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value="Sedol"/></identifiers><balance>2564430</balance><units>NS</units><curCd>USD</curCd><valUSD>36209752</valUSD><pctVal>0.825</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Annexon Inc</name><lei>N/A</lei><title>Annexon Inc</title><cusip>03589W102</cusip><identifiers><isin value="US03589W1027"/><ticker value="ANNX US"/><other otherDesc="BMVV9R5" 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value="Sedol"/></identifiers><balance>177183</balance><units>NS</units><curCd>USD</curCd><valUSD>47589582</valUSD><pctVal>1.085</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Aprea Therapeutics Inc</name><lei>N/A</lei><title>Aprea Therapeutics Inc</title><cusip>03836J102</cusip><identifiers><isin value="US03836J1025"/><ticker value="APRE US"/><other otherDesc="BKLG749" value="Sedol"/></identifiers><balance>343726</balance><units>NS</units><curCd>USD</curCd><valUSD>8270048</valUSD><pctVal>0.188</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Axsome Therapeutics Inc</name><lei>549300EXGR0XLRJEIB95</lei><title>Axsome Therapeutics Inc</title><cusip>05464T104</cusip><identifiers><isin value="US05464T1043"/><ticker value="AXSM US"/><other otherDesc="BYZR4X4" value="Sedol"/></identifiers><balance>202598</balance><units>NS</units><curCd>USD</curCd><valUSD>14435108</valUSD><pctVal>0.329</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Baxter International Inc</name><lei>J5OIVXX3P24RJRW5CK77</lei><title>Baxter International Inc</title><cusip>071813109</cusip><identifiers><isin value="US0718131099"/><ticker value="BAX US"/><other otherDesc="2085102" value="Sedol"/></identifiers><balance>495850</balance><units>NS</units><curCd>USD</curCd><valUSD>39876257</valUSD><pctVal>0.909</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>BioMarin Pharmaceutical Inc</name><lei>NSLL8ITTRR0J5HEMR848</lei><title>BioMarin Pharmaceutical Inc</title><cusip>09061G101</cusip><identifiers><isin value="US09061G1013"/><ticker value="BMRN US"/><other otherDesc="2437071" value="Sedol"/></identifiers><balance>670084</balance><units>NS</units><curCd>USD</curCd><valUSD>50979991</valUSD><pctVal>1.162</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>BioNTech SE</name><lei>894500UZJ5LG1F8J1U58</lei><title>BioNTech SE</title><cusip>09075V102</cusip><identifiers><isin value="US09075V1026"/><ticker value="BNTX US"/><other otherDesc="BK6H543" value="Sedol"/></identifiers><balance>156971</balance><units>NS</units><curCd>USD</curCd><valUSD>10867102</valUSD><pctVal>0.248</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>DE</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>AstraZeneca PLC</name><lei>PY6ZZQWO2IZFZC3IOL08</lei><title>AstraZeneca PLC</title><cusip>G0593M107</cusip><identifiers><isin value="GB0009895292"/><ticker value="AZN LN"/><other otherDesc="989529" value="Sedol"/></identifiers><balance>1202704</balance><units>NS</units><currencyConditional curCd="GBP" exchangeRt="0.77513"/><valUSD>130878718</valUSD><pctVal>2.983</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>GB</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>2</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Boston Scientific Corp</name><lei>Y6ZDD9FP4P8JSSJMW954</lei><title>Boston Scientific Corp</title><cusip>101137107</cusip><identifiers><isin value="US1011371077"/><ticker value="BSX US"/><other otherDesc="2113434" value="Sedol"/></identifiers><balance>2779951</balance><units>NS</units><curCd>USD</curCd><valUSD>106221928</valUSD><pctVal>2.421</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Bridgebio Pharma Inc</name><lei>54930028YG89VTY2J114</lei><title>Bridgebio Pharma Inc</title><cusip>10806X102</cusip><identifiers><isin value="US10806X1028"/><ticker value="BBIO US"/><other otherDesc="BK1KWG8" value="Sedol"/></identifiers><balance>445351</balance><units>NS</units><curCd>USD</curCd><valUSD>16709570</valUSD><pctVal>0.381</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><loanByFundCondition isLoanByFund="Y" loanVal="12391882.3"/></securityLending></invstOrSec><invstOrSec><name>Bristol-Myers Squibb Co</name><lei>HLYYNH7UQUORYSJQCN42</lei><title>Bristol-Myers Squibb Co</title><cusip>110122108</cusip><identifiers><isin value="US1101221083"/><ticker value="BMY US"/><other otherDesc="2126335" value="Sedol"/></identifiers><balance>1667258</balance><units>NS</units><curCd>USD</curCd><valUSD>100518985</valUSD><pctVal>2.291</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Catalent Inc</name><lei>N/A</lei><title>Catalent Inc</title><cusip>148806102</cusip><identifiers><isin