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value="Sedol"/></identifiers><balance>884273</balance><units>NS</units><curCd>USD</curCd><valUSD>58326647</valUSD><pctVal>1.257</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Arcellx Inc</name><lei>N/A</lei><title>Arcellx Inc</title><cusip>03940C100</cusip><identifiers><isin value="US03940C1009"/><ticker value="ACLX US"/><other otherDesc="BPCJ1Q2" value="Sedol"/></identifiers><balance>449538</balance><units>NS</units><curCd>USD</curCd><valUSD>13850266</valUSD><pctVal>0.299</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Ardelyx Inc</name><lei>549300F542QR4SXHCY32</lei><title>Ardelyx, Inc.</title><cusip>039697107</cusip><identifiers><isin value="US0396971071"/><ticker value="ARDX US"/><other otherDesc="BN89V40" value="Sedol"/></identifiers><balance>4865807</balance><units>NS</units><curCd>USD</curCd><valUSD>23307216</valUSD><pctVal>0.502</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>BioMarin Pharmaceutical Inc</name><lei>NSLL8ITTRR0J5HEMR848</lei><title>BioMarin Pharmaceutical Inc</title><cusip>09061G101</cusip><identifiers><isin value="US09061G1013"/><ticker value="BMRN US"/><other otherDesc="2437071" value="Sedol"/></identifiers><balance>591263</balance><units>NS</units><curCd>USD</curCd><valUSD>57494414</valUSD><pctVal>1.239</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Biomea Fusion Inc</name><lei>N/A</lei><title>Biomea Fusion Inc</title><cusip>09077A106</cusip><identifiers><isin value="US09077A1060"/><ticker value="BMEA US"/><other otherDesc="BNKF6N0" value="Sedol"/></identifiers><balance>880406</balance><units>NS</units><curCd>USD</curCd><valUSD>27301390</valUSD><pctVal>0.588</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><loanByFundCondition isLoanByFund="Y" loanVal="829517.85"/></securityLending></invstOrSec><invstOrSec><name>AstraZeneca PLC</name><lei>PY6ZZQWO2IZFZC3IOL08</lei><title>AstraZeneca PLC</title><cusip>G0593M107</cusip><identifiers><isin value="GB0009895292"/><ticker value="AZN LN"/><other otherDesc="989529" value="Sedol"/></identifiers><balance>1484728</balance><units>NS</units><currencyConditional curCd="GBP" exchangeRt="0.81077"/><valUSD>206046294</valUSD><pctVal>4.441</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>GB</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>2</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Boston Scientific Corp</name><lei>Y6ZDD9FP4P8JSSJMW954</lei><title>Boston Scientific Corp</title><cusip>101137107</cusip><identifiers><isin value="US1011371077"/><ticker value="BSX US"/><other otherDesc="2113434" value="Sedol"/></identifiers><balance>2123307</balance><units>NS</units><curCd>USD</curCd><valUSD>106229049</valUSD><pctVal>2.29</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Bristol-Myers Squibb Co</name><lei>HLYYNH7UQUORYSJQCN42</lei><title>Bristol-Myers Squibb Co</title><cusip>110122108</cusip><identifiers><isin value="US1101221083"/><ticker value="BMY US"/><other otherDesc="2126335" value="Sedol"/></identifiers><balance>1272505</balance><units>NS</units><curCd>USD</curCd><valUSD>88197322</valUSD><pctVal>1.901</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Catalent Inc</name><lei>N/A</lei><title>Catalent Inc</title><cusip>148806102</cusip><identifiers><isin value="US1488061029"/><ticker value="CTLT US"/><other otherDesc="BP96PQ4" value="Sedol"/></identifiers><balance>638492</balance><units>NS</units><curCd>USD</curCd><valUSD>41955309</valUSD><pctVal>0.904</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Centene Corp</name><lei>549300Z7JJ4TQSQGT333</lei><title>Centene Corp</title><cusip>15135B101</cusip><identifiers><isin value="US15135B1017"/><ticker value="CNC US"/><other otherDesc="2807061" value="Sedol"/></identifiers><balance>1009481</balance><units>NS</units><curCd>USD</curCd><valUSD>63809294</valUSD><pctVal>1.375</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Cerevel Therapeutics Holdings</name><lei>254900RJNIRS9COSQR41</lei><title>Cerevel Therapeutics Holdings Inc COM</title><cusip>15678U128</cusip><identifiers><isin value="US15678U1280"/><ticker value="CERE US"/><other otherDesc="BMVMJ12" value="Sedol"/></identifiers><balance>418860</balance><units>NS</units><curCd>USD</curCd><valUSD>10215995</valUSD><pctVal>0.22</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Collegium Pharmaceutical Inc</name><lei>54930049FXZMTLW8D496</lei><title>Collegium Pharmaceutical Inc</title><cusip>19459J104</cusip><identifiers><isin value="US19459J1043"/><ticker value="COLL US"/><other otherDesc="BX7RSN3" value="Sedol"/></identifiers><balance>529194</balance><units>NS</units><curCd>USD</curCd><valUSD>12695364</valUSD><pctVal>0.274</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Cooper Cos Inc/The</name><lei>QJKMVPIGLH7530PCUE20</lei><title>Cooper Cos Inc</title><cusip>216648402</cusip><identifiers><isin value="US2166484020"/><ticker value="COO US"/><other otherDesc="2222631" value="Sedol"/></identifiers><balance>126469</balance><units>NS</units><curCd>USD</curCd><valUSD>47218466</valUSD><pctVal>1.018</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>CymaBay Therapeutics Inc.