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value="Sedol"/></identifiers><balance>179153</balance><units>NS</units><curCd>USD</curCd><valUSD>79595886</valUSD><pctVal>1.641</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Apellis Pharmaceuticals Inc</name><lei>254900HS0ZFRXXSB9D42</lei><title>Apellis Pharmaceuticals Inc</title><cusip>03753U106</cusip><identifiers><isin value="US03753U1060"/><ticker value="APLS US"/><other otherDesc="BYTQ6X1" value="Sedol"/></identifiers><balance>364923</balance><units>NS</units><curCd>USD</curCd><valUSD>33244485</valUSD><pctVal>0.685</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Arcellx Inc</name><lei>N/A</lei><title>Arcellx Inc</title><cusip>03940C100</cusip><identifiers><isin value="US03940C1009"/><ticker value="ACLX US"/><other otherDesc="BPCJ1Q2" value="Sedol"/></identifiers><balance>487797</balance><units>NS</units><curCd>USD</curCd><valUSD>15424141</valUSD><pctVal>0.318</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Ardelyx Inc</name><lei>549300F542QR4SXHCY32</lei><title>Ardelyx, Inc.</title><cusip>039697107</cusip><identifiers><isin value="US0396971071"/><ticker value="ARDX US"/><other otherDesc="BN89V40" value="Sedol"/></identifiers><balance>4902617</balance><units>NS</units><curCd>USD</curCd><valUSD>16619872</valUSD><pctVal>0.343</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Baxter International Inc</name><lei>J5OIVXX3P24RJRW5CK77</lei><title>Baxter International Inc</title><cusip>071813109</cusip><identifiers><isin value="US0718131099"/><ticker value="BAX US"/><other otherDesc="2085102" value="Sedol"/></identifiers><balance>766508</balance><units>NS</units><curCd>USD</curCd><valUSD>34922104</valUSD><pctVal>0.72</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>BioMarin Pharmaceutical Inc</name><lei>NSLL8ITTRR0J5HEMR848</lei><title>BioMarin Pharmaceutical Inc</title><cusip>09061G101</cusip><identifiers><isin value="US09061G1013"/><ticker value="BMRN US"/><other otherDesc="2437071" value="Sedol"/></identifiers><balance>571792</balance><units>NS</units><curCd>USD</curCd><valUSD>49562931</valUSD><pctVal>1.022</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Biomea Fusion Inc</name><lei>N/A</lei><title>Biomea Fusion Inc</title><cusip>09077A106</cusip><identifiers><isin value="US09077A1060"/><ticker value="BMEA US"/><other otherDesc="BNKF6N0" value="Sedol"/></identifiers><balance>859270</balance><units>NS</units><curCd>USD</curCd><valUSD>18860977</valUSD><pctVal>0.389</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><loanByFundCondition isLoanByFund="Y" loanVal="13552683.66"/></securityLending></invstOrSec><invstOrSec><name>AstraZeneca PLC</name><lei>PY6ZZQWO2IZFZC3IOL08</lei><title>AstraZeneca PLC</title><cusip>G0593M107</cusip><identifiers><isin value="GB0009895292"/><ticker value="AZN LN"/><other otherDesc="989529" value="Sedol"/></identifiers><balance>1426133</balance><units>NS</units><currencyConditional curCd="GBP" exchangeRt="0.78753"/><valUSD>204196357</valUSD><pctVal>4.21</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>GB</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Boston Scientific Corp</name><lei>Y6ZDD9FP4P8JSSJMW954</lei><title>Boston Scientific Corp</title><cusip>101137107</cusip><identifiers><isin value="US1011371077"/><ticker value="BSX US"/><other otherDesc="2113434" value="Sedol"/></identifiers><balance>2060729</balance><units>NS</units><curCd>USD</curCd><valUSD>111464832</valUSD><pctVal>2.298</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Bristol-Myers Squibb Co</name><lei>HLYYNH7UQUORYSJQCN42</lei><title>Bristol-Myers Squibb Co</title><cusip>110122108</cusip><identifiers><isin value="US1101221083"/><ticker value="BMY US"/><other otherDesc="2126335" value="Sedol"/></identifiers><balance>969026</balance><units>NS</units><curCd>USD</curCd><valUSD>61969213</valUSD><pctVal>1.278</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Catalent Inc</name><lei>N/A</lei><title>Catalent Inc</title><cusip>148806102</cusip><identifiers><isin value="US1488061029"/><ticker value="CTLT US"/><other otherDesc="BP96PQ4" value="Sedol"/></identifiers><balance>593024</balance><units>NS</units><curCd>USD</curCd><valUSD>25713521</valUSD><pctVal>0.53</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Centene Corp</name><lei>549300Z7JJ4TQSQGT333</lei><title>Centene