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value="Sedol"/></identifiers><balance>174058</balance><units>NS</units><curCd>USD</curCd><valUSD>89286532</valUSD><pctVal>1.889</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Apellis Pharmaceuticals Inc</name><lei>254900HS0ZFRXXSB9D42</lei><title>Apellis Pharmaceuticals Inc</title><cusip>03753U106</cusip><identifiers><isin value="US03753U1060"/><ticker value="APLS US"/><other otherDesc="BYTQ6X1" value="Sedol"/></identifiers><balance>830045</balance><units>NS</units><curCd>USD</curCd><valUSD>42921627</valUSD><pctVal>0.908</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Arcellx Inc</name><lei>N/A</lei><title>Arcellx Inc</title><cusip>03940C100</cusip><identifiers><isin value="US03940C1009"/><ticker value="ACLX US"/><other otherDesc="BPCJ1Q2" value="Sedol"/></identifiers><balance>429038</balance><units>NS</units><curCd>USD</curCd><valUSD>13291597</valUSD><pctVal>0.281</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><loanByFundCondition isLoanByFund="Y" loanVal="1035540"/></securityLending></invstOrSec><invstOrSec><name>Ardelyx Inc</name><lei>549300F542QR4SXHCY32</lei><title>Ardelyx, Inc.</title><cusip>039697107</cusip><identifiers><isin value="US0396971071"/><ticker value="ARDX US"/><other otherDesc="BN89V40" value="Sedol"/></identifiers><balance>2941625</balance><units>NS</units><curCd>USD</curCd><valUSD>8383631</valUSD><pctVal>0.177</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>BioCryst Pharmaceuticals Inc</name><lei>549300Z0INP1Z5NP6J59</lei><title>BioCryst Pharmaceuticals Inc</title><cusip>09058V103</cusip><identifiers><isin value="US09058V1035"/><ticker value="BCRX US"/><other otherDesc="2100362" value="Sedol"/></identifiers><balance>317975</balance><units>NS</units><curCd>USD</curCd><valUSD>3650353</valUSD><pctVal>0.077</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>BioMarin Pharmaceutical Inc</name><lei>NSLL8ITTRR0J5HEMR848</lei><title>BioMarin Pharmaceutical Inc</title><cusip>09061G101</cusip><identifiers><isin value="US09061G1013"/><ticker value="BMRN US"/><other otherDesc="2437071" value="Sedol"/></identifiers><balance>623591</balance><units>NS</units><curCd>USD</curCd><valUSD>64535433</valUSD><pctVal>1.365</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Biomea Fusion Inc</name><lei>N/A</lei><title>Biomea Fusion Inc</title><cusip>09077A106</cusip><identifiers><isin value="US09077A1060"/><ticker value="BMEA US"/><other otherDesc="BNKF6N0" value="Sedol"/></identifiers><balance>729522</balance><units>NS</units><curCd>USD</curCd><valUSD>6149870</valUSD><pctVal>0.13</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>BioAtla Inc</name><lei>N/A</lei><title>BioAtla LLC</title><cusip>09077B104</cusip><identifiers><isin value="US09077B1044"/><ticker value="BCAB US"/><other otherDesc="BNC5F86" value="Sedol"/></identifiers><balance>486009</balance><units>NS</units><curCd>USD</curCd><valUSD>4009574</valUSD><pctVal>0.085</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><loanByFundCondition isLoanByFund="Y" loanVal="1878507.85"/></securityLending></invstOrSec><invstOrSec><name>AstraZeneca PLC</name><lei>PY6ZZQWO2IZFZC3IOL08</lei><title>AstraZeneca PLC</title><cusip>G0593M107</cusip><identifiers><isin value="GB0009895292"/><ticker value="AZN LN"/><other otherDesc="989529" value="Sedol"/></identifiers><balance>1531969</balance><units>NS</units><currencyConditional curCd="GBP" exchangeRt="0.82734"/><valUSD>207867500</valUSD><pctVal>4.398</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>GB</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>2</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Boston Scientific Corp</name><lei>Y6ZDD9FP4P8JSSJMW954</lei><title>Boston Scientific Corp</title><cusip>101137107</cusip><identifiers><isin value="US1011371077"/><ticker value="BSX US"/><other otherDesc="2113434" value="Sedol"/></identifiers><balance>2324190</balance><units>NS</units><curCd>USD</curCd><valUSD>107540271</valUSD><pctVal>2.275</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Bristol-Myers Squibb Co</name><lei>HLYYNH7UQUORYSJQCN42</lei><title>Bristol-Myers Squibb Co</title><cusip>110122108</cusip><identifiers><isin value="US1101221083"/><ticker value="BMY US"/><other otherDesc="2126335" value="Sedol"/></identifiers><balance>1387567</balance><units>NS</units><curCd>USD</curCd><valUSD>99835446</valUSD><pctVal>2.112</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>C4 Therapeutics Inc</name><lei>N/A</lei><title>C4 Therapeutics Inc</title><cusip>12529R107</cusip><identifiers><isin value="US12529R1077"/><ticker value="CCCC US"/><other otherDesc="BKX9NQ0" value="Sedol"/></identifiers><balance>335365</balance><units>NS</units><curCd>USD</curCd><valUSD>1978654</valUSD><pctVal>0.042</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Catalent Inc</name><lei>N/A</lei><title>Catalent Inc</title><cusip>148806102</cusip><identifiers><isin value="US1488061029"/><ticker value="CTLT US"/><other