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value="Sedol"/></identifiers><balance>555230</balance><units>NS</units><curCd>USD</curCd><valUSD>49054571</valUSD><pctVal>0.985</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Biomea Fusion Inc</name><lei>N/A</lei><title>Biomea Fusion Inc</title><cusip>09077A106</cusip><identifiers><isin value="US09077A1060"/><ticker value="BMEA US"/><other otherDesc="BNKF6N0" value="Sedol"/></identifiers><balance>652813</balance><units>NS</units><curCd>USD</curCd><valUSD>4863457</valUSD><pctVal>0.098</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><loanByFundCondition isLoanByFund="Y" loanVal="985312"/></securityLending></invstOrSec><invstOrSec><name>BioAtla Inc</name><lei>N/A</lei><title>BioAtla LLC</title><cusip>09077B104</cusip><identifiers><isin value="US09077B1044"/><ticker value="BCAB US"/><other otherDesc="BNC5F86" value="Sedol"/></identifiers><balance>515628</balance><units>NS</units><curCd>USD</curCd><valUSD>10121778</valUSD><pctVal>0.203</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>AstraZeneca PLC</name><lei>PY6ZZQWO2IZFZC3IOL08</lei><title>AstraZeneca PLC</title><cusip>G0593M107</cusip><identifiers><isin value="GB0009895292"/><ticker value="AZN LN"/><other otherDesc="989529" value="Sedol"/></identifiers><balance>1684170</balance><units>NS</units><currencyConditional curCd="GBP" exchangeRt="0.73893"/><valUSD>197789063</valUSD><pctVal>3.97</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>GB</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Boston Scientific Corp</name><lei>Y6ZDD9FP4P8JSSJMW954</lei><title>Boston Scientific Corp</title><cusip>101137107</cusip><identifiers><isin value="US1011371077"/><ticker value="BSX US"/><other otherDesc="2113434" 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value="Sedol"/></identifiers><balance>752286</balance><units>NS</units><curCd>USD</curCd><valUSD>4521239</valUSD><pctVal>0.091</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Caribou Biosciences Inc</name><lei>N/A</lei><title>Caribou Biosciences Inc</title><cusip>N/A</cusip><identifiers><isin value="US1420381089"/><ticker value="CRBU US"/><other otherDesc="BNYJR68" value="Sedol"/></identifiers><balance>433947</balance><units>NS</units><curCd>USD</curCd><valUSD>6548260</valUSD><pctVal>0.131</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Catalent Inc</name><lei>N/A</lei><title>Catalent Inc</title><cusip>148806102</cusip><identifiers><isin value="US1488061029"/><ticker value="CTLT US"/><other otherDesc="BP96PQ4" value="Sedol"/></identifiers><balance>300826</balance><units>NS</units><curCd>USD</curCd><valUSD>38514753</valUSD><pctVal>0.773</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Centene Corp</name><lei>549300Z7JJ4TQSQGT333</lei><title>Centene Corp</title><cusip>15135B101</cusip><identifiers><isin value="US15135B1017"/><ticker value="CNC US"/><other otherDesc="2807061" value="Sedol"/></identifiers><balance>985820</balance><units>NS</units><curCd>USD</curCd><valUSD>81231568</valUSD><pctVal>1.631</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Collegium Pharmaceutical Inc</name><lei>54930049FXZMTLW8D496</lei><title>Collegium Pharmaceutical Inc</title><cusip>19459J104</cusip><identifiers><isin value="US19459J1043"/><ticker value="COLL US"/><other otherDesc="BX7RSN3" value="Sedol"/></identifiers><balance>779280</balance><units>NS</units><curCd>USD</curCd><valUSD>14556950</valUSD><pctVal>0.292</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Cooper Cos Inc/The</name><lei>QJKMVPIGLH7530PCUE20</lei><title>Cooper Cos Inc</title><cusip>216648402</cusip><identifiers><isin value="US2166484020"/><ticker value="COO US"/><other otherDesc="2222631" value="Sedol"/></identifiers><balance>119447</balance><units>NS</units><curCd>USD</curCd><valUSD>50041126</valUSD><pctVal>1.005</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Cyteir