X0306 4 2016-08-05 0000310158 Merck & Co., Inc. MRK 0001181175 FRAZIER KENNETH C MERCK & CO., INC. 2000 GALLOPING HILL ROAD KENILWORTH NJ 07033 1 1 Chairman, President & CEO Common Stock 2016-08-05 4 M 0 252000.0000 44.3000 A 760877.0630 D Common Stock 2016-08-05 4 M 0 140000.0000 23.4500 A 900877.0630 D Common Stock 2016-08-05 4 S 0 19048.0000 62.0759 D 881829.0630 D Common Stock 2016-08-05 4 S 0 140000.0000 62.2400 D 741829.0630 D Common Stock 2016-08-05 4 S 0 232952.0000 61.5366 D 508877.0630 D Common Stock - 401(k) Plan 3725.9791 I By 401(k) Stock Option (right to buy) 44.3000 2016-08-05 4 M 0 252000.0000 0.0000 D 2009-02-28 2018-02-28 Common Stock 252000.0000 0.0000 D Stock Option (right to buy) 23.4500 2016-08-05 4 M 0 140000.0000 0.0000 D 2010-04-24 2019-04-23 Common Stock 140000.0000 140000.0000 D The exercise and sale transactions reported in this Form 4 are made pursuant to a Rule 10b5-1 trading plan. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $62.0100 to $62.3800, inclusive. The reporting person undertakes to provide to Merck & Co., Inc., any security holder of Merck & Co., Inc., or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth above in this footnote. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $61.3000 to $61.9200, inclusive. The reporting person undertakes to provide to Merck & Co., Inc., any security holder of Merck & Co., Inc., or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth above in this footnote. Holdings include shares acquired in dividend reinvestment transactions. Includes shares acquired and dividends earned through July 8, 2016, in the Merck U.S. Savings Plan, a 401(k) plan. The option became exercisable in equal installments on 2/28/2009, 2/28/2010 and 2/28/2011. The option became exercisable in equal installments on 4/24/2010, 4/24/2011 and 4/24/2012. Katie Fedosz as Attorney-in-Fact for Kenneth C. Frazier 2016-08-05