value="US1488061029"/><ticker value="CTLT US"/><other otherDesc="BP96PQ4" value="Sedol"/></identifiers><balance>623601</balance><units>NS</units><curCd>USD</curCd><valUSD>53417662</valUSD><pctVal>1.218</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Centene Corp</name><lei>549300Z7JJ4TQSQGT333</lei><title>Centene Corp</title><cusip>15135B101</cusip><identifiers><isin value="US15135B1017"/><ticker value="CNC US"/><other otherDesc="2807061" value="Sedol"/></identifiers><balance>987805</balance><units>NS</units><curCd>USD</curCd><valUSD>57618666</valUSD><pctVal>1.313</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Collegium Pharmaceutical Inc</name><lei>54930049FXZMTLW8D496</lei><title>Collegium Pharmaceutical Inc</title><cusip>19459J104</cusip><identifiers><isin value="US19459J1043"/><ticker value="COLL US"/><other otherDesc="BX7RSN3" value="Sedol"/></identifiers><balance>974305</balance><units>NS</units><curCd>USD</curCd><valUSD>20285030</valUSD><pctVal>0.462</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Cooper Cos Inc/The</name><lei>QJKMVPIGLH7530PCUE20</lei><title>Cooper Cos Inc</title><cusip>216648402</cusip><identifiers><isin value="US2166484020"/><ticker value="COO US"/><other otherDesc="2222631" value="Sedol"/></identifiers><balance>104082</balance><units>NS</units><curCd>USD</curCd><valUSD>35088124</valUSD><pctVal>0.8</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Danaher Corp</name><lei>S4BKK9OTCEWQ3YHPFM11</lei><title>Danaher Corp</title><cusip>235851102</cusip><identifiers><isin value="US2358511028"/><ticker value="DHR US"/><other otherDesc="2250870" value="Sedol"/></identifiers><balance>395854</balance><units>NS</units><curCd>USD</curCd><valUSD>85239242</valUSD><pctVal>1.943</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>DENTSPLY SIRONA Inc</name><lei>9NHEHR1SOZCYXDO8HO28</lei><title>DENTSPLY SIRONA Inc</title><cusip>24906P109</cusip><identifiers><isin value="US24906P1093"/><ticker value="XRAY US"/><other otherDesc="BYNPPC6" value="Sedol"/></identifiers><balance>551805</balance><units>NS</units><curCd>USD</curCd><valUSD>24130433</valUSD><pctVal>0.55</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>DexCom Inc</name><lei>549300YSK3QDSFR5EU59</lei><title>DexCom Inc</title><cusip>252131107</cusip><identifiers><isin value="US2521311074"/><ticker value="DXCM US"/><other otherDesc="B0796X4" value="Sedol"/></identifiers><balance>50222</balance><units>NS</units><curCd>USD</curCd><valUSD>20703015</valUSD><pctVal>0.472</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Dyne Therapeutics Inc</name><lei>N/A</lei><title>DYNE THERAPEUTICS INC</title><cusip>26818M108</cusip><identifiers><isin value="US26818M1080"/><ticker value="DYN US"/><other otherDesc="BN15WD1" value="Sedol"/></identifiers><balance>381834</balance><units>NS</units><curCd>USD</curCd><valUSD>7709228</valUSD><pctVal>0.176</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Edwards Lifesciences Corp</name><lei>YA13X31F3V31L8TMPR58</lei><title>Edwards Lifesciences Corp</title><cusip>28176E108</cusip><identifiers><isin value="US28176E1082"/><ticker value="EW US"/><other otherDesc="2567116" value="Sedol"/></identifiers><balance>430730</balance><units>NS</units><curCd>USD</curCd><valUSD>34380869</valUSD><pctVal>0.784</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Elanco Animal Health Inc</name><lei>549300SHPNDCE059M934</lei><title>Elanco Animal Health Inc</title><cusip>28414H103</cusip><identifiers><isin value="US28414H1032"/><ticker value="ELAN US"/><other otherDesc="BF5L3T2" value="Sedol"/></identifiers><balance>2464791</balance><units>NS</units><curCd>USD</curCd><valUSD>68841613</valUSD><pctVal>1.569</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Exelixis Inc</name><lei>N/A</lei><title>Exelixis Inc</title><cusip>30161Q104</cusip><identifiers><isin value="US30161Q1040"/><ticker value="EXEL US"/><other otherDesc="2576941" value="Sedol"/></identifiers><balance>945369</balance><units>NS</units><curCd>USD</curCd><valUSD>23114272</valUSD><pctVal>0.527</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Fate Therapeutics Inc</name><lei>549300L14Q4UHOODLA90</lei><title>Fate Therapeutics Inc</title><cusip>31189P102</cusip><identifiers><isin value="US31189P1021"/><ticker value="FATE US"/><other otherDesc="BCZS820" value="Sedol"/></identifiers><balance>569522</balance><units>NS</units><curCd>USD</curCd><valUSD>22763794</valUSD><pctVal>0.519</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>FibroGen Inc</name><lei>549300Q914ULWWY95822</lei><title>FibroGen Inc</title><cusip>31572Q808</cusip><identifiers><isin