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value="Sedol"/></identifiers><balance>1611891</balance><units>NS</units><curCd>USD</curCd><valUSD>49813073</valUSD><pctVal>1.38</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>2</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Anthem Inc</name><lei>8MYN82XMYQH89CTMTH67</lei><title>Anthem Inc</title><cusip>036752103</cusip><identifiers><isin value="US0367521038"/><ticker value="ANTM"/><other otherDesc="BSPHGL4" value="Sedol"/></identifiers><balance>351832</balance><units>NS</units><curCd>USD</curCd><valUSD>84474863</valUSD><pctVal>2.34</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Assembly Biosciences Inc</name><lei>N/A</lei><title>Assembly Biosciences Inc</title><cusip>045396108</cusip><identifiers><isin value="US0453961080"/><ticker value="ASMB"/><other otherDesc="BP4WW00" value="Sedol"/></identifiers><balance>403990</balance><units>NS</units><curCd>USD</curCd><valUSD>3971222</valUSD><pctVal>0.11</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Baxter International Inc</name><lei>J5OIVXX3P24RJRW5CK77</lei><title>Baxter International Inc</title><cusip>071813109</cusip><identifiers><isin value="US0718131099"/><ticker value="BAX"/><other otherDesc="2085102" value="Sedol"/></identifiers><balance>664825</balance><units>NS</units><curCd>USD</curCd><valUSD>58152243</valUSD><pctVal>1.61</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>BioCryst Pharmaceuticals Inc</name><lei>549300Z0INP1Z5NP6J59</lei><title>BioCryst Pharmaceuticals Inc</title><cusip>09058V103</cusip><identifiers><isin value="US09058V1035"/><ticker value="BCRX"/><other otherDesc="2100362" value="Sedol"/></identifiers><balance>4098091</balance><units>NS</units><curCd>USD</curCd><valUSD>11741031</valUSD><pctVal>0.33</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>AstraZeneca PLC</name><lei>PY6ZZQWO2IZFZC3IOL08</lei><title>AstraZeneca PLC</title><cusip>G0593M107</cusip><identifiers><isin value="GB0009895292"/><ticker value="AZN"/><other otherDesc="989529" value="Sedol"/></identifiers><balance>1335928</balance><units>NS</units><currencyConditional curCd="GBP" exchangeRt="0.81347"/><valUSD>119244388</valUSD><pctVal>3.31</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>GB</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Boston Scientific Corp</name><lei>Y6ZDD9FP4P8JSSJMW954</lei><title>Boston Scientific Corp</title><cusip>101137107</cusip><identifiers><isin value="US1011371077"/><ticker value="BSX"/><other otherDesc="2113434" value="Sedol"/></identifiers><balance>2153892</balance><units>NS</units><curCd>USD</curCd><valUSD>87641865</valUSD><pctVal>2.43</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Bristol-Myers Squibb Co</name><lei>HLYYNH7UQUORYSJQCN42</lei><title>Bristol-Myers Squibb Co</title><cusip>110122108</cusip><identifiers><isin value="US1101221083"/><ticker value="BMY"/><other otherDesc="2126335" value="Sedol"/></identifiers><balance>1876956</balance><units>NS</units><curCd>USD</curCd><valUSD>95180439</valUSD><pctVal>2.64</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Catalent Inc</name><lei>N/A</lei><title>Catalent Inc</title><cusip>148806102</cusip><identifiers><isin value="US1488061029"/><ticker value="CTLT"/><other otherDesc="BP96PQ4" value="Sedol"/></identifiers><balance>1040159</balance><units>NS</units><curCd>USD</curCd><valUSD>49573978</valUSD><pctVal>1.37</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Celgene Corp</name><lei>4SIHMF0MOSTTL8CD0X64</lei><title>Celgene Corp</title><cusip>151020104</cusip><identifiers><isin value="US1510201049"/><ticker value="CELG"/><other otherDesc="2182348" value="Sedol"/></identifiers><balance>371032</balance><units>NS</units><curCd>USD</curCd><valUSD>36843478</valUSD><pctVal>1.02</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>BridgeBio Pharma LLC</name><lei>549300J8WJIVTOJ8IH97</lei><title>BridgeBio Pharma LLC</title><cusip>N/A</cusip><identifiers><ticker