Corp</title><cusip>15135B101</cusip><identifiers><isin value="US15135B1017"/><ticker value="CNC US"/><other otherDesc="2807061" value="Sedol"/></identifiers><balance>973546</balance><units>NS</units><curCd>USD</curCd><valUSD>65665678</valUSD><pctVal>1.354</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Cerevel Therapeutics Holdings</name><lei>254900RJNIRS9COSQR41</lei><title>Cerevel Therapeutics Holdings Inc COM</title><cusip>15678U128</cusip><identifiers><isin value="US15678U1280"/><ticker value="CERE US"/><other otherDesc="BMVMJ12" value="Sedol"/></identifiers><balance>396675</balance><units>NS</units><curCd>USD</curCd><valUSD>12610298</valUSD><pctVal>0.26</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Collegium Pharmaceutical Inc</name><lei>54930049FXZMTLW8D496</lei><title>Collegium Pharmaceutical Inc</title><cusip>19459J104</cusip><identifiers><isin value="US19459J1043"/><ticker value="COLL US"/><other otherDesc="BX7RSN3" value="Sedol"/></identifiers><balance>502437</balance><units>NS</units><curCd>USD</curCd><valUSD>10797371</valUSD><pctVal>0.223</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Cooper Cos Inc/The</name><lei>QJKMVPIGLH7530PCUE20</lei><title>Cooper Cos Inc</title><cusip>216648402</cusip><identifiers><isin value="US2166484020"/><ticker value="COO US"/><other otherDesc="2222631" value="Sedol"/></identifiers><balance>125527</balance><units>NS</units><curCd>USD</curCd><valUSD>48130818</valUSD><pctVal>0.992</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>CymaBay Therapeutics Inc.</name><lei>549300YT9GNL852E7F84</lei><title>CymaBay Therapeutics Inc</title><cusip>23257D103</cusip><identifiers><isin value="US23257D1037"/><ticker value="CBAY"/><other otherDesc="BJ3WDH3" value="Sedol"/></identifiers><balance>1663467</balance><units>NS</units><curCd>USD</curCd><valUSD>18214964</valUSD><pctVal>0.376</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Cytokinetics Inc</name><lei>549300BE5DY1HW7IHA64</lei><title>Cytokinetics Inc</title><cusip>23282W605</cusip><identifiers><isin value="US23282W6057"/><ticker value="CYTK"/><other otherDesc="BBBSBJ5" value="Sedol"/></identifiers><balance>699791</balance><units>NS</units><curCd>USD</curCd><valUSD>22827182</valUSD><pctVal>0.471</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>DICE Therapeutics Inc</name><lei>N/A</lei><title>DICE Therapeutics Inc</title><cusip>23345J104</cusip><identifiers><isin value="US23345J1043"/><ticker value="DICE US"/><other otherDesc="BNRPLC7" value="Sedol"/></identifiers><balance>42021</balance><units>NS</units><curCd>USD</curCd><valUSD>1952296</valUSD><pctVal>0.04</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Danaher Corp</name><lei>S4BKK9OTCEWQ3YHPFM11</lei><title>Danaher Corp</title><cusip>235851102</cusip><identifiers><isin value="US2358511028"/><ticker value="DHR US"/><other otherDesc="2250870" value="Sedol"/></identifiers><balance>412709</balance><units>NS</units><curCd>USD</curCd><valUSD>99050160</valUSD><pctVal>2.042</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>DENTSPLY SIRONA Inc</name><lei>9NHEHR1SOZCYXDO8HO28</lei><title>DENTSPLY SIRONA Inc</title><cusip>24906P109</cusip><identifiers><isin value="US24906P1093"/><ticker value="XRAY US"/><other otherDesc="BYNPPC6" value="Sedol"/></identifiers><balance>590359</balance><units>NS</units><curCd>USD</curCd><valUSD>23626167</valUSD><pctVal>0.487</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Design Therapeutics Inc</name><lei>N/A</lei><title>Design Therapeutics Inc</title><cusip>25056L103</cusip><identifiers><isin value="US25056L1035"/><ticker value="DSGN US"/><other otherDesc="BMFK3H6" value="Sedol"/></identifiers><balance>390858</balance><units>NS</units><curCd>USD</curCd><valUSD>2462405</valUSD><pctVal>0.051</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Dexcom Inc</name><lei>549300YSK3QDSFR5EU59</lei><title>DexCom Inc</title><cusip>252131107</cusip><identifiers><isin value="US2521311074"/><ticker value="DXCM US"/><other otherDesc="B0796X4" value="Sedol"/></identifiers><balance>371145</balance><units>NS</units><curCd>USD</curCd><valUSD>47695844</valUSD><pctVal>0.983</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Edwards Lifesciences Corp</name><lei>YA13X31F3V31L8TMPR58</lei><title>Edwards Lifesciences Corp</title><cusip>28176E108</cusip><identifiers><isin value="US28176E1082"/><ticker value="EW US"/><other otherDesc="2567116" value="Sedol"/></identifiers><balance>561963</balance><units>NS</units><curCd>USD</curCd><valUSD>53009970</valUSD><pctVal>1.093</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>89bio Inc.