&RPHULFD,QFRUSRUDWHG )LUVW4XDUWHU )LQDQFLDO5HYLHZ $SULO 6DIH+DUERU6WDWHPHQW Any statements in this presentation that are not historical facts are forward-looking statements as defined in the Private Securities Litigation Reform Act of 1995. Words such as “anticipates,” “believes,” “contemplates,” “feels,” “expects,” “estimates,” “seeks,” “strives,” “plans,” “intends,” “outlook,” “forecast,” “position,” “target,” “mission,” “assume,” “achievable,” “potential,” “strategy,” “goal,” “aspiration,” “opportunity,” “initiative,” “outcome,” “continue,” “remain,” “maintain,” “on track,” “trend,” “objective,” “looks forward,” “projects,” “models” and variations of such words and similar expressions, or future or conditional verbs such as “will,” “would,” “should,” “could,” “might,” “can,” “may” or similar expressions, as they relate to Comerica or its management, are intended to identify forward-looking statements. These forward-looking statements are predicated on the beliefs and assumptions of Comerica's management based on information known to Comerica's management as of the date of this presentation and do not purport to speak as of any other date. Forward-looking statements may include descriptions of plans and objectives of Comerica's management for future or past operations, products or services, and forecasts of Comerica's revenue, earnings or other measures of economic performance, including statements of profitability, business segments and subsidiaries as well as estimates of credit trends and global stability. Such statements reflect the view of Comerica's management as of this date with respect to future events and are subject to risks and uncertainties. Should one or more of these risks materialize or should underlying beliefs or assumptions prove incorrect, Comerica's actual results could differ materially from those discussed. Factors that could cause or contribute to such differences are changes in general economic, political or industry conditions; changes in monetary and fiscal policies; operational, systems or infrastructure failures; reliance on other companies to provide certain key components of business infrastructure; cybersecurity risks; whether Comerica may achieve opportunities for revenue enhancements and efficiency improvements under the GEAR Up initiative, or changes in the scope or assumptions underlying the GEAR Up initiative; Comerica's ability to maintain adequate sources of funding and liquidity; the effects of more stringent capital requirements; declines or other changes in the businesses or industries of Comerica's customers; unfavorable developments concerning credit quality; changes in regulation or oversight; heightened legislative and regulatory focus on cybersecurity and data privacy; fluctuations in interest rates and their impact on deposit pricing; transitions away from LIBOR towards new interest rate benchmarks; reductions in Comerica's credit rating; damage to Comerica's reputation; Comerica's ability to utilize technology to efficiently and effectively develop, market and deliver new products and services; competitive product and pricing pressures among financial institutions within Comerica's markets; the interdependence of financial service companies; the implementation of Comerica's strategies and business initiatives; changes in customer behavior; management's ability to maintain and expand customer relationships; the