otherDesc="BP96PQ4" value="Sedol"/></identifiers><balance>308457</balance><units>NS</units><curCd>USD</curCd><valUSD>13883650</valUSD><pctVal>0.294</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Centene Corp</name><lei>549300Z7JJ4TQSQGT333</lei><title>Centene Corp</title><cusip>15135B101</cusip><identifiers><isin value="US15135B1017"/><ticker value="CNC US"/><other otherDesc="2807061" value="Sedol"/></identifiers><balance>983771</balance><units>NS</units><curCd>USD</curCd><valUSD>80679060</valUSD><pctVal>1.707</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Cerevel Therapeutics Holdings</name><lei>254900RJNIRS9COSQR41</lei><title>Cerevel Therapeutics Holdings Inc COM</title><cusip>15678U128</cusip><identifiers><isin value="US15678U1280"/><ticker value="CERE US"/><other otherDesc="BMVMJ12" value="Sedol"/></identifiers><balance>463125</balance><units>NS</units><curCd>USD</curCd><valUSD>14606962</valUSD><pctVal>0.309</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Collegium Pharmaceutical Inc</name><lei>54930049FXZMTLW8D496</lei><title>Collegium Pharmaceutical Inc</title><cusip>19459J104</cusip><identifiers><isin value="US19459J1043"/><ticker value="COLL US"/><other otherDesc="BX7RSN3" value="Sedol"/></identifiers><balance>616212</balance><units>NS</units><curCd>USD</curCd><valUSD>14296118</valUSD><pctVal>0.302</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Cooper Cos Inc/The</name><lei>QJKMVPIGLH7530PCUE20</lei><title>Cooper Cos Inc</title><cusip>216648402</cusip><identifiers><isin value="US2166484020"/><ticker value="COO US"/><other otherDesc="2222631" value="Sedol"/></identifiers><balance>113786</balance><units>NS</units><curCd>USD</curCd><valUSD>37625617</valUSD><pctVal>0.796</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>DICE Therapeutics Inc</name><lei>N/A</lei><title>DICE Therapeutics Inc</title><cusip>23345J104</cusip><identifiers><isin value="US23345J1043"/><ticker value="DICE US"/><other otherDesc="BNRPLC7" value="Sedol"/></identifiers><balance>372367</balance><units>NS</units><curCd>USD</curCd><valUSD>11617850</valUSD><pctVal>0.246</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><loanByFundCondition isLoanByFund="Y" loanVal="336528"/></securityLending></invstOrSec><invstOrSec><name>Danaher Corp</name><lei>S4BKK9OTCEWQ3YHPFM11</lei><title>Danaher Corp</title><cusip>235851102</cusip><identifiers><isin value="US2358511028"/><ticker value="DHR US"/><other otherDesc="2250870" value="Sedol"/></identifiers><balance>363803</balance><units>NS</units><curCd>USD</curCd><valUSD>96560592</valUSD><pctVal>2.043</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>DENTSPLY SIRONA Inc</name><lei>9NHEHR1SOZCYXDO8HO28</lei><title>DENTSPLY SIRONA Inc</title><cusip>24906P109</cusip><identifiers><isin value="US24906P1093"/><ticker value="XRAY US"/><other otherDesc="BYNPPC6" value="Sedol"/></identifiers><balance>436233</balance><units>NS</units><curCd>USD</curCd><valUSD>13889659</valUSD><pctVal>0.294</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Design Therapeutics Inc</name><lei>N/A</lei><title>Design Therapeutics Inc</title><cusip>25056L103</cusip><identifiers><isin value="US25056L1035"/><ticker value="DSGN US"/><other otherDesc="BMFK3H6" value="Sedol"/></identifiers><balance>492234</balance><units>NS</units><curCd>USD</curCd><valUSD>5050321</valUSD><pctVal>0.107</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><loanByFundCondition isLoanByFund="Y" loanVal="3504678"/></securityLending></invstOrSec><invstOrSec><name>Dexcom Inc</name><lei>549300YSK3QDSFR5EU59</lei><title>DexCom Inc</title><cusip>252131107</cusip><identifiers><isin value="US2521311074"/><ticker value="DXCM US"/><other otherDesc="B0796X4" value="Sedol"/></identifiers><balance>307960</balance><units>NS</units><curCd>USD</curCd><valUSD>34873390</valUSD><pctVal>0.738</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Edgewise Therapeutics Inc</name><lei>N/A</lei><title>Edgewise Therapeutics Inc</title><cusip>28036F105</cusip><identifiers><isin value="US28036F1057"/><ticker value="EWTX US"/><other otherDesc="BKY5JZ8" value="Sedol"/></identifiers><balance>391509</balance><units>NS</units><curCd>USD</curCd><valUSD>3500090</valUSD><pctVal>0.074</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><loanByFundCondition isLoanByFund="Y" loanVal="2571576.84"/></securityLending></invstOrSec><invstOrSec><name>Edwards Lifesciences Corp</name><lei>YA13X31F3V31L8TMPR58</lei><title>Edwards Lifesciences Corp</title><cusip>28176E108</cusip><identifiers><isin value="US28176E1082"/><ticker value="EW US"/><other otherDesc="2567116" value="Sedol"/></identifiers><balance>512609</balance><units>NS</units><curCd>USD</curCd><valUSD>38245757</valUSD><pctVal>0.809</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Elanco Animal Health Inc</name><lei>549300SHPNDCE059M934</lei><title>Elanco Animal Health Inc</title><cusip>28414H103</cusip><identifiers><isin value="US28414H1032"/><ticker value="ELAN US"/><other otherDesc="BF5L3T2" value="Sedol"/></identifiers><balance>1422724</balance><units>NS</units><curCd>USD</curCd><valUSD>17385687</valUSD><pctVal>0.368</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Magnolia