</name><lei>549300YT9GNL852E7F84</lei><title>CymaBay Therapeutics Inc</title><cusip>23257D103</cusip><identifiers><isin value="US23257D1037"/><ticker value="CBAY"/><other otherDesc="BJ3WDH3" value="Sedol"/></identifiers><balance>1385347</balance><units>NS</units><curCd>USD</curCd><valUSD>12080226</valUSD><pctVal>0.26</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Cytokinetics Inc</name><lei>549300BE5DY1HW7IHA64</lei><title>Cytokinetics Inc</title><cusip>23282W605</cusip><identifiers><isin value="US23282W6057"/><ticker value="CYTK"/><other otherDesc="BBBSBJ5" value="Sedol"/></identifiers><balance>515314</balance><units>NS</units><curCd>USD</curCd><valUSD>18133900</valUSD><pctVal>0.391</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>DICE Therapeutics Inc</name><lei>N/A</lei><title>DICE Therapeutics Inc</title><cusip>23345J104</cusip><identifiers><isin value="US23345J1043"/><ticker value="DICE US"/><other otherDesc="BNRPLC7" value="Sedol"/></identifiers><balance>368853</balance><units>NS</units><curCd>USD</curCd><valUSD>10567638</valUSD><pctVal>0.228</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Danaher Corp</name><lei>S4BKK9OTCEWQ3YHPFM11</lei><title>Danaher Corp</title><cusip>235851102</cusip><identifiers><isin value="US2358511028"/><ticker value="DHR US"/><other otherDesc="2250870" value="Sedol"/></identifiers><balance>397295</balance><units>NS</units><curCd>USD</curCd><valUSD>100134232</valUSD><pctVal>2.158</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>DENTSPLY SIRONA Inc</name><lei>9NHEHR1SOZCYXDO8HO28</lei><title>DENTSPLY SIRONA Inc</title><cusip>24906P109</cusip><identifiers><isin value="US24906P1093"/><ticker value="XRAY US"/><other otherDesc="BYNPPC6" value="Sedol"/></identifiers><balance>594773</balance><units>NS</units><curCd>USD</curCd><valUSD>23362683</valUSD><pctVal>0.504</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Design Therapeutics Inc</name><lei>N/A</lei><title>Design Therapeutics Inc</title><cusip>25056L103</cusip><identifiers><isin value="US25056L1035"/><ticker value="DSGN US"/><other otherDesc="BMFK3H6" value="Sedol"/></identifiers><balance>393781</balance><units>NS</units><curCd>USD</curCd><valUSD>2272116</valUSD><pctVal>0.049</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Dexcom Inc</name><lei>549300YSK3QDSFR5EU59</lei><title>DexCom Inc</title><cusip>252131107</cusip><identifiers><isin value="US2521311074"/><ticker value="DXCM US"/><other otherDesc="B0796X4" value="Sedol"/></identifiers><balance>300655</balance><units>NS</units><curCd>USD</curCd><valUSD>34930098</valUSD><pctVal>0.753</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Edgewise Therapeutics Inc</name><lei>N/A</lei><title>Edgewise Therapeutics Inc</title><cusip>28036F105</cusip><identifiers><isin value="US28036F1057"/><ticker value="EWTX US"/><other otherDesc="BKY5JZ8" value="Sedol"/></identifiers><balance>133390</balance><units>NS</units><curCd>USD</curCd><valUSD>889711</valUSD><pctVal>0.019</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Edwards Lifesciences Corp</name><lei>YA13X31F3V31L8TMPR58</lei><title>Edwards Lifesciences Corp</title><cusip>28176E108</cusip><identifiers><isin value="US28176E1082"/><ticker value="EW US"/><other otherDesc="2567116" value="Sedol"/></identifiers><balance>561826</balance><units>NS</units><curCd>USD</curCd><valUSD>46479865</valUSD><pctVal>1.002</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>89bio Inc.