting Information [Line Items]        
Sales 13 19 23 25
Pharmaceutical | Operating Segments | Bridion        
Segment Reporting Information [Line Items]        
Sales 502 426 989 821
Pharmaceutical | Operating Segments | Bridion | U.S.        
Segment Reporting Information [Line Items]        
Sales 299 237 576 432
Pharmaceutical | Operating Segments | Bridion | Int’l        
Segment Reporting Information [Line Items]        
Sales 203 190 413 389
Pharmaceutical | Operating Segments | Prevymis        
Segment Reporting Information [Line Items]        
Sales 143 103 273 197
Pharmaceutical | Operating Segments | Prevymis | U.S.        
Segment Reporting Information [Line Items]        
Sales 61 47 116 87
Pharmaceutical | Operating Segments | Prevymis | Int’l        
Segment Reporting Information [Line Items]        
Sales 82 56 157 110
Pharmaceutical | Operating Segments | Dificid        
Segment Reporting Information [Line Items]        
Sales 76 66 141 119
Pharmaceutical | Operating Segments | Dificid | U.S.        
Segment Reporting Information [Line Items]        
Sales 68 63 130 113
Pharmaceutical | Operating Segments | Dificid | Int’l        
Segment Reporting Information [Line Items]        
Sales 8 3 11 6
Pharmaceutical | Operating Segments | Primaxin        
Segment Reporting Information [Line Items]        
Sales 53 64 133 122
Pharmaceutical | Operating Segments | Primaxin | U.S.        
Segment Reporting Information [Line Items]        
Sales (2) 0 2 1
Pharmaceutical | Operating Segments | Primaxin | Int’l        
Segment Reporting Information [Line Items]        
Sales 56 64 132 122
Pharmaceutical | Operating Segments | Noxafil        
Segment Reporting Information [Line Items]        
Sales 55 60 116 118
Pharmaceutical | Operating Segments | Noxafil | U.S.        
Segment Reporting Information [Line Items]        
Sales 11 16 25 25
Pharmaceutical | Operating Segments | Noxafil | Int’l        
Segment Reporting Information [Line Items]        
Sales 45 45 91 92
Pharmaceutical | Operating Segments | Zerbaxa        
Segment Reporting Information [Line Items]        
Sales 54 46 104 76
Pharmaceutical | Operating Segments | Zerbaxa | U.S.        
Segment Reporting Information [Line Items]        
Sales 30 22 57 40
Pharmaceutical | Operating Segments | Zerbaxa | Int’l        
Segment Reporting Information [Line Items]        
Sales 24 24 47 36
Pharmaceutical | Operating Segments | Alliance revenue - Adempas/Verquvo        
Segment Reporting Information [Line Items]        
Sales 68 98 167 170
Pharmaceutical | Operating Segments | Alliance revenue - Adempas/Verquvo | U.S.        
Segment Reporting Information [Line Items]        
Sales 70 88 153 159
Pharmaceutical | Operating Segments | Alliance revenue - Adempas/Verquvo | Int’l        
Segment Reporting Information [Line Items]        
Sales (2) 10 14 11
Pharmaceutical | Operating Segments | Adempas        
Segment Reporting Information [Line Items]        
Sales 65 63 125 124
Pharmaceutical | Operating Segments | Adempas | U.S.        
Segment Reporting Information [Line Items]        
Sales 0 0 0 0
Pharmaceutical | Operating Segments | Adempas | Int’l        
Segment Reporting Information [Line Items]        
Sales 65 63 125 124
Pharmaceutical | Operating Segments | Lagevrio        
Segment Reporting Information [Line Items]        
Sales 203 1,177 595 4,424
Pharmaceutical | Operating Segments | Lagevrio | U.S.        
Segment Reporting Information [Line Items]        
Sales 2 0 0 1,523
Pharmaceutical | Operating Segments | Lagevrio | Int’l        
Segment Reporting Information [Line Items]        
Sales 201 1,177 595 2,901
Pharmaceutical | Operating Segments | Isentress/Isentress HD        
Segment Reporting Information [Line Items]        
Sales 136 147 259 305
Pharmaceutical | Operating Segments | Isentress/Isentress HD | U.S.        