Medical Technologies Inc</name><lei>N/A</lei><title>Magnolia Medical Technologies Inc</title><cusip>N/A</cusip><identifiers><isin value="DU0000105108"/></identifiers><balance>1</balance><units>NS</units><curCd>USD</curCd><valUSD>0</valUSD><pctVal>0</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>SomaLogic Inc</name><lei>N/A</lei><title>SomaLogic Inc</title><cusip>N/A</cusip><identifiers><isin value="DU0000104520"/></identifiers><balance>722708</balance><units>NS</units><curCd>USD</curCd><valUSD>1</valUSD><pctVal>0</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>2</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>4D Molecular Therapeutics Inc</name><lei>N/A</lei><title>4D Molecular Therapeutics Inc</title><cusip>35104E100</cusip><identifiers><isin value="US35104E1001"/><ticker value="FDMT US"/><other otherDesc="BKLXFX5" value="Sedol"/></identifiers><balance>444198</balance><units>NS</units><curCd>USD</curCd><valUSD>9865638</valUSD><pctVal>0.209</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Gilead Sciences Inc</name><lei>549300WTZWR07K8MNV44</lei><title>Gilead Sciences Inc</title><cusip>375558103</cusip><identifiers><isin value="US3755581036"/><ticker value="GILD US"/><other otherDesc="2369174" value="Sedol"/></identifiers><balance>372723</balance><units>NS</units><curCd>USD</curCd><valUSD>31998270</valUSD><pctVal>0.677</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Globus Medical Inc</name><lei>5299003M2P4CIK0RF205</lei><title>Globus Medical Inc</title><cusip>379577208</cusip><identifiers><isin value="US3795772082"/><ticker value="GMED US"/><other otherDesc="B7D65M0" 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value="Sedol"/></identifiers><balance>147101</balance><units>NS</units><curCd>USD</curCd><valUSD>39033250</valUSD><pctVal>0.826</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>IQVIA Holdings Inc</name><lei>549300W3R20NM4KQPH86</lei><title>IQVIA Holdings Inc</title><cusip>46266C105</cusip><identifiers><isin value="US46266C1053"/><ticker value="IQV US"/><other otherDesc="BDR73G1" 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value="Sedol"/></identifiers><balance>287224</balance><units>NS</units><curCd>USD</curCd><valUSD>50738120</valUSD><pctVal>1.074</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Bayer AG</name><lei>549300J4U55H3WP1XT59</lei><title>Bayer AG</title><cusip>D0712D163</cusip><identifiers><isin value="DE000BAY0017"/><ticker value="BAYN GR"/><other otherDesc="5069211" value="Sedol"/></identifiers><balance>538151</balance><units>NS</units><currencyConditional curCd="EUR" exchangeRt="0.93432"/><valUSD>27782115</valUSD><pctVal>0.588</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>DE</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>2</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Eli Lilly &amp; Co</name><lei>FRDRIPF3EKNDJ2CQJL29</lei><title>Eli Lilly &amp; Co</title><cusip>532457108</cusip><identifiers><isin value="US5324571083"/><ticker value="LLY US"/><other otherDesc="2516152" value="Sedol"/></identifiers><balance>386933</balance><units>NS</units><curCd>USD</curCd><valUSD>141555569</valUSD><pctVal>2.995</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Sanofi</name><lei>549300E9PC51EN656011</lei><title>Sanofi</title><cusip>F5548N101</cusip><identifiers><isin value="FR0000120578"/><ticker value="SAN FP"/><other otherDesc="5671735" value="Sedol"/></identifiers><balance>1269194</balance><units>NS</units><currencyConditional curCd="EUR" 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value="Sedol"/></identifiers><balance>1276139</balance><units>NS</units><curCd>USD</curCd><valUSD>141587622</valUSD><pctVal>2.996</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Mirati Therapeutics Inc</name><lei>529900GYRW59IDQV6N54</lei><title>Mirati Therapeutics Inc</title><cusip>60468T105</cusip><identifiers><isin value="US60468T1051"/><ticker value="MRTX US"/><other otherDesc="BBPK0J0" value="Sedol"/></identifiers><balance>107105</balance><units>NS</units><curCd>USD</curCd><valUSD>4852928</valUSD><pctVal>0.103</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>NeoGenomics Inc</name><lei>549300KN62PPGHBVXB46</lei><title>NeoGenomics Inc</title><cusip>64049M209</cusip><identifiers><isin value="US64049M2098"/><ticker value="NEO US"/><other otherDesc="2598246" value="Sedol"/></identifiers><balance>1668087</balance><units>NS</units><curCd>USD</curCd><valUSD>15413124</valUSD><pctVal>0.326</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Neurocrine Biosciences Inc</name><lei>549300FECER0XBN49756</lei><title>Neurocrine Biosciences Inc</title><cusip>64125C109</cusip><identifiers><isin value="US64125C1099"/><ticker value="NBIX US"/><other otherDesc="2623911" value="Sedol"/></identifiers><balance>465421</balance><units>NS</units><curCd>USD</curCd><valUSD>55589884</valUSD><pctVal>1.176</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Olema Pharmaceuticals