Therapeutics Inc</name><lei>N/A</lei><title>Cyteir Therapeutics Inc</title><cusip>23284P103</cusip><identifiers><isin value="US23284P1030"/><ticker value="CYT US"/><other otherDesc="BM95GX4" value="Sedol"/></identifiers><balance>119382</balance><units>NS</units><curCd>USD</curCd><valUSD>1357373</valUSD><pctVal>0.027</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><loanByFundCondition isLoanByFund="Y" loanVal="904883.63"/></securityLending></invstOrSec><invstOrSec><name>DICE Therapeutics Inc</name><lei>N/A</lei><title>DICE Therapeutics Inc</title><cusip>23345J104</cusip><identifiers><isin value="US23345J1043"/><ticker value="DICE US"/><other otherDesc="BNRPLC7" value="Sedol"/></identifiers><balance>384579</balance><units>NS</units><curCd>USD</curCd><valUSD>9733695</valUSD><pctVal>0.195</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><loanByFundCondition isLoanByFund="Y" loanVal="465460"/></securityLending></invstOrSec><invstOrSec><name>Danaher Corp</name><lei>S4BKK9OTCEWQ3YHPFM11</lei><title>Danaher Corp</title><cusip>235851102</cusip><identifiers><isin value="US2358511028"/><ticker value="DHR US"/><other otherDesc="2250870" value="Sedol"/></identifiers><balance>389648</balance><units>NS</units><curCd>USD</curCd><valUSD>128198088</valUSD><pctVal>2.573</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>DENTSPLY SIRONA Inc</name><lei>9NHEHR1SOZCYXDO8HO28</lei><title>DENTSPLY SIRONA Inc</title><cusip>24906P109</cusip><identifiers><isin value="US24906P1093"/><ticker value="XRAY US"/><other otherDesc="BYNPPC6" value="Sedol"/></identifiers><balance>801839</balance><units>NS</units><curCd>USD</curCd><valUSD>44734598</valUSD><pctVal>0.898</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Dexcom Inc</name><lei>549300YSK3QDSFR5EU59</lei><title>DexCom Inc</title><cusip>252131107</cusip><identifiers><isin value="US2521311074"/><ticker value="DXCM US"/><other otherDesc="B0796X4" 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value="Sedol"/></identifiers><balance>532805</balance><units>NS</units><curCd>USD</curCd><valUSD>8141260</valUSD><pctVal>0.163</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Edwards Lifesciences Corp</name><lei>YA13X31F3V31L8TMPR58</lei><title>Edwards Lifesciences Corp</title><cusip>28176E108</cusip><identifiers><isin value="US28176E1082"/><ticker value="EW US"/><other otherDesc="2567116" value="Sedol"/></identifiers><balance>690786</balance><units>NS</units><curCd>USD</curCd><valUSD>89491326</valUSD><pctVal>1.796</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Elanco Animal Health Inc</name><lei>549300SHPNDCE059M934</lei><title>Elanco Animal Health Inc</title><cusip>28414H103</cusip><identifiers><isin value="US28414H1032"/><ticker value="ELAN US"/><other otherDesc="BF5L3T2" value="Sedol"/></identifiers><balance>1210929</balance><units>NS</units><curCd>USD</curCd><valUSD>34366165</valUSD><pctVal>0.69</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Essa Pharma Inc</name><lei>N/A</lei><title>ESSA Pharma Inc</title><cusip>29668H708</cusip><identifiers><isin value="CA29668H7085"/><ticker value="EPIX US"/><other otherDesc="BDTYY56" value="Sedol"/></identifiers><balance>443979</balance><units>NS</units><curCd>USD</curCd><valUSD>6304502</valUSD><pctVal>0.127</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Fate Therapeutics Inc</name><lei>549300L14Q4UHOODLA90</lei><title>Fate Therapeutics Inc</title><cusip>31189P102</cusip><identifiers><isin value="US31189P1021"/><ticker value="FATE US"/><other otherDesc="BCZS820" value="Sedol"/></identifiers><balance>227771</balance><units>NS</units><curCd>USD</curCd><valUSD>13326881</valUSD><pctVal>0.268</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Janux Therapeutics