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value="Sedol"/></identifiers><balance>171163</balance><units>NS</units><curCd>USD</curCd><valUSD>77749081</valUSD><pctVal>1.949</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>BioMarin Pharmaceutical Inc</name><lei>NSLL8ITTRR0J5HEMR848</lei><title>BioMarin Pharmaceutical Inc</title><cusip>09061G101</cusip><identifiers><isin value="US09061G1013"/><ticker value="BMRN US"/><other otherDesc="2437071" value="Sedol"/></identifiers><balance>640448</balance><units>NS</units><curCd>USD</curCd><valUSD>54290777</valUSD><pctVal>1.361</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Biomea Fusion Inc</name><lei>N/A</lei><title>Biomea Fusion Inc</title><cusip>09077A106</cusip><identifiers><isin value="US09077A1060"/><ticker value="BMEA US"/><other otherDesc="BNKF6N0" value="Sedol"/></identifiers><balance>708936</balance><units>NS</units><curCd>USD</curCd><valUSD>6933394</valUSD><pctVal>0.174</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><loanByFundCondition isLoanByFund="Y" loanVal="562858.86"/></securityLending></invstOrSec><invstOrSec><name>BioAtla Inc</name><lei>N/A</lei><title>BioAtla LLC</title><cusip>09077B104</cusip><identifiers><isin value="US09077B1044"/><ticker value="BCAB US"/><other otherDesc="BNC5F86" value="Sedol"/></identifiers><balance>496318</balance><units>NS</units><curCd>USD</curCd><valUSD>3821649</valUSD><pctVal>0.096</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><loanByFundCondition isLoanByFund="Y" loanVal="2245149.97"/></securityLending></invstOrSec><invstOrSec><name>AstraZeneca PLC</name><lei>PY6ZZQWO2IZFZC3IOL08</lei><title>AstraZeneca PLC</title><cusip>G0593M107</cusip><identifiers><isin value="GB0009895292"/><ticker value="AZN LN"/><other otherDesc="989529" value="Sedol"/></identifiers><balance>1516829</balance><units>NS</units><currencyConditional curCd="GBP" exchangeRt="0.89582"/><valUSD>166767789</valUSD><pctVal>4.18</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>GB</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>2</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Boston Scientific Corp</name><lei>Y6ZDD9FP4P8JSSJMW954</lei><title>Boston Scientific Corp</title><cusip>101137107</cusip><identifiers><isin value="US1011371077"/><ticker value="BSX US"/><other otherDesc="2113434" value="Sedol"/></identifiers><balance>2298614</balance><units>NS</units><curCd>USD</curCd><valUSD>89025320</valUSD><pctVal>2.231</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Bristol-Myers Squibb Co</name><lei>HLYYNH7UQUORYSJQCN42</lei><title>Bristol-Myers Squibb Co</title><cusip>110122108</cusip><identifiers><isin value="US1101221083"/><ticker value="BMY US"/><other otherDesc="2126335" value="Sedol"/></identifiers><balance>1502227</balance><units>NS</units><curCd>USD</curCd><valUSD>106793317</valUSD><pctVal>2.677</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>C4 Therapeutics Inc</name><lei>N/A</lei><title>C4 Therapeutics Inc</title><cusip>12529R107</cusip><identifiers><isin value="US12529R1077"/><ticker value="CCCC US"/><other otherDesc="BKX9NQ0" value="Sedol"/></identifiers><balance>323981</balance><units>NS</units><curCd>USD</curCd><valUSD>2841313</valUSD><pctVal>0.071</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Catalent Inc</name><lei>N/A</lei><title>Catalent Inc</title><cusip>148806102</cusip><identifiers><isin value="US1488061029"/><ticker value="CTLT US"/><other otherDesc="BP96PQ4" value="Sedol"/></identifiers><balance>190535</balance><units>NS</units><curCd>USD</curCd><valUSD>13787113</valUSD><pctVal>0.346</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Centene Corp</name><lei>549300Z7JJ4TQSQGT333</lei><title>Centene Corp</title><cusip>15135B101</cusip><identifiers><isin value="US15135B1017"/><ticker value="CNC US"/><other otherDesc="2807061" value="Sedol"/></identifiers><balance>936020</balance><units>NS</units><curCd>USD</curCd><valUSD>72831716</valUSD><pctVal>1.825</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Cerevel Therapeutics Holdings</name><lei>254900RJNIRS9COSQR41</lei><title>Cerevel Therapeutics Holdings Inc COM</title><cusip>15678U128</cusip><identifiers><isin value="US15678U1280"/><ticker value="CERE US"/><other