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value="Sedol"/></identifiers><balance>658927</balance><units>NS</units><curCd>USD</curCd><valUSD>54605281</valUSD><pctVal>1.326</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Biomea Fusion Inc</name><lei>N/A</lei><title>Biomea Fusion Inc</title><cusip>09077A106</cusip><identifiers><isin value="US09077A1060"/><ticker value="BMEA US"/><other otherDesc="BNKF6N0" 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value="Sedol"/></identifiers><balance>500302</balance><units>NS</units><curCd>USD</curCd><valUSD>1425861</valUSD><pctVal>0.035</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><loanByFundCondition isLoanByFund="Y" loanVal="169544.27"/></securityLending></invstOrSec><invstOrSec><name>AstraZeneca PLC</name><lei>PY6ZZQWO2IZFZC3IOL08</lei><title>AstraZeneca PLC</title><cusip>G0593M107</cusip><identifiers><isin value="GB0009895292"/><ticker value="AZN LN"/><other otherDesc="989529" value="Sedol"/></identifiers><balance>1488985</balance><units>NS</units><currencyConditional curCd="GBP" exchangeRt="0.82163"/><valUSD>195721164</valUSD><pctVal>4.752</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>GB</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Boston Scientific Corp</name><lei>Y6ZDD9FP4P8JSSJMW954</lei><title>Boston Scientific Corp</title><cusip>101137107</cusip><identifiers><isin value="US1011371077"/><ticker value="BSX US"/><other otherDesc="2113434" value="Sedol"/></identifiers><balance>2395066</balance><units>NS</units><curCd>USD</curCd><valUSD>89264110</valUSD><pctVal>2.167</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Bristol-Myers Squibb Co</name><lei>HLYYNH7UQUORYSJQCN42</lei><title>Bristol-Myers Squibb Co</title><cusip>110122108</cusip><identifiers><isin value="US1101221083"/><ticker value="BMY US"/><other otherDesc="2126335" value="Sedol"/></identifiers><balance>1458944</balance><units>NS</units><curCd>USD</curCd><valUSD>112338688</valUSD><pctVal>2.727</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>C4 Therapeutics Inc</name><lei>N/A</lei><title>C4 Therapeutics Inc</title><cusip>12529R107</cusip><identifiers><isin value="US12529R1077"/><ticker value="CCCC US"/><other otherDesc="BKX9NQ0" value="Sedol"/></identifiers><balance>327379</balance><units>NS</units><curCd>USD</curCd><valUSD>2468438</valUSD><pctVal>0.06</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><loanByFundCondition isLoanByFund="Y" loanVal="738073.7"/></securityLending></invstOrSec><invstOrSec><name>Catalent Inc</name><lei>N/A</lei><title>Catalent Inc</title><cusip>148806102</cusip><identifiers><isin value="US1488061029"/><ticker value="CTLT US"/><other otherDesc="BP96PQ4" value="Sedol"/></identifiers><balance>215738</balance><units>NS</units><curCd>USD</curCd><valUSD>23146530</valUSD><pctVal>0.562</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Centene Corp</name><lei>549300Z7JJ4TQSQGT333</lei><title>Centene Corp</title><cusip>15135B101</cusip><identifiers><isin value="US15135B1017"/><ticker value="CNC US"/><other otherDesc="2807061" value="Sedol"/></identifiers><balance>928747</balance><units>NS</units><curCd>USD</curCd><valUSD>78581284</valUSD><pctVal>1.908</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Collegium Pharmaceutical Inc</name><lei>54930049FXZMTLW8D496</lei><title>Collegium Pharmaceutical Inc</title><cusip>19459J104</cusip><identifiers><isin value="US19459J1043"/><ticker value="COLL US"/><other otherDesc="BX7RSN3" value="Sedol"/></identifiers><balance>734481</balance><units>NS</units><curCd>USD</curCd><valUSD>13015003</valUSD><pctVal>0.316</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Cooper Cos Inc/The</name><lei>QJKMVPIGLH7530PCUE20</lei><title>Cooper Cos Inc</title><cusip>216648402</cusip><identifiers><isin value="US2166484020"/><ticker value="COO US"/><other otherDesc="2222631" value="Sedol"/></identifiers><balance>112853</balance><units>NS</units><curCd>USD</curCd><valUSD>35336531</valUSD><pctVal>0.858</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>DICE Therapeutics Inc</name><lei>N/A</lei><title>DICE Therapeutics Inc</title><cusip>23345J104</cusip><identifiers><isin value="US23345J1043"/><ticker value="DICE US"/><other otherDesc="BNRPLC7" value="Sedol"/></identifiers><balance>330384</balance><units>NS</units><curCd>USD</curCd><valUSD>5127560</valUSD><pctVal>0.124</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><loanByFundCondition isLoanByFund="Y" loanVal="3786200.64"/></securityLending></invstOrSec><invstOrSec><name>Danaher Corp</name><lei>S4BKK9OTCEWQ3YHPFM11</lei><title>Danaher Corp</title><cusip>235851102</cusip><identifiers><isin