Inc</name><lei>N/A</lei><title>Olema Pharmaceuticals Inc</title><cusip>68062P106</cusip><identifiers><isin value="US68062P1066"/><ticker value="OLMA US"/><other otherDesc="BMZ4LN0" value="Sedol"/></identifiers><balance>745574</balance><units>NS</units><curCd>USD</curCd><valUSD>1826656</valUSD><pctVal>0.039</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Organon &amp; Co</name><lei>549300AMCKY57OK2CO56</lei><title>Organon &amp; Co COMMON STOCK</title><cusip>68622V106</cusip><identifiers><isin value="US68622V1061"/><ticker value="OGN US"/><other otherDesc="BLDC8J4" value="Sedol"/></identifiers><balance>1827838</balance><units>NS</units><curCd>USD</curCd><valUSD>51051515</valUSD><pctVal>1.08</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Takeda Pharmaceutical Co Ltd</name><lei>549300ZLMVP4X0OGR454</lei><title>Takeda Pharmaceutical Co Ltd</title><cusip>J8129E108</cusip><identifiers><isin value="JP3463000004"/><ticker value="4502 JP"/><other otherDesc="6870445" value="Sedol"/></identifiers><balance>781836</balance><units>NS</units><currencyConditional curCd="JPY" 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value="Sedol"/></identifiers><balance>569062</balance><units>NS</units><curCd>USD</curCd><valUSD>21721097</valUSD><pctVal>0.46</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Astellas Pharma Inc</name><lei>529900IB708DY2HBBB35</lei><title>Astellas Pharma Inc</title><cusip>J03393105</cusip><identifiers><isin value="JP3942400007"/><ticker value="4503 JP"/><other otherDesc="6985383" value="Sedol"/></identifiers><balance>2952500</balance><units>NS</units><currencyConditional curCd="JPY" 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value="Sedol"/></identifiers><balance>1253293</balance><units>NS</units><curCd>USD</curCd><valUSD>64218733</valUSD><pctVal>1.359</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Privia Health Group Inc</name><lei>N/A</lei><title>Privia Health Group Inc</title><cusip>74276R102</cusip><identifiers><isin value="US74276R1023"/><ticker value="PRVA US"/><other otherDesc="BMDP209" 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value="Sedol"/></identifiers><balance>246058</balance><units>NS</units><curCd>USD</curCd><valUSD>9384652</valUSD><pctVal>0.199</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Sarepta Therapeutics Inc</name><lei>549300IKDPIED8J8IG21</lei><title>Sarepta Therapeutics Inc</title><cusip>803607100</cusip><identifiers><isin value="US8036071004"/><ticker value="SRPT US"/><other otherDesc="B8DPDT7" 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value="Sedol"/></identifiers><balance>3055514</balance><units>NS</units><curCd>USD</curCd><valUSD>17110878</valUSD><pctVal>0.362</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Silk Road Medical Inc</name><lei>549300VL8KC0ZPDQHE14</lei><title>Silk Road Medical Inc</title><cusip>82710M100</cusip><identifiers><isin value="US82710M1009"/><ticker value="SILK US"/><other otherDesc="BGHVXJ7" value="Sedol"/></identifiers><balance>226996</balance><units>NS</units><curCd>USD</curCd><valUSD>11996739</valUSD><pctVal>0.254</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>SomaLogic Inc</name><lei>549300D3W3Q8CN30YO25</lei><title>SomaLogic Inc</title><cusip>83444K105</cusip><identifiers><isin value="US83444K1051"/><ticker value="SLGC US"/><other otherDesc="BLGYRD4" value="Sedol"/></identifiers><balance>1019345</balance><units>NS</units><curCd>USD</curCd><valUSD>2558556</valUSD><pctVal>0.054</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Stryker Corp</name><lei>5493002F0SC4JTBU5137</lei><title>Stryker Corp</title><cusip>863667101</cusip><identifiers><isin value="US8636671013"/><ticker value="SYK US"/><other otherDesc="2853688" value="Sedol"/></identifiers><balance>193356</balance><units>NS</units><curCd>USD</curCd><valUSD>47273608</valUSD><pctVal>1</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Tandem Diabetes Care Inc</name><lei>549300JEPFOD0K4D3I05</lei><title>Tandem Diabetes Care Inc</title><cusip>875372203</cusip><identifiers><isin value="US8753722037"/><ticker value="TNDM US"/><other otherDesc="BF3W461" value="Sedol"/></identifiers><balance>214236</balance><units>NS</units><curCd>USD</curCd><valUSD>9629908</valUSD><pctVal>0.204</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Teleflex Inc</name><lei>UUL85LWXB4NGSWWXIQ25</lei><title>Teleflex Inc</title><cusip>879369106</cusip><identifiers><isin value="US8793691069"/><ticker value="TFX US"/><other otherDesc="2881407" value="Sedol"/></identifiers><balance>121410</balance><units>NS</units><curCd>USD</curCd><valUSD>30307578</valUSD><pctVal>0.641</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Thermo Fisher Scientific Inc</name><lei>HCHV7422L5HDJZCRFL38</lei><title>THERMO FISHER SCIENTIFIC INC</title><cusip>883556102</cusip><identifiers><isin value="US8835561023"/><ticker value="TMO US"/><other otherDesc="2886907" value="Sedol"/></identifiers><balance>199869</balance><units>NS</units><curCd>USD</curCd><valUSD>110065860</valUSD><pctVal>2.329</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Travere