otherDesc="BMVMJ12" value="Sedol"/></identifiers><balance>415935</balance><units>NS</units><curCd>USD</curCd><valUSD>11754323</valUSD><pctVal>0.295</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Collegium Pharmaceutical Inc</name><lei>54930049FXZMTLW8D496</lei><title>Collegium Pharmaceutical Inc</title><cusip>19459J104</cusip><identifiers><isin value="US19459J1043"/><ticker value="COLL US"/><other otherDesc="BX7RSN3" value="Sedol"/></identifiers><balance>665534</balance><units>NS</units><curCd>USD</curCd><valUSD>10661855</valUSD><pctVal>0.267</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Cooper Cos Inc/The</name><lei>QJKMVPIGLH7530PCUE20</lei><title>Cooper Cos Inc</title><cusip>216648402</cusip><identifiers><isin value="US2166484020"/><ticker value="COO US"/><other otherDesc="2222631" value="Sedol"/></identifiers><balance>109922</balance><units>NS</units><curCd>USD</curCd><valUSD>29008416</valUSD><pctVal>0.727</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>DICE Therapeutics Inc</name><lei>N/A</lei><title>DICE Therapeutics Inc</title><cusip>23345J104</cusip><identifiers><isin value="US23345J1043"/><ticker value="DICE US"/><other otherDesc="BNRPLC7" value="Sedol"/></identifiers><balance>355532</balance><units>NS</units><curCd>USD</curCd><valUSD>7210189</valUSD><pctVal>0.181</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><loanByFundCondition isLoanByFund="Y" loanVal="3160348.8"/></securityLending></invstOrSec><invstOrSec><name>Danaher Corp</name><lei>S4BKK9OTCEWQ3YHPFM11</lei><title>Danaher Corp</title><cusip>235851102</cusip><identifiers><isin value="US2358511028"/><ticker value="DHR US"/><other otherDesc="2250870" value="Sedol"/></identifiers><balance>352481</balance><units>NS</units><curCd>USD</curCd><valUSD>91042317</valUSD><pctVal>2.282</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>DENTSPLY SIRONA Inc</name><lei>9NHEHR1SOZCYXDO8HO28</lei><title>DENTSPLY SIRONA Inc</title><cusip>24906P109</cusip><identifiers><isin value="US24906P1093"/><ticker value="XRAY US"/><other otherDesc="BYNPPC6" value="Sedol"/></identifiers><balance>710007</balance><units>NS</units><curCd>USD</curCd><valUSD>20128698</valUSD><pctVal>0.505</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Design Therapeutics Inc</name><lei>N/A</lei><title>Design Therapeutics Inc</title><cusip>25056L103</cusip><identifiers><isin value="US25056L1035"/><ticker value="DSGN US"/><other otherDesc="BMFK3H6" value="Sedol"/></identifiers><balance>400276</balance><units>NS</units><curCd>USD</curCd><valUSD>6692615</valUSD><pctVal>0.168</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><loanByFundCondition isLoanByFund="Y" loanVal="493105.51"/></securityLending></invstOrSec><invstOrSec><name>Dexcom Inc</name><lei>549300YSK3QDSFR5EU59</lei><title>DexCom Inc</title><cusip>252131107</cusip><identifiers><isin value="US2521311074"/><ticker value="DXCM US"/><other otherDesc="B0796X4" value="Sedol"/></identifiers><balance>329527</balance><units>NS</units><curCd>USD</curCd><valUSD>26540105</valUSD><pctVal>0.665</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Edgewise Therapeutics Inc</name><lei>N/A</lei><title>Edgewise Therapeutics Inc</title><cusip>28036F105</cusip><identifiers><isin value="US28036F1057"/><ticker value="EWTX US"/><other otherDesc="BKY5JZ8" value="Sedol"/></identifiers><balance>408268</balance><units>NS</units><curCd>USD</curCd><valUSD>4017357</valUSD><pctVal>0.101</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><loanByFundCondition isLoanByFund="Y" loanVal="16118.4"/></securityLending></invstOrSec><invstOrSec><name>Edwards Lifesciences Corp</name><lei>YA13X31F3V31L8TMPR58</lei><title>Edwards Lifesciences Corp</title><cusip>28176E108</cusip><identifiers><isin value="US28176E1082"/><ticker value="EW US"/><other otherDesc="2567116" value="Sedol"/></identifiers><balance>569803</balance><units>NS</units><curCd>USD</curCd><valUSD>47082822</valUSD><pctVal>1.18</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Elanco Animal Health Inc</name><lei>549300SHPNDCE059M934</lei><title>Elanco Animal Health Inc</title><cusip>28414H103</cusip><identifiers><isin value="US28414H1032"/><ticker value="ELAN US"/><other