value="US2358511028"/><ticker value="DHR US"/><other otherDesc="2250870" value="Sedol"/></identifiers><balance>355126</balance><units>NS</units><curCd>USD</curCd><valUSD>90031544</valUSD><pctVal>2.186</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>DENTSPLY SIRONA Inc</name><lei>9NHEHR1SOZCYXDO8HO28</lei><title>DENTSPLY SIRONA Inc</title><cusip>24906P109</cusip><identifiers><isin value="US24906P1093"/><ticker value="XRAY US"/><other otherDesc="BYNPPC6" value="Sedol"/></identifiers><balance>736502</balance><units>NS</units><curCd>USD</curCd><valUSD>26315216</valUSD><pctVal>0.639</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Design Therapeutics Inc</name><lei>N/A</lei><title>Design Therapeutics Inc</title><cusip>25056L103</cusip><identifiers><isin value="US25056L1035"/><ticker value="DSGN US"/><other otherDesc="BMFK3H6" value="Sedol"/></identifiers><balance>409338</balance><units>NS</units><curCd>USD</curCd><valUSD>5730732</valUSD><pctVal>0.139</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><loanByFundCondition isLoanByFund="Y" loanVal="690751.38"/></securityLending></invstOrSec><invstOrSec><name>Dexcom Inc</name><lei>549300YSK3QDSFR5EU59</lei><title>DexCom Inc</title><cusip>252131107</cusip><identifiers><isin value="US2521311074"/><ticker value="DXCM US"/><other otherDesc="B0796X4" value="Sedol"/></identifiers><balance>392278</balance><units>NS</units><curCd>USD</curCd><valUSD>29236479</valUSD><pctVal>0.71</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Edgewise Therapeutics Inc</name><lei>N/A</lei><title>Edgewise Therapeutics Inc</title><cusip>28036F105</cusip><identifiers><isin value="US28036F1057"/><ticker value="EWTX US"/><other otherDesc="BKY5JZ8" value="Sedol"/></identifiers><balance>412550</balance><units>NS</units><curCd>USD</curCd><valUSD>3283898</valUSD><pctVal>0.08</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><loanByFundCondition isLoanByFund="Y" loanVal="36331"/></securityLending></invstOrSec><invstOrSec><name>Edwards Lifesciences Corp</name><lei>YA13X31F3V31L8TMPR58</lei><title>Edwards Lifesciences Corp</title><cusip>28176E108</cusip><identifiers><isin value="US28176E1082"/><ticker value="EW US"/><other otherDesc="2567116" value="Sedol"/></identifiers><balance>586582</balance><units>NS</units><curCd>USD</curCd><valUSD>55778082</valUSD><pctVal>1.354</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Elanco Animal Health Inc</name><lei>549300SHPNDCE059M934</lei><title>Elanco Animal Health Inc</title><cusip>28414H103</cusip><identifiers><isin value="US28414H1032"/><ticker value="ELAN US"/><other otherDesc="BF5L3T2" value="Sedol"/></identifiers><balance>1272730</balance><units>NS</units><curCd>USD</curCd><valUSD>24983690</valUSD><pctVal>0.607</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Essa Pharma Inc</name><lei>N/A</lei><title>ESSA Pharma Inc</title><cusip>29668H708</cusip><identifiers><isin value="CA29668H7085"/><ticker value="EPIX US"/><other otherDesc="BDTYY56" value="Sedol"/></identifiers><balance>415972</balance><units>NS</units><curCd>USD</curCd><valUSD>1310312</valUSD><pctVal>0.032</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><loanByFundCondition isLoanByFund="Y" loanVal="328536.36"/></securityLending></invstOrSec><invstOrSec><name>Fate Therapeutics Inc</name><lei>549300L14Q4UHOODLA90</lei><title>Fate Therapeutics Inc</title><cusip>31189P102</cusip><identifiers><isin value="US31189P1021"/><ticker value="FATE US"/><other otherDesc="BCZS820" value="Sedol"/></identifiers><balance>209501</balance><units>NS</units><curCd>USD</curCd><valUSD>5191435</valUSD><pctVal>0.126</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Magnolia Medical Technologies Inc</name><lei>N/A</lei><title>Magnolia Medical Technologies Inc</title><cusip>N/A</cusip><identifiers><isin value="DU0000105108"/></identifiers><balance>1</balance><units>NS</units><curCd>USD</curCd><valUSD>0</valUSD><pctVal>0</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>SomaLogic Inc</name><lei>N/A</lei><title>SomaLogic Inc</title><cusip>N/A</cusip><identifiers><isin value="DU0000104520"/></identifiers><balance>722708</balance><units>NS</units><curCd>USD</curCd><valUSD>14454</valUSD><pctVal>0</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>2</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Canbridge Pharmaceuticals Inc</name><lei>8755009KKZM9ETBOF853</lei><title>Canbridge Pharmaceuticals Inc</title><cusip>N/A</cusip><identifiers><isin value="DU0000104636"/><ticker value="1786005D"/></identifiers><balance>2960030</balance><units>NS</units><currencyConditional