Inc</name><lei>N/A</lei><title>Janux Therapeutics Inc</title><cusip>N/A</cusip><identifiers><isin value="DU0000104383"/><ticker value="1870655D"/></identifiers><balance>245474</balance><units>NS</units><curCd>USD</curCd><valUSD>4601042</valUSD><pctVal>0.092</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>2</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Cyteir Therapeutics Inc</name><lei>N/A</lei><title>Cyteir Therapeutics Inc</title><cusip>N/A</cusip><identifiers><isin value="DU0000104238"/><ticker value="1340516D"/></identifiers><balance>549652</balance><units>NS</units><curCd>USD</curCd><valUSD>5937066</valUSD><pctVal>0.119</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>2</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>SomaLogic Inc</name><lei>N/A</lei><title>SomaLogic Inc</title><cusip>N/A</cusip><identifiers><isin 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value="DU0000102346"/></identifiers><balance>785378</balance><units>NS</units><curCd>USD</curCd><valUSD>8401188</valUSD><pctVal>0.169</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>2</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Design Therapeutics Inc</name><lei>N/A</lei><title>Design Therapeutics Inc</title><cusip>N/A</cusip><identifiers><isin value="DU0000101665"/><ticker value="1792009D"/></identifiers><balance>522185</balance><units>NS</units><curCd>USD</curCd><valUSD>10620982</valUSD><pctVal>0.213</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>2</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Icosavax Inc</name><lei>N/A</lei><title>Icosavax Inc</title><cusip>N/A</cusip><identifiers><isin value="DU0000102382"/><ticker value="1755329D"/></identifiers><balance>337717</balance><units>NS</units><curCd>USD</curCd><valUSD>7340617</valUSD><pctVal>0.147</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>2</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Verve Therapeutics Inc</name><lei>N/A</lei><title>Verve Therapeutics Inc</title><cusip>N/A</cusip><identifiers><isin value="DU0000102335"/><ticker value="1715307D"/></identifiers><balance>260405</balance><units>NS</units><curCd>USD</curCd><valUSD>9121076</valUSD><pctVal>0.183</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>2</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Pyxis Oncology Inc</name><lei>N/A</lei><title>Pyxis Oncology Inc PP</title><cusip>N/A</cusip><identifiers><isin value="DU0000102370"/><ticker value="1733859D"/></identifiers><balance>286086</balance><units>NS</units><curCd>USD</curCd><valUSD>2824527</valUSD><pctVal>0.057</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>2</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Graphite Bio Inc</name><lei>N/A</lei><title>Graphite Bio Inc</title><cusip>N/A</cusip><identifiers><isin value="DU0000102373"/><ticker value="1830598D"/></identifiers><balance>309302</balance><units>NS</units><curCd>USD</curCd><valUSD>3652393</valUSD><pctVal>0.073</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>2</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Ventyx Biosciences Inc</name><lei>N/A</lei><title>Ventyx Biosciences Inc PP</title><cusip>N/A</cusip><identifiers><isin value="DU0000101917"/><ticker value="1806419D"/></identifiers><balance>297621</balance><units>NS</units><curCd>USD</curCd><valUSD>5319678</valUSD><pctVal>0.107</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>2</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Day One Biopharmaceuticals Inc</name><lei>N/A</lei><title>Day One Biopharmaceuticals</title><cusip>N/A</cusip><identifiers><isin value="DU0000101920"/><ticker value="1803228D"/></identifiers><balance>406888</balance><units>NS</units><curCd>USD</curCd><valUSD>6513260</valUSD><pctVal>0.131</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>2</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>DiCE