NPORT-Pfalse0000277751XXXXXXXXS000010467C000028923C000077659C000077660C000077661C000077662C000077663C000083515C000114870JANUS INVESTMENT FUND811-018790000277751W6UYDZFUOFJ4HQQ32382151 DETROIT STREETDENVER802063033333863Janus Henderson Growth and Income FundS0000104675Y0L1HFYUGXP9RNAEB692022-09-302021-12-31N77944737027380028778709367400000000000000NAbbott LaboratoriesHQD377W2YR662HK5JX27Abbott Laboratories0028241001109995NSUSD1562206962.006LongECCORPUSN1NNNAbbVie IncFR5LCKFTG8054YNNRU85AbbVie Inc00287Y109870255NSUSD1178325271.513LongECCORPUSN1NNNActivision Blizzard Inc549300TPQQDBP9GNOF40Activision Blizzard Inc00507V109578324NSUSD384758960.494LongECCORPUSN1NNNAir Products and Chemicals Inc7QEON6Y1RL5XR3R1W237Air Products & Chemicals Inc009158106127034NSUSD386513650.496LongECCORPUSN1NNNAmerican Express CoR4PP93JZOLY261QX3811American Express Co0258161091018182NSUSD1665745752.139LongECCORPUSN1NNNApple IncHWUPKR0MPOU8FGXBT394Apple Inc0378331003751619NSUSD6661749868.555LongECCORPUSN1NNNAutomatic Data Processing IncHGBOLILQXWER4SAL2I23Automatic Data Processing Inc053015103327909NSUSD808558011.038LongECCORPUSN1NNNBest Buy Co IncHL5XPTVRV0O8TUN5LL90Best Buy Co Inc086516101321792NSUSD326940670.42LongECCORPUSN1NNNBooz Allen Hamilton Holding Co529900JPV47PIUWMA015Booz Allen Hamilton Holding Corp099502106274162NSUSD232461960.299LongECCORPUSN1NNNCME Group IncLCZ7XYGSLJUHFXXNXD88CME Group Inc12572Q105689999NSUSD1576371712.024LongECCORPUSN1NNNCognizant Technology Solutions5493006IEVQEFQO40L83Cognizant Technology Solutions Corp192446102451955NSUSD400974480.515LongECCORPUSN1NNNComcast Corp51M0QTTNCGUN7KFCFZ59Comcast Corp20030N1013501027NSUSD1762066892.263LongECCORPUSN1NNNConstellation Brands Inc5493005GKEG8QCVY7037Constellation Brands Inc21036P108129667NSUSD325425270.418LongECCORPUSN1NNNCorning Inc549300X2937PB0CJ7I56Corning Inc2193501052186513NSUSD814038791.045LongECCORPUSN1NNNCostco Wholesale Corp29DX7H14B9S6O3FD6V18Costco Wholesale Corp22160K105224403NSUSD1273935831.636LongECCORPUSN1NNNDeere & CoPWFTNG3EI0Y73OXWDH08Deere & Co244199105484099NSUSD1659927062.132LongECCORPUSN1NNNDENTSPLY SIRONA Inc9NHEHR1SOZCYXDO8HO28DENTSPLY SIRONA Inc24906P1091123655NSUSD626887120.805LongECCORPUSN1NNNeBay IncOML71K8X303XQONU6T67eBay Inc2786421031092238NSUSD726338270.933LongECCORPUSN1NNNElectronic Arts Inc549300O7A67PUEYKDL45Electronic Arts Inc285512109339646NSUSD447993070.575LongECCORPUSN1NNNFidelity National Information6WQI0GK1PRFVBA061U48Fidelity National Information Services Inc31620M106673872NSUSD735531290.945LongECCORPUSN1NNNGeneral Dynamics Corp9C1X8XOOTYY2FNYTVH06General Dynamics Corp369550108524869NSUSD1094194401.405LongECCORPUSN1NNNGilead Sciences Inc549300WTZWR07K8MNV44Gilead Sciences Inc3755581031135214NSUSD824278891.059LongECCORPUSN1NNNHasbro Inc549300NUB6D2R1ITYR45Hasbro Inc4180561071098057NSUSD1117602411.435LongECCORPUSN1NNNHershey Co/The21X2CX66SU2BR6QTAD08Hershey Co427866108492284NSUSD952421851.223LongECCORPUSN1NNNHome Depot Inc/TheQEKMOTMBBKA8I816DO57HOME DEPOT INC437076102389971NSUSD1618418652.078LongECCORPUSN1NNNHoneywell International IncISRPG12PN4EIEOEMW547Honeywell International Inc438516106649472NSUSD1354214071.739LongECCORPUSN1NNNInterpublic Group of Cos Inc/T5493008IUOJ5VWTRC333Interpublic Group of Cos Inc4606901001004602NSUSD376223450.483LongECCORPUSN1NNNIntuit IncVI90HBPH7XSFMB9E4M29Intuit Inc461202103113378NSUSD729269970.937LongECCORPUSN1NNNJPMorgan Chase & Co8I5DZWZKVSZI1NUHU748JPMorgan Chase & Co46625H1001519069NSUSD2405445763.089LongECCORPUSN1NNNKLA Corp549300H0BF5JCG96TJ81KLA Corp482480100543084NSUSD2335858593LongECCORPUSN1NNNL3Harris Technologies