value="US31572Q8087"/><ticker value="FGEN US"/><other otherDesc="BSDRYR8" value="Sedol"/></identifiers><balance>385852</balance><units>NS</units><curCd>USD</curCd><valUSD>15866234</valUSD><pctVal>0.362</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Forma Therapeutics Holdings In</name><lei>N/A</lei><title>FORMA Therapeutics Inc</title><cusip>34633R104</cusip><identifiers><isin value="US34633R1041"/><ticker value="FMTX US"/><other otherDesc="BLB2Y98" value="Sedol"/></identifiers><balance>461670</balance><units>NS</units><curCd>USD</curCd><valUSD>23009633</valUSD><pctVal>0.524</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Gilead Sciences Inc</name><lei>549300WTZWR07K8MNV44</lei><title>Gilead Sciences Inc</title><cusip>375558103</cusip><identifiers><isin value="US3755581036"/><ticker value="GILD US"/><other otherDesc="2369174" value="Sedol"/></identifiers><balance>882790</balance><units>NS</units><curCd>USD</curCd><valUSD>55783500</valUSD><pctVal>1.271</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Global Blood Therapeutics Inc</name><lei>549300U4G0QKK99GRT15</lei><title>Global Blood Therapeutics Inc</title><cusip>37890U108</cusip><identifiers><isin value="US37890U1088"/><ticker value="GBT US"/><other otherDesc="BZ05388" value="Sedol"/></identifiers><balance>740172</balance><units>NS</units><curCd>USD</curCd><valUSD>40813084</valUSD><pctVal>0.93</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Globus Medical Inc</name><lei>5299003M2P4CIK0RF205</lei><title>Globus Medical Inc</title><cusip>379577208</cusip><identifiers><isin value="US3795772082"/><ticker value="GMED US"/><other otherDesc="B7D65M0" value="Sedol"/></identifiers><balance>598094</balance><units>NS</units><curCd>USD</curCd><valUSD>29617615</valUSD><pctVal>0.675</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Vaxcyte Inc</name><lei>N/A</lei><title>Vaxcyte Inc</title><cusip>N/A</cusip><identifiers><isin value="N/A"/></identifiers><balance>229851</balance><units>NS</units><curCd>USD</curCd><valUSD>10782540</valUSD><pctVal>0.246</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>2</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Kymera Therapeutics LLC</name><lei>N/A</lei><title>KYMERA THERAPEUTICS LLC</title><cusip>N/A</cusip><identifiers><ticker value="1552002D"/></identifiers><balance>325521</balance><units>NS</units><curCd>USD</curCd><valUSD>9465825</valUSD><pctVal>0.216</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>2</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Heska Corp</name><lei>N/A</lei><title>C4 Therapeutics Inc PP</title><cusip>N/A</cusip><identifiers><other otherDesc="3968594" value="Internal 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value="DU0000102184"/></identifiers><balance>470901</balance><units>NS</units><curCd>USD</curCd><valUSD>12811804</valUSD><pctVal>0.292</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>2</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Harmony Biosciences Holdings I</name><lei>N/A</lei><title>Harmony Biosciences Holdings Inc</title><cusip>413197104</cusip><identifiers><isin value="US4131971040"/><ticker value="HRMY US"/><other otherDesc="BKSGZN7" value="Sedol"/></identifiers><balance>324205</balance><units>NS</units><curCd>USD</curCd><valUSD>10990550</valUSD><pctVal>0.251</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><loanByFundCondition isLoanByFund="Y" loanVal="2262500"/></securityLending></invstOrSec><invstOrSec><name>Health Catalyst Inc</name><lei>549300223PL6GWKVJG92</lei><title>Health Catalyst Inc</title><cusip>42225T107</cusip><identifiers><isin value="US42225T1079"/><ticker value="HCAT US"/><other otherDesc="BKLCX50" value="Sedol"/></identifiers><balance>500510</balance><units>NS</units><curCd>USD</curCd><valUSD>18318666</valUSD><pctVal>0.418</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><loanByFundCondition isLoanByFund="Y" loanVal="1471645.71"/></securityLending></invstOrSec><invstOrSec><name>Humana Inc</name><lei>529900YLDW34GJAO4J06</lei><title>Humana Inc</title><cusip>444859102</cusip><identifiers><isin value="US4448591028"/><ticker value="HUM US"/><other otherDesc="2445063" value="Sedol"/></identifiers><balance>271777</balance><units>NS</units><curCd>USD</curCd><valUSD>112485783</valUSD><pctVal>2.564</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>ICU Medical Inc</name><lei>5493003NRW7LS2QZRH60</lei><title>ICU Medical Inc</title><cusip>44930G107</cusip><identifiers><isin value="US44930G1076"/><ticker value="ICUI US"/><other