otherDesc="BF5L3T2" value="Sedol"/></identifiers><balance>1259513</balance><units>NS</units><curCd>USD</curCd><valUSD>15630556</valUSD><pctVal>0.392</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Fate Therapeutics Inc</name><lei>549300L14Q4UHOODLA90</lei><title>Fate Therapeutics Inc</title><cusip>31189P102</cusip><identifiers><isin value="US31189P1021"/><ticker value="FATE US"/><other otherDesc="BCZS820" value="Sedol"/></identifiers><balance>207327</balance><units>NS</units><curCd>USD</curCd><valUSD>4646198</valUSD><pctVal>0.116</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Magnolia Medical Technologies Inc</name><lei>N/A</lei><title>Magnolia Medical Technologies Inc</title><cusip>N/A</cusip><identifiers><isin value="DU0000105108"/></identifiers><balance>1</balance><units>NS</units><curCd>USD</curCd><valUSD>0</valUSD><pctVal>0</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>SomaLogic Inc</name><lei>N/A</lei><title>SomaLogic Inc</title><cusip>N/A</cusip><identifiers><isin value="DU0000104520"/></identifiers><balance>722708</balance><units>NS</units><curCd>USD</curCd><valUSD>1</valUSD><pctVal>0</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>2</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>4D Molecular Therapeutics Inc</name><lei>N/A</lei><title>4D Molecular Therapeutics Inc</title><cusip>35104E100</cusip><identifiers><isin value="US35104E1001"/><ticker value="FDMT US"/><other otherDesc="BKLXFX5" value="Sedol"/></identifiers><balance>329440</balance><units>NS</units><curCd>USD</curCd><valUSD>2648698</valUSD><pctVal>0.066</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Gilead Sciences Inc</name><lei>549300WTZWR07K8MNV44</lei><title>Gilead Sciences Inc</title><cusip>375558103</cusip><identifiers><isin value="US3755581036"/><ticker value="GILD US"/><other otherDesc="2369174" value="Sedol"/></identifiers><balance>469294</balance><units>NS</units><curCd>USD</curCd><valUSD>28950747</valUSD><pctVal>0.726</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Global Blood Therapeutics Inc</name><lei>549300U4G0QKK99GRT15</lei><title>Global Blood Therapeutics Inc</title><cusip>37890U108</cusip><identifiers><isin value="US37890U1088"/><ticker value="GBT US"/><other otherDesc="BZ05388" value="Sedol"/></identifiers><balance>166668</balance><units>NS</units><curCd>USD</curCd><valUSD>11350091</valUSD><pctVal>0.284</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Globus Medical Inc</name><lei>5299003M2P4CIK0RF205</lei><title>Globus Medical Inc</title><cusip>379577208</cusip><identifiers><isin value="US3795772082"/><ticker value="GMED US"/><other otherDesc="B7D65M0" value="Sedol"/></identifiers><balance>480233</balance><units>NS</units><curCd>USD</curCd><valUSD>28607480</valUSD><pctVal>0.717</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>DICE Therapeutics Inc</name><lei>N/A</lei><title>DICE Therapeutics Inc</title><cusip>N/A</cusip><identifiers><isin value="DU0000102059"/></identifiers><balance>192261</balance><units>NS</units><curCd>USD</curCd><valUSD>3899053</valUSD><pctVal>0.098</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Harmony Biosciences Holdings I</name><lei>N/A</lei><title>Harmony Biosciences Holdings Inc</title><cusip>413197104</cusip><identifiers><isin value="US4131971040"/><ticker value="HRMY US"/><other otherDesc="BKSGZN7" value="Sedol"/></identifiers><balance>392800</balance><units>NS</units><curCd>USD</curCd><valUSD>17397112</valUSD><pctVal>0.436</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Health Catalyst Inc</name><lei>549300223PL6GWKVJG92</lei><title>Health Catalyst Inc</title><cusip>42225T107</cusip><identifiers><isin value="US42225T1079"/><ticker value="HCAT US"/><other otherDesc="BKLCX50" 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value="Sedol"/></identifiers><balance>1249728</balance><units>NS</units><curCd>USD</curCd><valUSD>107626575</valUSD><pctVal>2.698</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Mirati Therapeutics Inc</name><lei>529900GYRW59IDQV6N54</lei><title>Mirati Therapeutics Inc</title><cusip>60468T105</cusip><identifiers><isin value="US60468T1051"/><ticker value="MRTX US"/><other otherDesc="BBPK0J0" 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value="Sedol"/></identifiers><balance>590365</balance><units>NS</units><curCd>USD</curCd><valUSD>62702667</valUSD><pctVal>1.572</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Nuvalent