curCd="HKD" exchangeRt="7.8466"/><valUSD>1508949</valUSD><pctVal>0.037</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>KY</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>4D Molecular Therapeutics Inc</name><lei>N/A</lei><title>4D Molecular Therapeutics Inc</title><cusip>35104E100</cusip><identifiers><isin value="US35104E1001"/><ticker value="FDMT US"/><other otherDesc="BKLXFX5" value="Sedol"/></identifiers><balance>332895</balance><units>NS</units><curCd>USD</curCd><valUSD>2323607</valUSD><pctVal>0.056</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Gilead Sciences Inc</name><lei>549300WTZWR07K8MNV44</lei><title>Gilead Sciences Inc</title><cusip>375558103</cusip><identifiers><isin value="US3755581036"/><ticker value="GILD US"/><other otherDesc="2369174" value="Sedol"/></identifiers><balance>522058</balance><units>NS</units><curCd>USD</curCd><valUSD>32268405</valUSD><pctVal>0.783</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Global Blood Therapeutics Inc</name><lei>549300U4G0QKK99GRT15</lei><title>Global Blood Therapeutics Inc</title><cusip>37890U108</cusip><identifiers><isin value="US37890U1088"/><ticker value="GBT US"/><other otherDesc="BZ05388" value="Sedol"/></identifiers><balance>1030590</balance><units>NS</units><curCd>USD</curCd><valUSD>32927351</valUSD><pctVal>0.799</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Globus Medical Inc</name><lei>5299003M2P4CIK0RF205</lei><title>Globus Medical Inc</title><cusip>379577208</cusip><identifiers><isin value="US3795772082"/><ticker value="GMED US"/><other otherDesc="B7D65M0" value="Sedol"/></identifiers><balance>485270</balance><units>NS</units><curCd>USD</curCd><valUSD>27243058</valUSD><pctVal>0.661</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Ventyx Biosciences Inc</name><lei>N/A</lei><title>Ventyx Biosciences Inc</title><cusip>N/A</cusip><identifiers><isin value="DU0000101917"/><ticker value="1806419D"/></identifiers><balance>59254</balance><units>NS</units><curCd>USD</curCd><valUSD>724676</valUSD><pctVal>0.018</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>DICE Therapeutics Inc</name><lei>N/A</lei><title>DICE Therapeutics Inc</title><cusip>N/A</cusip><identifiers><isin value="DU0000102059"/></identifiers><balance>192261</balance><units>NS</units><curCd>USD</curCd><valUSD>2983891</valUSD><pctVal>0.072</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Harmony Biosciences Holdings I</name><lei>N/A</lei><title>Harmony Biosciences Holdings Inc</title><cusip>413197104</cusip><identifiers><isin value="US4131971040"/><ticker value="HRMY US"/><other otherDesc="BKSGZN7" 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value="Sedol"/></identifiers><balance>1231996</balance><units>NS</units><curCd>USD</curCd><valUSD>112321075</valUSD><pctVal>2.727</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Mirati Therapeutics Inc</name><lei>529900GYRW59IDQV6N54</lei><title>Mirati Therapeutics Inc</title><cusip>60468T105</cusip><identifiers><isin value="US60468T1051"/><ticker value="MRTX US"/><other otherDesc="BBPK0J0" 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value="Sedol"/></identifiers><balance>80447</balance><units>NS</units><curCd>USD</curCd><valUSD>11491854</valUSD><pctVal>0.279</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Neurocrine Biosciences Inc</name><lei>549300FECER0XBN49756</lei><title>Neurocrine Biosciences Inc</title><cusip>64125C109</cusip><identifiers><isin value="US64125C1099"/><ticker value="NBIX US"/><other otherDesc="2623911" value="Sedol"/></identifiers><balance>656400</balance><units>NS</units><curCd>USD</curCd><valUSD>63985872</valUSD><pctVal>1.553</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Nuvalent Inc</name><lei>N/A</lei><title>Nuvalent  Inc - Class A</title><cusip>670703107</cusip><identifiers><isin value="US6707031075"/><ticker value="NUVL US"/><other otherDesc="BMVBZD3" value="Sedol"/></identifiers><balance>504191</balance><units>NS</units><curCd>USD</curCd><valUSD>6836830</valUSD><pctVal>0.166</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><loanByFundCondition isLoanByFund="Y" loanVal="5275094.85"/></securityLending></invstOrSec><invstOrSec><name>Olema Pharmaceuticals Inc</name><lei>N/A</lei><title>Olema Pharmaceuticals Inc</title><cusip>68062P106</cusip><identifiers><isin value="US68062P1066"/><ticker value="OLMA US"/><other otherDesc="BMZ4LN0" 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exchangeRt="135.66"/><valUSD>45160847</valUSD><pctVal>1.096</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>JP</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Penumbra Inc</name><lei>549300RGE06P3ECANU72</lei><title>Penumbra