Therapeutics Inc</name><lei>N/A</lei><title>Travere Therapeutics Inc</title><cusip>89422G107</cusip><identifiers><isin value="US89422G1076"/><ticker value="TVTX US"/><other otherDesc="BLFGJD5" 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value="DU0000100962"/></identifiers><balance>16893319</balance><units>NS</units><curCd>USD</curCd><valUSD>16896698</valUSD><pctVal>0.358</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>PF</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>2</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Janus Henderson Cash Collateral Fund</name><lei>N/A</lei><title>Janus Henderson Cash Collateral Fund</title><cusip>N/A</cusip><identifiers><other otherDesc="896" value="Internal ID"/></identifiers><balance>16361734</balance><units>NS</units><curCd>USD</curCd><valUSD>16361734</valUSD><pctVal>0.346</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>PF</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>2</fairValLevel><securityLending><cashCollateralCondition cashCollateralVal="16361734" isCashCollateral="Y"/><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>United Therapeutics Corp</name><lei>5299005C4HZL4UWROC14</lei><title>United Therapeutics Corp</title><cusip>91307C102</cusip><identifiers><isin value="US91307C1027"/><ticker value="UTHR US"/><other otherDesc="2430412" value="Sedol"/></identifiers><balance>159472</balance><units>NS</units><curCd>USD</curCd><valUSD>44347568</valUSD><pctVal>0.938</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>UnitedHealth Group Inc</name><lei>549300GHBMY8T5GXDE41</lei><title>UnitedHealth Group Inc</title><cusip>91324P102</cusip><identifiers><isin value="US91324P1021"/><ticker value="UNH US"/><other otherDesc="2917766" value="Sedol"/></identifiers><balance>585776</balance><units>NS</units><curCd>USD</curCd><valUSD>310566720</valUSD><pctVal>6.571</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Vaxcyte Inc</name><lei>254900M7NMHTGASX8D95</lei><title>Vaxcyte Inc</title><cusip>92243G108</cusip><identifiers><isin value="US92243G1085"/><ticker value="PCVX US"/><other otherDesc="BKPVGH6" value="Sedol"/></identifiers><balance>1081918</balance><units>NS</units><curCd>USD</curCd><valUSD>51877968</valUSD><pctVal>1.098</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Ventyx Biosciences Inc</name><lei>N/A</lei><title>Ventyx Biosciences Inc</title><cusip>92332V107</cusip><identifiers><isin value="US92332V1070"/><ticker value="VTYX US"/><other otherDesc="BMG99Y1" value="Sedol"/></identifiers><balance>533449</balance><units>NS</units><curCd>USD</curCd><valUSD>17491793</valUSD><pctVal>0.37</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><loanByFundCondition isLoanByFund="Y" loanVal="1329564"/></securityLending></invstOrSec><invstOrSec><name>Vertex Pharmaceuticals Inc</name><lei>54930015RAQRRZ5ZGJ91</lei><title>Vertex Pharmaceuticals Inc</title><cusip>92532F100</cusip><identifiers><isin value="US92532F1003"/><ticker value="VRTX US"/><other otherDesc="2931034" value="Sedol"/></identifiers><balance>341726</balance><units>NS</units><curCd>USD</curCd><valUSD>98683634</valUSD><pctVal>2.088</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Novo Nordisk A/S</name><lei>549300DAQ1CVT6CXN342</lei><title>Novo Nordisk A/S</title><cusip>K72807132</cusip><identifiers><isin value="DK0060534915"/><ticker value="NOVOB DC"/><other otherDesc="BHC8X90" value="Sedol"/></identifiers><balance>634763</balance><units>NS</units><currencyConditional curCd="DKK" exchangeRt="6.9456"/><valUSD>85961729</valUSD><pctVal>1.819</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>DK</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>2</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Canbridge Pharmaceuticals Inc</name><lei>8755009KKZM9ETBOF853</lei><title>Canbridge Pharmaceuticals Inc USD0.00001</title><cusip>G1821D109</cusip><identifiers><isin value="KYG1821D1097"/><ticker value="1228 HK"/><other otherDesc="BMZQ5M3" value="Sedol"/></identifiers><balance>3901000</balance><units>NS</units><currencyConditional curCd="HKD" exchangeRt="7.805"/><valUSD>1224529</valUSD><pctVal>0.026</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>HK</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Biohaven Ltd</name><lei>N/A</lei><title>Biohaven Ltd</title><cusip>G1110E107</cusip><identifiers><isin value="VGG1110E1079"/><ticker value="BHVN US"/><other otherDesc="BPLZ7S5" value="Sedol"/></identifiers><balance>1022578</balance><units>NS</units><curCd>USD</curCd><valUSD>14193383</valUSD><pctVal>0.3</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Horizon Therapeutics Plc</name><lei>529900P0GSQ79OOZEV53</lei><title>Horizon Therapeutics Plc</title><cusip>G46188101</cusip><identifiers><isin value="IE00BQPVQZ61"/><ticker value="HZNP US"/><other otherDesc="BQPVQZ6" value="Sedol"/></identifiers><balance>536977</balance><units>NS</units><curCd>USD</curCd><valUSD>61107983</valUSD><pctVal>1.293</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>ICON