Molecules Holding LLC</name><lei>N/A</lei><title>DiCE Molecules Holdings LLC PP</title><cusip>N/A</cusip><identifiers><isin value="DU0000102059"/></identifiers><balance>192261</balance><units>NS</units><curCd>USD</curCd><valUSD>4622820</valUSD><pctVal>0.093</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>2</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Harmony Biosciences Holdings I</name><lei>N/A</lei><title>Harmony Biosciences Holdings Inc</title><cusip>413197104</cusip><identifiers><isin value="US4131971040"/><ticker value="HRMY US"/><other otherDesc="BKSGZN7" 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value="Sedol"/></identifiers><balance>252106</balance><units>NS</units><curCd>USD</curCd><valUSD>4800098</valUSD><pctVal>0.096</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><loanByFundCondition isLoanByFund="Y" loanVal="3593211.29"/></securityLending></invstOrSec><invstOrSec><name>Olema Pharmaceuticals Inc</name><lei>N/A</lei><title>Olema Pharmaceuticals Inc</title><cusip>68062P106</cusip><identifiers><isin value="US68062P1066"/><ticker value="OLMA US"/><other otherDesc="BMZ4LN0" value="Sedol"/></identifiers><balance>772047</balance><units>NS</units><curCd>USD</curCd><valUSD>7226360</valUSD><pctVal>0.145</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Takeda Pharmaceutical Co Ltd</name><lei>549300ZLMVP4X0OGR454</lei><title>Takeda Pharmaceutical Co Ltd</title><cusip>J8129E108</cusip><identifiers><isin value="JP3463000004"/><ticker value="4502 JP"/><other otherDesc="6870445" value="Sedol"/></identifiers><balance>668136</balance><units>NS</units><currencyConditional curCd="JPY" 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value="Sedol"/></identifiers><balance>701804</balance><units>NS</units><curCd>USD</curCd><valUSD>27952853</valUSD><pctVal>0.561</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Astellas Pharma Inc</name><lei>529900IB708DY2HBBB35</lei><title>Astellas Pharma Inc</title><cusip>J03393105</cusip><identifiers><isin value="JP3942400007"/><ticker value="4503 JP"/><other otherDesc="6985383" value="Sedol"/></identifiers><balance>3039700</balance><units>NS</units><currencyConditional curCd="JPY" 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value="Sedol"/></identifiers><balance>156852</balance><units>NS</units><curCd>USD</curCd><valUSD>1720666</valUSD><pctVal>0.035</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Quest Diagnostics Inc</name><lei>8MCWUBXQ0WE04KMXBX50</lei><title>Quest Diagnostics Inc</title><cusip>74834L100</cusip><identifiers><isin value="US74834L1008"/><ticker value="DGX US"/><other otherDesc="2702791" 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value="DU0000100962"/></identifiers><balance>10293213</balance><units>NS</units><curCd>USD</curCd><valUSD>10294243</valUSD><pctVal>0.207</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>PF</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>2</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Janus Henderson Cash Collateral Fund</name><lei>N/A</lei><title>Janus Henderson Cash Collateral Fund</title><cusip>N/A</cusip><identifiers><other otherDesc="896" value="Internal 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exchangeRt="7.7973"/><valUSD>6149767</valUSD><pctVal>0.123</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>HK</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Biohaven Pharmaceutical Holdin</name><lei>5299007STZTNN32O9920</lei><title>Biohaven Pharmaceutical Holding Co Ltd</title><cusip>G11196105</cusip><identifiers><isin value="VGG111961055"/><ticker value="BHVN US"/><other otherDesc="BZ8FXC4" 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value="Sedol"/></identifiers><balance>665484</balance><units>NS</units><curCd>USD</curCd><valUSD>71712556</valUSD><pctVal>1.44</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>ICON