Inc</title><cusip>70975L107</cusip><identifiers><isin value="US70975L1070"/><ticker value="PEN US"/><other otherDesc="BZ0V201" 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value="Sedol"/></identifiers><balance>750297</balance><units>NS</units><curCd>USD</curCd><valUSD>3113733</valUSD><pctVal>0.076</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><loanByFundCondition isLoanByFund="Y" loanVal="4270"/></securityLending></invstOrSec><invstOrSec><name>Sage Therapeutics Inc</name><lei>5493000JX4BJS9W6CN35</lei><title>Sage Therapeutics Inc</title><cusip>78667J108</cusip><identifiers><isin value="US78667J1088"/><ticker value="SAGE US"/><other otherDesc="BP4GNK9" value="Sedol"/></identifiers><balance>255247</balance><units>NS</units><curCd>USD</curCd><valUSD>8244478</valUSD><pctVal>0.2</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Sarepta Therapeutics Inc</name><lei>549300IKDPIED8J8IG21</lei><title>Sarepta Therapeutics Inc</title><cusip>803607100</cusip><identifiers><isin value="US8036071004"/><ticker value="SRPT US"/><other otherDesc="B8DPDT7" value="Sedol"/></identifiers><balance>1175794</balance><units>NS</units><curCd>USD</curCd><valUSD>88137518</valUSD><pctVal>2.14</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Seres Therapeutics Inc</name><lei>549300GMXBE5NUWISF13</lei><title>Seres Therapeutics Inc</title><cusip>81750R102</cusip><identifiers><isin value="US81750R1023"/><ticker value="MCRB US"/><other otherDesc="BYNQNP8" value="Sedol"/></identifiers><balance>1413236</balance><units>NS</units><curCd>USD</curCd><valUSD>4847399</valUSD><pctVal>0.118</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Silk Road Medical Inc</name><lei>549300VL8KC0ZPDQHE14</lei><title>Silk Road Medical Inc</title><cusip>82710M100</cusip><identifiers><isin value="US82710M1009"/><ticker value="SILK US"/><other otherDesc="BGHVXJ7" value="Sedol"/></identifiers><balance>287257</balance><units>NS</units><curCd>USD</curCd><valUSD>10453282</valUSD><pctVal>0.254</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>SomaLogic Inc</name><lei>549300D3W3Q8CN30YO25</lei><title>SomaLogic Inc</title><cusip>83444K105</cusip><identifiers><isin value="US83444K1051"/><ticker value="SLGC US"/><other otherDesc="BLGYRD4" value="Sedol"/></identifiers><balance>995071</balance><units>NS</units><curCd>USD</curCd><valUSD>4497721</valUSD><pctVal>0.109</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Sotera Health Co</name><lei>N/A</lei><title>Sotera Health Co</title><cusip>83601L102</cusip><identifiers><isin value="US83601L1026"/><ticker value="SHC US"/><other otherDesc="BNKVRZ7" value="Sedol"/></identifiers><balance>399099</balance><units>NS</units><curCd>USD</curCd><valUSD>7818349</valUSD><pctVal>0.19</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Stryker Corp</name><lei>5493002F0SC4JTBU5137</lei><title>Stryker Corp</title><cusip>863667101</cusip><identifiers><isin value="US8636671013"/><ticker value="SYK US"/><other otherDesc="2853688" value="Sedol"/></identifiers><balance>185504</balance><units>NS</units><curCd>USD</curCd><valUSD>36902311</valUSD><pctVal>0.896</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Tandem Diabetes Care Inc</name><lei>549300JEPFOD0K4D3I05</lei><title>Tandem Diabetes Care Inc</title><cusip>875372203</cusip><identifiers><isin value="US8753722037"/><ticker value="TNDM US"/><other otherDesc="BF3W461" value="Sedol"/></identifiers><balance>114528</balance><units>NS</units><curCd>USD</curCd><valUSD>6778912</valUSD><pctVal>0.165</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Teleflex Inc</name><lei>UUL85LWXB4NGSWWXIQ25</lei><title>Teleflex Inc</title><cusip>879369106</cusip><identifiers><isin value="US8793691069"/><ticker value="TFX US"/><other otherDesc="2881407" value="Sedol"/></identifiers><balance>194791</balance><units>NS</units><curCd>USD</curCd><valUSD>47889367</valUSD><pctVal>1.163</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Thermo Fisher Scientific Inc</name><lei>HCHV7422L5HDJZCRFL38</lei><title>THERMO FISHER SCIENTIFIC INC</title><cusip>883556102</cusip><identifiers><isin value="US8835561023"/><ticker value="TMO US"/><other otherDesc="2886907" value="Sedol"/></identifiers><balance>199096</balance><units>NS</units><curCd>USD</curCd><valUSD>108164875</valUSD><pctVal>2.626</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Travere Therapeutics Inc</name><lei>N/A</lei><title>Travere Therapeutics Inc</title><cusip>89422G107</cusip><identifiers><isin value="US89422G1076"/><ticker value="TVTX US"/><other otherDesc="BLFGJD5" 