effectiveness of methods of reducing risk exposures; the effects of catastrophic events including, but not limited to, hurricanes, tornadoes, earthquakes, fires, droughts and floods; the impacts of future legislative, administrative or judicial changes to tax regulations; any future strategic acquisitions or divestitures; management's ability to retain key officers and employees; the impact of legal and regulatory proceedings or determinations; losses due to fraud; the effects of terrorist activities and other hostilities; changes in accounting standards; the critical nature of Comerica's accounting policies; controls and procedures failures; and the volatility of Comerica’s stock price. Comerica cautions that the foregoing list of factors is not all-inclusive. For discussion of factors that may cause actual results to differ from expectations, please refer to our filings with the Securities and Exchange Commission. In particular, please refer to “Item 1A. Risk Factors” beginning on page 12 of Comerica's Annual Report on Form 10-K for the year ended December 31, 2018. Forward-looking statements speak only as of the date they are made. Comerica does not undertake to update forward-looking statements to reflect facts, circumstances, assumptions or events that occur after the date the forward-looking statements are made. For any forward-looking statements made in this presentation or in any documents, Comerica claims the protection of the safe harbor for forward-looking statements contained in the Private Securities Litigation Reform Act of 1995. 2

)LQDQFLDO6XPPDU\ LQPLOOLRQVH[FHSWSHUVKDUHGDWD 4 4 4 (DUQLQJVSHUVKDUH $2.11 $1.88 $1.59 $GMXVWHGHDUQLQJVSHUVKDUH 2.08 1.95 1.54 1HWLQWHUHVWLQFRPH 606 614 549 3URYLVLRQIRUFUHGLWORVVHV (13) 16 12 1RQLQWHUHVWLQFRPH 238 250 244 $GMXVWHGQRQLQWHUHVWLQFRPH 246 250 244 1RQLQWHUHVWH[SHQVHV 433 448 446 $GMXVWHGQRQLQWHUHVWH[SHQVHV 433 434 430 3URYLVLRQIRULQFRPHWD[HV 85 90 54 $GMXVWHGSURYLVLRQIRULQFRPHWD[HV 98 93 80 1HWLQFRPH 339 310 281 $GMXVWHGQHWLQFRPH 334 321 271 52( 18.44% 16.36% 14.37% 52$ 1.97 1.74 1.62 (IILFLHQF\5DWLR 51% 52% 56% 1Diluted earnings per common share Ⴠ 2See Reconciliation of Non-GAAP Financial Measures slide Ⴠ 3Includes gain/(loss) related to deferred compensation plan as follows: $2MM in 1Q19; $(7)MM in 4Q18; $1MM in 1Q18. Amounts offset in noninterest expense. Ⴠ 41Q19 adj. excludes $8MM loss related to repositioning of securities portfolio Ⴠ 5Return on average common shareholders’ equity Ⴠ 6Return on average assets Ⴠ 7Noninterest expenses as a percentage of net interest income & noninterest income excluding net gains (losses) from securities & derivative contract tied to the conversion rate of Visa Class B shares 3 5HFRQFLOLDWLRQRI$GMXVWHG1HW,QFRPH 4 4 4 3HU 3HU 3HU LQPLOOLRQVH[FHSWSHUVKDUHGDWD  6KDUH  6KDUH  6KDUH 1HWLQFRPH $339 $2.11 $310 $1.88 $281 $1.59 6HFXULWLHVUHSRVLWLRQLQJ 6 0.04 - - - - 5HVWUXFWXULQJFKDUJHV - - 11 0.07 12 0.07 'LVFUHWHWD[LWHPV (11) (0.07) - - (22) (0.12) $GMXVWHGQHWLQFRPH $334 $2.08 $321 $1.95 $271 $1.54 4DGMXVWPHQWV • 7D[SURYLVLRQUHGXFHGE\00LQGLVFUHWHWD[EHQHILWVIURP HPSOR\HHVWRFNWUDQVDFWLRQV • 3URYLGHGRSSRUWXQLW\WRUHSRVLWLRQ%RIORZHU\LHOGLQJWUHDVXU\ VHFXULWLHVUHVXOWLQJLQDQPLOOLRQSUHWD[ORVV7KLVDFWLRQZLOO LQFUHDVHLQWHUHVWUHYHQXHE\f00SHUTXDUWHU 1Based on diluted average common shares Ⴠ 2Net of tax Ⴠ See Reconciliation of Non-GAAP Financial Measures slide 4