Inc</name><lei>N/A</lei><title>Nuvalent  Inc - Class A</title><cusip>670703107</cusip><identifiers><isin value="US6707031075"/><ticker value="NUVL US"/><other otherDesc="BMVBZD3" 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value="Sedol"/></identifiers><balance>1595174</balance><units>NS</units><curCd>USD</curCd><valUSD>37327072</valUSD><pctVal>0.936</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Takeda Pharmaceutical Co Ltd</name><lei>549300ZLMVP4X0OGR454</lei><title>Takeda Pharmaceutical Co Ltd</title><cusip>J8129E108</cusip><identifiers><isin value="JP3463000004"/><ticker value="4502 JP"/><other otherDesc="6870445" value="Sedol"/></identifiers><balance>755736</balance><units>NS</units><currencyConditional curCd="JPY" 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value="Sedol"/></identifiers><balance>2466664</balance><units>NS</units><curCd>USD</curCd><valUSD>15835983</valUSD><pctVal>0.397</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Silk Road Medical Inc</name><lei>549300VL8KC0ZPDQHE14</lei><title>Silk Road Medical Inc</title><cusip>82710M100</cusip><identifiers><isin value="US82710M1009"/><ticker value="SILK US"/><other otherDesc="BGHVXJ7" 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value="Sedol"/></identifiers><balance>984737</balance><units>NS</units><curCd>USD</curCd><valUSD>2855737</valUSD><pctVal>0.072</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Stryker Corp</name><lei>5493002F0SC4JTBU5137</lei><title>Stryker Corp</title><cusip>863667101</cusip><identifiers><isin value="US8636671013"/><ticker value="SYK US"/><other otherDesc="2853688" value="Sedol"/></identifiers><balance>193719</balance><units>NS</units><curCd>USD</curCd><valUSD>39235846</valUSD><pctVal>0.983</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Tandem Diabetes Care Inc</name><lei>549300JEPFOD0K4D3I05</lei><title>Tandem Diabetes Care Inc</title><cusip>875372203</cusip><identifiers><isin value="US8753722037"/><ticker value="TNDM US"/><other otherDesc="BF3W461" value="Sedol"/></identifiers><balance>177080</balance><units>NS</units><curCd>USD</curCd><valUSD>8473278</valUSD><pctVal>0.212</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Teleflex Inc</name><lei>UUL85LWXB4NGSWWXIQ25</lei><title>Teleflex Inc</title><cusip>879369106</cusip><identifiers><isin value="US8793691069"/><ticker value="TFX US"/><other otherDesc="2881407" value="Sedol"/></identifiers><balance>161220</balance><units>NS</units><curCd>USD</curCd><valUSD>32479381</valUSD><pctVal>0.814</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Thermo Fisher Scientific Inc</name><lei>HCHV7422L5HDJZCRFL38</lei><title>THERMO FISHER SCIENTIFIC INC</title><cusip>883556102</cusip><identifiers><isin value="US8835561023"/><ticker value="TMO US"/><other otherDesc="2886907" value="Sedol"/></identifiers><balance>194296</balance><units>NS</units><curCd>USD</curCd><valUSD>98544988</valUSD><pctVal>2.47</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Travere Therapeutics Inc</name><lei>N/A</lei><title>Travere Therapeutics Inc</title><cusip>89422G107</cusip><identifiers><isin value="US89422G1076"/><ticker value="TVTX US"/><other otherDesc="BLFGJD5" 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value="DU0000100962"/></identifiers><balance>5298408</balance><units>NS</units><curCd>USD</curCd><valUSD>5298938</valUSD><pctVal>0.133</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>PF</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>2</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Janus Henderson Cash Collateral Fund</name><lei>N/A</lei><title>Janus Henderson Cash Collateral Fund</title><cusip>N/A</cusip><identifiers><other otherDesc="896" value="Internal 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value="Sedol"/></identifiers><balance>155416</balance><units>NS</units><curCd>USD</curCd><valUSD>32541002</valUSD><pctVal>0.816</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>UnitedHealth Group Inc</name><lei>549300GHBMY8T5GXDE41</lei><title>UnitedHealth Group Inc</title><cusip>91324P102</cusip><identifiers><isin value="US91324P1021"/><ticker value="UNH US"/><other