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value="DU0000100962"/></identifiers><balance>4105005</balance><units>NS</units><curCd>USD</curCd><valUSD>4105415</valUSD><pctVal>0.1</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>PF</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>2</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Janus Henderson Cash Collateral Fund</name><lei>N/A</lei><title>Janus Henderson Cash Collateral Fund</title><cusip>N/A</cusip><identifiers><other otherDesc="896" value="Internal 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value="Sedol"/></identifiers><balance>157046</balance><units>NS</units><curCd>USD</curCd><valUSD>37006319</valUSD><pctVal>0.898</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>UnitedHealth Group Inc</name><lei>549300GHBMY8T5GXDE41</lei><title>UnitedHealth Group Inc</title><cusip>91324P102</cusip><identifiers><isin value="US91324P1021"/><ticker value="UNH US"/><other otherDesc="2917766" value="Sedol"/></identifiers><balance>523008</balance><units>NS</units><curCd>USD</curCd><valUSD>268632599</valUSD><pctVal>6.522</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Vaxcyte Inc</name><lei>254900M7NMHTGASX8D95</lei><title>Vaxcyte Inc</title><cusip>92243G108</cusip><identifiers><isin value="US92243G1085"/><ticker value="PCVX US"/><other otherDesc="BKPVGH6" value="Sedol"/></identifiers><balance>419551</balance><units>NS</units><curCd>USD</curCd><valUSD>9129430</valUSD><pctVal>0.222</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Ventyx Biosciences Inc</name><lei>N/A</lei><title>Ventyx Biosciences Inc</title><cusip>92332V107</cusip><identifiers><isin value="US92332V1070"/><ticker value="VTYX US"/><other otherDesc="BMG99Y1" value="Sedol"/></identifiers><balance>474503</balance><units>NS</units><curCd>USD</curCd><valUSD>5803172</valUSD><pctVal>0.141</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><loanByFundCondition isLoanByFund="Y" loanVal="4252730.15"/></securityLending></invstOrSec><invstOrSec><name>Vertex Pharmaceuticals Inc</name><lei>54930015RAQRRZ5ZGJ91</lei><title>Vertex Pharmaceuticals Inc</title><cusip>92532F100</cusip><identifiers><isin value="US92532F1003"/><ticker value="VRTX US"/><other otherDesc="2931034" value="Sedol"/></identifiers><balance>355810</balance><units>NS</units><curCd>USD</curCd><valUSD>100263700</valUSD><pctVal>2.434</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Novo Nordisk A/S</name><lei>549300DAQ1CVT6CXN342</lei><title>Novo Nordisk A/S</title><cusip>K72807132</cusip><identifiers><isin value="DK0060534915"/><ticker value="NOVOB DC"/><other otherDesc="BHC8X90" value="Sedol"/></identifiers><balance>616188</balance><units>NS</units><currencyConditional curCd="DKK" 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exchangeRt="7.8466"/><valUSD>661863</valUSD><pctVal>0.016</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>HK</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Biohaven Pharmaceutical Holdin</name><lei>5299007STZTNN32O9920</lei><title>Biohaven Pharmaceutical Holding Co Ltd</title><cusip>G11196105</cusip><identifiers><isin value="VGG111961055"/><ticker value="BHVN US"/><other otherDesc="BZ8FXC4" value="Sedol"/></identifiers><balance>54204</balance><units>NS</units><curCd>USD</curCd><valUSD>7898065</valUSD><pctVal>0.192</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Horizon Therapeutics Plc</name><lei>529900P0GSQ79OOZEV53</lei><title>Horizon Therapeutics Plc</title><cusip>G46188101</cusip><identifiers><isin value="IE00BQPVQZ61"/><ticker value="HZNP US"/><other otherDesc="BQPVQZ6" value="Sedol"/></identifiers><balance>661044</balance><units>NS</units><curCd>USD</curCd><valUSD>52724869</valUSD><pctVal>1.28</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>ICON PLC</name><lei>6354008SRQGEMC4XFI67</lei><title>ICON PLC</title><cusip>G4705A100</cusip><identifiers><isin value="IE0005711209"/><ticker value="ICLR US"/><other otherDesc="B94G471" value="Sedol"/></identifiers><balance>92143</balance><units>NS</units><curCd>USD</curCd><valUSD>19967388</valUSD><pctVal>0.485</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Jazz Pharmaceuticals PLC</name><lei>635400GAUMJCLEZRRV50</lei><title>Jazz Pharmaceuticals PLC</title><cusip>G50871105</cusip><identifiers><isin value="IE00B4Q5ZN47"/><ticker value="JAZZ US"/><other otherDesc="B4Q5ZN4" value="Sedol"/></identifiers><balance>360373</balance><units>NS</units><curCd>USD</curCd><valUSD>56221792</valUSD><pctVal>1.365</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Medtronic PLC</name><lei>549300GX3ZBSQWUXY261</lei><title>Medtronic PLC</title><cusip>G5960L103</cusip><identifiers><isin value="IE00BTN1Y115"/><ticker value="MDT US"/><other