otherDesc="2451918" value="Sedol"/></identifiers><balance>156808</balance><units>NS</units><curCd>USD</curCd><valUSD>28658230</valUSD><pctVal>0.653</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>IGM Biosciences Inc</name><lei>5493008XCQES2N0VY969</lei><title>IGM Biosciences Inc</title><cusip>449585108</cusip><identifiers><isin value="US4495851085"/><ticker value="IGMS US"/><other otherDesc="BKS3SM8" value="Sedol"/></identifiers><balance>332070</balance><units>NS</units><curCd>USD</curCd><valUSD>24510087</valUSD><pctVal>0.559</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><loanByFundCondition isLoanByFund="Y" loanVal="12182880"/></securityLending></invstOrSec><invstOrSec><name>Illumina Inc</name><lei>SQ95QG8SR5Q56LSNF682</lei><title>Illumina Inc</title><cusip>452327109</cusip><identifiers><isin value="US4523271090"/><ticker value="ILMN US"/><other otherDesc="2613990" value="Sedol"/></identifiers><balance>56942</balance><units>NS</units><curCd>USD</curCd><valUSD>17599633</valUSD><pctVal>0.401</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Insmed Inc</name><lei>529900Q55QAG41CCAC11</lei><title>Insmed Inc</title><cusip>457669307</cusip><identifiers><isin value="US4576693075"/><ticker value="INSM US"/><other otherDesc="2614487" value="Sedol"/></identifiers><balance>1473822</balance><units>NS</units><curCd>USD</curCd><valUSD>47368639</valUSD><pctVal>1.08</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Intuitive Surgical Inc</name><lei>54930052SRG011710797</lei><title>Intuitive Surgical Inc</title><cusip>46120E602</cusip><identifiers><isin value="US46120E6023"/><ticker value="ISRG US"/><other otherDesc="2871301" value="Sedol"/></identifiers><balance>50532</balance><units>NS</units><curCd>USD</curCd><valUSD>35854475</valUSD><pctVal>0.817</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>IQVIA Holdings Inc</name><lei>549300W3R20NM4KQPH86</lei><title>IQVIA Holdings Inc</title><cusip>46266C105</cusip><identifiers><isin value="US46266C1053"/><ticker value="IQV US"/><other otherDesc="BDR73G1" value="Sedol"/></identifiers><balance>358273</balance><units>NS</units><curCd>USD</curCd><valUSD>56474573</valUSD><pctVal>1.287</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Ironwood Pharmaceuticals Inc</name><lei>549300PC8MR6QHH6P296</lei><title>Ironwood Pharmaceuticals Inc</title><cusip>46333X108</cusip><identifiers><isin value="US46333X1081"/><ticker value="IRWD US"/><other otherDesc="B3MZ6K5" value="Sedol"/></identifiers><balance>1341793</balance><units>NS</units><curCd>USD</curCd><valUSD>12069428</valUSD><pctVal>0.275</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>iTeos Therapeutics Inc</name><lei>N/A</lei><title>iTeos Therapeutics Inc</title><cusip>46565G104</cusip><identifiers><isin value="US46565G1040"/><ticker value="ITOS US"/><other otherDesc="BMWXFT4" value="Sedol"/></identifiers><balance>357955</balance><units>NS</units><curCd>USD</curCd><valUSD>8830750</valUSD><pctVal>0.201</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><loanByFundCondition isLoanByFund="Y" loanVal="2977728"/></securityLending></invstOrSec><invstOrSec><name>Johnson &amp; Johnson</name><lei>549300G0CFPGEF6X2043</lei><title>Johnson &amp; Johnson</title><cusip>478160104</cusip><identifiers><isin value="US4781601046"/><ticker value="JNJ US"/><other otherDesc="2475833" value="Sedol"/></identifiers><balance>471594</balance><units>NS</units><curCd>USD</curCd><valUSD>70210915</valUSD><pctVal>1.6</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Eli Lilly and Co</name><lei>FRDRIPF3EKNDJ2CQJL29</lei><title>Eli Lilly &amp; Co</title><cusip>532457108</cusip><identifiers><isin value="US5324571083"/><ticker value="LLY US"/><other otherDesc="2516152" value="Sedol"/></identifiers><balance>586038</balance><units>NS</units><curCd>USD</curCd><valUSD>86745345</valUSD><pctVal>1.977</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Sanofi</name><lei>549300E9PC51EN656011</lei><title>Sanofi</title><cusip>F5548N101</cusip><identifiers><isin value="FR0000120578"/><ticker value="SAN FP"/><other otherDesc="5671735" value="Sedol"/></identifiers><balance>963880</balance><units>NS</units><currencyConditional curCd="EUR" exchangeRt="0.85302"/><valUSD>96635426</valUSD><pctVal>2.203</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>FR</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>2</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Merck &amp; Co Inc</name><lei>4YV9Y5M8S0BRK1RP0397</lei><title>Merck &amp; Co Inc</title><cusip>58933Y105</cusip><identifiers><isin value="US58933Y1055"/><ticker value="MRK US"/><other