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Income Taxes - Variation Between Expected and Effective Tax Rate (Details)
12 Months Ended
Dec. 31, 2020
Dec. 31, 2019
Dec. 31, 2018
Income Tax Disclosure [Abstract]      
Statutory federal income tax rate 21.00% 21.00% 21.00%
State income taxes (net of federal benefit) 4.60% 3.60% 5.30%
Foreign derived intangible income deduction (0.004) (0.012) 0
Stock-based compensation expense (1.40%) (2.10%) (1.90%)
Research and development tax credits (13.80%) (7.80%) (32.00%)
Other tax credits (0.30%) 0.00% (1.20%)
Changes in valuation allowance (0.40%) (1.60%) 0.70%
Non-deductible book expenses 3.60% 3.90% 8.20%
Changes in deferred tax assets (0.20%) (2.20%) 12.10%
Changes in tax reserves (4.60%) 1.20% 1.20%
Other 0.70% (0.80%) (1.40%)
Effective income tax rate 8.80% 14.00% 12.00%
Tax credit, percent (3.40%)