otherDesc="BTN1Y11" value="Sedol"/></identifiers><balance>386213</balance><units>NS</units><curCd>USD</curCd><valUSD>34662617</valUSD><pctVal>0.842</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Myovant Sciences Ltd</name><lei>N/A</lei><title>Myovant Sciences Ltd</title><cusip>G637AM102</cusip><identifiers><isin value="BMG637AM1024"/><ticker value="MYOV US"/><other otherDesc="BD3WG49" value="Sedol"/></identifiers><balance>1421510</balance><units>NS</units><curCd>USD</curCd><valUSD>17669369</valUSD><pctVal>0.429</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><loanByFundCondition isLoanByFund="Y" loanVal="1712856"/></securityLending></invstOrSec><invstOrSec><name>Royalty Pharma PLC</name><lei>549300FGFN7VOK8BZR03</lei><title>Royalty Pharma PLC - Class A</title><cusip>G7709Q104</cusip><identifiers><isin value="GB00BMVP7Y09"/><ticker value="RPRX US"/><other otherDesc="BMVP7Y0" value="Sedol"/></identifiers><balance>931926</balance><units>NS</units><curCd>USD</curCd><valUSD>39178169</valUSD><pctVal>0.951</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>STERIS PLC</name><lei>N/A</lei><title>STERIS PLC</title><cusip>G8473T100</cusip><identifiers><isin value="IE00BFY8C754"/><ticker value="STE US"/><other otherDesc="BFY8C75" value="Sedol"/></identifiers><balance>164953</balance><units>NS</units><curCd>USD</curCd><valUSD>34005061</valUSD><pctVal>0.826</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Element Biosciences Inc</name><lei>N/A</lei><title>Element Biosciences Inc PP</title><cusip>N/A</cusip><identifiers><isin value="DU0000104465"/><ticker value="1726116D"/></identifiers><balance>425023</balance><units>NS</units><curCd>USD</curCd><valUSD>6991628</valUSD><pctVal>0.17</pctVal><payoffProfile>Long</payoffProfile><assetCat>EP</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Shoreline Biosciences Inc</name><lei>N/A</lei><title>Shoreline Biosciences Inc PP</title><cusip>N/A</cusip><identifiers><isin value="DU0000104569"/><ticker value="1868807D"/></identifiers><balance>747187</balance><units>NS</units><curCd>USD</curCd><valUSD>6017769</valUSD><pctVal>0.146</pctVal><payoffProfile>Long</payoffProfile><assetCat>EP</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Attralus Inc</name><lei>N/A</lei><title>Attralus Inc PP</title><cusip>N/A</cusip><identifiers><isin value="DU0000104336"/><ticker value="1829635D"/></identifiers><balance>669935</balance><units>NS</units><curCd>USD</curCd><valUSD>3483662</valUSD><pctVal>0.085</pctVal><payoffProfile>Long</payoffProfile><assetCat>EP</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Lexeo Therapeutics Inc</name><lei>N/A</lei><title>LEXEO Therapeutics Inc - Series A PP</title><cusip>N/A</cusip><identifiers><isin value="DU0000104012"/></identifiers><balance>3643715</balance><units>NS</units><curCd>USD</curCd><valUSD>6268975</valUSD><pctVal>0.152</pctVal><payoffProfile>Long</payoffProfile><assetCat>EP</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Lexeo Therapeutics Inc</name><lei>N/A</lei><title>LEXEO Therapeutics Inc - Series B PP</title><cusip>N/A</cusip><identifiers><isin value="DU0000104331"/><ticker value="1848501D US"/></identifiers><balance>883469</balance><units>NS</units><curCd>USD</curCd><valUSD>1520000</valUSD><pctVal>0.037</pctVal><payoffProfile>Long</payoffProfile><assetCat>EP</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>VALENZABIO INC</name><lei>N/A</lei><title>VALENZABIO INC</title><cusip>N/A</cusip><identifiers><isin value="DU0000104263"/></identifiers><balance>700559</balance><units>NS</units><curCd>USD</curCd><valUSD>6235276</valUSD><pctVal>0.151</pctVal><payoffProfile>Long</payoffProfile><assetCat>EP</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Sonoma Biotherapeutics Inc</name><lei>N/A</lei><title>Sonoma Biotherapeutics Inc PP</title><cusip>N/A</cusip><identifiers><isin value="DU0000104500"/><ticker value="1783532D"/></identifiers><balance>1255200</balance><units>NS</units><curCd>USD</curCd><valUSD>2480652</valUSD><pctVal>0.06</pctVal><payoffProfile>Long</payoffProfile><assetCat>EP</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Arbor Biotechnologies Inc</name><lei>N/A</lei><title>Arbor Biotechnologies Inc PP</title><cusip>N/A</cusip><identifiers><isin value="DU0000104275"/><ticker value="1584091D"/></identifiers><balance>156426</balance><units>NS</units><curCd>USD</curCd><valUSD>2591979</valUSD><pctVal>0.063</pctVal><payoffProfile>Long</payoffProfile><assetCat>EP</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Freenome Holdings Inc</name><lei>254900QDTSQ6S0QOCS43</lei><title>Freenome Holdings Inc PP</title><cusip>N/A</cusip><identifiers><isin