</name><lei>N/A</lei><title>89bio Inc</title><cusip>282559103</cusip><identifiers><isin value="US2825591033"/><ticker value="ETNB"/><other otherDesc="BK1K484" value="Sedol"/></identifiers><balance>1166064</balance><units>NS</units><curCd>USD</curCd><valUSD>17759155</valUSD><pctVal>0.383</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><loanByFundCondition isLoanByFund="Y" loanVal="8032752.97"/></securityLending></invstOrSec><invstOrSec><name>FLAME BIOSCIENCE NPV PRIVATE PLACEMENT</name><lei>N/A</lei><title>Leap Therapeutics Inc</title><cusip>N/A</cusip><identifiers><isin value="DU0000106242"/></identifiers><balance>599269</balance><units>NS</units><curCd>USD</curCd><valUSD>203751</valUSD><pctVal>0.004</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Magnolia Medical Technologies Inc</name><lei>N/A</lei><title>Magnolia Medical Technologies Inc</title><cusip>N/A</cusip><identifiers><isin value="DU0000105108"/></identifiers><balance>1</balance><units>NS</units><curCd>USD</curCd><valUSD>0</valUSD><pctVal>0</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>SomaLogic Inc</name><lei>N/A</lei><title>SomaLogic Inc</title><cusip>N/A</cusip><identifiers><isin value="DU0000104520"/></identifiers><balance>722708</balance><units>NS</units><curCd>USD</curCd><valUSD>1</valUSD><pctVal>0</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>2</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Disc Medicine Inc</name><lei>N/A</lei><title>Disc Medicine Inc</title><cusip>N/A</cusip><identifiers><isin value="DU0000104507"/><ticker value="1762523D"/></identifiers><balance>118870</balance><units>NS</units><curCd>USD</curCd><valUSD>2392913</valUSD><pctVal>0.052</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>2</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>4D Molecular Therapeutics Inc</name><lei>N/A</lei><title>4D Molecular Therapeutics Inc</title><cusip>35104E100</cusip><identifiers><isin value="US35104E1001"/><ticker value="FDMT US"/><other otherDesc="BKLXFX5" value="Sedol"/></identifiers><balance>550454</balance><units>NS</units><curCd>USD</curCd><valUSD>9462304</valUSD><pctVal>0.204</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Gilead Sciences Inc</name><lei>549300WTZWR07K8MNV44</lei><title>Gilead Sciences Inc</title><cusip>375558103</cusip><identifiers><isin value="US3755581036"/><ticker value="GILD US"/><other otherDesc="2369174" value="Sedol"/></identifiers><balance>342256</balance><units>NS</units><curCd>USD</curCd><valUSD>28396980</valUSD><pctVal>0.612</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Globus Medical Inc</name><lei>5299003M2P4CIK0RF205</lei><title>Globus Medical Inc</title><cusip>379577208</cusip><identifiers><isin value="US3795772082"/><ticker value="GMED US"/><other otherDesc="B7D65M0" value="Sedol"/></identifiers><balance>655881</balance><units>NS</units><curCd>USD</curCd><valUSD>37149100</valUSD><pctVal>0.801</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Humana Inc</name><lei>529900YLDW34GJAO4J06</lei><title>HUMANA INC</title><cusip>444859102</cusip><identifiers><isin value="US4448591028"/><ticker value="HUM US"/><other otherDesc="2445063" 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value="Sedol"/></identifiers><balance>201358</balance><units>NS</units><curCd>USD</curCd><valUSD>10903536</valUSD><pctVal>0.235</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Intuitive Surgical Inc</name><lei>54930052SRG011710797</lei><title>Intuitive Surgical Inc</title><cusip>46120E602</cusip><identifiers><isin value="US46120E6023"/><ticker value="ISRG US"/><other otherDesc="2871301" value="Sedol"/></identifiers><balance>144205</balance><units>NS</units><curCd>USD</curCd><valUSD>36840051</valUSD><pctVal>0.794</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>IQVIA Holdings Inc</name><lei>549300W3R20NM4KQPH86</lei><title>IQVIA Holdings Inc</title><cusip>46266C105</cusip><identifiers><isin value="US46266C1053"/><ticker value="IQV US"/><other otherDesc="BDR73G1" value="Sedol"/></identifiers><balance>155899</balance><units>NS</units><curCd>USD</curCd><valUSD>31006752</valUSD><pctVal>0.668</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>IVERIC bio Inc</name><lei>549300GZXI59U71XPM70</lei><title>IVERIC bio Inc</title><cusip>46583P102</cusip><identifiers><isin value="US46583P1021"/><ticker value="ISEE US"/><other otherDesc="BK8Y8K9" 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value="Sedol"/></identifiers><balance>282001</balance><units>NS</units><curCd>USD</curCd><valUSD>43710155</valUSD><pctVal>0.942</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Bayer AG</name><lei>549300J4U55H3WP1XT59</lei><title>Bayer AG</title><cusip>D0712D163</cusip><identifiers><isin value="DE000BAY0017"/><ticker value="BAYN GR"/><other otherDesc="5069211" value="Sedol"/></identifiers><balance>725102</balance><units>NS</units><currencyConditional curCd="EUR" 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value="Sedol"/></identifiers><balance>12715</balance><units>NS</units><curCd>USD</curCd><valUSD>3080336</valUSD><pctVal>0.066</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Sanofi</name><lei>549300E9PC51EN656011</lei><title>Sanofi</title><cusip>F5548N101</cusip><identifiers><isin