)LUVW4XDUWHU5HVXOWV Expense discipline, strong credit & capital management drove ROE over 18% .H\4R43HUIRUPDQFH'ULYHUV &KDQJH)URP LQPLOOLRQVH[FHSWSHUVKDUHGDWD 4 4 4 ƒ %URDGEDVHGORDQJURZWK RYHUFDPHWUDGLWLRQDOVHDVRQDOLW\ $YHUDJHORDQV $49,677 $845 $1,256 ƒ 'HSRVLWVVKRZHGW\SLFDO4GHFOLQH $YHUDJHGHSRVLWV 53,996 (1,733) (2,094) ƒ 1HWLQWHUHVWLQFRPHDLGHGE\UDWH 1HWLQWHUHVWLQFRPH $606 $(8) $57 LQFUHDVH ORDQJURZWKPRUHWKDQ RIIVHWE\IHZHUGD\V ORZHU 3URYLVLRQIRUFUHGLWORVVHV (13) (29) (25) EDODQFHVDW)HG 1HWLQWHUHVW PDUJLQXSESV 1RQLQWHUHVWLQFRPH 238 (12) (6) ƒ 6WURQJFUHGLWTXDOLW\FRQWLQXHG $GMXVWHG1RQLQWHUHVWLQFRPH 246 (4) 2 ƒ $GMXVWHGQRQLQWHUHVW LQFRPH 1RQLQWHUHVWH[SHQVHV 433 (15) (13) GHFUHDVHGIURPVWURQJ4 $GMXVWHG1RQLQWHUHVWH[SHQVH 433 (1) 3 ƒ $GMXVWHGH[SHQVHVUHODWLYHO\VWDEOH ZLWKDQQXDOVWRFNFRPSRIIVHWE\ 3URYLVLRQIRULQFRPHWD[ 85 (5) 31 UHGXFWLRQLQVHYHUDOFDWHJRULHV 1HWLQFRPH 339 29 58 ƒ 4GLVFUHWHWD[EHQHILWVRI 00UHODWHGWRHPSOR\HHVWRFN (DUQLQJVSHUVKDUH $2.11 $0.23 $0.52 WUDQVDFWLRQV  $GMXVWHG(DUQLQJVSHUVKDUH 2.08 0.13 0.54 ƒ 5HSXUFKDVHG00VKDUHV 159,518 (3,983) (15,626) UHWXUQHG00WRVKDUHKROGHUV $YHUDJHGLOXWHGVKDUHV WKURXJKEX\EDFN GLYLGHQG 1Q19 compared to 4Q18 Ⴠ 11Q19 included $8MM loss related to repositioning of securities portfolio Ⴠ 2Includes gain/(loss) related to deferred compensation plan as follows: $2MM in 1Q19; $(7)MM in 4Q18; $1MM in 1Q18. Amounts offset in noninterest expense Ɣ 3See Reconciliation of Non-GAAP Financial Measures slide Ⴠ 4Diluted earnings per common share Ⴠ 51Q19 repurchases under the share repurchase program 5 $YHUDJH/RDQV Loans increase 1.7%; Loan yields increase 17 basis points with higher rates 7RWDO/RDQV $YHUDJHORDQVLQFUHDVH00 LQELOOLRQV Loan Yields 001DWLRQDO'HDOHU6HUYLFHV 50.2 50.3 49.7 00(QHUJ\ 49.2 48.8 48.4 48.6 00*HQHUDO0LGGOH0DUNHW 00(TXLW\)XQGV6HUYLFHV 00&RPPHUFLDO5HDO(VWDWH 0086%DQNLQJ 5.07 4.90  000RUWJDJH%DQNHU 4.74 4.63 4.26 /RDQ&RPPLWPHQWV LQELOOLRQV 3HULRGHQG 51.8 53.1 52.9 49.6 51.1 1Q18 2Q18 3Q18 4Q18 1Q19 4Q18 1Q19 $YHUDJH%DODQFHV 3HULRGHQG 1Q18 2Q18 3Q18 4Q18 1Q19 1Q19 compared to 4Q18 6

$YHUDJH'HSRVLWV Reflects seasonality 7RWDO'HSRVLWV $YHUDJHGHSRVLWV LQELOOLRQV ƒ 1RQLQWHUHVWEHDULQJGHFOLQH% Deposit Rates1 ƒ ,QWHUHVWEHDULQJVWDEOH ƒ 0DUFKGHSRVLWVJUHZ%RYHU)HEUXDU\ 56.1 55.8 56.1 55.7 55.6 54.0 54.1 3HULRGHQGGHSRVLWVGHFUHDVH%  %JRYHUQPHQWSUHSDLGFDUGWLPLQJ /RDQWRGHSRVLWUDWLR RI 'HSRVLW6HDVRQDOLW\ LQELOOLRQV$YHUDJH Avg. QoQ deposit growth (since 2015) 1Q19/4Q18 0.78 1.3% 1.3% 0.62 0.51 0.42 -3.1% -0.3% 0.25 -3.1% 1Q18 2Q18 3Q18 4Q18 1Q19 4Q18 1Q19 $YHUDJH%DODQFHV 3HULRGHQG Q1/Q4 Q2/Q1 Q3/Q2 Q4/Q3 1Q19 compared to 4Q18 Ⴠ 1Interest costs on interest-bearing deposits Ⴠ 2At 3/31/19 7 6HFXULWLHV3RUWIROLR Yields increase 4 basis points 6HFXULWLHV3RUWIROLR 'XUDWLRQRI\HDUV LQELOOLRQV Treasury Securities & Other ƒ ([WHQGVWR \HDUVXQGHUDESV Mortgage-backed Securities (MBS) LQVWDQWDQHRXVUDWHLQFUHDVH Securities Yields 1HWXQUHDOL]HGSUHWD[ORVVRI00 12.0 12.0 12.2 11.9 11.8 11.8 11.8 1HWXQDPRUWL]HGSUHPLXPRI00 <LHOGVEHQHILWWHGIURPW\SLFDOTXDUWHUO\ SD\GRZQRI00 00EHLQJ 9.5 9.2 9.1 9.1 9.1 9.2 9.3 UHSODFHGDWKLJKHU\LHOG 5HSRVLWLRQHG%7UHDVXULHV 2.39 2.35 ƒ $YHUDJH\LHOGZLOOLQFUHDVHf00SHUTXDUWHU 2.17 2.09 2.12 • RQVHFXULWLHVVROG • RQVHFXULWLHVSXUFKDVHG ƒ \HDUGXUDWLRQRQVHFXULWLHVSXUFKDVHG 1Q18 2Q18 3Q18 4Q18 1Q19 4Q18 1Q19 $YHUDJH%DODQFHV 3HULRGHQG 3/31/19 Ɣ 1Estimated as of 3/31/19 Ɣ 2Net unrealized pre-tax gain/loss on the available-for-sale (AFS) portfolio Ɣ 3Net unamortized premium on the MBS portfolio 8