value="DU0000104596"/><ticker value="1411948D"/></identifiers><balance>342803</balance><units>NS</units><curCd>USD</curCd><valUSD>4000511</valUSD><pctVal>0.097</pctVal><payoffProfile>Long</payoffProfile><assetCat>EP</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Hemoshear Therapeutics LLC</name><lei>N/A</lei><title>HemoShear Therapeutics LLC PP</title><cusip>N/A</cusip><identifiers><isin value="DU0000104239"/><ticker value="0611670D US"/></identifiers><balance>289280</balance><units>NS</units><curCd>USD</curCd><valUSD>3839396</valUSD><pctVal>0.093</pctVal><payoffProfile>Long</payoffProfile><assetCat>EP</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Disc Medicine Inc</name><lei>N/A</lei><title>Disc Medicine Inc PP</title><cusip>N/A</cusip><identifiers><isin value="DU0000104507"/><ticker value="1762523D"/></identifiers><balance>1084584</balance><units>NS</units><curCd>USD</curCd><valUSD>2603002</valUSD><pctVal>0.063</pctVal><payoffProfile>Long</payoffProfile><assetCat>EP</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Neurogene Inc</name><lei>N/A</lei><title>Neurogene Inc PP - Series B</title><cusip>N/A</cusip><identifiers><isin value="DU0000105180"/><ticker value="1697089D"/></identifiers><balance>1486727</balance><units>NS</units><curCd>USD</curCd><valUSD>3627614</valUSD><pctVal>0.088</pctVal><payoffProfile>Long</payoffProfile><assetCat>EP</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Twinstrand Biosciences Inc</name><lei>N/A</lei><title>TwinStrand Biosciences Inc PP</title><cusip>N/A</cusip><identifiers><isin value="DU0000104396"/><ticker value="1724622D US"/></identifiers><balance>344314</balance><units>NS</units><curCd>USD</curCd><valUSD>2750002</valUSD><pctVal>0.067</pctVal><payoffProfile>Long</payoffProfile><assetCat>EP</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Magnolia Medical Technologies</name><lei>N/A</lei><title>Magnolia Medical Technologies Inc</title><cusip>N/A</cusip><identifiers><isin value="DU0000105101"/><ticker value="1426815D"/></identifiers><balance>1821717</balance><units>NS</units><curCd>USD</curCd><valUSD>3092693</valUSD><pctVal>0.075</pctVal><payoffProfile>Long</payoffProfile><assetCat>EP</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Synthekine Inc</name><lei>N/A</lei><title>Synthekine Inc PP</title><cusip>N/A</cusip><identifiers><isin value="DU0000104328"/><ticker value="1830940D"/></identifiers><balance>2192937</balance><units>NS</units><curCd>USD</curCd><valUSD>6290001</valUSD><pctVal>0.153</pctVal><payoffProfile>Long</payoffProfile><assetCat>EP</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Asher Biotherapeutics Inc</name><lei>N/A</lei><title>Asher Biotherapeutics Inc PP</title><cusip>N/A</cusip><identifiers><isin value="DU0000101918"/><ticker value="1741988D"/></identifiers><balance>1214301</balance><units>NS</units><curCd>USD</curCd><valUSD>1951139</valUSD><pctVal>0.047</pctVal><payoffProfile>Long</payoffProfile><assetCat>EP</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Freenome Holdings Inc</name><lei>254900QDTSQ6S0QOCS43</lei><title>Freenome Inc PP</title><cusip>N/A</cusip><identifiers><isin value="DU0000103893"/><ticker value="1411948D US"/></identifiers><balance>337474</balance><units>NS</units><curCd>USD</curCd><valUSD>3938322</valUSD><pctVal>0.096</pctVal><payoffProfile>Long</payoffProfile><assetCat>EP</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Neurogene Inc</name><lei>N/A</lei><title>Neurogene Inc PP</title><cusip>N/A</cusip><identifiers><isin value="DU0000102304"/><ticker value="1697089D US"/></identifiers><balance>1336317</balance><units>NS</units><curCd>USD</curCd><valUSD>3260613</valUSD><pctVal>0.079</pctVal><payoffProfile>Long</payoffProfile><assetCat>EP</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Flame Biosciences Inc</name><lei>N/A</lei><title>Flame Biosciences PP</title><cusip>N/A</cusip><identifiers><isin value="DU0000103955"/><ticker value="1826446D US"/></identifiers><balance>919200</balance><units>NS</units><curCd>USD</curCd><valUSD>3018653</valUSD><pctVal>0.073</pctVal><payoffProfile>Long</payoffProfile><assetCat>EP</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Bigfoot Biomedical Inc</name><lei>N/A</lei><title>Bigfoot Biomedical Inc - Series C-1 PP</title><cusip>N/A</cusip><identifiers><isin value="DU0000104002"/><ticker value="BIGFOOTC1"/></identifiers><balance>168418</balance><units>NS</units><curCd>USD</curCd><valUSD>1594792</valUSD><pctVal>0.039</pctVal><payoffProfile>Long</payoffProfile><assetCat>EP</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Bigfoot Biomedical