value="1537831D"/></identifiers><balance>1795381</balance><units>NS</units><curCd>USD</curCd><valUSD>36619489</valUSD><pctVal>1.02</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>2</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Akero Therapeutics Inc</name><lei>549300SI3KG74LBE2955</lei><title>AKERO THERAPEUTICS INC</title><cusip>N/A</cusip><identifiers><isin value="US00973Y1082"/><ticker value="1630074D"/><other otherDesc="BK7Y2V9" value="Sedol"/></identifiers><balance>859440</balance><units>NS</units><curCd>USD</curCd><valUSD>18574647</valUSD><pctVal>0.52</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>2</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Clementia Pharmaceuticals Inc</name><lei>N/A</lei><title>CLEMENTIA PHARMACEUTICALS IN - CVR</title><cusip>N/A</cusip><identifiers><isin value="CA185575CVR1"/><ticker value="CMTA CVR"/></identifiers><balance>874311</balance><units>NS</units><curCd>USD</curCd><valUSD>1180320</valUSD><pctVal>0.03</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Collegium Pharmaceutical Inc</name><lei>54930049FXZMTLW8D496</lei><title>Collegium Pharmaceutical Inc</title><cusip>19459J104</cusip><identifiers><isin value="US19459J1043"/><ticker value="COLL"/><other otherDesc="BX7RSN3" value="Sedol"/></identifiers><balance>1054445</balance><units>NS</units><curCd>USD</curCd><valUSD>12105029</valUSD><pctVal>0.34</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Cooper Cos Inc</name><lei>QJKMVPIGLH7530PCUE20</lei><title>Cooper Cos Inc</title><cusip>216648402</cusip><identifiers><isin value="US2166484020"/><ticker value="COO"/><other otherDesc="2222631" value="Sedol"/></identifiers><balance>173347</balance><units>NS</units><curCd>USD</curCd><valUSD>51484059</valUSD><pctVal>1.43</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Danaher Corp</name><lei>S4BKK9OTCEWQ3YHPFM11</lei><title>Danaher Corp</title><cusip>235851102</cusip><identifiers><isin value="US2358511028"/><ticker value="DHR"/><other otherDesc="2250870" value="Sedol"/></identifiers><balance>422551</balance><units>NS</units><curCd>USD</curCd><valUSD>61029041</valUSD><pctVal>1.69</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>DexCom Inc</name><lei>549300YSK3QDSFR5EU59</lei><title>DexCom Inc</title><cusip>252131107</cusip><identifiers><isin value="US2521311074"/><ticker value="DXCM"/><other otherDesc="B0796X4" value="Sedol"/></identifiers><balance>122719</balance><units>NS</units><curCd>USD</curCd><valUSD>18314583</valUSD><pctVal>0.51</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Edwards Lifesciences Corp</name><lei>YA13X31F3V31L8TMPR58</lei><title>Edwards Lifesciences Corp</title><cusip>28176E108</cusip><identifiers><isin value="US28176E1082"/><ticker value="EW"/><other otherDesc="2567116" value="Sedol"/></identifiers><balance>243002</balance><units>NS</units><curCd>USD</curCd><valUSD>53438570</valUSD><pctVal>1.48</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Elanco Animal Health Inc</name><lei>549300SHPNDCE059M934</lei><title>Elanco Animal Health Inc</title><cusip>28414H103</cusip><identifiers><isin value="US28414H1032"/><ticker value="ELAN"/><other otherDesc="BF5L3T2" value="Sedol"/></identifiers><balance>1047915</balance><units>NS</units><curCd>USD</curCd><valUSD>27864060</valUSD><pctVal>0.77</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Enanta Pharmaceuticals Inc</name><lei>529900SSN4DODDQSN594</lei><title>Enanta Pharmaceuticals Inc</title><cusip>29251M106</cusip><identifiers><isin value="US29251M1062"/><ticker value="ENTA"/><other otherDesc="B9L5200" value="Sedol"/></identifiers><balance>207329</balance><units>NS</units><curCd>USD</curCd><valUSD>12456326</valUSD><pctVal>0.35</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>FibroGen Inc</name><lei>549300Q914ULWWY95822</lei><title>FibroGen Inc</title><cusip>31572Q808</cusip><identifiers><isin value="US31572Q8087"/><ticker value="FGEN"/><other