PLC</name><lei>6354008SRQGEMC4XFI67</lei><title>ICON PLC</title><cusip>G4705A100</cusip><identifiers><isin value="IE0005711209"/><ticker value="ICLR US"/><other otherDesc="B94G471" value="Sedol"/></identifiers><balance>82452</balance><units>NS</units><curCd>USD</curCd><valUSD>16016301</valUSD><pctVal>0.339</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Jazz Pharmaceuticals PLC</name><lei>635400GAUMJCLEZRRV50</lei><title>Jazz Pharmaceuticals PLC</title><cusip>G50871105</cusip><identifiers><isin value="IE00B4Q5ZN47"/><ticker value="JAZZ US"/><other otherDesc="B4Q5ZN4" value="Sedol"/></identifiers><balance>420006</balance><units>NS</units><curCd>USD</curCd><valUSD>66911156</valUSD><pctVal>1.416</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Medtronic PLC</name><lei>549300GX3ZBSQWUXY261</lei><title>Medtronic PLC</title><cusip>G5960L103</cusip><identifiers><isin value="IE00BTN1Y115"/><ticker value="MDT US"/><other otherDesc="BTN1Y11" 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value="Sedol"/></identifiers><balance>425921</balance><units>NS</units><curCd>USD</curCd><valUSD>25661740</valUSD><pctVal>0.543</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Royalty Pharma PLC</name><lei>549300FGFN7VOK8BZR03</lei><title>Royalty Pharma PLC - Class A</title><cusip>G7709Q104</cusip><identifiers><isin value="GB00BMVP7Y09"/><ticker value="RPRX US"/><other otherDesc="BMVP7Y0" value="Sedol"/></identifiers><balance>952283</balance><units>NS</units><curCd>USD</curCd><valUSD>37634224</valUSD><pctVal>0.796</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>STERIS PLC</name><lei>N/A</lei><title>STERIS PLC</title><cusip>G8473T100</cusip><identifiers><isin value="IE00BFY8C754"/><ticker value="STE US"/><other otherDesc="BFY8C75" value="Sedol"/></identifiers><balance>170535</balance><units>NS</units><curCd>USD</curCd><valUSD>31496109</valUSD><pctVal>0.666</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Dummy Issuer</name><lei>N/A</lei><title>Curevo Inc</title><cusip>N/A</cusip><identifiers><isin value="DU0000105594"/><ticker value="CUREVOPP"/></identifiers><balance>2031087</balance><units>NS</units><curCd>USD</curCd><valUSD>5330344</valUSD><pctVal>0.113</pctVal><payoffProfile>Long</payoffProfile><assetCat>EP</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Element Biosciences Inc</name><lei>N/A</lei><title>Element Biosciences Inc</title><cusip>N/A</cusip><identifiers><isin value="DU0000104465"/><ticker value="1726116D"/></identifiers><balance>425023</balance><units>NS</units><curCd>USD</curCd><valUSD>6991628</valUSD><pctVal>0.148</pctVal><payoffProfile>Long</payoffProfile><assetCat>EP</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Shoreline Biosciences Inc</name><lei>N/A</lei><title>Shoreline Biosciences Inc</title><cusip>N/A</cusip><identifiers><isin value="DU0000104569"/><ticker value="1868807D"/></identifiers><balance>747187</balance><units>NS</units><curCd>USD</curCd><valUSD>6017769</valUSD><pctVal>0.127</pctVal><payoffProfile>Long</payoffProfile><assetCat>EP</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Attralus Inc</name><lei>N/A</lei><title>Attralus Inc</title><cusip>N/A</cusip><identifiers><isin value="DU0000104336"/><ticker value="1829635D"/></identifiers><balance>669935</balance><units>NS</units><curCd>USD</curCd><valUSD>3483662</valUSD><pctVal>0.074</pctVal><payoffProfile>Long</payoffProfile><assetCat>EP</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Lexeo Therapeutics Inc</name><lei>N/A</lei><title>LEXEO Therapeutics Inc - Series A</title><cusip>N/A</cusip><identifiers><isin value="DU0000104012"/></identifiers><balance>3643715</balance><units>NS</units><curCd>USD</curCd><valUSD>6268975</valUSD><pctVal>0.133</pctVal><payoffProfile>Long</payoffProfile><assetCat>EP</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Lexeo Therapeutics Inc</name><lei>N/A</lei><title>LEXEO Therapeutics Inc - Series B</title><cusip>N/A</cusip><identifiers><isin value="DU0000104331"/><ticker value="1848501D US"/></identifiers><balance>883469</balance><units>NS</units><curCd>USD</curCd><valUSD>1520000</valUSD><pctVal>0.032</pctVal><payoffProfile>Long</payoffProfile><assetCat>EP</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>VALENZABIO INC</name><lei>N/A</lei><title>VALENZABIO INC</title><cusip>N/A</cusip><identifiers><isin value="DU0000104263"/></identifiers><balance>700559</balance><units>NS</units><curCd>USD</curCd><valUSD>6235276</valUSD><pctVal>0.132</pctVal><payoffProfile>Long</payoffProfile><assetCat>EP</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Sonoma Biotherapeutics Inc</name><lei>N/A</lei><title>Sonoma Biotherapeutics Inc</title><cusip>N/A</cusip><identifiers><isin value="DU0000104500"/><ticker value="1783532D"/></identifiers><balance>1924628</balance><units>NS</units><curCd>USD</curCd><valUSD>5705560</valUSD><pctVal>0.121</pctVal><payoffProfile>Long</payoffProfile><assetCat>EP</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Arbor Biotechnologies Inc</name><lei>N/A</lei><title>Arbor Biotechnologies