</name><lei>N/A</lei><title>89bio Inc</title><cusip>282559103</cusip><identifiers><isin value="US2825591033"/><ticker value="ETNB"/><other otherDesc="BK1K484" value="Sedol"/></identifiers><balance>963407</balance><units>NS</units><curCd>USD</curCd><valUSD>18256563</valUSD><pctVal>0.376</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><loanByFundCondition isLoanByFund="Y" loanVal="12803674.6"/></securityLending></invstOrSec><invstOrSec><name>FLAME BIOSCIENCE NPV PRIVATE PLACEMENT</name><lei>N/A</lei><title>Leap Therapeutics Inc</title><cusip>N/A</cusip><identifiers><isin value="DU0000106242"/></identifiers><balance>59926</balance><units>NS</units><curCd>USD</curCd><valUSD>187568</valUSD><pctVal>0.004</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>FLAME BIOSCIENCE NPV PRIVATE PLACEMENT</name><lei>N/A</lei><title>Leap Therapeutics Inc</title><cusip>N/A</cusip><identifiers><isin value="DU0000106240"/></identifiers><balance>366000</balance><units>NS</units><curCd>USD</curCd><valUSD>1145580</valUSD><pctVal>0.024</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>2</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Magnolia Medical Technologies Inc</name><lei>N/A</lei><title>Magnolia Medical Technologies Inc</title><cusip>N/A</cusip><identifiers><isin value="DU0000105108"/></identifiers><balance>1</balance><units>NS</units><curCd>USD</curCd><valUSD>0</valUSD><pctVal>0</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>SomaLogic Inc</name><lei>N/A</lei><title>SomaLogic Inc</title><cusip>N/A</cusip><identifiers><isin value="DU0000104520"/></identifiers><balance>722708</balance><units>NS</units><curCd>USD</curCd><valUSD>1</valUSD><pctVal>0</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>2</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Disc Medicine Inc</name><lei>N/A</lei><title>Disc Medicine Inc</title><cusip>N/A</cusip><identifiers><isin value="DU0000104507"/><ticker value="1762523D"/></identifiers><balance>118870</balance><units>NS</units><curCd>USD</curCd><valUSD>5277828</valUSD><pctVal>0.109</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>2</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>4D Molecular Therapeutics Inc</name><lei>N/A</lei><title>4D Molecular Therapeutics Inc</title><cusip>35104E100</cusip><identifiers><isin value="US35104E1001"/><ticker value="FDMT US"/><other otherDesc="BKLXFX5" value="Sedol"/></identifiers><balance>914430</balance><units>NS</units><curCd>USD</curCd><valUSD>16523750</valUSD><pctVal>0.341</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Gilead Sciences Inc</name><lei>549300WTZWR07K8MNV44</lei><title>Gilead Sciences Inc</title><cusip>375558103</cusip><identifiers><isin value="US3755581036"/><ticker value="GILD US"/><other otherDesc="2369174" 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value="Sedol"/></identifiers><balance>3718755</balance><units>NS</units><curCd>USD</curCd><valUSD>70172907</valUSD><pctVal>1.447</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Insmed Inc</name><lei>529900Q55QAG41CCAC11</lei><title>Insmed Inc</title><cusip>457669307</cusip><identifiers><isin value="US4576693075"/><ticker value="INSM US"/><other otherDesc="2614487" value="Sedol"/></identifiers><balance>658113</balance><units>NS</units><curCd>USD</curCd><valUSD>13886184</valUSD><pctVal>0.286</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Intra-Cellular Therapies Inc</name><lei>5299002U2KGF193IJA20</lei><title>Intra-Cellular Therapies Inc</title><cusip>46116X101</cusip><identifiers><isin value="US46116X1019"/><ticker value="ITCI"/><other otherDesc="BHCB0P4" value="Sedol"/></identifiers><balance>184643</balance><units>NS</units><curCd>USD</curCd><valUSD>11691595</valUSD><pctVal>0.241</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Intuitive Surgical Inc</name><lei>54930052SRG011710797</lei><title>Intuitive Surgical Inc</title><cusip>46120E602</cusip><identifiers><isin value="US46120E6023"/><ticker value="ISRG US"/><other otherDesc="2871301" value="Sedol"/></identifiers><balance>143989</balance><units>NS</units><curCd>USD</curCd><valUSD>49235599</valUSD><pctVal>1.015</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>IQVIA