otherDesc="2917766" value="Sedol"/></identifiers><balance>554181</balance><units>NS</units><curCd>USD</curCd><valUSD>279883572</valUSD><pctVal>7.015</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Vaxcyte Inc</name><lei>254900M7NMHTGASX8D95</lei><title>Vaxcyte Inc</title><cusip>92243G108</cusip><identifiers><isin value="US92243G1085"/><ticker value="PCVX US"/><other otherDesc="BKPVGH6" value="Sedol"/></identifiers><balance>632312</balance><units>NS</units><curCd>USD</curCd><valUSD>15175488</valUSD><pctVal>0.38</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Ventyx Biosciences Inc</name><lei>N/A</lei><title>Ventyx Biosciences Inc</title><cusip>92332V107</cusip><identifiers><isin value="US92332V1070"/><ticker value="VTYX US"/><other otherDesc="BMG99Y1" value="Sedol"/></identifiers><balance>449056</balance><units>NS</units><curCd>USD</curCd><valUSD>15676545</valUSD><pctVal>0.393</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><loanByFundCondition isLoanByFund="Y" loanVal="6602384.4"/></securityLending></invstOrSec><invstOrSec><name>Vertex Pharmaceuticals Inc</name><lei>54930015RAQRRZ5ZGJ91</lei><title>Vertex Pharmaceuticals Inc</title><cusip>92532F100</cusip><identifiers><isin value="US92532F1003"/><ticker value="VRTX US"/><other otherDesc="2931034" value="Sedol"/></identifiers><balance>332482</balance><units>NS</units><curCd>USD</curCd><valUSD>96266838</valUSD><pctVal>2.413</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Novo Nordisk A/S</name><lei>549300DAQ1CVT6CXN342</lei><title>Novo Nordisk A/S</title><cusip>K72807132</cusip><identifiers><isin value="DK0060534915"/><ticker value="NOVOB DC"/><other otherDesc="BHC8X90" value="Sedol"/></identifiers><balance>603204</balance><units>NS</units><currencyConditional curCd="DKK" exchangeRt="7.5851"/><valUSD>60134852</valUSD><pctVal>1.507</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>DK</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>2</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Canbridge Pharmaceuticals Inc</name><lei>8755009KKZM9ETBOF853</lei><title>Canbridge Pharmaceuticals Inc USD0.00001</title><cusip>G1821D109</cusip><identifiers><isin value="KYG1821D1097"/><ticker value="1228 HK"/><other otherDesc="BMZQ5M3" value="Sedol"/></identifiers><balance>4250920</balance><units>NS</units><currencyConditional curCd="HKD" exchangeRt="7.8494"/><valUSD>1613848</valUSD><pctVal>0.04</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>HK</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Horizon Therapeutics Plc</name><lei>529900P0GSQ79OOZEV53</lei><title>Horizon Therapeutics Plc</title><cusip>G46188101</cusip><identifiers><isin value="IE00BQPVQZ61"/><ticker value="HZNP US"/><other otherDesc="BQPVQZ6" value="Sedol"/></identifiers><balance>733226</balance><units>NS</units><curCd>USD</curCd><valUSD>45379357</valUSD><pctVal>1.137</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>ICON PLC</name><lei>6354008SRQGEMC4XFI67</lei><title>ICON PLC</title><cusip>G4705A100</cusip><identifiers><isin value="IE0005711209"/><ticker value="ICLR US"/><other otherDesc="B94G471" value="Sedol"/></identifiers><balance>83643</balance><units>NS</units><curCd>USD</curCd><valUSD>15371911</valUSD><pctVal>0.385</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Jazz Pharmaceuticals PLC</name><lei>635400GAUMJCLEZRRV50</lei><title>Jazz Pharmaceuticals PLC</title><cusip>G50871105</cusip><identifiers><isin value="IE00B4Q5ZN47"/><ticker value="JAZZ US"/><other otherDesc="B4Q5ZN4" 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value="Sedol"/></identifiers><balance>884615</balance><units>NS</units><curCd>USD</curCd><valUSD>35543831</valUSD><pctVal>0.891</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>STERIS PLC</name><lei>N/A</lei><title>STERIS PLC</title><cusip>G8473T100</cusip><identifiers><isin value="IE00BFY8C754"/><ticker value="STE US"/><other otherDesc="BFY8C75" value="Sedol"/></identifiers><balance>163241</balance><units>NS</units><curCd>USD</curCd><valUSD>27143713</valUSD><pctVal>0.68</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Element Biosciences Inc</name><lei>N/A</lei><title>Element Biosciences Inc PP</title><cusip>N/A</cusip><identifiers><isin value="DU0000104465"/><ticker