value="FR0000120578"/><ticker value="SAN FP"/><other otherDesc="5671735" value="Sedol"/></identifiers><balance>1303831</balance><units>NS</units><currencyConditional curCd="EUR" 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value="Sedol"/></identifiers><balance>1214649</balance><units>NS</units><curCd>USD</curCd><valUSD>129226507</valUSD><pctVal>2.785</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>NeoGenomics Inc</name><lei>549300KN62PPGHBVXB46</lei><title>NeoGenomics Inc</title><cusip>64049M209</cusip><identifiers><isin value="US64049M2098"/><ticker value="NEO US"/><other otherDesc="2598246" value="Sedol"/></identifiers><balance>1549603</balance><units>NS</units><curCd>USD</curCd><valUSD>26978588</valUSD><pctVal>0.581</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Neurocrine Biosciences Inc</name><lei>549300FECER0XBN49756</lei><title>Neurocrine Biosciences Inc</title><cusip>64125C109</cusip><identifiers><isin value="US64125C1099"/><ticker value="NBIX US"/><other otherDesc="2623911" value="Sedol"/></identifiers><balance>447035</balance><units>NS</units><curCd>USD</curCd><valUSD>45248883</valUSD><pctVal>0.975</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Olema Pharmaceuticals Inc</name><lei>N/A</lei><title>Olema Pharmaceuticals Inc</title><cusip>68062P106</cusip><identifiers><isin value="US68062P1066"/><ticker value="OLMA US"/><other otherDesc="BMZ4LN0" value="Sedol"/></identifiers><balance>445475</balance><units>NS</units><curCd>USD</curCd><valUSD>1545798</valUSD><pctVal>0.033</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Organon &amp; Co</name><lei>549300AMCKY57OK2CO56</lei><title>Organon &amp; Co COMMON STOCK</title><cusip>68622V106</cusip><identifiers><isin value="US68622V1061"/><ticker value="OGN US"/><other otherDesc="BLDC8J4" value="Sedol"/></identifiers><balance>1574351</balance><units>NS</units><curCd>USD</curCd><valUSD>37028736</valUSD><pctVal>0.798</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Takeda Pharmaceutical Co Ltd</name><lei>549300ZLMVP4X0OGR454</lei><title>Takeda Pharmaceutical Co Ltd</title><cusip>J8129E108</cusip><identifiers><isin value="JP3463000004"/><ticker value="4502 JP"/><other otherDesc="6870445" value="Sedol"/></identifiers><balance>748736</balance><units>NS</units><currencyConditional curCd="JPY" exchangeRt="132.76"/><valUSD>24595490</valUSD><pctVal>0.53</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>JP</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>2</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>PTC Therapeutics Inc</name><lei>549300UJLWOIWFDGB318</lei><title>PTC Therapeutics Inc</title><cusip>69366J200</cusip><identifiers><isin value="US69366J2006"/><ticker value="PTCT US"/><other otherDesc="B17VCN9" value="Sedol"/></identifiers><balance>996808</balance><units>NS</units><curCd>USD</curCd><valUSD>48285380</valUSD><pctVal>1.041</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Astellas Pharma Inc</name><lei>529900IB708DY2HBBB35</lei><title>Astellas Pharma Inc</title><cusip>J03393105</cusip><identifiers><isin value="JP3942400007"/><ticker value="4503 JP"/><other otherDesc="6985383" value="Sedol"/></identifiers><balance>2912900</balance><units>NS</units><currencyConditional curCd="JPY" 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exchangeRt="0.9147"/><valUSD>90277579</valUSD><pctVal>1.946</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>CH</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>2</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Pfizer Inc</name><lei>765LHXWGK1KXCLTFYQ30</lei><title>Pfizer Inc</title><cusip>717081103</cusip><identifiers><isin value="US7170811035"/><ticker value="PFE US"/><other otherDesc="2684703" value="Sedol"/></identifiers><balance>1248966</balance><units>NS</units><curCd>USD</curCd><valUSD>50957813</valUSD><pctVal>1.098</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Privia Health Group Inc</name><lei>N/A</lei><title>Privia Health Group Inc</title><cusip>74276R102</cusip><identifiers><isin value="US74276R1023"/><ticker value="PRVA US"/><other otherDesc="BMDP209" 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value="Sedol"/></identifiers><balance>195603</balance><units>NS</units><curCd>USD</curCd><valUSD>112739701</valUSD><pctVal>2.43</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Travere Therapeutics Inc</name><lei>N/A</lei><title>Travere Therapeutics Inc</title><cusip>89422G107</cusip><identifiers><isin