Inc</name><lei>N/A</lei><title>Bigfoot Biomedical Inc - Series B PP</title><cusip>N/A</cusip><identifiers><isin value="DU0000100959"/><ticker value="1450137D US"/><other otherDesc="B4N0JJ6" value="Sedol"/></identifiers><balance>1035873</balance><units>NS</units><curCd>USD</curCd><valUSD>9808940</valUSD><pctVal>0.238</pctVal><payoffProfile>Long</payoffProfile><assetCat>EP</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Argenx SE</name><lei>7245009C5FZE6G9ODQ71</lei><title>Argenx SE (ADR)</title><cusip>04016X101</cusip><identifiers><isin value="US04016X1019"/><ticker value="ARGX US"/><other otherDesc="BDVLM39" value="Sedol"/></identifiers><balance>171256</balance><units>NS</units><curCd>USD</curCd><valUSD>64885473</valUSD><pctVal>1.575</pctVal><payoffProfile>Long</payoffProfile><assetConditional assetCat="OTHER" desc="GDR"/><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Ascendis Pharma A/S</name><lei>549300B66JN3W3J8GH73</lei><title>Ascendis Pharma A/S (ADR)</title><cusip>04351P101</cusip><identifiers><isin value="US04351P1012"/><ticker value="ASND US"/><other otherDesc="BV9G6B8" value="Sedol"/></identifiers><balance>519816</balance><units>NS</units><curCd>USD</curCd><valUSD>48322095</valUSD><pctVal>1.173</pctVal><payoffProfile>Long</payoffProfile><assetConditional assetCat="OTHER" desc="GDR"/><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><loanByFundCondition isLoanByFund="Y" loanVal="2524560"/></securityLending></invstOrSec><invstOrSec><name>Bicycle Therapeutics PLC</name><lei>213800XKUI6R7GKC3E43</lei><title>Bicycle Therapeutics Ltd (ADR)</title><cusip>088786108</cusip><identifiers><isin value="US0887861088"/><ticker value="BCYC US"/><other otherDesc="BKDQKM6" value="Sedol"/></identifiers><balance>464709</balance><units>NS</units><curCd>USD</curCd><valUSD>7797817</valUSD><pctVal>0.189</pctVal><payoffProfile>Long</payoffProfile><assetConditional assetCat="OTHER" desc="GDR"/><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><loanByFundCondition isLoanByFund="Y" loanVal="190476"/></securityLending></invstOrSec><invstOrSec><name>Centessa Pharmaceuticals PLC</name><lei>213800GIDAARDSKOI827</lei><title>Centessa Pharmacuticals PLC (ADR)</title><cusip>152309100</cusip><identifiers><isin value="US1523091007"/><ticker value="CNTA US"/><other otherDesc="BLB0YQ9" value="Sedol"/></identifiers><balance>771287</balance><units>NS</units><curCd>USD</curCd><valUSD>3756168</valUSD><pctVal>0.091</pctVal><payoffProfile>Long</payoffProfile><assetConditional assetCat="OTHER" desc="GDR"/><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><loanByFundCondition isLoanByFund="Y" loanVal="111820.91"/></securityLending></invstOrSec><invstOrSec><name>Clementia Pharmaceuticals Inc</name><lei>N/A</lei><title>Clementia Pharmaceuticals Inc CVR</title><cusip>N/A</cusip><identifiers><isin value="US185CVR0169"/><ticker value="CMTA CVR"/></identifiers><balance>874311</balance><units>NS</units><curCd>USD</curCd><valUSD>1</valUSD><pctVal>0</pctVal><payoffProfile>Long</payoffProfile><assetConditional assetCat="OTHER" desc="Rights"/><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Novartis AG</name><lei>5493007HIVTX6SY6XD66</lei><title>Novartis AG (ADR)</title><cusip>66987V109</cusip><identifiers><isin value="US66987V1098"/><ticker value="NVS US"/><other otherDesc="2620105" value="Sedol"/></identifiers><balance>1114085</balance><units>NS</units><curCd>USD</curCd><valUSD>94173605</valUSD><pctVal>2.286</pctVal><payoffProfile>Long</payoffProfile><assetConditional assetCat="OTHER" desc="GDR"/><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Zai Lab Ltd</name><lei>549300P2UYQ9U5LY1T58</lei><title>Zai Lab Ltd (ADR)</title><cusip>98887Q104</cusip><identifiers><isin value="US98887Q1040"/><ticker value="ZLAB US"/><other otherDesc="BD9GVY0" value="Sedol"/></identifiers><balance>675188</balance><units>NS</units><curCd>USD</curCd><valUSD>23415520</valUSD><pctVal>0.568</pctVal><payoffProfile>Long</payoffProfile><assetConditional assetCat="OTHER" desc="GDR"/><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec></invstOrSecs><explntrNotes><explntrNote note="Monthly returns presented in Item B.5(a) have been calculated without deducting any applicable sales loads or redemption fees." noteItem="B.5.a"/></explntrNotes><signature><ncom:dateSigned>2022-08-14</ncom:dateSigned><ncom:nameOfApplicant>JANUS INVESTMENT FUND</ncom:nameOfApplicant><ncom:signature>JESPER NERGAARD</ncom:signature><ncom:signerName>JESPER NERGAARD</ncom:signerName><ncom:title>VP, CFO, TREASURER, AND PRINCIPAL ACCOUNTING OFFICER</ncom:title></signature></formData><documents>XXXX</documents></edgarSubmission>