otherDesc="BSDRYR8" value="Sedol"/></identifiers><balance>399796</balance><units>NS</units><curCd>USD</curCd><valUSD>14784456</valUSD><pctVal>0.41</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>GW Pharmaceuticals PLC</name><lei>213800ISBN5CNUZMHZ39</lei><title>GW Pharmaceuticals PLC (ADR)</title><cusip>36197T103</cusip><identifiers><isin value="US36197T1034"/><ticker value="GWPH"/><other otherDesc="B94RPL5" value="Sedol"/></identifiers><balance>118734</balance><units>NS</units><curCd>USD</curCd><valUSD>13657972</valUSD><pctVal>0.38</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>GB</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Gilead Sciences Inc</name><lei>549300WTZWR07K8MNV44</lei><title>Gilead Sciences Inc</title><cusip>375558103</cusip><identifiers><isin value="US3755581036"/><ticker value="GILD"/><other otherDesc="2369174" value="Sedol"/></identifiers><balance>1118013</balance><units>NS</units><curCd>USD</curCd><valUSD>70859664</valUSD><pctVal>1.97</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Global Blood Therapeutics Inc</name><lei>549300U4G0QKK99GRT15</lei><title>Global Blood Therapeutics Inc</title><cusip>37890U108</cusip><identifiers><isin value="US37890U1088"/><ticker value="GBT"/><other otherDesc="BZ05388" value="Sedol"/></identifiers><balance>484911</balance><units>NS</units><curCd>USD</curCd><valUSD>23527882</valUSD><pctVal>0.65</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Globus Medical Inc</name><lei>5299003M2P4CIK0RF205</lei><title>Globus Medical Inc</title><cusip>379577208</cusip><identifiers><isin value="US3795772082"/><ticker value="GMED"/><other otherDesc="B7D65M0" value="Sedol"/></identifiers><balance>801260</balance><units>NS</units><curCd>USD</curCd><valUSD>40960411</valUSD><pctVal>1.14</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Celgene Corp</name><lei>4SIHMF0MOSTTL8CD0X64</lei><title>Celgene Corp CVR USD (06/09/2019)</title><cusip>N/A</cusip><identifiers><isin value="DU0000103521"/><ticker value="CELGCVR"/></identifiers><balance>2654756</balance><units>NS</units><curCd>USD</curCd><valUSD>5176774</valUSD><pctVal>0.14</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>2</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Heron Therapeutics Inc</name><lei>549300DR2I1DOPD2IX53</lei><title>Heron Therapeutics Inc</title><cusip>427746102</cusip><identifiers><isin value="US4277461020"/><ticker value="HRTX"/><other otherDesc="BJ0XLZ3" value="Sedol"/></identifiers><balance>650448</balance><units>NS</units><curCd>USD</curCd><valUSD>12033288</valUSD><pctVal>0.33</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Humana Inc</name><lei>529900YLDW34GJAO4J06</lei><title>Humana Inc</title><cusip>444859102</cusip><identifiers><isin value="US4448591028"/><ticker value="HUM"/><other otherDesc="2445063" value="Sedol"/></identifiers><balance>325655</balance><units>NS</units><curCd>USD</curCd><valUSD>83260214</valUSD><pctVal>2.31</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>ICU Medical Inc</name><lei>5493003NRW7LS2QZRH60</lei><title>ICU Medical Inc</title><cusip>44930G107</cusip><identifiers><isin value="US44930G1076"/><ticker value="ICUI"/><other otherDesc="2451918" value="Sedol"/></identifiers><balance>203050</balance><units>NS</units><curCd>USD</curCd><valUSD>32406780</valUSD><pctVal>0.9</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Immunomedics Inc</name><lei>5493007ZU7DDO8PSIM59</lei><title>Immunomedics Inc</title><cusip>452907108</cusip><identifiers><isin value="US4529071080"/><ticker value="IMMU"/><other otherDesc="2457961" value="Sedol"/></identifiers><balance>1219203</balance><units>NS</units><curCd>USD</curCd><valUSD>16166632</valUSD><pctVal>0.45</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Insmed Inc</name><lei>529900Q55QAG41CCAC11</lei><title>Insmed Inc</title><cusip>457669307</cusip><identifiers><isin value="US4576693075"/><ticker value="INSM"/><other otherDesc="2614487" 