value="1726116D"/></identifiers><balance>425023</balance><units>NS</units><curCd>USD</curCd><valUSD>6991628</valUSD><pctVal>0.175</pctVal><payoffProfile>Long</payoffProfile><assetCat>EP</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Shoreline Biosciences Inc</name><lei>N/A</lei><title>Shoreline Biosciences Inc PP</title><cusip>N/A</cusip><identifiers><isin value="DU0000104569"/><ticker value="1868807D"/></identifiers><balance>747187</balance><units>NS</units><curCd>USD</curCd><valUSD>6017769</valUSD><pctVal>0.151</pctVal><payoffProfile>Long</payoffProfile><assetCat>EP</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Attralus Inc</name><lei>N/A</lei><title>Attralus Inc PP</title><cusip>N/A</cusip><identifiers><isin value="DU0000104336"/><ticker value="1829635D"/></identifiers><balance>669935</balance><units>NS</units><curCd>USD</curCd><valUSD>3483662</valUSD><pctVal>0.087</pctVal><payoffProfile>Long</payoffProfile><assetCat>EP</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Lexeo Therapeutics Inc</name><lei>N/A</lei><title>LEXEO Therapeutics Inc - Series A PP</title><cusip>N/A</cusip><identifiers><isin value="DU0000104012"/></identifiers><balance>3643715</balance><units>NS</units><curCd>USD</curCd><valUSD>6268975</valUSD><pctVal>0.157</pctVal><payoffProfile>Long</payoffProfile><assetCat>EP</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Lexeo Therapeutics Inc</name><lei>N/A</lei><title>LEXEO Therapeutics Inc - Series B PP</title><cusip>N/A</cusip><identifiers><isin value="DU0000104331"/><ticker value="1848501D US"/></identifiers><balance>883469</balance><units>NS</units><curCd>USD</curCd><valUSD>1520000</valUSD><pctVal>0.038</pctVal><payoffProfile>Long</payoffProfile><assetCat>EP</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>VALENZABIO INC</name><lei>N/A</lei><title>VALENZABIO INC</title><cusip>N/A</cusip><identifiers><isin value="DU0000104263"/></identifiers><balance>700559</balance><units>NS</units><curCd>USD</curCd><valUSD>6235276</valUSD><pctVal>0.156</pctVal><payoffProfile>Long</payoffProfile><assetCat>EP</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Sonoma Biotherapeutics Inc</name><lei>N/A</lei><title>Sonoma Biotherapeutics Inc PP</title><cusip>N/A</cusip><identifiers><isin value="DU0000104500"/><ticker value="1783532D"/></identifiers><balance>1255200</balance><units>NS</units><curCd>USD</curCd><valUSD>2480652</valUSD><pctVal>0.062</pctVal><payoffProfile>Long</payoffProfile><assetCat>EP</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Arbor Biotechnologies Inc</name><lei>N/A</lei><title>Arbor Biotechnologies Inc PP</title><cusip>N/A</cusip><identifiers><isin value="DU0000104275"/><ticker value="1584091D"/></identifiers><balance>156426</balance><units>NS</units><curCd>USD</curCd><valUSD>2591979</valUSD><pctVal>0.065</pctVal><payoffProfile>Long</payoffProfile><assetCat>EP</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Freenome Holdings Inc</name><lei>254900QDTSQ6S0QOCS43</lei><title>Freenome Holdings Inc PP</title><cusip>N/A</cusip><identifiers><isin value="DU0000104596"/><ticker value="1411948D"/></identifiers><balance>342803</balance><units>NS</units><curCd>USD</curCd><valUSD>4000511</valUSD><pctVal>0.1</pctVal><payoffProfile>Long</payoffProfile><assetCat>EP</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Hemoshear Therapeutics LLC</name><lei>N/A</lei><title>HemoShear Therapeutics LLC PP</title><cusip>N/A</cusip><identifiers><isin value="DU0000104239"/><ticker value="0611670D US"/></identifiers><balance>289280</balance><units>NS</units><curCd>USD</curCd><valUSD>3839396</valUSD><pctVal>0.096</pctVal><payoffProfile>Long</payoffProfile><assetCat>EP</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Disc Medicine Inc</name><lei>N/A</lei><title>Disc Medicine Inc PP</title><cusip>N/A</cusip><identifiers><isin value="DU0000104507"/><ticker value="1762523D"/></identifiers><balance>1084584</balance><units>NS</units><curCd>USD</curCd><valUSD>1769255</valUSD><pctVal>0.044</pctVal><payoffProfile>Long</payoffProfile><assetCat>EP</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Neurogene Inc</name><lei>N/A</lei><title>Neurogene Inc PP - Series B</title><cusip>N/A</cusip><identifiers><isin value="DU0000105180"/><ticker