Taxes on Income - Reconciliation Between Effective Tax Rate and US Statutory Rate (Details) - USD ($) $ in Millions	12 Months Ended
Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020
Amount
U.S. statutory rate applied to income from continuing operations before taxes	$ 3,453	$ 2,915	$ 1,231
Differential arising from:
Foreign earnings	(1,835)	(1,446)	(965)
GILTI and the foreign-derived intangible income deduction	462	(75)	349
State taxes	(110)	2	57
R&D tax credit	(81)	(81)	(108)
Tax settlements	(10)	(275)	(13)
Valuation allowances	108	102	37
Restructuring	11	61	105
Acquisition of VelosBio	0	(9)	559
Acquisition of Pandion	0	356	0
Acquisition of OncoImmune	0	0	97
Other	(80)	(29)	(9)
Taxes on income	$ 1,918	$ 1,521	$ 1,340
Tax Rate
U.S. statutory rate applied to income from continuing operations before taxes	21.00%	21.00%	21.00%
Differential arising from:
Foreign earnings	(11.10%)	(10.40%)	(16.50%)
GILTI and the foreign-derived intangible income deduction	2.80%	(0.50%)	6.00%
State taxes	(0.70%)	0.00%	1.00%
R&D tax credit	(0.50%)	(0.60%)	(1.80%)
Tax settlements	(0.10%)	(2.00%)	(0.20%)
Valuation allowances	0.70%	0.70%	0.60%
Restructuring	0.10%	0.40%	1.80%
Acquisition of VelosBio	0.00%	(0.10%)	9.50%
Acquisition of Pandion	0.00%	2.60%	0.00%
Acquisition of OncoImmune	0.00%	0.00%	1.70%
Other	(0.50%)	(0.10%)	(0.20%)
Total, Tax Rate	11.70%	11.00%	22.90%

Effective Income Tax Rate Reconciliation, Asset Acquisition, Percent

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