PLC</name><lei>6354008SRQGEMC4XFI67</lei><title>ICON PLC</title><cusip>G4705A100</cusip><identifiers><isin value="IE0005711209"/><ticker value="ICLR US"/><other otherDesc="B94G471" value="Sedol"/></identifiers><balance>98377</balance><units>NS</units><curCd>USD</curCd><valUSD>30467357</valUSD><pctVal>0.612</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Jazz Pharmaceuticals PLC</name><lei>635400GAUMJCLEZRRV50</lei><title>Jazz Pharmaceuticals PLC</title><cusip>G50871105</cusip><identifiers><isin value="IE00B4Q5ZN47"/><ticker value="JAZZ US"/><other otherDesc="B4Q5ZN4" 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value="Sedol"/></identifiers><balance>787632</balance><units>NS</units><curCd>USD</curCd><valUSD>31387135</valUSD><pctVal>0.63</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>STERIS PLC</name><lei>N/A</lei><title>STERIS PLC</title><cusip>G8473T100</cusip><identifiers><isin value="IE00BFY8C754"/><ticker value="STE US"/><other otherDesc="BFY8C75" value="Sedol"/></identifiers><balance>182353</balance><units>NS</units><curCd>USD</curCd><valUSD>44386544</valUSD><pctVal>0.891</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Element Biosciences Inc</name><lei>N/A</lei><title>Element Biosciences Inc PP</title><cusip>N/A</cusip><identifiers><isin value="DU0000104465"/><ticker value="1726116D"/></identifiers><balance>425023</balance><units>NS</units><curCd>USD</curCd><valUSD>8737070</valUSD><pctVal>0.175</pctVal><payoffProfile>Long</payoffProfile><assetCat>EP</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Shoreline Biosciences Inc</name><lei>N/A</lei><title>Shoreline Biosciences Inc</title><cusip>N/A</cusip><identifiers><isin value="DU0000104569"/><ticker value="1868807D"/></identifiers><balance>747187</balance><units>NS</units><curCd>USD</curCd><valUSD>7522230</valUSD><pctVal>0.151</pctVal><payoffProfile>Long</payoffProfile><assetCat>EP</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Attralus Inc</name><lei>N/A</lei><title>Attralus Inc PP</title><cusip>N/A</cusip><identifiers><isin value="DU0000104336"/><ticker value="1829635D"/></identifiers><balance>669935</balance><units>NS</units><curCd>USD</curCd><valUSD>5198696</valUSD><pctVal>0.104</pctVal><payoffProfile>Long</payoffProfile><assetCat>EP</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Lexeo Therapeutics Inc</name><lei>N/A</lei><title>LEXEO Therapeutics Inc PP</title><cusip>N/A</cusip><identifiers><isin value="DU0000104012"/></identifiers><balance>3643715</balance><units>NS</units><curCd>USD</curCd><valUSD>6268975</valUSD><pctVal>0.126</pctVal><payoffProfile>Long</payoffProfile><assetCat>EP</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Lexeo Therapeutics Inc</name><lei>N/A</lei><title>LEXEO Therapeutics Inc</title><cusip>N/A</cusip><identifiers><isin value="DU0000104331"/><ticker value="1848501D 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value="DU0000104263"/></identifiers><balance>700559</balance><units>NS</units><curCd>USD</curCd><valUSD>6235276</valUSD><pctVal>0.125</pctVal><payoffProfile>Long</payoffProfile><assetCat>EP</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Sonoma Biotherapeutics Inc</name><lei>N/A</lei><title>Sonoma Biotherapeutics Inc PP</title><cusip>N/A</cusip><identifiers><isin value="DU0000104500"/><ticker value="1783532D"/></identifiers><balance>1255200</balance><units>NS</units><curCd>USD</curCd><valUSD>2480652</valUSD><pctVal>0.05</pctVal><payoffProfile>Long</payoffProfile><assetCat>EP</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Arbor Biotechnologies Inc</name><lei>N/A</lei><title>Arbor Biotechnologies Inc</title><cusip>N/A</cusip><identifiers><isin value="DU0000104275"/><ticker