Inc549300UTE50ZMDBG8A20L3Harris Technologies Inc502431109170511NSUSD363597660.467LongECCORPUSN1NNNEli Lilly & CoFRDRIPF3EKNDJ2CQJL29Eli Lilly & Co532457108647614NSUSD1788839392.297LongECCORPUSN1NNNMcDonald's CorpUE2136O97NLB5BYP9H04McDonald's Corp580135101700755NSUSD1878513932.412LongECCORPUSN1NNNMerck & Co Inc4YV9Y5M8S0BRK1RP0397Merck & Co Inc58933Y1051131729NSUSD867357111.114LongECCORPUSN1NNNMicrosoft CorpINR2EJN1ERAN0W5ZP974MICROSOFT CORP5949181042140753NSUSD7199780499.246LongECCORPUSN1NNNMorgan StanleyIGJSJL3JD5P30I6NJZ34Morgan Stanley6174464481651391NSUSD1621005412.082LongECCORPUSN1NNNMotorola Solutions Inc6S552MUG6KGJVEBSEC55Motorola Solutions Inc620076307253052NSUSD687542280.883LongECCORPUSN1NNNOracle Corp1Z4GXXU7ZHVWFCD8TV52Oracle Corp68389X105975498NSUSD850731811.092LongECCORPUSN1NNNProcter & Gamble Co/The2572IBTT8CCZW6AU4141Procter & Gamble Co742718109960062NSUSD1570469422.017LongECCORPUSN1NNNQuest Diagnostics Inc8MCWUBXQ0WE04KMXBX50Quest Diagnostics Inc74834L100196788NSUSD340462920.437LongECCORPUSN1NNNRockwell Automation IncVH3R4HHBHH12O0EXZJ88Rockwell Automation Inc773903109238404NSUSD831672351.068LongECCORPUSN1NNNS&P Global IncY6X4K52KMJMZE7I7MY94S&P Global Inc78409V10491569NSUSD432141580.555LongECCORPUSN1NNNCharles Schwab Corp/The549300VSGCJ7E698NM85Charles Schwab Corp808513105521460NSUSD438547860.563LongECCORPUSN1NNNSherwin-Williams Co/TheZ15BMIOX8DDH0X2OBP21Sherwin-Williams Co824348106163718NSUSD576549310.74LongECCORPUSN1NNNStarbucks CorpOQSJ1DU9TAOC51A47K68Starbucks Corp855244109935308NSUSD1094029771.405LongECCORPUSN1NNNStryker Corp5493002F0SC4JTBU5137Stryker Corp863667101209711NSUSD560809160.72LongECCORPUSN1NNNSysco Corp5RGWIFLMGH3YS7KWI652Sysco Corp871829107638043NSUSD501182780.644LongECCORPUSN1NNNTarget Corp8WDDFXB5T1Z6J0XC1L66Target Corp87612E106390634NSUSD904083331.161LongECCORPUSN1NNNTexas Instruments IncWDJNR2L6D8RWOEB8T652TEXAS INSTRUMENTS INC882508104995685NSUSD1876567522.41LongECCORPUSN1NNNJanus Capital Group Inc8T2ZO87FU1KVPZIG9I59Janus Henderson Cash Liquidity FundN/A6700305NSUSD67009750.086LongECPFUSN2NNNUnion Pacific Corp549300LMMRSZZCZ8CL11Union Pacific Corp907818108236707NSUSD596335940.766LongECCORPUSN1NNNUnited Parcel Service IncD01LMJZU09ULLNCY6Z23United Parcel Service Inc911312106703521NSUSD1507926911.936LongECCORPUSN1NNNUnitedHealth Group Inc549300GHBMY8T5GXDE41UnitedHealth Group Inc91324P102457240NSUSD2295984942.948LongECCORPUSN1NNNVF CorpCWAJJ9DJ5Z7P057HV541VF Corp9182041081521908NSUSD1114341041.431LongECCORPUSN1NNNVisa Inc549300JZ4OKEHW3DPJ59Visa Inc92826C839673815NSUSD1460224491.875LongECCORPUSN1NNNWarner Music Group CorpN/AWarner Music Group Corp - Class A9345502031147660NSUSD495559590.636LongECCORPUSN1NNNWaste Management Inc549300YX8JIID70NFS41Waste Management Inc94106L109228513NSUSD381388200.49LongECCORPUSN1NNNZoetis Inc549300HD9Q1LOC9KLJ48Zoetis Inc98978V103318268NSUSD776669400.997LongECCORPUSN1NNNAccenture PLCN/AAccenture PLCG1151C101946606NSUSD3924155175.039LongECCORPUSN1NNNMedtronic PLC549300GX3ZBSQWUXY261Medtronic PLCG5960L1031105337NSUSD1143471131.468LongECCORPUSN1NNNTrane Technologies PLC549300BURLR9SLYY2705TRANE TECHNOLOGIES PLCG8994E103261908NSUSD529132730.679LongECCORPUSN1NNNGarmin Ltd2549001E0HIPIJQ0W046Garmin LtdH2906T109797996NSUSD1086631151.395LongECCORPUSN1NNNTE Connectivity Ltd894500ZRIX9K13RHXR17TE CONNECTIVITY LTDH84989104995814NSUSD1606646312.063LongECCORPUSN1NNNAstraZeneca PLCPY6ZZQWO2IZFZC3IOL08AstraZeneca PLC (ADR)046353108239478NSUSD139495930.179LongCORPUSN1NNN2022-02-14JANUS INVESTMENT FUNDJESPER NERGAARDJESPER NERGAARDVP, CFO, TREASURER, AND PRINCIPAL ACCOUNTING OFFICERXXXX