Inc</title><cusip>N/A</cusip><identifiers><isin value="DU0000104275"/><ticker value="1584091D"/></identifiers><balance>156426</balance><units>NS</units><curCd>USD</curCd><valUSD>2591979</valUSD><pctVal>0.055</pctVal><payoffProfile>Long</payoffProfile><assetCat>EP</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Freenome Holdings Inc</name><lei>254900QDTSQ6S0QOCS43</lei><title>Freenome Holdings Inc</title><cusip>N/A</cusip><identifiers><isin value="DU0000104596"/><ticker value="1411948D"/></identifiers><balance>342803</balance><units>NS</units><curCd>USD</curCd><valUSD>4000511</valUSD><pctVal>0.085</pctVal><payoffProfile>Long</payoffProfile><assetCat>EP</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Hemoshear Therapeutics LLC</name><lei>N/A</lei><title>HemoShear Therapeutics LLC</title><cusip>N/A</cusip><identifiers><isin value="DU0000104239"/><ticker value="0611670D US"/></identifiers><balance>289280</balance><units>NS</units><curCd>USD</curCd><valUSD>2109430</valUSD><pctVal>0.045</pctVal><payoffProfile>Long</payoffProfile><assetCat>EP</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Disc Medicine Inc</name><lei>N/A</lei><title>Disc Medicine Inc</title><cusip>N/A</cusip><identifiers><isin value="DU0000104507"/><ticker value="1762523D"/></identifiers><balance>1084584</balance><units>NS</units><curCd>USD</curCd><valUSD>2127899</valUSD><pctVal>0.045</pctVal><payoffProfile>Long</payoffProfile><assetCat>EP</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>2</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Neurogene Inc</name><lei>N/A</lei><title>Neurogene Inc - Series B</title><cusip>N/A</cusip><identifiers><isin value="DU0000105180"/><ticker value="1697089D"/></identifiers><balance>1486727</balance><units>NS</units><curCd>USD</curCd><valUSD>3627614</valUSD><pctVal>0.077</pctVal><payoffProfile>Long</payoffProfile><assetCat>EP</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Twinstrand Biosciences Inc</name><lei>N/A</lei><title>TwinStrand Biosciences Inc</title><cusip>N/A</cusip><identifiers><isin value="DU0000104396"/><ticker value="1724622D US"/></identifiers><balance>344314</balance><units>NS</units><curCd>USD</curCd><valUSD>749606</valUSD><pctVal>0.016</pctVal><payoffProfile>Long</payoffProfile><assetCat>EP</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Magnolia Medical Technologies</name><lei>N/A</lei><title>Magnolia Medical Technologies Inc</title><cusip>N/A</cusip><identifiers><isin value="DU0000105101"/><ticker value="1426815D"/></identifiers><balance>1821717</balance><units>NS</units><curCd>USD</curCd><valUSD>3092693</valUSD><pctVal>0.065</pctVal><payoffProfile>Long</payoffProfile><assetCat>EP</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Synthekine Inc</name><lei>N/A</lei><title>Synthekine Inc</title><cusip>N/A</cusip><identifiers><isin value="DU0000104328"/><ticker value="1830940D"/></identifiers><balance>2192937</balance><units>NS</units><curCd>USD</curCd><valUSD>5661001</valUSD><pctVal>0.12</pctVal><payoffProfile>Long</payoffProfile><assetCat>EP</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Asher Biotherapeutics Inc</name><lei>N/A</lei><title>Asher Biotherapeutics Inc</title><cusip>N/A</cusip><identifiers><isin value="DU0000101918"/><ticker value="1741988D"/></identifiers><balance>1214301</balance><units>NS</units><curCd>USD</curCd><valUSD>1951139</valUSD><pctVal>0.041</pctVal><payoffProfile>Long</payoffProfile><assetCat>EP</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Freenome Holdings Inc</name><lei>254900QDTSQ6S0QOCS43</lei><title>Freenome Inc</title><cusip>N/A</cusip><identifiers><isin value="DU0000103893"/><ticker value="1411948D US"/></identifiers><balance>337474</balance><units>NS</units><curCd>USD</curCd><valUSD>3938322</valUSD><pctVal>0.083</pctVal><payoffProfile>Long</payoffProfile><assetCat>EP</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Neurogene Inc</name><lei>N/A</lei><title>Neurogene Inc</title><cusip>N/A</cusip><identifiers><isin value="DU0000102304"/><ticker value="1697089D US"/></identifiers><balance>1336317</balance><units>NS</units><curCd>USD</curCd><valUSD>3260613</valUSD><pctVal>0.069</pctVal><payoffProfile>Long</payoffProfile><assetCat>EP</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Flame Biosciences Inc</name><lei>N/A</lei><title>Flame Biosciences</title><cusip>N/A</cusip><identifiers><isin value="DU0000103955"/><ticker value="1826446D US"/></identifiers><balance>919200</balance><units>NS</units><curCd>USD</curCd><valUSD>2837662</valUSD><pctVal>0.06</pctVal><payoffProfile>Long</payoffProfile><assetCat>EP</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Bigfoot Biomedical Inc</name><lei>N/A</lei><title>Bigfoot Biomedical Inc - Series C-1</title><cusip>N/A</cusip><identifiers><isin value="DU0000104002"/><ticker value="BIGFOOTC1"/></identifiers><balance>168418</balance><units>NS</units><curCd>USD</curCd><valUSD>1372354</valUSD><pctVal>0.029</pctVal><payoffProfile>Long</payoffProfile><assetCat>EP</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Bigfoot