value="1697089D"/></identifiers><balance>1486727</balance><units>NS</units><curCd>USD</curCd><valUSD>3627614</valUSD><pctVal>0.091</pctVal><payoffProfile>Long</payoffProfile><assetCat>EP</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Twinstrand Biosciences Inc</name><lei>N/A</lei><title>TwinStrand Biosciences Inc PP</title><cusip>N/A</cusip><identifiers><isin value="DU0000104396"/><ticker value="1724622D US"/></identifiers><balance>344314</balance><units>NS</units><curCd>USD</curCd><valUSD>2750001</valUSD><pctVal>0.069</pctVal><payoffProfile>Long</payoffProfile><assetCat>EP</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Magnolia Medical Technologies</name><lei>N/A</lei><title>Magnolia Medical Technologies Inc</title><cusip>N/A</cusip><identifiers><isin value="DU0000105101"/><ticker value="1426815D"/></identifiers><balance>1821717</balance><units>NS</units><curCd>USD</curCd><valUSD>3092692</valUSD><pctVal>0.078</pctVal><payoffProfile>Long</payoffProfile><assetCat>EP</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Synthekine Inc</name><lei>N/A</lei><title>Synthekine Inc PP</title><cusip>N/A</cusip><identifiers><isin value="DU0000104328"/><ticker value="1830940D"/></identifiers><balance>2192937</balance><units>NS</units><curCd>USD</curCd><valUSD>6290001</valUSD><pctVal>0.158</pctVal><payoffProfile>Long</payoffProfile><assetCat>EP</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Asher Biotherapeutics Inc</name><lei>N/A</lei><title>Asher Biotherapeutics Inc PP</title><cusip>N/A</cusip><identifiers><isin value="DU0000101918"/><ticker value="1741988D"/></identifiers><balance>1214301</balance><units>NS</units><curCd>USD</curCd><valUSD>1951139</valUSD><pctVal>0.049</pctVal><payoffProfile>Long</payoffProfile><assetCat>EP</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Freenome Holdings Inc</name><lei>254900QDTSQ6S0QOCS43</lei><title>Freenome Inc PP</title><cusip>N/A</cusip><identifiers><isin value="DU0000103893"/><ticker value="1411948D US"/></identifiers><balance>337474</balance><units>NS</units><curCd>USD</curCd><valUSD>3938322</valUSD><pctVal>0.099</pctVal><payoffProfile>Long</payoffProfile><assetCat>EP</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Neurogene Inc</name><lei>N/A</lei><title>Neurogene Inc PP</title><cusip>N/A</cusip><identifiers><isin value="DU0000102304"/><ticker value="1697089D US"/></identifiers><balance>1336317</balance><units>NS</units><curCd>USD</curCd><valUSD>3260613</valUSD><pctVal>0.082</pctVal><payoffProfile>Long</payoffProfile><assetCat>EP</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Flame Biosciences Inc</name><lei>N/A</lei><title>Flame Biosciences PP</title><cusip>N/A</cusip><identifiers><isin value="DU0000103955"/><ticker value="1826446D US"/></identifiers><balance>919200</balance><units>NS</units><curCd>USD</curCd><valUSD>2837662</valUSD><pctVal>0.071</pctVal><payoffProfile>Long</payoffProfile><assetCat>EP</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Bigfoot Biomedical Inc</name><lei>N/A</lei><title>Bigfoot Biomedical Inc - Series C-1 PP</title><cusip>N/A</cusip><identifiers><isin value="DU0000104002"/><ticker value="BIGFOOTC1"/></identifiers><balance>168418</balance><units>NS</units><curCd>USD</curCd><valUSD>1372354</valUSD><pctVal>0.034</pctVal><payoffProfile>Long</payoffProfile><assetCat>EP</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Bigfoot Biomedical Inc</name><lei>N/A</lei><title>Bigfoot Biomedical Inc - Series B PP</title><cusip>N/A</cusip><identifiers><isin value="DU0000100959"/><ticker value="1450137D US"/><other otherDesc="B4N0JJ6" value="Sedol"/></identifiers><balance>1035873</balance><units>NS</units><curCd>USD</curCd><valUSD>8440811</valUSD><pctVal>0.212</pctVal><payoffProfile>Long</payoffProfile><assetCat>EP</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Argenx SE</name><lei>7245009C5FZE6G9ODQ71</lei><title>Argenx SE (ADR)</title><cusip>04016X101</cusip><identifiers><isin value="US04016X1019"/><ticker value="ARGX US"/><other otherDesc="BDVLM39" value="Sedol"/></identifiers><balance>177953</balance><units>NS</units><curCd>USD</curCd><valUSD>62826307</valUSD><pctVal>1.575</pctVal><payoffProfile>Long</payoffProfile><assetConditional assetCat="OTHER" desc="GDR"/><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Ascendis