1HW,QWHUHVW,QFRPH NIM increased 9 basis points 1HW,QWHUHVW,QFRPH $614MM 4Q18 3.70% LQPLOOLRQV NIM 614 + 17MM Loans + 0.14 599 606 590 +$21MM Higher rates +0.13 549 + 10MM Higher balances +0.02 - 12MM 2 fewer days -- - 2MM Mix shift -0.01 + 1MM Securities + 0.01 +0.01 3.79 + 1MM Higher rates 3.70 - 12MM Balances at Fed + 0.05 3.62 3.60 + 1MM Higher rates +0.01 3.41 - 12MM Lower balances +0.04 - 1MM 2 fewer days -- - 9MM Deposits - 0.07 - 10MM Higher rates -0.07 + 1MM 2 fewer days -- - 5MM Wholesale funding - 0.04 - 2MM Higher rates -0.02 1Q18 2Q18 3Q18 4Q18 1Q19 - 3MM Higher balances -0.02 1HW,PSDFWGXHWRUDWHV $606MM 1Q19 3.79% 00 ESVRQWKH1,0 1Q19 compared to 4Q18 9 &UHGLW4XDOLW\6WURQJ Allowance for loan losses remained strong at 1.29% $OORZDQFHIRU&UHGLW/RVVHV  LQPLOOLRQV ƒ 00LQQHWFKDUJHRIIV RUESV Allowance for Loan Losses as a % of Total Loans ƒ 00GHFUHDVHLQQRQDFFUXDOORDQVWR 738 711 697 701 677 00RUESVRIWRWDOORDQV ƒ 6XVWDLQHGVWURQJSRUWIROLRSHUIRUPDQFH  1.42 1.36 1.35 1.34 VROLGHFRQRPLFFRQGLWLRQVUHVXOWHGLQ 1.29 UHVHUYHUHOHDVH ƒ 5HPDLQYLJLODQWQRWVHHLQJDQ\FRQFHUQLQJ WUHQGV 1Q18 2Q18 3Q18 4Q18 1Q19 &ULWLFL]HG/RDQV $OORZDQFHIRU/RDQ/RVVHV7RWDO13/V LQPLOOLRQV NALsNAL CriticizedCiti i d as a % off TotalTtl LLoans 3.3 x 2,120 2.8 x 2.9 x 2.6 x 1,765 1,806 1,670 1,548 2.1 x 4.3 3.6 3.5 3.4 3.1 326 254 230 221 191 1Q18 2Q18 3Q18 4Q18 1Q19 1Q18 2Q18 3Q18 4Q18 1Q19 3/31/19 Ɣ1Criticized loans are consistent with regulatory defined Special Mention, Substandard, & Doubtful categories Ɣ 2Net credit-related charge-offs 10

1RQLQWHUHVW,QFRPH Reflects strong 4Q18 that included seasonality 1RQLQWHUHVW,QFRPH LQPLOOLRQV Securities losses due to repositioning 254 250 1RQLQWHUHVWLQFRPH GHFUHDVHG00 244 248 246 H[FOXGLQJ006HFXULWLHVORVVHV 20 8 238 234  00)LGXFLDU\LQFRPH  00VHDVRQDOGHFOLQHVLQVHYHUDOFDWHJRULHV 1Q18 2Q18 3Q18 4Q18 1Q19 1Q19 compared to 4Q18 Ɣ 1See Reconciliation of Non-GAAP Financial Measures slide 11 1RQLQWHUHVW([SHQVH Careful cost management drives efficiency ratio1 to 51% 1RQLQWHUHVW([SHQVHV LQPLOOLRQV Restructuring Efficiency Ratio 1RQLQWHUHVWH[SHQVHVWDEOH H[FOXGLQJ004UHVWUXFWXULQJH[SHQVH 446 448 452 448 006DODULHV EHQHILWV 12 433 $QQXDOVWRFNFRPS KLJKHUSD\UROOWD[HV 16 11 14 440  /RZHUH[HFXWLYHLQFHQWLYHV 437 434 433 430  7ZRIHZHUGD\VLQ4  00/HJDO4UHFRYHULHV  003HQVLRQFRVWV  00(TXLSPHQW VRIWZDUH 56%  00$GYHUWLVLQJVHDVRQDO 53% 53% 52%  002XWVLGHSURFHVVLQJVHDVRQDO 51%  002FFXSDQF\VHDVRQDO 1Q18 2Q18 3Q18 4Q18 1Q19 1Q19 compared to 4Q18 Ⴠ 1Noninterest expenses as a percentage of net interest income & noninterest income excluding net gains (losses) from securities & a derivative contract tied to the conversion rate of Visa Class B shares Ɣ 2See Reconciliation of Non-GAAP 3 Financial Measures slide Ɣ Included in other noninterest expenses 12

$FWLYH&DSLWDO0DQDJHPHQW Capital Target 9.5% - 10.0% CET1 by FYE191 5HWXUQHG00WRVKDUHKROGHUV 6KDUHKROGHU3D\RXW ƒ 00VKDUHVUHSXUFKDVHG00 LQPLOOLRQV ƒ ,QFUHDVHGGLYLGHQGWRSHUVKDUH Equity Repurchases Dividends 600 599 (PSOR\HHVWRFNDFWLYLW\ 530 ƒ 100 99 fVKDUHVLVVXHG 105 500 500 $FWLYHO\PDQDJHFDSLWDOJLYLQJFDUHIXO 425 201 227 FRQVLGHUDWLRQWR 52 58 ƒ (DUQLQJVJHQHUDWLRQ 149 169 ƒ &DSLWDOQHHGVLHORDQJURZWK ƒ 0DUNHWFRQGLWLRQV 1Q18 2Q18 3Q18 4Q18 1Q19 6WURQJ&DSLWDO*HQHUDWLRQ&(7 'LYLGHQGV3HU6KDUH*URZWK ,QSHUFHQWDJHSRLQWV 11.98 11.89 11.68 11.14 0.67 10.78 0.60 0.60 0.30 0.34 1Q18 2Q18 3Q18 4Q18 1Q19 3 1Q18 2Q18 