value="US89422G1076"/><ticker value="TVTX US"/><other otherDesc="BLFGJD5" 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value="DU0000100962"/></identifiers><balance>18363156</balance><units>NS</units><curCd>USD</curCd><valUSD>18366829</valUSD><pctVal>0.396</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>PF</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>2</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Janus Henderson Cash Collateral Fund</name><lei>N/A</lei><title>Janus Henderson Cash Collateral Fund</title><cusip>N/A</cusip><identifiers><other otherDesc="896" value="Internal 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value="Sedol"/></identifiers><balance>192241</balance><units>NS</units><curCd>USD</curCd><valUSD>43054294</valUSD><pctVal>0.928</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>UnitedHealth Group Inc</name><lei>549300GHBMY8T5GXDE41</lei><title>UnitedHealth Group Inc</title><cusip>91324P102</cusip><identifiers><isin value="US91324P1021"/><ticker value="UNH US"/><other otherDesc="2917766" value="Sedol"/></identifiers><balance>602235</balance><units>NS</units><curCd>USD</curCd><valUSD>284610239</valUSD><pctVal>6.134</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Vaxcyte Inc</name><lei>254900M7NMHTGASX8D95</lei><title>Vaxcyte Inc</title><cusip>92243G108</cusip><identifiers><isin value="US92243G1085"/><ticker value="PCVX US"/><other otherDesc="BKPVGH6" value="Sedol"/></identifiers><balance>1248401</balance><units>NS</units><curCd>USD</curCd><valUSD>46790070</valUSD><pctVal>1.008</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Ventyx Biosciences Inc</name><lei>N/A</lei><title>Ventyx Biosciences Inc</title><cusip>92332V107</cusip><identifiers><isin value="US92332V1070"/><ticker value="VTYX US"/><other otherDesc="BMG99Y1" value="Sedol"/></identifiers><balance>522757</balance><units>NS</units><curCd>USD</curCd><valUSD>17512360</valUSD><pctVal>0.377</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Vertex Pharmaceuticals Inc</name><lei>54930015RAQRRZ5ZGJ91</lei><title>Vertex Pharmaceuticals Inc</title><cusip>92532F100</cusip><identifiers><isin value="US92532F1003"/><ticker value="VRTX US"/><other otherDesc="2931034" value="Sedol"/></identifiers><balance>335349</balance><units>NS</units><curCd>USD</curCd><valUSD>105658409</valUSD><pctVal>2.277</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Zoetis Inc</name><lei>549300HD9Q1LOC9KLJ48</lei><title>Zoetis Inc</title><cusip>98978V103</cusip><identifiers><isin value="US98978V1035"/><ticker value="ZTS US"/><other otherDesc="B95WG16" 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value="Sedol"/></identifiers><balance>1269561</balance><units>NS</units><curCd>USD</curCd><valUSD>17342203</valUSD><pctVal>0.374</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>ICON PLC</name><lei>6354008SRQGEMC4XFI67</lei><title>ICON PLC</title><cusip>G4705A100</cusip><identifiers><isin value="IE0005711209"/><ticker value="ICLR US"/><other otherDesc="B94G471" value="Sedol"/></identifiers><balance>78562</balance><units>NS</units><curCd>USD</curCd><valUSD>16780058</valUSD><pctVal>0.362</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Jazz Pharmaceuticals PLC</name><lei>635400GAUMJCLEZRRV50</lei><title>Jazz Pharmaceuticals PLC</title><cusip>G50871105</cusip><identifiers><isin value="IE00B4Q5ZN47"/><ticker value="JAZZ US"/><other otherDesc="B4Q5ZN4" 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value="Sedol"/></identifiers><balance>969222</balance><units>NS</units><curCd>USD</curCd><valUSD>34921069</valUSD><pctVal>0.753</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>STERIS PLC</name><lei>N/A</lei><title>STERIS PLC</title><cusip>G8473T100</cusip><identifiers><isin value="IE00BFY8C754"/><ticker value="STE US"/><other otherDesc="BFY8C75" value="Sedol"/></identifiers><balance>178435</balance><units>NS</units><curCd>USD</curCd><valUSD>34131047</valUSD><pctVal>0.736</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Dummy Issuer</name><lei>N/A</lei><title>Curevo Inc</title><cusip>N/A</cusip><identifiers><isin value="DU0000105594"/><ticker value="CUREVOPP"/></identifiers><balance>2031087</balance><units>NS</units><curCd>USD</curCd><valUSD>5330344</valUSD><pctVal>0.115</pctVal><payoffProfile>Long</payoffProfile><assetCat>EP</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Element Biosciences Inc</name><lei>N/A</lei><title>Element Biosciences Inc</title><cusip>N/A</cusip><identifiers><isin value="DU0000104465"/><ticker