otherDesc="2778844" value="Sedol"/></identifiers><balance>1959715</balance><units>NS</units><curCd>USD</curCd><valUSD>162558359</valUSD><pctVal>3.705</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>ITEOS THERAPEUTICS</name><lei>N/A</lei><title>iTeos Therapeutics SA</title><cusip>N/A</cusip><identifiers><isin value="N/A"/></identifiers><balance>827499</balance><units>NS</units><curCd>USD</curCd><valUSD>18372960</valUSD><pctVal>0.419</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>2</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Mirati Therapeutics Inc</name><lei>529900GYRW59IDQV6N54</lei><title>Mirati Therapeutics Inc</title><cusip>60468T105</cusip><identifiers><isin value="US60468T1051"/><ticker value="MRTX US"/><other otherDesc="BBPK0J0" value="Sedol"/></identifiers><balance>283096</balance><units>NS</units><curCd>USD</curCd><valUSD>47008091</valUSD><pctVal>1.071</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>NeoGenomics Inc</name><lei>549300KN62PPGHBVXB46</lei><title>NeoGenomics Inc</title><cusip>64049M209</cusip><identifiers><isin value="US64049M2098"/><ticker value="NEO US"/><other otherDesc="2598246" value="Sedol"/></identifiers><balance>549544</balance><units>NS</units><curCd>USD</curCd><valUSD>20272678</valUSD><pctVal>0.462</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Neurocrine Biosciences Inc</name><lei>549300FECER0XBN49756</lei><title>Neurocrine Biosciences Inc</title><cusip>64125C109</cusip><identifiers><isin value="US64125C1099"/><ticker value="NBIX US"/><other otherDesc="2623911" value="Sedol"/></identifiers><balance>784577</balance><units>NS</units><curCd>USD</curCd><valUSD>75444924</valUSD><pctVal>1.72</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Odonate Therapeutics Inc</name><lei>549300D50X5LSJ208C14</lei><title>Odonate Therapeutics Inc</title><cusip>676079106</cusip><identifiers><isin value="US6760791060"/><ticker value="ODT US"/><other otherDesc="BD1KGM3" value="Sedol"/></identifiers><balance>947745</balance><units>NS</units><curCd>USD</curCd><valUSD>12728215</valUSD><pctVal>0.29</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Takeda Pharmaceutical Co Ltd</name><lei>549300ZLMVP4X0OGR454</lei><title>Takeda Pharmaceutical Co Ltd</title><cusip>J8129E108</cusip><identifiers><isin value="JP3463000004"/><ticker value="4502 JP"/><other otherDesc="6870445" value="Sedol"/></identifiers><balance>1171936</balance><units>NS</units><currencyConditional curCd="JPY" exchangeRt="105.45"/><valUSD>41752616</valUSD><pctVal>0.952</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>JP</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>2</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>PTC Therapeutics Inc</name><lei>549300UJLWOIWFDGB318</lei><title>PTC Therapeutics Inc</title><cusip>69366J200</cusip><identifiers><isin value="US69366J2006"/><ticker value="PTCT US"/><other otherDesc="B17VCN9" value="Sedol"/></identifiers><balance>525394</balance><units>NS</units><curCd>USD</curCd><valUSD>24562170</valUSD><pctVal>0.56</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Astellas Pharma Inc</name><lei>529900IB708DY2HBBB35</lei><title>Astellas Pharma Inc</title><cusip>J03393105</cusip><identifiers><isin value="JP3942400007"/><ticker value="4503 JP"/><other otherDesc="6985383" value="Sedol"/></identifiers><balance>1479000</balance><units>NS</units><currencyConditional curCd="JPY" exchangeRt="105.45"/><valUSD>22020320</valUSD><pctVal>0.502</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>JP</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>2</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Roche Holding AG</name><lei>549300U41AUUVOAAOB37</lei><title>Roche Holding AG</title><cusip>H69293217</cusip><identifiers><isin value="CH0012032048"/><ticker value="ROG SW"/><other otherDesc="7110388" value="Sedol"/></identifiers><balance>386550</balance><units>NS</units><currencyConditional curCd="CHF" exchangeRt="0.9208"/><valUSD>132285184</valUSD><pctVal>3.015</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>CH</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>2</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Phathom Pharmaceuticals Inc</name><lei>N/A</lei><title>Phathom Pharmaceuticals Inc</title><cusip>71722W107</cusip><identifiers><isin value="US71722W1071"/><ticker value="PHAT US"/><other otherDesc="BJLKVS6" value="Sedol"/></identifiers><balance>484604</balance><units>NS</units><curCd>USD</curCd><valUSD>17770429</valUSD><pctVal>0.405</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Lonza Group AG</name><lei>549300EFW4H2TCZ71055</lei><title>Lonza Group