3Q18 4Q18 1Q19 3/31/19 Ⴠ 1Outlook as of 4/16/19 Ⴠ 2Shares repurchased under share repurchase program Ⴠ 3Estimated 13 0DQDJHPHQW2XWORRNIRU)< $VVXPLQJFRQWLQXDWLRQRIFXUUHQWHFRQRPLF UDWHHQYLURQPHQW $YHUDJH • *URZWKLQPRVWEXVLQHVVOLQHV  /RDQV • 0DLQWDLQSULFLQJ XQGHUZULWLQJGLVFLSOLQH $YHUDJH • &XVWRPHUVbHIILFLHQWPDQDJHPHQWRIFDVKGULYLQJDGHFOLQHLQQRQLQWHUHVWEHDULQJGHSRVLWV  'HSRVLWV • &RQWLQXHGIRFXVRQUHODWLRQVKLSDSSURDFKWRDWWUDFWDQGUHWDLQFXVWRPHUV 1HW,QWHUHVW • 8SGDWHG WRLQFOXGHGHSRVLWSULFLQJDGMXVWPHQWV ORZHUWKDQH[SHFWHG/,%25PRYHPHQW  • 1HWEHQHILWIURPKLJKHUUDWHVORDQJURZWK VHFXULWLHVSRUWIROLRUHSRVLWLRQLQJ ,QFRPH • +HDGZLQGVKLJKHUZKROHVDOHIXQGLQJGHSRVLWPL[VKLIW ORZHUQRQDFFUXDOUHFRYHULHV • 8SGDWHG IRUEHWWHUWKDQH[SHFWHG4UHVXOWV 3URYLVLRQ ESV • 6WURQJFUHGLWTXDOLW\FRQWLQXHV1HWFKDUJHRIIVWRUHPDLQORZ 1RQLQWHUHVW • 8SGDWHG WRLQFOXGHVHFXULWLHVORVVLQ400  • ,QFUHDVHVLQFDUGDQGILGXFLDU\IHHV ,QFRPH • 3DUWO\RIIVHWE\ORZHUGHULYDWLYHV GHSRVLWVHUYLFHFKDUJHV 1RQLQWHUHVW • 6WDEOHH[FOXGLQJ)<00LQUHVWUXFWXULQJH[SHQVHV  • /RZHUFRPSHQVDWLRQLQFHQWLYHVSDUWO\RIIVHWE\PHULWSHQVLRQ )',&H[SHQVH00 ([SHQVHV • 5LVHLQRXWVLGHSURFHVVLQJWLHGWRUHYHQXHWHFKQRORJ\FRVWV LQIODWLRQDU\SUHVVXUHV • ([FOXGHVLPSDFWIURPHPSOR\HHVWRFNWUDQVDFWLRQV 7D[5DWH f • )<LQFOXGHG00LQGLVFUHWHEHQHILWV &DSLWDO • 5HDFKWDUJHWE\)<(WKURXJKFRQWLQXHGUHWXUQRIH[FHVVFDSLWDODWDPHDVXUHGSDFH  • 6WURQJSHUIRUPDQFH H[FHVVFDSLWDOGULYHEX\EDFNZKLFKLVDVLJQLILFDQWFRQWULEXWRUWR 0DQDJHPHQW &(77DUJHW LQFUHDVLQJHDUQLQJVSHUVKDUH Outlook as of 4/16/19 Ⴠ FY19 outlook compared to FY18 actual results based on GAAP reported amounts 14

$SSHQGL[ $YHUDJH/RDQVE\%XVLQHVVDQG0DUNHW %\/LQHRI%XVLQHVV 4 4 4 %\0DUNHW 4 4 4 Middle Market Michigan $12.6 $12.5 $12.6 General $12.0 $11.7 $11.8 Energy 2.3 2.0 1.9 California 18.8 18.3 18.3 National Dealer Services 7.8 7.4 7.3 Entertainment 0.8 0.8 0.7 Texas 10.3 9.9 9.8 Tech. & Life Sciences 1.3 1.4 1.4 Other Markets1 8.1 8.2 7.6 Equity Fund Services 2.6 2.5 2.1 Environmental Services 1.2 1.2 1.0 TOTAL $49.7 $48.8 $48.4 Total Middle Market $28.0 $27.0 $26.2 Corporate Banking US Banking 3.0 2.9 3.2 International 1.3 1.3 1.3 ƒ 0LGGOH0DUNHW6HUYLQJFRPSDQLHVZLWK Commercial Real Estate 5.3 5.2 5.3 UHYHQXHVJHQHUDOO\EHWZHHQ00 Mortgage Banker Finance 1.3 1.7 1.4 ƒ &RUSRUDWH%DQNLQJ6HUYLQJFRPSDQLHV Small Business 3.5 3.6 3.7 DQGWKHLU86EDVHGVXEVLGLDULHVZLWK BUSINESS BANK $42.5 $41.7 $41.1 UHYHQXHVJHQHUDOO\RYHU00 Retail Banking 2.1 2.1 2.1 ƒ 6PDOO%XVLQHVV6HUYLQJFRPSDQLHVZLWK RETAIL BANK $2.1 $2.1 $2.1 UHYHQXHVJHQHUDOO\XQGHU00 Private Banking 5.0 5.0 5.2 WEALTH MANAGEMENT $5.0 $5.0 $5.2 TOTAL $49.7 $48.8 $48.4 $ in billions Ⴠ Totals shown above may not foot due to rounding Ⴠ 1Other Markets includes Florida, Arizona, the International Finance Division and businesses that have a significant presence outside of the three primary geographic markets 16

$YHUDJH'HSRVLWVE\%XVLQHVVDQG0DUNHW %\/LQHRI%XVLQHVV 4 4 4 %\0DUNHW 4 4 4 Middle Market Michigan $19.9 $20.2 $21.2 General $13.3 $13.7 $14.0 Energy 0.5 0.5 0.6 California 16.2 17.2 17.1 National Dealer Services 0.3 0.3 0.3 Texas 8.7 8.9 9.2 Entertainment 0.1 0.1 0.1 1 Tech. & Life Sciences 5.0 5.2 5.0 Other Markets 7.9 8.3 7.7 Equity Fund Services 0.8 0.9 0.9 Finance/Other2 1.3 1.1 0.9 Environmental Services 0.2 0.1 0.2 TOTAL $54.0 $55.7 $56.1 Total Middle Market $20.1 $20.9 $21.1 Corporate Banking US Banking 1.8 2.0 2.0 International 1.6 1.8 2.0 ƒ Commercial Real Estate 1.5 1.5 1.6 0LGGOH0DUNHW6HUYLQJFRPSDQLHVZLWK