Pharma A/S</name><lei>549300B66JN3W3J8GH73</lei><title>Ascendis Pharma A/S (ADR)</title><cusip>04351P101</cusip><identifiers><isin value="US04351P1012"/><ticker value="ASND US"/><other otherDesc="BV9G6B8" value="Sedol"/></identifiers><balance>471014</balance><units>NS</units><curCd>USD</curCd><valUSD>48636906</valUSD><pctVal>1.219</pctVal><payoffProfile>Long</payoffProfile><assetConditional assetCat="OTHER" desc="GDR"/><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><loanByFundCondition isLoanByFund="Y" loanVal="4505018"/></securityLending></invstOrSec><invstOrSec><name>Bicycle Therapeutics PLC</name><lei>213800XKUI6R7GKC3E43</lei><title>Bicycle Therapeutics Ltd (ADR)</title><cusip>088786108</cusip><identifiers><isin value="US0887861088"/><ticker value="BCYC US"/><other otherDesc="BKDQKM6" value="Sedol"/></identifiers><balance>486491</balance><units>NS</units><curCd>USD</curCd><valUSD>11315781</valUSD><pctVal>0.284</pctVal><payoffProfile>Long</payoffProfile><assetConditional assetCat="OTHER" desc="GDR"/><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><loanByFundCondition isLoanByFund="Y" loanVal="6694416.41"/></securityLending></invstOrSec><invstOrSec><name>Centessa Pharmaceuticals PLC</name><lei>213800GIDAARDSKOI827</lei><title>Centessa Pharmacuticals PLC (ADR)</title><cusip>152309100</cusip><identifiers><isin value="US1523091007"/><ticker value="CNTA US"/><other otherDesc="BLB0YQ9" value="Sedol"/></identifiers><balance>764786</balance><units>NS</units><curCd>USD</curCd><valUSD>3074440</valUSD><pctVal>0.077</pctVal><payoffProfile>Long</payoffProfile><assetConditional assetCat="OTHER" desc="GDR"/><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><loanByFundCondition isLoanByFund="Y" loanVal="225632.5"/></securityLending></invstOrSec><invstOrSec><name>Clementia Pharmaceuticals Inc</name><lei>N/A</lei><title>Clementia Pharmaceuticals Inc CVR</title><cusip>N/A</cusip><identifiers><isin value="US185CVR0169"/><ticker value="CMTA CVR"/></identifiers><balance>874311</balance><units>NS</units><curCd>USD</curCd><valUSD>1</valUSD><pctVal>0</pctVal><payoffProfile>Long</payoffProfile><assetConditional assetCat="OTHER" desc="Rights"/><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Legend Biotech Corp</name><lei>254900EIUFZTW136H859</lei><title>Legend Biotech Corp (ADR)</title><cusip>52490G102</cusip><identifiers><isin value="US52490G1022"/><ticker value="LEGN US"/><other otherDesc="BMX9K07" value="Sedol"/></identifiers><balance>503187</balance><units>NS</units><curCd>USD</curCd><valUSD>20530030</valUSD><pctVal>0.515</pctVal><payoffProfile>Long</payoffProfile><assetConditional assetCat="OTHER" desc="GDR"/><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Novartis AG</name><lei>5493007HIVTX6SY6XD66</lei><title>Novartis AG (ADR)</title><cusip>66987V109</cusip><identifiers><isin value="US66987V1098"/><ticker value="NVS US"/><other otherDesc="2620105" value="Sedol"/></identifiers><balance>1203666</balance><units>NS</units><curCd>USD</curCd><valUSD>91490653</valUSD><pctVal>2.293</pctVal><payoffProfile>Long</payoffProfile><assetConditional assetCat="OTHER" desc="GDR"/><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Zai Lab Ltd</name><lei>549300P2UYQ9U5LY1T58</lei><title>Zai Lab Ltd (ADR)</title><cusip>98887Q104</cusip><identifiers><isin value="US98887Q1040"/><ticker value="ZLAB US"/><other otherDesc="BD9GVY0" value="Sedol"/></identifiers><balance>612499</balance><units>NS</units><curCd>USD</curCd><valUSD>20947466</valUSD><pctVal>0.525</pctVal><payoffProfile>Long</payoffProfile><assetConditional assetCat="OTHER" desc="GDR"/><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec></invstOrSecs><explntrNotes><explntrNote note="Monthly returns presented in Item B.5(a) have been calculated without deducting any applicable sales loads or redemption fees." noteItem="B.5.a"/></explntrNotes><signature><ncom:dateSigned>2022-11-14</ncom:dateSigned><ncom:nameOfApplicant>JANUS INVESTMENT FUND</ncom:nameOfApplicant><ncom:signature>JESPER NERGAARD</ncom:signature><ncom:signerName>JESPER NERGAARD</ncom:signerName><ncom:title>VP, CFO, TREASURER, AND PRINCIPAL ACCOUNTING OFFICER</ncom:title></signature></formData></edgarSubmission>