Holdings Inc</name><lei>549300W3R20NM4KQPH86</lei><title>IQVIA Holdings Inc</title><cusip>46266C105</cusip><identifiers><isin value="US46266C1053"/><ticker value="IQV US"/><other otherDesc="BDR73G1" 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value="Sedol"/></identifiers><balance>575428</balance><units>NS</units><curCd>USD</curCd><valUSD>6830330</valUSD><pctVal>0.141</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Johnson &amp; Johnson</name><lei>549300G0CFPGEF6X2043</lei><title>Johnson &amp; Johnson</title><cusip>478160104</cusip><identifiers><isin value="US4781601046"/><ticker value="JNJ US"/><other otherDesc="2475833" 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exchangeRt="0.91651"/><valUSD>39245850</valUSD><pctVal>0.809</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>DE</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Eli Lilly &amp; Co</name><lei>FRDRIPF3EKNDJ2CQJL29</lei><title>Eli Lilly &amp; Co</title><cusip>532457108</cusip><identifiers><isin value="US5324571083"/><ticker value="LLY US"/><other otherDesc="2516152" value="Sedol"/></identifiers><balance>378386</balance><units>NS</units><curCd>USD</curCd><valUSD>177455466</valUSD><pctVal>3.659</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Madrigal Pharmaceuticals Inc</name><lei>549300CHIMT2EUSNJB60</lei><title>Madrigal Pharmaceuticals Inc</title><cusip>558868105</cusip><identifiers><isin value="US5588681057"/><ticker value="MDGL US"/><other otherDesc="BD59BS7" 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exchangeRt="0.91651"/><valUSD>141206631</valUSD><pctVal>2.911</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>FR</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Merck &amp; Co Inc</name><lei>4YV9Y5M8S0BRK1RP0397</lei><title>Merck &amp; Co Inc</title><cusip>58933Y105</cusip><identifiers><isin value="US58933Y1055"/><ticker value="MRK US"/><other otherDesc="2778844" value="Sedol"/></identifiers><balance>1223346</balance><units>NS</units><curCd>USD</curCd><valUSD>141161895</valUSD><pctVal>2.911</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Moderna Inc</name><lei>549300EI6OKH5K5Q2G38</lei><title>Moderna Inc</title><cusip>60770K107</cusip><identifiers><isin value="US60770K1079"/><ticker value="MRNA US"/><other otherDesc="BGSXTS3" 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value="Sedol"/></identifiers><balance>1288562</balance><units>NS</units><curCd>USD</curCd><valUSD>20707191</valUSD><pctVal>0.427</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Neurocrine Biosciences Inc</name><lei>549300FECER0XBN49756</lei><title>Neurocrine Biosciences Inc</title><cusip>64125C109</cusip><identifiers><isin value="US64125C1099"/><ticker value="NBIX US"/><other otherDesc="2623911" value="Sedol"/></identifiers><balance>449921</balance><units>NS</units><curCd>USD</curCd><valUSD>42427550</valUSD><pctVal>0.875</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Organon &amp; Co</name><lei>549300AMCKY57OK2CO56</lei><title>Organon &amp; Co COMMON STOCK</title><cusip>68622V106</cusip><identifiers><isin value="US68622V1061"/><ticker value="OGN US"/><other otherDesc="BLDC8J4" value="Sedol"/></identifiers><balance>1394329</balance><units>NS</units><curCd>USD</curCd><valUSD>29015986</valUSD><pctVal>0.598</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Takeda Pharmaceutical Co Ltd</name><lei>549300ZLMVP4X0OGR454</lei><title>Takeda Pharmaceutical Co Ltd</title><cusip>J8129E108</cusip><identifiers><isin value="JP3463000004"/><ticker value="4502 JP"/><other otherDesc="6870445" value="Sedol"/></identifiers><balance>721536</balance><units>NS</units><currencyConditional curCd="JPY" exchangeRt="144.28"/><valUSD>22639267</valUSD><pctVal>0.467</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>JP</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>PTC Therapeutics Inc</name><lei>549300UJLWOIWFDGB318</lei><title>PTC Therapeutics Inc</title><cusip>69366J200</cusip><identifiers><isin value="US69366J2006"/><ticker value="PTCT US"/><other otherDesc="B17VCN9" value="Sedol"/></identifiers><balance>1091801</balance><units>NS</units><curCd>USD</curCd><valUSD>44403547</valUSD><pctVal>0.916</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Astellas Pharma Inc</name><lei>529900IB708DY2HBBB35</lei><title>Astellas