UHYHQXHVJHQHUDOO\EHWZHHQ00 Mortgage Banker Finance 0.6 0.6 0.6 Small Business 2.9 3.1 3.2 ƒ &RUSRUDWH%DQNLQJ6HUYLQJFRPSDQLHV DQGWKHLU86EDVHGVXEVLGLDULHVZLWK BUSINESS BANK $28.5 $30.0 $30.5 UHYHQXHVJHQHUDOO\RYHU00 Retail Banking 20.5 20.6 20.9 ƒ RETAIL BANK $20.5 $20.6 $20.9 6PDOO%XVLQHVV6HUYLQJFRPSDQLHVZLWK UHYHQXHVJHQHUDOO\XQGHU00 Private Banking 3.5 3.8 3.6 WEALTH MANAGEMENT $3.8 $4.1 $3.8 Finance/Other2 1.3 1.1 0.9 TOTAL $54.0 $55.7 $56.1 $ in billions Ⴠ Totals shown above may not foot due to rounding Ⴠ 1Other Markets includes Florida, Arizona, the International Finance Division and businesses that have a significant presence outside of the three primary geographic markets Ⴠ 2Finance/Other includes items not directly associated with the geographic markets or the three major business segments 17 ,QWHUHVW5DWH6HQVLWLYLW\ 0.10.1 6WDQGDUG0RGHO$VVXPSWLRQV (VWLPDWHG1HW,QWHUHVW,QFRPH $QQXDOPRQWK6HQVLWLYLWLHV ESVJUDGXDO %DVHGRQ9DULRXV$VVXPSWLRQV ,QWHUHVW5DWHV QRQSDUDOOHOULVH $GGLWLRQDO6FHQDULRVDUH5HODWLYHWR46WDQGDUG0RGHO LQPLOOLRQV /RDQ%DODQFHV 0RGHVWLQFUHDVH 'HSRVLW %DODQFHV 0RGHUDWHGHFUHDVH ~130 ~135 'HSRVLW3ULFLQJ +LVWRULFDOSULFH ~100 PRYHPHQWVZLWKVKRUW ~75 %HWD WHUPUDWHV ~50 +HOGIODWZLWK 6HFXULWLHV3RUWIROLR SUHSD\PHQWUHLQYHVWPHQW /RDQ6SUHDGV +HOGDWFXUUHQWOHYHOV 7KLUGSDUW\SURMHFWLRQV 0%63UHSD\PHQWV DQGKLVWRULFDOH[SHULHQFH ~(65) 1R DGGLWLRQV +HGJLQJ 6ZDSV Down 50 Up 100 bps Addl. $2B Addl. 20% Standard Addl. ~3% PRGHOHG bps Deposit Increase in Model Loan Decline Beta Growth 3/31/19 Ⴠ For methodology see the Company’s Form 10-K, as filed with the SEC. Estimates are based on simulation modeling analysis. 18

+HGJLQJ3URJUDP Gradually layer in interest rate swaps /RDQV3UHGRPLQDQWO\)ORDWLQJ5DWH +HGJLQJ2YHUYLHZ LQELOOLRQV4 3HULRGHQG 3XUSRVH 5HGXFHLPSDFWZKHQUDWHVGHFOLQHLQ Fixed Rate RUGHUWRPDLQWDLQVWHDG\PDUJLQDVUDWHVPRYH 8% WKURXJKW\SLFDOF\FOH Prime- Total 30-Day based 7RROV 2YHUWLPHJUDGXDOO\OD\HULQLQWHUHVWUDWH $50.3 LIBOR 16% 67% VZDSVSD\IORDWLQJUHFHLYHIL[HGZLWKYDULRXV 60-Day+ WHQRUV &ROODUVRUIORRUVZLOODOVREHFRQVLGHUHG LIBOR 9% )LQDQFLDOLPSDFW'HSHQGVRQVZDSUDWHV  VKRUWWHUPUDWHV&XUUHQWPDUNHWFRQGLWLRQV 'HSRVLWV3ULPDULO\1RQLQWHUHVWEHDULQJ LQGLFDWHWKDWWKHQHDUWHUPHIIHFWRQQHW LQELOOLRQV4$YHUDJH LQWHUHVWLQFRPHLVH[SHFWHGWREHQRPLQDO • &RPPHUFLDORIQRQLQWHUHVWEHDULQJ • 5HWDLORILQWHUHVWEHDULQJ 4$FWLYLW\ ƒ Retail Commercial 00SD\IORDWLQJUHFHLYHIL[HGKHGJHV Noninterest- Noninterest- • \HDUDYHUDJHWHUP bearing bearing • DYHUDJHIL[HGUDWH 8% Total 42% 4$FWLYLW\WKUX Retail $54.0 Commercial ƒ 00SD\IORDWLQJUHFHLYHIL[HGKHGJHV Interest- Interest- • bearing bearing \HDUDYHUDJHWHUP 29% 21% • DYHUDJHIL[HGUDWH 3/31/19 19 &RPPHUFLDO5HDO(VWDWH/LQHRI%XVLQHVV Long history of working with well established, proven developers &5(E\3URSHUW\7\SH &5(E\0DUNHW LQPLOOLRQV3HULRGHQG LQPLOOLRQV3HULRGHQGEDVHGRQORFDWLRQRISURSHUW\ Single Office Family Multi use Michigan Commercial 7% 7% 3% 5% 9% Land Carry 5% Other Retail 14% 11% Other Total 6% Total California $4,627 $4,627 46% Texas Multifamily 35% 52% &UHGLW4XDOLW\ &5(E\/RDQ7\SH LQPLOOLRQV3HULRGHQG 4 4 4 LQPLOOLRQV3HULRGHQG 4 4 &ULWLFL]HG $64 $84 $84 5HDO(VWDWH &RQVWUXFWLRQ $2,687 53% $2,888 53% 5DWLR 1.2% 1.7% 1.5% &RPPHUFLDO0RUWJDJHV 1,743 34% 1,739 32% 1RQDFFUXDO $3 $2 $2 $4,430 87% $4,627 85% 5DWLR 0.06% 0.04% 0.04% &RPPHUFLDO 2WKHU 661 13% 788 15% 1HWFKDUJHRIIV UHFRYHULHV -0- -0- -0- 7RWDO $5,091 100% $5,415 100% 3/31/19 Ⴠ 1Excludes CRE line of business loans not secured by real estate Ⴠ 2Criticized loans are consistent with regulatory defined Special Mention, Substandard & Doubtful categories 20