value="1726116D"/></identifiers><balance>425023</balance><units>NS</units><curCd>USD</curCd><valUSD>6991628</valUSD><pctVal>0.151</pctVal><payoffProfile>Long</payoffProfile><assetCat>EP</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Sonoma Biotherapeutics Inc</name><lei>N/A</lei><title>Sonoma Biotherapeutics Series B Preferred Stock</title><cusip>N/A</cusip><identifiers><isin value="DU0000106193"/><ticker value="1783532D"/></identifiers><balance>669428</balance><units>NS</units><curCd>USD</curCd><valUSD>1984519</valUSD><pctVal>0.043</pctVal><payoffProfile>Long</payoffProfile><assetCat>EP</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>FLAME BIOSCIENCE NPV PRIVATE PLACEMENT</name><lei>N/A</lei><title>Leap Therapeutics Inc</title><cusip>N/A</cusip><identifiers><isin value="DU0000106240"/></identifiers><balance>3666</balance><units>NS</units><curCd>USD</curCd><valUSD>1246440</valUSD><pctVal>0.027</pctVal><payoffProfile>Long</payoffProfile><assetCat>EP</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>2</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>VALENZABIO INC</name><lei>N/A</lei><title>Acelyrin Inc. Common Shares</title><cusip>N/A</cusip><identifiers><isin value="DU0000106204"/></identifiers><balance>988781</balance><units>NS</units><curCd>USD</curCd><valUSD>6150317</valUSD><pctVal>0.133</pctVal><payoffProfile>Long</payoffProfile><assetCat>EP</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Shoreline Biosciences Inc</name><lei>N/A</lei><title>Shoreline Biosciences Inc</title><cusip>N/A</cusip><identifiers><isin value="DU0000104569"/><ticker value="1868807D"/></identifiers><balance>747187</balance><units>NS</units><curCd>USD</curCd><valUSD>6017769</valUSD><pctVal>0.13</pctVal><payoffProfile>Long</payoffProfile><assetCat>EP</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>VALENZABIO INC</name><lei>N/A</lei><title>Acelyrin Inc. Indemnity Holdback Shares</title><cusip>N/A</cusip><identifiers><isin value="DU0000106203"/></identifiers><balance>120152</balance><units>NS</units><curCd>USD</curCd><valUSD>373679</valUSD><pctVal>0.008</pctVal><payoffProfile>Long</payoffProfile><assetCat>EP</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Attralus Inc</name><lei>N/A</lei><title>Attralus Inc</title><cusip>N/A</cusip><identifiers><isin value="DU0000104336"/><ticker value="1829635D"/></identifiers><balance>669935</balance><units>NS</units><curCd>USD</curCd><valUSD>3483662</valUSD><pctVal>0.075</pctVal><payoffProfile>Long</payoffProfile><assetCat>EP</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Lexeo Therapeutics Inc</name><lei>N/A</lei><title>LEXEO Therapeutics Inc - Series A</title><cusip>N/A</cusip><identifiers><isin value="DU0000104012"/></identifiers><balance>3643715</balance><units>NS</units><curCd>USD</curCd><valUSD>6268975</valUSD><pctVal>0.135</pctVal><payoffProfile>Long</payoffProfile><assetCat>EP</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Lexeo Therapeutics Inc</name><lei>N/A</lei><title>LEXEO Therapeutics Inc - Series B</title><cusip>N/A</cusip><identifiers><isin value="DU0000104331"/><ticker value="1848501D US"/></identifiers><balance>883469</balance><units>NS</units><curCd>USD</curCd><valUSD>1520000</valUSD><pctVal>0.033</pctVal><payoffProfile>Long</payoffProfile><assetCat>EP</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Sonoma Biotherapeutics Inc</name><lei>N/A</lei><title>Sonoma Biotherapeutics Inc</title><cusip>N/A</cusip><identifiers><isin value="DU0000104500"/><ticker value="1783532D"/></identifiers><balance>1255200</balance><units>NS</units><curCd>USD</curCd><valUSD>3721040</valUSD><pctVal>0.08</pctVal><payoffProfile>Long</payoffProfile><assetCat>EP</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Arbor Biotechnologies Inc</name><lei>N/A</lei><title>Arbor Biotechnologies Inc</title><cusip>N/A</cusip><identifiers><isin value="DU0000104275"/><ticker value="1584091D"/></identifiers><balance>156426</balance><units>NS</units><curCd>USD</curCd><valUSD>2591979</valUSD><pctVal>0.056</pctVal><payoffProfile>Long</payoffProfile><assetCat>EP</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Freenome Holdings Inc</name><lei>254900QDTSQ6S0QOCS43</lei><title>Freenome Holdings Inc</title><cusip>N/A</cusip><identifiers><isin value="DU0000104596"/><ticker value="1411948D"/></identifiers><balance>342803</balance><units>NS</units><curCd>USD</curCd><valUSD>4000511</valUSD><pctVal>0.086</pctVal><payoffProfile>Long</payoffProfile><assetCat>EP</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Hemoshear Therapeutics LLC</name><lei>N/A</lei><title>HemoShear Therapeutics