Pharma Inc</title><cusip>J03393105</cusip><identifiers><isin value="JP3942400007"/><ticker value="4503 JP"/><other otherDesc="6985383" value="Sedol"/></identifiers><balance>2890500</balance><units>NS</units><currencyConditional curCd="JPY" exchangeRt="144.28"/><valUSD>43052984</valUSD><pctVal>0.888</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>JP</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Penumbra Inc</name><lei>549300RGE06P3ECANU72</lei><title>Penumbra Inc</title><cusip>70975L107</cusip><identifiers><isin value="US70975L1070"/><ticker value="PEN US"/><other otherDesc="BZ0V201" value="Sedol"/></identifiers><balance>114318</balance><units>NS</units><curCd>USD</curCd><valUSD>39332251</valUSD><pctVal>0.811</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Roche Holding AG</name><lei>549300U41AUUVOAAOB37</lei><title>Roche Holding AG</title><cusip>H69293217</cusip><identifiers><isin value="CH0012032048"/><ticker value="ROG SW"/><other otherDesc="7110388" value="Sedol"/></identifiers><balance>306884</balance><units>NS</units><currencyConditional curCd="CHF" exchangeRt="0.8948"/><valUSD>93800597</valUSD><pctVal>1.934</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>CH</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Pfizer Inc</name><lei>765LHXWGK1KXCLTFYQ30</lei><title>Pfizer Inc</title><cusip>717081103</cusip><identifiers><isin value="US7170811035"/><ticker value="PFE US"/><other otherDesc="2684703" 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value="Sedol"/></identifiers><balance>359031</balance><units>NS</units><curCd>USD</curCd><valUSD>9604079</valUSD><pctVal>0.198</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Rhythm Pharmaceuticals Inc</name><lei>529900JPNWXQ8DPLA551</lei><title>Rhythm Pharmaceuticals Inc</title><cusip>76243J105</cusip><identifiers><isin value="US76243J1051"/><ticker value="RYTM US"/><other otherDesc="BF2YWG4" value="Sedol"/></identifiers><balance>502056</balance><units>NS</units><curCd>USD</curCd><valUSD>8278903</valUSD><pctVal>0.171</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Sarepta Therapeutics Inc</name><lei>549300IKDPIED8J8IG21</lei><title>Sarepta Therapeutics Inc</title><cusip>803607100</cusip><identifiers><isin value="US8036071004"/><ticker value="SRPT US"/><other otherDesc="B8DPDT7" value="Sedol"/></identifiers><balance>958722</balance><units>NS</units><curCd>USD</curCd><valUSD>109792843</valUSD><pctVal>2.264</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Seres Therapeutics Inc</name><lei>549300GMXBE5NUWISF13</lei><title>Seres Therapeutics Inc</title><cusip>81750R102</cusip><identifiers><isin value="US81750R1023"/><ticker value="MCRB US"/><other otherDesc="BYNQNP8" value="Sedol"/></identifiers><balance>1679810</balance><units>NS</units><curCd>USD</curCd><valUSD>8046290</valUSD><pctVal>0.166</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Stryker Corp</name><lei>5493002F0SC4JTBU5137</lei><title>Stryker Corp</title><cusip>863667101</cusip><identifiers><isin value="US8636671013"/><ticker value="SYK US"/><other otherDesc="2853688" value="Sedol"/></identifiers><balance>244762</balance><units>NS</units><curCd>USD</curCd><valUSD>74674439</valUSD><pctVal>1.54</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Tandem Diabetes Care Inc</name><lei>549300JEPFOD0K4D3I05</lei><title>Tandem Diabetes Care Inc</title><cusip>875372203</cusip><identifiers><isin value="US8753722037"/><ticker value="TNDM US"/><other otherDesc="BF3W461" value="Sedol"/></identifiers><balance>653997</balance><units>NS</units><curCd>USD</curCd><valUSD>16049086</valUSD><pctVal>0.331</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Teleflex Inc</name><lei>UUL85LWXB4NGSWWXIQ25</lei><title>Teleflex Inc</title><cusip>879369106</cusip><identifiers><isin value="US8793691069"/><ticker value="TFX US"/><other otherDesc="2881407" value="Sedol"/></identifiers><balance>137292</balance><units>NS</units><curCd>USD</curCd><valUSD>33228783</valUSD><pctVal>0.685</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Thermo Fisher Scientific Inc</name><lei>HCHV7422L5HDJZCRFL38</lei><title>THERMO FISHER SCIENTIFIC INC</title><cusip>883556102</cusip><identifiers><isin value="US8835561023"/><ticker value="TMO US"/><other otherDesc="2886907" 