(QHUJ\/LQHRI%XVLQHVV Nonaccrual loans continue to decline ƒ 5HPDLQFRPPLWWHGWRVXSSRUWLQJFXVWRPHUV (QHUJ\/LQHRI%XVLQHVV/RDQV LQPLOOLRQV3HULRGHQG ƒ )RFXVRQIXOOUHODWLRQVKLSVZLWKODUJHU VRSKLVWLFDWHG( 3FRPSDQLHVDFFHVVWRD Midstream Services Exploration & Production YDULHW\RIFDSLWDOVRXUFHVKHGJLQJ GLYHUVH 2,385 JHRJUDSKLFIRRWSULQW 2,163 ƒ /RDQJURZWKGULYHQE\KLJKHUERUURZLQJ EDVHVIURPVWURQJGULOOLQJUHVXOWV  FRQWLQXHGFDSH[ 1,848 1,832 Mixed 1,734 ƒ 5REXVWDQDO\VLVRIFROODWHUDO18% 1,857 (QHUJ\/LQHRI%XVLQHVV  1,771 468 &ULWLFL]HG/RDQV 1,395 LQPLOOLRQVLQPLOOLRQV 1,400 1,499 NALs 319 269 240 205 75 152 94 91 100 453 301 243 233 298 102 60 53 48 33 1Q18 2Q18 3Q18 4Q18 1Q19 1Q18 2Q18 3Q18 4Q18 1Q19 3/31/19 Ɣ 1Criticized loans are consistent with regulatory defined Special Mention, Substandard & Doubtful categories 21 0RUWJDJH%DQNHU)LQDQFH 50+ years experience with reputation for consistent, reliable approach $YHUDJH/RDQV ƒ 3URYLGHZDUHKRXVHILQDQFLQJEULGJHIURP LQPLOOLRQV UHVLGHQWLDOPRUWJDJHRULJLQDWLRQWRVDOHWR Actual MBA Mortgage Origination Volumes 1,2 HQGPDUNHW ƒ ([WHQVLYHEDFNURRPSURYLGHVFROODWHUDO 2,544 2,352 2,145 2,136 2,089 1,974 PRQLWRULQJDQGFXVWRPHUVHUYLFH 1,961 1,861 1,784 1,780 1,742 1,677 1,674 1,450 1,435 1,399 ƒ )RFXVRQIXOOEDQNLQJUHODWLRQVKLSV 1,335 ƒ *UDQXODUSRUWIROLRZLWKfUHODWLRQVKLSV ƒ 8QGHUO\LQJPRUWJDJHVDUHW\SLFDOO\UHODWHG 1Q15 2Q15 3Q15 4Q15 1Q16 2Q16 3Q16 4Q16 1Q17 2Q17 3Q17 4Q17 1Q18 2Q18 3Q18 4Q18 1Q19 WRKRPHSXUFKDVHVDVRSSRVHGWR 0%$0RUWJDJH2ULJLQDWLRQV)RUHFDVW UHILQDQFHV LQELOOLRQV $VRI4 Purchase Refinance • &RPHULFDSXUFKDVH 478 460 •  396 ,QGXVWU\SXUFKDVH 325 338 ƒ 6WURQJFUHGLWTXDOLW\ • 1RFKDUJHRIIVVLQFH ƒ 3HULRGHQGORDQV% 1Q19 2Q19 3Q19 4Q19 1Q20 3/31/19 Ɣ 1Source: Mortgage Bankers Association (MBA) Mortgage Finance Forecast as of 3/21/19; 1Q19 estimated Ɣ 2$ in billions 22

1DWLRQDO'HDOHU6HUYLFHV 65+ years of floor plan lending )UDQFKLVH'LVWULEXWLRQ ƒ 7RSWLHUVWUDWHJ\ %DVHGRQSHULRGHQGORDQRXWVWDQGLQJV Honda/Acura ƒ )RFXVRQn0HJD'HDOHU|ILYHRUPRUH 16% GHDOHUVKLSVLQJURXS Toyota/Lexus Ford ƒ 6WURQJFUHGLWTXDOLW\ 14% 9% ƒ 5REXVWPRQLWRULQJRIFRPSDQ\LQYHQWRU\ DQGSHUIRUPDQFH GM 8% Other 1 Total 10% $7.9B Fiat/Chrysler $YHUDJH/RDQV 11% LQELOOLRQV Floor Plan Mercedes 7.8 7.4 7.4 3% 7.3 7.1 7.1 Other Asian 7.0 6.9 6.8 6.6 6.5 6.3 6.2 6.2 12% 6.0 6.0 Nissan/ Infiniti 5.9 Other European 5% 12% *HRJUDSKLF'LVSHUVLRQ 4.5 4.3 4.3 4.2 4.1 4.1 4.1 4.0 4.0 3.9 3.8 3.8 3.8 3.7 3.6 3.5 California 58% Texas 7% 3.5 Michigan 23% Other 12% 1Q15 2Q15 3Q15 4Q15 1Q16 2Q16 3Q16 4Q16 1Q17 2Q17 3Q17 4Q17 1Q18 2Q18 3Q18 4Q18 1Q19 3/31/19 Ɣ 1Other includes obligations where a primary franchise is indeterminable (rental car and leasing companies, heavy truck, recreational vehicles, and non-floor plan loans) 23 7HFKQRORJ\DQG/LIH6FLHQFHV (TXLW\)XQG6HUYLFHV Deep expertise & strong relationships with top-tier investors 7HFKQRORJ\ /LIH6FLHQFHV$YJ/RDQV (TXLW\)XQG6HUYLFHV LQPLOOLRQV LQPLOOLRQV 22,632 632 2,432 25792,579 2,539 1,437 1,416 1,396 1,353 1,323 2,074 1Q18 2Q18 3Q18 4Q18 1Q19 1Q18 2Q18 3Q18 4Q18 1Q19 ƒ fFXVWRPHUV ƒ fFXVWRPHUV ƒ 0DQDJHFRQFHQWUDWLRQWRQXPHURXVYHUWLFDOV ƒ &RPPHUFLDOEDQNLQJVHUYLFHVIRUYHQWXUH WRHQVXUHZLGHO\GLYHUVLILHGSRUWIROLR FDSLWDO SULYDWHHTXLW\ILUPV ƒ &ORVHO\PRQLWRUFDVKEDODQFHV PDLQWDLQ UREXVWEDFNURRPRSHUDWLRQ ƒ %ULGJHILQDQFLQJIRUFDSLWDOFDOOV ƒ RIILFHVWKURXJKRXW86 &DQDGD ƒ 6WURQJFUHGLWSURILOH Customer Segment ~45% ~25% ~20% ~10% Overview 1 Growth Late Stage Early Stage Leveraged Finance 3/31/19 Ɣ 1Based on 1Q19 period-end loans totaling $1.3B 24

