X0101 EFFECT 33 LIVE 2011-05-04 0000950123-11-044300 485APOS 0000277751 JANUS INVESTMENT FUND 002-34393 S000031892 Janus Protected Series - Growth C000099318 Class A S000031892 Janus Protected Series - Growth C000099319 Class C S000031892 Janus Protected Series - Growth C000099320 Class D S000031892 Janus Protected Series - Growth C000099321 Class I S000031892 Janus Protected Series - Growth C000099322 Class S S000031892 Janus Protected Series - Growth C000099323 Class T