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value="DU0000100962"/></identifiers><balance>15559450</balance><units>NS</units><curCd>USD</curCd><valUSD>15562562</valUSD><pctVal>0.321</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>PF</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>2</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Janus Henderson Cash Collateral Fund</name><lei>N/A</lei><title>Janus Henderson Cash Collateral Fund</title><cusip>N/A</cusip><identifiers><other otherDesc="896" value="Internal 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value="Sedol"/></identifiers><balance>200131</balance><units>NS</units><curCd>USD</curCd><valUSD>44178918</valUSD><pctVal>0.911</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>UnitedHealth Group Inc</name><lei>549300GHBMY8T5GXDE41</lei><title>UnitedHealth Group Inc</title><cusip>91324P102</cusip><identifiers><isin value="US91324P1021"/><ticker value="UNH US"/><other otherDesc="2917766" value="Sedol"/></identifiers><balance>615428</balance><units>NS</units><curCd>USD</curCd><valUSD>295799314</valUSD><pctVal>6.099</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Vaxcyte Inc</name><lei>254900M7NMHTGASX8D95</lei><title>Vaxcyte Inc</title><cusip>92243G108</cusip><identifiers><isin value="US92243G1085"/><ticker value="PCVX US"/><other otherDesc="BKPVGH6" value="Sedol"/></identifiers><balance>1134729</balance><units>NS</units><curCd>USD</curCd><valUSD>56668366</valUSD><pctVal>1.168</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Ventyx Biosciences Inc</name><lei>N/A</lei><title>Ventyx Biosciences Inc</title><cusip>92332V107</cusip><identifiers><isin value="US92332V1070"/><ticker value="VTYX US"/><other otherDesc="BMG99Y1" value="Sedol"/></identifiers><balance>569606</balance><units>NS</units><curCd>USD</curCd><valUSD>18683077</valUSD><pctVal>0.385</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Vertex Pharmaceuticals Inc</name><lei>54930015RAQRRZ5ZGJ91</lei><title>Vertex Pharmaceuticals Inc</title><cusip>92532F100</cusip><identifiers><isin value="US92532F1003"/><ticker value="VRTX US"/><other otherDesc="2931034" 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value="Sedol"/></identifiers><balance>211160</balance><units>NS</units><curCd>USD</curCd><valUSD>36363864</valUSD><pctVal>0.75</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Novo Nordisk A/S</name><lei>549300DAQ1CVT6CXN342</lei><title>Novo Nordisk A/S</title><cusip>K72807132</cusip><identifiers><isin value="DK0060534915"/><ticker value="NOVOB DC"/><other otherDesc="BHC8X90" value="Sedol"/></identifiers><balance>706287</balance><units>NS</units><currencyConditional curCd="DKK" exchangeRt="6.8225"/><valUSD>113813401</valUSD><pctVal>2.347</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>DK</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>New Horizon Health Ltd</name><lei>6556003WN0RS45SU3L67</lei><title>NEW HORIZON HEALTH LTD</title><cusip>G6485S102</cusip><identifiers><isin value="KYG6485S1021"/><ticker value="6606 HK"/><other otherDesc="BKPS6M2" value="Sedol"/></identifiers><balance>3776000</balance><units>NS</units><currencyConditional curCd="HKD" exchangeRt="7.8357"/><valUSD>13179882</valUSD><pctVal>0.272</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>HK</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Canbridge Pharmaceuticals Inc</name><lei>8755009KKZM9ETBOF853</lei><title>Canbridge Pharmaceuticals Inc USD0.00001</title><cusip>G1821D109</cusip><identifiers><isin value="KYG1821D1097"/><ticker value="1228 HK"/><other otherDesc="BMZQ5M3" value="Sedol"/></identifiers><balance>2946000</balance><units>NS</units><currencyConditional curCd="HKD" exchangeRt="7.8357"/><valUSD>612834</valUSD><pctVal>0.013</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>HK</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Biohaven Ltd</name><lei>N/A</lei><title>Biohaven Ltd</title><cusip>G1110E107</cusip><identifiers><isin value="VGG1110E1079"/><ticker value="BHVN US"/><other otherDesc="BPLZ7S5" value="Sedol"/></identifiers><balance>1393044</balance><units>NS</units><curCd>USD</curCd><valUSD>33321612</valUSD><pctVal>0.687</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>ICON PLC</name><lei>6354008SRQGEMC4XFI67</lei><title>ICON PLC</title><cusip>G4705A100</cusip><identifiers><isin value="IE0005711209"/><ticker value="ICLR US"/><other