26 d enhances comparability of results with prior periods. periods. prior with results of comparability enhances d an operations ongoing of understanding greater a provides ation ation present this in and above shown data adjusted the believes ca Comeri trends. performance our evaluate to analysts and regulators made by management, investors, investors, management, by made commonly adjustments reflect they because meaningful are measures non-GAAP believes Comerica Cuts and Jobs Act. Jobs and Cuts dutdpoiinfricm ae 9 9 $80 $93 $98 taxes income for provision Adjusted erred taxes resulting from the Tax Tax the from resulting taxes erred def adjust to charge the and transactions iceetxies1 22 — 11 items tax Discrete uded the tax benefit from employee stock stock employee from benefit tax the uded incl primarily items tax Discrete • a nrsrcuigcags—34 3 — charges restructuring on Tax a nscrte eoiinn — — 2 repositioning securities on Tax milar duration of 4 years. 4 of duration milar si a with treasuries yielding rvso o noeTxs 8 9 $54 $90 $85 Taxes: Income for Provision rities that were replaced by higher- by replaced were that rities secu treasury of billion $1 approximately Provision for Income Taxes: Income for Provision Securities repositioning refers to losses incurred on the sale of of sale the on incurred losses to refers repositioning Securities • dutdpetxicm 42$1 $351 $414 $432 income pre-tax Adjusted etutrn hre 416 14 — charges Restructuring dutddltderig e omnsae$.8$.5$1.54 $1.95 $2.08 share common per earnings diluted Adjusted euiisrpstoig8—— — 8 repositioning Securities iceetxies(.7 (0.12) — (0.07) items tax Discrete r-a noe$2 40$335 $400 $424 income Pre-tax etutrn hre,nto a .70.07 0.07 — tax of net charges, Restructuring Pre-tax Income: Pre-tax euiisrpstoig e ftx00 — — 0.04 tax of net repositioning, Securities dutdnnneetepne 43$3 $430 $434 $433 expenses noninterest Adjusted iue annsprcmo hr 21 18 $1.59 $1.88 $2.11 share common per earnings Diluted etutrn hre 1)(16) (14) — charges Restructuring Diluted Earnings per Common Share: Common per Earnings Diluted oitrs xess$3 48$446 $448 $433 expenses Noninterest dutdnticm 34$2 $271 $321 $334 income net Adjusted Noninterest Expenses: Noninterest iceetxies(1 (22) — (11) items tax Discrete dutdnnneeticm 26$5 $244 $250 $246 income noninterest Adjusted etutrn hre,nto a 112 11 — tax of net charges, Restructuring euiisrpstoig e ftx6—— — 6 tax of net repositioning, Securities euiisrpstoig8—— — 8 repositioning Securities e noe 39$1 $281 $310 $339 income Net oitrs noe$3 20$244 $250 $238 income Noninterest Net Income: Net Noninterest Income: Noninterest (dollar amounts in millions, except per share data) share per except millions, in amounts (dollar Q941 1Q18 4Q18 1Q19 (dollar amounts in millions, except per share data) share per except millions, in amounts (dollar Q941 1Q18 4Q18 1Q19 5HFRQFLOLDWLRQRI1RQ*$$3)LQDQFLDO0HDVXUHV 25 Ⴠ Ⴠ to buy, sell, or hold securities hold or sell, buy, to recommendation a not are Ratings Debt Intelligence Market Global S&P Source: 4/10/19 of As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bV 6HQLRU8QVHFXUHG/RQJ7HUP,VVXHU5DWLQJ +ROGLQJ&RPSDQ\'HEW5DWLQJ