LLC</title><cusip>N/A</cusip><identifiers><isin value="DU0000104239"/><ticker value="0611670D US"/></identifiers><balance>289280</balance><units>NS</units><curCd>USD</curCd><valUSD>2109430</valUSD><pctVal>0.045</pctVal><payoffProfile>Long</payoffProfile><assetCat>EP</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>HeartFlow Inc</name><lei>N/A</lei><title>Heartflow Inc</title><cusip>N/A</cusip><identifiers><isin value="DU0000106398"/><ticker value="0348323Z"/></identifiers><balance>1934015</balance><units>NS</units><curCd>USD</curCd><valUSD>5512910</valUSD><pctVal>0.119</pctVal><payoffProfile>Long</payoffProfile><assetCat>EP</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Neurogene Inc</name><lei>N/A</lei><title>Neurogene Inc - Series B</title><cusip>N/A</cusip><identifiers><isin value="DU0000105180"/><ticker value="1697089D"/></identifiers><balance>1486727</balance><units>NS</units><curCd>USD</curCd><valUSD>3627614</valUSD><pctVal>0.078</pctVal><payoffProfile>Long</payoffProfile><assetCat>EP</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Twinstrand Biosciences Inc</name><lei>N/A</lei><title>TwinStrand Biosciences Inc</title><cusip>N/A</cusip><identifiers><isin value="DU0000104396"/><ticker value="1724622D US"/></identifiers><balance>344314</balance><units>NS</units><curCd>USD</curCd><valUSD>749606</valUSD><pctVal>0.016</pctVal><payoffProfile>Long</payoffProfile><assetCat>EP</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Magnolia Medical Technologies</name><lei>N/A</lei><title>Magnolia Medical Technologies Inc</title><cusip>N/A</cusip><identifiers><isin value="DU0000105101"/><ticker value="1426815D"/></identifiers><balance>1821717</balance><units>NS</units><curCd>USD</curCd><valUSD>3092693</valUSD><pctVal>0.067</pctVal><payoffProfile>Long</payoffProfile><assetCat>EP</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>FLAME BIOSCIENCE NPV PRIVATE PLACEMENT</name><lei>N/A</lei><title>Leap Therapeutics Inc. Indemnity Holdback shares</title><cusip>N/A</cusip><identifiers><isin value="DU0000106241"/></identifiers><balance>475</balance><units>NS</units><curCd>USD</curCd><valUSD>80750</valUSD><pctVal>0.002</pctVal><payoffProfile>Long</payoffProfile><assetCat>EP</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Synthekine Inc</name><lei>N/A</lei><title>Synthekine Inc</title><cusip>N/A</cusip><identifiers><isin value="DU0000104328"/><ticker value="1830940D"/></identifiers><balance>2192937</balance><units>NS</units><curCd>USD</curCd><valUSD>5661001</valUSD><pctVal>0.122</pctVal><payoffProfile>Long</payoffProfile><assetCat>EP</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Asher Biotherapeutics Inc</name><lei>N/A</lei><title>Asher Biotherapeutics Inc</title><cusip>N/A</cusip><identifiers><isin value="DU0000101918"/><ticker value="1741988D"/></identifiers><balance>1214301</balance><units>NS</units><curCd>USD</curCd><valUSD>1951139</valUSD><pctVal>0.042</pctVal><payoffProfile>Long</payoffProfile><assetCat>EP</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Freenome Holdings Inc</name><lei>254900QDTSQ6S0QOCS43</lei><title>Freenome Inc</title><cusip>N/A</cusip><identifiers><isin value="DU0000103893"/><ticker value="1411948D US"/></identifiers><balance>337474</balance><units>NS</units><curCd>USD</curCd><valUSD>3938322</valUSD><pctVal>0.085</pctVal><payoffProfile>Long</payoffProfile><assetCat>EP</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Neurogene Inc</name><lei>N/A</lei><title>Neurogene Inc</title><cusip>N/A</cusip><identifiers><isin value="DU0000102304"/><ticker value="1697089D US"/></identifiers><balance>1336317</balance><units>NS</units><curCd>USD</curCd><valUSD>3260613</valUSD><pctVal>0.07</pctVal><payoffProfile>Long</payoffProfile><assetCat>EP</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Bigfoot Biomedical Inc</name><lei>N/A</lei><title>Bigfoot Biomedical Inc - Series C-1</title><cusip>N/A</cusip><identifiers><isin value="DU0000104002"/><ticker value="BIGFOOTC1"/></identifiers><balance>168418</balance><units>NS</units><curCd>USD</curCd><valUSD>1096199</valUSD><pctVal>0.024</pctVal><payoffProfile>Long</payoffProfile><assetCat>EP</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Bigfoot Biomedical Inc</name><lei>N/A</lei><title>Bigfoot Biomedical Inc - Series B</title><cusip>N/A</cusip><identifiers><isin value="DU0000100959"/><ticker value="1450137D US"/><other otherDesc="B4N0JJ6" value="Sedol"/></identifiers><balance>1035873</balance><units>NS</units><curCd>USD</curCd><valUSD>6742290</valUSD><pctVal>0.145</pctVal><payoffProfile>Long</payoffProfile><assetCat>EP</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Argenx