Segment Reporting Information [Line Items]        
Sales 56 67 108 128
Pharmaceutical | Operating Segments | Isentress/Isentress HD | Int’l        
Segment Reporting Information [Line Items]        
Sales 80 80 151 177
Pharmaceutical | Operating Segments | Belsomra        
Segment Reporting Information [Line Items]        
Sales 63 69 119 137
Pharmaceutical | Operating Segments | Belsomra | U.S.        
Segment Reporting Information [Line Items]        
Sales 21 19 37 39
Pharmaceutical | Operating Segments | Belsomra | Int’l        
Segment Reporting Information [Line Items]        
Sales 42 50 82 98
Pharmaceutical | Operating Segments | Simponi        
Segment Reporting Information [Line Items]        
Sales 180 181 359 366
Pharmaceutical | Operating Segments | Simponi | U.S.        
Segment Reporting Information [Line Items]        
Sales 0 0 0 0
Pharmaceutical | Operating Segments | Simponi | Int’l        
Segment Reporting Information [Line Items]        
Sales 180 181 359 366
Pharmaceutical | Operating Segments | Remicade        
Segment Reporting Information [Line Items]        
Sales 48 53 99 114
Pharmaceutical | Operating Segments | Remicade | U.S.        
Segment Reporting Information [Line Items]        
Sales 0 0 0 0
Pharmaceutical | Operating Segments | Remicade | Int’l        
Segment Reporting Information [Line Items]        
Sales 48 53 99 114
Pharmaceutical | Operating Segments | Januvia        
Segment Reporting Information [Line Items]        
Sales 511 756 1,062 1,535
Pharmaceutical | Operating Segments | Januvia | U.S.        
Segment Reporting Information [Line Items]        
Sales 243 301 514 626
Pharmaceutical | Operating Segments | Januvia | Int’l        
Segment Reporting Information [Line Items]        
Sales 267 455 548 909
Pharmaceutical | Operating Segments | Janumet        
Segment Reporting Information [Line Items]        
Sales 354 476 683 931
Pharmaceutical | Operating Segments | Janumet | U.S.        
Segment Reporting Information [Line Items]        
Sales 82 105 138 168
Pharmaceutical | Operating Segments | Janumet | Int’l        
Segment Reporting Information [Line Items]        
Sales 272 371 544 762
Pharmaceutical | Operating Segments | Other pharmaceutical        
Segment Reporting Information [Line Items]        
Sales 553 528 1,138 1,131
Pharmaceutical | Operating Segments | Other pharmaceutical | U.S.        
Segment Reporting Information [Line Items]        
Sales 171 157 342 317
Pharmaceutical | Operating Segments | Other pharmaceutical | Int’l        
Segment Reporting Information [Line Items]        
Sales 382 372 793 814
Animal Health | Operating Segments        
Segment Reporting Information [Line Items]        
Sales 1,456 1,467 2,947 2,949
Animal Health | Operating Segments | U.S.        
Segment Reporting Information [Line Items]        
Sales 475 477 956 951
Animal Health | Operating Segments | Int’l        
Segment Reporting Information [Line Items]        
Sales 982 990 1,991 1,998
Animal Health | Operating Segments | Livestock        
Segment Reporting Information [Line Items]        
Sales 807 826 1,656 1,658
Animal Health | Operating Segments | Livestock | U.S.        
Segment Reporting Information [Line Items]        
Sales 165 164 338 335
Animal Health | Operating Segments | Livestock | Int’l        
Segment Reporting Information [Line Items]        
Sales 643 662 1,318 1,322
Animal Health | Operating Segments | Companion Animal        
Segment Reporting Information [Line Items]        
Sales 649 641 1,291 1,291
Animal Health | Operating Segments | Companion Animal | U.S.        
Segment Reporting Information [Line Items]        
Sales 310 313 618 616
Animal Health | Operating Segments | Companion Animal | Int’l        
Segment Reporting Information [Line Items]        
Sales $ 339 $ 328 $ 673 $ 676