AG</title><cusip>H50524133</cusip><identifiers><isin value="CH0013841017"/><ticker value="LONN SW"/><other otherDesc="7333378" value="Sedol"/></identifiers><balance>34730</balance><units>NS</units><currencyConditional curCd="CHF" exchangeRt="0.9208"/><valUSD>21443964</valUSD><pctVal>0.489</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>CH</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>2</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Quest Diagnostics Inc</name><lei>8MCWUBXQ0WE04KMXBX50</lei><title>Quest Diagnostics Inc</title><cusip>74834L100</cusip><identifiers><isin value="US74834L1008"/><ticker value="DGX US"/><other otherDesc="2702791" value="Sedol"/></identifiers><balance>267210</balance><units>NS</units><curCd>USD</curCd><valUSD>30592873</valUSD><pctVal>0.697</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Regeneron Pharmaceuticals Inc</name><lei>549300RCBFWIRX3HYQ56</lei><title>Regeneron Pharmaceuticals Inc</title><cusip>75886F107</cusip><identifiers><isin value="US75886F1075"/><ticker value="REGN US"/><other otherDesc="2730190" 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value="Sedol"/></identifiers><balance>373120</balance><units>NS</units><curCd>USD</curCd><valUSD>25077395</valUSD><pctVal>0.572</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Stryker Corp</name><lei>5493002F0SC4JTBU5137</lei><title>Stryker Corp</title><cusip>863667101</cusip><identifiers><isin value="US8636671013"/><ticker value="SYK US"/><other otherDesc="2853688" 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value="Sedol"/></identifiers><balance>257309</balance><units>NS</units><curCd>USD</curCd><valUSD>70018925</valUSD><pctVal>1.596</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>ALX Oncology Inc</name><lei>N/A</lei><title>ALX Oncology Ltd</title><cusip>ALXPP1234</cusip><identifiers><isin value="N/A"/><ticker value="1784511D 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exchangeRt="7.7498"/><valUSD>11625633</valUSD><pctVal>0.265</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>CN</invCountry><isRestrictedSec>Y</isRestrictedSec><fairValLevel>2</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><loanByFundCondition isLoanByFund="Y" loanVal="5353036.2593"/></securityLending></invstOrSec><invstOrSec><name>Novo Nordisk A/S</name><lei>549300DAQ1CVT6CXN342</lei><title>Novo Nordisk A/S</title><cusip>K72807132</cusip><identifiers><isin value="DK0060534915"/><ticker value="NOVOB DC"/><other otherDesc="BHC8X90" value="Sedol"/></identifiers><balance>724119</balance><units>NS</units><currencyConditional curCd="DKK" 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value="Sedol"/></identifiers><balance>964286</balance><units>NS</units><curCd>USD</curCd><valUSD>74905737</valUSD><pctVal>1.707</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Jazz Pharmaceuticals PLC</name><lei>635400GAUMJCLEZRRV50</lei><title>Jazz Pharmaceuticals PLC</title><cusip>G50871105</cusip><identifiers><isin value="IE00B4Q5ZN47"/><ticker value="JAZZ US"/><other otherDesc="B4Q5ZN4" 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value="Sedol"/></identifiers><balance>533922</balance><units>NS</units><curCd>USD</curCd><valUSD>8179685</valUSD><pctVal>0.186</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Medtronic PLC</name><lei>549300GX3ZBSQWUXY261</lei><title>Medtronic PLC</title><cusip>G5960L103</cusip><identifiers><isin value="IE00BTN1Y115"/><ticker value="MDT US"/><other otherDesc="BTN1Y11" 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value="Sedol"/></identifiers><balance>1180210</balance><units>NS</units><curCd>USD</curCd><valUSD>47168688</valUSD><pctVal>1.075</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>2</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Aligos Therapeutics Inc</name><lei>549300UU2UJIKJYX0S67</lei><title>Aligos Therapeutics Inc</title><cusip>1766593P2</cusip><identifiers><isin value="DU0000103972"/><ticker value="1766593D"/></identifiers><balance>1468150</balance><units>NS</units><curCd>USD</curCd><valUSD>1765245</valUSD><pctVal>0.04</pctVal><payoffProfile>Long</payoffProfile><assetCat>EP</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Aligos Therapeutics Inc</name><lei>549300UU2UJIKJYX0S67</lei><title>ALIGOS THERAPEUTICS INC USD SERIES B-1</title><cusip>N/A</cusip><identifiers><isin value="N/A"/><ticker value="1766593D"/></identifiers><balance>3434645</balance><units>NS</units><curCd>USD</curCd><valUSD>3754239</valUSD><pctVal>0.086</pctVal><payoffProfile>Long</payoffProfile><assetCat>EP</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Heska