SE</name><lei>7245009C5FZE6G9ODQ71</lei><title>Argenx SE (ADR)</title><cusip>04016X101</cusip><identifiers><isin value="US04016X1019"/><ticker value="ARGX US"/><other otherDesc="BDVLM39" value="Sedol"/></identifiers><balance>230662</balance><units>NS</units><curCd>USD</curCd><valUSD>85940048</valUSD><pctVal>1.852</pctVal><payoffProfile>Long</payoffProfile><assetConditional assetCat="OTHER" desc="GDR"/><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Ascendis Pharma A/S</name><lei>549300B66JN3W3J8GH73</lei><title>Ascendis Pharma A/S (ADR)</title><cusip>04351P101</cusip><identifiers><isin value="US04351P1012"/><ticker value="ASND US"/><other otherDesc="BV9G6B8" value="Sedol"/></identifiers><balance>455281</balance><units>NS</units><curCd>USD</curCd><valUSD>48815229</valUSD><pctVal>1.052</pctVal><payoffProfile>Long</payoffProfile><assetConditional assetCat="OTHER" desc="GDR"/><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Avadel Pharmaceuticals PLC</name><lei>549300E27PTSG2RHC762</lei><title>AVADEL PHARMACEUTICALS-ADR</title><cusip>05337M104</cusip><identifiers><isin value="US05337M1045"/><ticker value="AVDL"/><other otherDesc="BDTZ028" value="Sedol"/></identifiers><balance>1672778</balance><units>NS</units><curCd>USD</curCd><valUSD>15322646</valUSD><pctVal>0.33</pctVal><payoffProfile>Long</payoffProfile><assetConditional assetCat="OTHER" desc="GDR"/><issuerCat>CORP</issuerCat><invCountry>IE</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Bicycle Therapeutics PLC</name><lei>213800XKUI6R7GKC3E43</lei><title>Bicycle Therapeutics Ltd (ADR)</title><cusip>088786108</cusip><identifiers><isin value="US0887861088"/><ticker value="BCYC US"/><other otherDesc="BKDQKM6" value="Sedol"/></identifiers><balance>521492</balance><units>NS</units><curCd>USD</curCd><valUSD>11092135</valUSD><pctVal>0.239</pctVal><payoffProfile>Long</payoffProfile><assetConditional assetCat="OTHER" desc="GDR"/><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><loanByFundCondition isLoanByFund="Y" loanVal="5285777.77"/></securityLending></invstOrSec><invstOrSec><name>Clementia Pharmaceuticals Inc</name><lei>N/A</lei><title>Clementia Pharmaceuticals Inc CVR</title><cusip>N/A</cusip><identifiers><isin value="US185CVR0169"/><ticker value="CMTA CVR"/></identifiers><balance>874311</balance><units>NS</units><curCd>USD</curCd><valUSD>1</valUSD><pctVal>0</pctVal><payoffProfile>Long</payoffProfile><assetConditional assetCat="OTHER" desc="Rights"/><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Legend Biotech Corp</name><lei>254900EIUFZTW136H859</lei><title>Legend Biotech Corp (ADR)</title><cusip>52490G102</cusip><identifiers><isin value="US52490G1022"/><ticker value="LEGN US"/><other otherDesc="BMX9K07" value="Sedol"/></identifiers><balance>558327</balance><units>NS</units><curCd>USD</curCd><valUSD>26922528</valUSD><pctVal>0.58</pctVal><payoffProfile>Long</payoffProfile><assetConditional assetCat="OTHER" desc="GDR"/><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Novartis AG</name><lei>5493007HIVTX6SY6XD66</lei><title>Novartis AG (ADR)</title><cusip>66987V109</cusip><identifiers><isin value="US66987V1098"/><ticker value="NVS US"/><other otherDesc="2620105" value="Sedol"/></identifiers><balance>1217478</balance><units>NS</units><curCd>USD</curCd><valUSD>112007976</valUSD><pctVal>2.414</pctVal><payoffProfile>Long</payoffProfile><assetConditional assetCat="OTHER" desc="GDR"/><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Zai Lab Ltd</name><lei>549300P2UYQ9U5LY1T58</lei><title>Zai Lab Ltd (ADR)</title><cusip>98887Q104</cusip><identifiers><isin value="US98887Q1040"/><ticker value="ZLAB US"/><other otherDesc="BD9GVY0" value="Sedol"/></identifiers><balance>767074</balance><units>NS</units><curCd>USD</curCd><valUSD>25512881</valUSD><pctVal>0.55</pctVal><payoffProfile>Long</payoffProfile><assetConditional assetCat="OTHER" desc="GDR"/><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec></invstOrSecs><explntrNotes><explntrNote note="Monthly returns presented in Item B.5(a) have been calculated without deducting any applicable sales loads or redemption fees." noteItem="B.5.a"/></explntrNotes><signature><ncom:dateSigned>2023-05-15</ncom:dateSigned><ncom:nameOfApplicant>JANUS INVESTMENT FUND</ncom:nameOfApplicant><ncom:signature>JESPER NERGAARD</ncom:signature><ncom:signerName>JESPER NERGAARD</ncom:signerName><ncom:title>VP, CFO, TREASURER, AND PRINCIPAL ACCOUNTING OFFICER</ncom:title></signature></formData></edgarSubmission>