Biomedical Inc</name><lei>N/A</lei><title>Bigfoot Biomedical Inc - Series B</title><cusip>N/A</cusip><identifiers><isin value="DU0000100959"/><ticker value="1450137D US"/><other otherDesc="B4N0JJ6" value="Sedol"/></identifiers><balance>1035873</balance><units>NS</units><curCd>USD</curCd><valUSD>8440811</valUSD><pctVal>0.179</pctVal><payoffProfile>Long</payoffProfile><assetCat>EP</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Argenx SE</name><lei>7245009C5FZE6G9ODQ71</lei><title>Argenx SE (ADR)</title><cusip>04016X101</cusip><identifiers><isin value="US04016X1019"/><ticker value="ARGX US"/><other otherDesc="BDVLM39" value="Sedol"/></identifiers><balance>204129</balance><units>NS</units><curCd>USD</curCd><valUSD>77330189</valUSD><pctVal>1.636</pctVal><payoffProfile>Long</payoffProfile><assetConditional assetCat="OTHER" desc="GDR"/><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Ascendis Pharma A/S</name><lei>549300B66JN3W3J8GH73</lei><title>Ascendis Pharma A/S (ADR)</title><cusip>04351P101</cusip><identifiers><isin value="US04351P1012"/><ticker value="ASND US"/><other otherDesc="BV9G6B8" value="Sedol"/></identifiers><balance>456948</balance><units>NS</units><curCd>USD</curCd><valUSD>55807059</valUSD><pctVal>1.181</pctVal><payoffProfile>Long</payoffProfile><assetConditional assetCat="OTHER" desc="GDR"/><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Bicycle Therapeutics PLC</name><lei>213800XKUI6R7GKC3E43</lei><title>Bicycle Therapeutics Ltd (ADR)</title><cusip>088786108</cusip><identifiers><isin value="US0887861088"/><ticker value="BCYC US"/><other otherDesc="BKDQKM6" value="Sedol"/></identifiers><balance>528203</balance><units>NS</units><curCd>USD</curCd><valUSD>15634809</valUSD><pctVal>0.331</pctVal><payoffProfile>Long</payoffProfile><assetConditional assetCat="OTHER" desc="GDR"/><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><loanByFundCondition isLoanByFund="Y" loanVal="1532863.36"/></securityLending></invstOrSec><invstOrSec><name>Centessa Pharmaceuticals PLC</name><lei>213800GIDAARDSKOI827</lei><title>Centessa Pharmacuticals PLC (ADR)</title><cusip>152309100</cusip><identifiers><isin value="US1523091007"/><ticker value="CNTA US"/><other otherDesc="BLB0YQ9" value="Sedol"/></identifiers><balance>691173</balance><units>NS</units><curCd>USD</curCd><valUSD>2142636</valUSD><pctVal>0.045</pctVal><payoffProfile>Long</payoffProfile><assetConditional assetCat="OTHER" desc="GDR"/><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><loanByFundCondition isLoanByFund="Y" loanVal="1575044.9"/></securityLending></invstOrSec><invstOrSec><name>Clementia Pharmaceuticals Inc</name><lei>N/A</lei><title>Clementia Pharmaceuticals Inc CVR</title><cusip>N/A</cusip><identifiers><isin value="US185CVR0169"/><ticker value="CMTA CVR"/></identifiers><balance>874311</balance><units>NS</units><curCd>USD</curCd><valUSD>1</valUSD><pctVal>0</pctVal><payoffProfile>Long</payoffProfile><assetConditional assetCat="OTHER" desc="Rights"/><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Legend Biotech Corp</name><lei>254900EIUFZTW136H859</lei><title>Legend Biotech Corp (ADR)</title><cusip>52490G102</cusip><identifiers><isin value="US52490G1022"/><ticker value="LEGN US"/><other otherDesc="BMX9K07" value="Sedol"/></identifiers><balance>520392</balance><units>NS</units><curCd>USD</curCd><valUSD>25977969</valUSD><pctVal>0.55</pctVal><payoffProfile>Long</payoffProfile><assetConditional assetCat="OTHER" desc="GDR"/><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Novartis AG</name><lei>5493007HIVTX6SY6XD66</lei><title>Novartis AG (ADR)</title><cusip>66987V109</cusip><identifiers><isin value="US66987V1098"/><ticker value="NVS US"/><other otherDesc="2620105" value="Sedol"/></identifiers><balance>1405032</balance><units>NS</units><curCd>USD</curCd><valUSD>127464503</valUSD><pctVal>2.697</pctVal><payoffProfile>Long</payoffProfile><assetConditional assetCat="OTHER" desc="GDR"/><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Zai Lab Ltd</name><lei>549300P2UYQ9U5LY1T58</lei><title>Zai Lab Ltd (ADR)</title><cusip>98887Q104</cusip><identifiers><isin value="US98887Q1040"/><ticker value="ZLAB US"/><other otherDesc="BD9GVY0" value="Sedol"/></identifiers><balance>659746</balance><units>NS</units><curCd>USD</curCd><valUSD>20254202</valUSD><pctVal>0.429</pctVal><payoffProfile>Long</payoffProfile><assetConditional assetCat="OTHER" desc="GDR"/><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec></invstOrSecs><explntrNotes><explntrNote note="Monthly returns presented in Item B.5(a) have been calculated without deducting any applicable sales loads or redemption fees." noteItem="B.5.a"/></explntrNotes><signature><ncom:dateSigned>2023-02-14</ncom:dateSigned><ncom:nameOfApplicant>JANUS INVESTMENT FUND</ncom:nameOfApplicant><ncom:signature>JESPER NERGAARD</ncom:signature><ncom:signerName>JESPER NERGAARD</ncom:signerName><ncom:title>VP, CFO, TREASURER, AND PRINCIPAL ACCOUNTING OFFICER</ncom:title></signature></formData><documents>XXXX</documents></edgarSubmission>