value="1584091D"/></identifiers><balance>156426</balance><units>NS</units><curCd>USD</curCd><valUSD>2591979</valUSD><pctVal>0.052</pctVal><payoffProfile>Long</payoffProfile><assetCat>EP</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Freenome Holdings Inc</name><lei>254900QDTSQ6S0QOCS43</lei><title>Freenome Holdings Inc</title><cusip>N/A</cusip><identifiers><isin value="DU0000104596"/><ticker value="1411948D"/></identifiers><balance>342803</balance><units>NS</units><curCd>USD</curCd><valUSD>4000511</valUSD><pctVal>0.08</pctVal><payoffProfile>Long</payoffProfile><assetCat>EP</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Hemoshear Therapeutics LLC</name><lei>N/A</lei><title>HemoShear Therapeutics LLC PP</title><cusip>N/A</cusip><identifiers><isin value="DU0000104239"/><ticker value="0611670D 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US"/></identifiers><balance>3083148</balance><units>NS</units><curCd>USD</curCd><valUSD>16851562</valUSD><pctVal>0.338</pctVal><payoffProfile>Long</payoffProfile><assetCat>EP</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>2</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Bigfoot Biomedical Inc</name><lei>N/A</lei><title>Bigfoot Biomedical Inc - Series C-1 PP</title><cusip>N/A</cusip><identifiers><isin value="DU0000104002"/><ticker value="BIGFOOTC1"/></identifiers><balance>168418</balance><units>NS</units><curCd>USD</curCd><valUSD>1594792</valUSD><pctVal>0.032</pctVal><payoffProfile>Long</payoffProfile><assetCat>EP</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Bigfoot Biomedical Inc</name><lei>N/A</lei><title>Bigfoot Biomedical Inc - Series B PP</title><cusip>N/A</cusip><identifiers><isin value="DU0000100959"/><ticker value="1450137D US"/><other otherDesc="B4N0JJ6" 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desc="GDR"/><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Bicycle Therapeutics PLC</name><lei>213800XKUI6R7GKC3E43</lei><title>Bicycle Therapeutics Ltd (ADR)</title><cusip>088786108</cusip><identifiers><isin value="US0887861088"/><ticker value="BCYC US"/><other otherDesc="BKDQKM6" value="Sedol"/></identifiers><balance>463421</balance><units>NS</units><curCd>USD</curCd><valUSD>28208436</valUSD><pctVal>0.566</pctVal><payoffProfile>Long</payoffProfile><assetConditional assetCat="OTHER" desc="GDR"/><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Clementia Pharmaceuticals Inc</name><lei>N/A</lei><title>Clementia Pharmaceuticals Inc CVR</title><cusip>N/A</cusip><identifiers><isin value="N/A"/><ticker value="CMTA CVR"/></identifiers><balance>874311</balance><units>NS</units><curCd>USD</curCd><valUSD>1</valUSD><pctVal>0</pctVal><payoffProfile>Long</payoffProfile><assetConditional assetCat="OTHER" desc="Rights"/><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Novartis AG</name><lei>5493007HIVTX6SY6XD66</lei><title>Novartis AG (ADR)</title><cusip>66987V109</cusip><identifiers><isin value="US66987V1098"/><ticker value="NVS US"/><other otherDesc="2620105" value="Sedol"/></identifiers><balance>1181313</balance><units>NS</units><curCd>USD</curCd><valUSD>103329448</valUSD><pctVal>2.074</pctVal><payoffProfile>Long</payoffProfile><assetConditional assetCat="OTHER" desc="GDR"/><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec></invstOrSecs><explntrNotes><explntrNote note="Monthly returns presented in Item B.5(a) have been calculated without deducting any applicable sales loads or redemption fees." noteItem="B.5.a"/></explntrNotes><signature><ncom:dateSigned>2022-02-14</ncom:dateSigned><ncom:nameOfApplicant>JANUS INVESTMENT FUND</ncom:nameOfApplicant><ncom:signature>JESPER NERGAARD</ncom:signature><ncom:signerName>JESPER NERGAARD</ncom:signerName><ncom:title>VP, CFO, TREASURER, AND PRINCIPAL ACCOUNTING OFFICER</ncom:title></signature></formData><documents>XXXX</documents></edgarSubmission>