Corp</name><lei>N/A</lei><title>Shattuck Labs Inc PP</title><cusip>N/A</cusip><identifiers><isin value="DU0000102161"/></identifiers><balance>98014</balance><units>NS</units><curCd>USD</curCd><valUSD>6163169</valUSD><pctVal>0.14</pctVal><payoffProfile>Long</payoffProfile><assetCat>EP</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Olema Pharmaceuticals Inc</name><lei>N/A</lei><title>Olema Pharmaceuticals Inc</title><cusip>N/A</cusip><identifiers><isin value="DU0000101913"/></identifiers><balance>1057577</balance><units>NS</units><curCd>USD</curCd><valUSD>4196275</valUSD><pctVal>0.096</pctVal><payoffProfile>Long</payoffProfile><assetCat>EP</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>FREENOME</name><lei>N/A</lei><title>Freenome Inc</title><cusip>N/A</cusip><identifiers><isin value="DU0000103893"/></identifiers><balance>337474</balance><units>NS</units><curCd>USD</curCd><valUSD>2231817</valUSD><pctVal>0.051</pctVal><payoffProfile>Long</payoffProfile><assetCat>EP</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>FLAME BIOSCIENCE NPV PRIVATE PLACEMENT</name><lei>N/A</lei><title>FLAME BIOSCIENCE NPV PRIVATE PLACEMENT</title><cusip>N/A</cusip><identifiers><isin value="DU0000103955"/></identifiers><balance>919200</balance><units>NS</units><curCd>USD</curCd><valUSD>6020760</valUSD><pctVal>0.137</pctVal><payoffProfile>Long</payoffProfile><assetCat>EP</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Kinnate Biopharma Inc</name><lei>N/A</lei><title>Kinnate Biopharma Inc</title><cusip>N/A</cusip><identifiers><isin value="DU0000102194"/></identifiers><balance>293052</balance><units>NS</units><curCd>USD</curCd><valUSD>2808610</valUSD><pctVal>0.064</pctVal><payoffProfile>Long</payoffProfile><assetCat>EP</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>VelosBio</name><lei>N/A</lei><title>VelosBio Inc</title><cusip>N/A</cusip><identifiers><isin value="DU0000102183"/></identifiers><balance>2407561</balance><units>NS</units><curCd>USD</curCd><valUSD>4695225</valUSD><pctVal>0.107</pctVal><payoffProfile>Long</payoffProfile><assetCat>EP</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>BioAlta LLC</name><lei>N/A</lei><title>BioAtla LLC</title><cusip>N/A</cusip><identifiers><isin value="DU0000102185"/></identifiers><balance>5503131</balance><units>NS</units><curCd>USD</curCd><valUSD>2837135</valUSD><pctVal>0.065</pctVal><payoffProfile>Long</payoffProfile><assetCat>EP</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Olema Pharmaceuticals, Inc. USD PRIVATE PLACEMENT</name><lei>N/A</lei><title>Olema Pharmaceuticals Inc</title><cusip>N/A</cusip><identifiers><other otherDesc="397410" value="Internal ID"/></identifiers><balance>3056701</balance><units>NS</units><curCd>USD</curCd><valUSD>12128439</valUSD><pctVal>0.276</pctVal><payoffProfile>Long</payoffProfile><assetCat>EP</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>4D MOLECULAR THERAPEUTICS, INC.</name><lei>N/A</lei><title>4D Molecular Therapeutics Inc - Series B</title><cusip>4DMTPRIV1</cusip><identifiers><isin value="N/A"/><ticker value="4DMT"/><other otherDesc="4DMTPRIV1" value="Internal ID"/></identifiers><balance>373334</balance><units>NS</units><curCd>USD</curCd><valUSD>6720012</valUSD><pctVal>0.153</pctVal><payoffProfile>Long</payoffProfile><assetCat>EP</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Everest Medicines US Ltd</name><lei>N/A</lei><title>EVEREST MEDICINES US LTD</title><cusip>N/A</cusip><identifiers><isin value="DU0000402835"/><ticker value="1737783D"/></identifiers><balance>1779419</balance><units>NS</units><currencyConditional curCd="HKD" exchangeRt="7.7498"/><valUSD>10332377</valUSD><pctVal>0.236</pctVal><payoffProfile>Long</payoffProfile><assetCat>EP</assetCat><issuerCat>CORP</issuerCat><invCountry>HK</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Acerta Project Management Co</name><lei>N/A</lei><title>Acerta Pharma BV PP - Series B</title><cusip>N/A</cusip><identifiers><isin value="N/A"/><ticker value="ACERTA"/><other otherDesc="B55PZY3" value="Sedol"/></identifiers><balance>143797410</balance><units>NS</units><curCd>USD</curCd><valUSD>18089714</valUSD><pctVal>0.412</pctVal><payoffProfile>Long</payoffProfile><assetCat>EP</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Bigfoot Biomedical Inc</name><lei>N/A</lei><title>Bigfoot Biomedical Inc - Series C</title><cusip>BIGFOOTC1</cusip><identifiers><isin value="N/A"/><ticker value="BIGFOOTC1"/></identifiers><balance>168418</balance><units>NS</units><curCd>USD</curCd><valUSD>1594792</valUSD><pctVal>0.036</pctVal><payoffProfile>Long</payoffProfile><assetCat>EP</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Bigfoot