otherDesc="B94G471" value="Sedol"/></identifiers><balance>60206</balance><units>NS</units><curCd>USD</curCd><valUSD>15063541</valUSD><pctVal>0.311</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Jazz Pharmaceuticals PLC</name><lei>635400GAUMJCLEZRRV50</lei><title>Jazz Pharmaceuticals PLC</title><cusip>G50871105</cusip><identifiers><isin value="IE00B4Q5ZN47"/><ticker value="JAZZ US"/><other otherDesc="B4Q5ZN4" value="Sedol"/></identifiers><balance>178303</balance><units>NS</units><curCd>USD</curCd><valUSD>22104223</valUSD><pctVal>0.456</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Medtronic PLC</name><lei>549300GX3ZBSQWUXY261</lei><title>Medtronic PLC</title><cusip>G5960L103</cusip><identifiers><isin value="IE00BTN1Y115"/><ticker value="MDT US"/><other otherDesc="BTN1Y11" value="Sedol"/></identifiers><balance>552897</balance><units>NS</units><curCd>USD</curCd><valUSD>48710226</valUSD><pctVal>1.004</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Prothena Corp PLC</name><lei>5299009ZXQ8NIIJ8OL30</lei><title>Prothena Corp PLC</title><cusip>G72800108</cusip><identifiers><isin value="IE00B91XRN20"/><ticker value="PRTA US"/><other otherDesc="B91XRN2" value="Sedol"/></identifiers><balance>467915</balance><units>NS</units><curCd>USD</curCd><valUSD>31949236</valUSD><pctVal>0.659</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Roivant Sciences Ltd</name><lei>549300DL466NY5J6U724</lei><title>Roivant Sciences Ltd</title><cusip>G76279101</cusip><identifiers><isin value="BMG762791017"/><ticker value="ROIV"/><other otherDesc="BMW4NZ9" 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value="Sedol"/></identifiers><balance>954789</balance><units>NS</units><curCd>USD</curCd><valUSD>29350214</valUSD><pctVal>0.605</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>STERIS PLC</name><lei>N/A</lei><title>STERIS PLC</title><cusip>G8473T100</cusip><identifiers><isin value="IE00BFY8C754"/><ticker value="STE US"/><other otherDesc="BFY8C75" 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value="CUREVOPP"/></identifiers><balance>2031087</balance><units>NS</units><curCd>USD</curCd><valUSD>5195724</valUSD><pctVal>0.107</pctVal><payoffProfile>Long</payoffProfile><assetCat>EP</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Element Biosciences Inc</name><lei>N/A</lei><title>Element Biosciences Inc</title><cusip>N/A</cusip><identifiers><isin value="DU0000104465"/><ticker value="1726116D"/></identifiers><balance>425023</balance><units>NS</units><curCd>USD</curCd><valUSD>6991628</valUSD><pctVal>0.144</pctVal><payoffProfile>Long</payoffProfile><assetCat>EP</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Sonoma Biotherapeutics Inc</name><lei>N/A</lei><title>Sonoma Biotherapeutics Series B Preferred Stock</title><cusip>N/A</cusip><identifiers><isin value="DU0000106193"/><ticker value="1783532D"/></identifiers><balance>669428</balance><units>NS</units><curCd>USD</curCd><valUSD>1984519</valUSD><pctVal>0.041</pctVal><payoffProfile>Long</payoffProfile><assetCat>EP</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>VALENZABIO INC</name><lei>N/A</lei><title>Acelyrin Inc. 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Series A</title><cusip>N/A</cusip><identifiers><isin value="DU0000104012"/></identifiers><balance>3643715</balance><units>NS</units><curCd>USD</curCd><valUSD>3795111</valUSD><pctVal>0.078</pctVal><payoffProfile>Long</payoffProfile><assetCat>EP</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Lexeo Therapeutics Inc</name><lei>N/A</lei><title>LEXEO Therapeutics Inc - Series B</title><cusip>N/A</cusip><identifiers><isin value="DU0000104331"/><ticker value="1848501D US"/></identifiers><balance>883469</balance><units>NS</units><curCd>USD</curCd><valUSD>920177</valUSD><pctVal>0.019</pctVal><payoffProfile>Long</payoffProfile><assetCat>EP</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Sonoma Biotherapeutics Inc</name><lei>N/A</lei><title>Sonoma Biotherapeutics Inc - Series B</title><cusip>N/A</cusip><identifiers><isin value="DU0000104500"/><ticker value="1783532D"/></identifiers><balance>1255200</balance><units>NS</units><curCd>USD</curCd><valUSD>3721040</valUSD><pctVal>0.077</pctVal><payoffProfile>Long</payoffProfile><assetCat>EP</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Arbor Biotechnologies Inc</name><lei>N/A</lei><title>Arbor Biotechnologies Inc</title><cusip>N/A</cusip><identifiers><isin