Biomedical Inc</name><lei>N/A</lei><title>Bigfoot Biomedical Inc - Series B</title><cusip>N/A</cusip><identifiers><isin value="N/A"/><ticker value="1450137D"/><other otherDesc="B4N0JJ6" value="Sedol"/></identifiers><balance>1035873</balance><units>NS</units><curCd>USD</curCd><valUSD>9808940</valUSD><pctVal>0.224</pctVal><payoffProfile>Long</payoffProfile><assetCat>EP</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Royalty Pharma PLC</name><lei>N/A</lei><title>RPI International Holdings LP</title><cusip>N/A</cusip><identifiers><isin value="N/A"/><ticker value="ROYPHARM"/></identifiers><balance>9205</balance><units>NS</units><curCd>USD</curCd><valUSD>3679091</valUSD><pctVal>0.084</pctVal><payoffProfile>Long</payoffProfile><assetCat>EP</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>2</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Argenx SE</name><lei>7245009C5FZE6G9ODQ71</lei><title>Argenx SE (ADR)</title><cusip>04016X101</cusip><identifiers><isin value="US04016X1019"/><ticker value="ARGX"/><other otherDesc="BDVLM39" value="Sedol"/></identifiers><balance>96393</balance><units>NS</units><curCd>USD</curCd><valUSD>25305090</valUSD><pctVal>0.577</pctVal><payoffProfile>Long</payoffProfile><assetConditional assetCat="OTHER" desc="GDR"/><issuerCat>CORP</issuerCat><invCountry>NL</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Ascendis Pharma A/S</name><lei>549300B66JN3W3J8GH73</lei><title>Ascendis Pharma A/S (ADR)</title><cusip>04351P101</cusip><identifiers><isin value="US04351P1012"/><ticker value="ASND"/><other otherDesc="BV9G6B8" value="Sedol"/></identifiers><balance>434752</balance><units>NS</units><curCd>USD</curCd><valUSD>67090929</valUSD><pctVal>1.529</pctVal><payoffProfile>Long</payoffProfile><assetConditional assetCat="OTHER" desc="GDR"/><issuerCat>CORP</issuerCat><invCountry>DK</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Bristol-Myers Squibb Co</name><lei>HLYYNH7UQUORYSJQCN42</lei><title>Bristol-Myers Squibb Co</title><cusip>110122157</cusip><identifiers><isin value="US1101221570"/><ticker value="BMY-R"/><other otherDesc="BKM7ZR0" value="Sedol"/></identifiers><balance>7448433</balance><units>NS</units><curCd>USD</curCd><valUSD>16758974</valUSD><pctVal>0.382</pctVal><payoffProfile>Long</payoffProfile><assetConditional assetCat="OTHER" desc="Rights"/><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Beech Tree SA</name><lei>N/A</lei><title>CLEMENTIA PHARMACEUTICALS IN - CVR</title><cusip>N/A</cusip><identifiers><isin value="N/A"/><ticker value="CMTA CVR"/></identifiers><balance>874311</balance><units>NS</units><curCd>USD</curCd><valUSD>1</valUSD><pctVal>0</pctVal><payoffProfile>Long</payoffProfile><assetConditional assetCat="OTHER" desc="Rights"/><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>GW Pharmaceuticals PLC</name><lei>213800ISBN5CNUZMHZ39</lei><title>GW Pharmaceuticals PLC (ADR)</title><cusip>36197T103</cusip><identifiers><isin value="US36197T1034"/><ticker value="GWPH"/><other otherDesc="B94RPL5" value="Sedol"/></identifiers><balance>420092</balance><units>NS</units><curCd>USD</curCd><valUSD>40895956</valUSD><pctVal>0.932</pctVal><payoffProfile>Long</payoffProfile><assetConditional assetCat="OTHER" desc="GDR"/><issuerCat>CORP</issuerCat><invCountry>GB</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><loanByFundCondition isLoanByFund="Y" loanVal="27200024.84"/></securityLending></invstOrSec><invstOrSec><name>Novartis AG</name><lei>5493007HIVTX6SY6XD66</lei><title>Novartis AG (ADR)</title><cusip>66987V109</cusip><identifiers><isin value="US66987V1098"/><ticker value="NVS"/><other otherDesc="2620105" value="Sedol"/></identifiers><balance>1693343</balance><units>NS</units><curCd>USD</curCd><valUSD>147253107</valUSD><pctVal>3.356</pctVal><payoffProfile>Long</payoffProfile><assetConditional assetCat="OTHER" desc="GDR"/><issuerCat>CORP</issuerCat><invCountry>CH</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec></invstOrSecs><explntrNotes><explntrNote note="Monthly returns presented in Item B.5(a) have been calculated without deducting any applicable sales loads or redemption fees." noteItem="B.5.a"/></explntrNotes><signature><ncom:dateSigned>2020-11-14</ncom:dateSigned><ncom:nameOfApplicant>JANUS INVESTMENT FUND</ncom:nameOfApplicant><ncom:signature>JESPER NERGAARD</ncom:signature><ncom:signerName>JESPER NERGAARD</ncom:signerName><ncom:title>VP, CFO, TREASURER, AND PRINCIPAL ACCOUNTING OFFICER</ncom:title></signature></nport:formData></nport:edgarSubmission>