value="DU0000104275"/><ticker value="1584091D"/></identifiers><balance>156426</balance><units>NS</units><curCd>USD</curCd><valUSD>2591979</valUSD><pctVal>0.053</pctVal><payoffProfile>Long</payoffProfile><assetCat>EP</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Freenome Holdings Inc</name><lei>254900QDTSQ6S0QOCS43</lei><title>Freenome Holdings Inc - Series D</title><cusip>N/A</cusip><identifiers><isin value="DU0000104596"/><ticker value="1411948D"/></identifiers><balance>342803</balance><units>NS</units><curCd>USD</curCd><valUSD>4000511</valUSD><pctVal>0.082</pctVal><payoffProfile>Long</payoffProfile><assetCat>EP</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Hemoshear Therapeutics LLC</name><lei>N/A</lei><title>HemoShear Therapeutics LLC</title><cusip>N/A</cusip><identifiers><isin value="DU0000104239"/><ticker value="0611670D US"/></identifiers><balance>289280</balance><units>NS</units><curCd>USD</curCd><valUSD>2109430</valUSD><pctVal>0.043</pctVal><payoffProfile>Long</payoffProfile><assetCat>EP</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>HeartFlow Inc</name><lei>N/A</lei><title>Heartflow Inc</title><cusip>N/A</cusip><identifiers><isin value="DU0000106398"/><ticker value="0348323Z"/></identifiers><balance>1934015</balance><units>NS</units><curCd>USD</curCd><valUSD>5512910</valUSD><pctVal>0.114</pctVal><payoffProfile>Long</payoffProfile><assetCat>EP</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Neurogene Inc</name><lei>N/A</lei><title>Neurogene Inc - 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value="1830940D"/></identifiers><balance>2192937</balance><units>NS</units><curCd>USD</curCd><valUSD>5661001</valUSD><pctVal>0.117</pctVal><payoffProfile>Long</payoffProfile><assetCat>EP</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Asher Biotherapeutics Inc</name><lei>N/A</lei><title>Asher Biotherapeutics Inc</title><cusip>N/A</cusip><identifiers><isin value="DU0000101918"/><ticker 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value="BIGFOOTC1"/></identifiers><balance>168418</balance><units>NS</units><curCd>USD</curCd><valUSD>1096199</valUSD><pctVal>0.023</pctVal><payoffProfile>Long</payoffProfile><assetCat>EP</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>BIGFOOT BIOMEDICAL INC</name><lei>N/A</lei><title>Bigfoot Biomedical Inc - Series B</title><cusip>N/A</cusip><identifiers><isin value="DU0000100959"/><ticker value="N/A"/><other otherDesc="B4N0JJ6" 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value="CMTA CVR"/></identifiers><balance>874311</balance><units>NS</units><curCd>USD</curCd><valUSD>1</valUSD><pctVal>0</pctVal><payoffProfile>Long</payoffProfile><assetConditional assetCat="OTHER" desc="Rights"/><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Legend Biotech Corp</name><lei>254900EIUFZTW136H859</lei><title>Legend Biotech Corp (ADR)</title><cusip>52490G102</cusip><identifiers><isin value="US52490G1022"/><ticker value="LEGN US"/><other otherDesc="BMX9K07" value="Sedol"/></identifiers><balance>531869</balance><units>NS</units><curCd>USD</curCd><valUSD>36714917</valUSD><pctVal>0.757</pctVal><payoffProfile>Long</payoffProfile><assetConditional assetCat="OTHER" 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desc="GDR"/><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Zai Lab Ltd</name><lei>549300P2UYQ9U5LY1T58</lei><title>Zai Lab Ltd (ADR)</title><cusip>98887Q104</cusip><identifiers><isin value="US98887Q1040"/><ticker value="ZLAB US"/><other otherDesc="BD9GVY0" value="Sedol"/></identifiers><balance>1208446</balance><units>NS</units><curCd>USD</curCd><valUSD>33510208</valUSD><pctVal>0.691</pctVal><payoffProfile>Long</payoffProfile><assetConditional assetCat="OTHER" desc="GDR"/><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec></invstOrSecs><explntrNotes><explntrNote note="Monthly returns presented in Item B.5(a) have been calculated without deducting any applicable sales loads or redemption fees." noteItem="B.5.a"/></explntrNotes><signature><ncom:dateSigned>2023-08-14</ncom:dateSigned><ncom:nameOfApplicant>JANUS INVESTMENT FUND</ncom:nameOfApplicant><ncom:signature>JESPER NERGAARD</ncom:signature><ncom:signerName>JESPER NERGAARD</ncom:signerName><ncom:title>VP, CFO, TREASURER, AND PRINCIPAL ACCOUNTING OFFICER</ncom:title></signature></formData><documents>XXXX</documents></edgarSubmission>