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value="Sedol"/></identifiers><balance>1966168</balance><units>NS</units><curCd>USD</curCd><valUSD>165512022</valUSD><pctVal>4.59</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Mirati Therapeutics Inc</name><lei>529900GYRW59IDQV6N54</lei><title>Mirati Therapeutics Inc</title><cusip>60468T105</cusip><identifiers><isin value="US60468T1051"/><ticker value="MRTX"/><other otherDesc="BBPK0J0" 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value="Sedol"/></identifiers><balance>708553</balance><units>NS</units><curCd>USD</curCd><valUSD>13547533</valUSD><pctVal>0.38</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Neurocrine Biosciences Inc</name><lei>549300FECER0XBN49756</lei><title>Neurocrine Biosciences Inc</title><cusip>64125C109</cusip><identifiers><isin value="US64125C1099"/><ticker value="NBIX"/><other otherDesc="2623911" value="Sedol"/></identifiers><balance>853708</balance><units>NS</units><curCd>USD</curCd><valUSD>76927628</valUSD><pctVal>2.13</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Novartis AG</name><lei>5493007HIVTX6SY6XD66</lei><title>Novartis AG (ADR)</title><cusip>66987V109</cusip><identifiers><isin value="US66987V1098"/><ticker value="NVS"/><other otherDesc="2620105" 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value="Sedol"/></identifiers><balance>549514</balance><units>NS</units><curCd>USD</curCd><valUSD>14303849</valUSD><pctVal>0.4</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Takeda Pharmaceutical Co Ltd</name><lei>549300ZLMVP4X0OGR454</lei><title>Takeda Pharmaceutical Co Ltd</title><cusip>J8129E108</cusip><identifiers><isin value="JP3463000004"/><ticker value="4502"/><other otherDesc="6870445" value="Sedol"/></identifiers><balance>2784136</balance><units>NS</units><currencyConditional curCd="JPY" 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value="Sedol"/></identifiers><balance>169141</balance><units>NS</units><curCd>USD</curCd><valUSD>36585198</valUSD><pctVal>1.01</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Teladoc Health Inc</name><lei>549300I2PVFBC9MFAC61</lei><title>Teladoc Health Inc</title><cusip>87918A105</cusip><identifiers><isin value="US87918A1051"/><ticker value="TDOC"/><other otherDesc="BYQRFY1" 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value="Sedol"/></identifiers><balance>16456730</balance><units>NS</units><curCd>USD</curCd><valUSD>16456730</valUSD><pctVal>0.46</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>PF</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>2</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Janus Henderson Cash Collateral Fund</name><lei>N/A</lei><title>Janus Henderson Cash Collateral Fund</title><cusip>N/A</cusip><identifiers><other otherDesc="B1RYG58" value="Sedol"/></identifiers><balance>39563912</balance><units>NS</units><curCd>USD</curCd><valUSD>39563912</valUSD><pctVal>1.1</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>PF</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>2</fairValLevel><securityLending><cashCollateralCondition cashCollateralVal="39563912" isCashCollateral="Y"/><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>UnitedHealth Group Inc</name><lei>549300GHBMY8T5GXDE41</lei><title>UnitedHealth Group Inc</title><cusip>91324P102</cusip><identifiers><isin value="US91324P1021"/><ticker value="UNH"/><other otherDesc="2917766" value="Sedol"/></identifiers><balance>473981</balance><units>NS</units><curCd>USD</curCd><valUSD>103005551</valUSD><pctVal>2.86</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Universal Health Services Inc</name><lei>549300YGMGQDO0NMJD09</lei><title>Universal Health Services Inc</title><cusip>913903100</cusip><identifiers><isin value="US9139031002"/><ticker value="UHS"/><other otherDesc="2923785" value="Sedol"/></identifiers><balance>248369</balance><units>NS</units><curCd>USD</curCd><valUSD>36944889</valUSD><pctVal>1.02</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Varian Medical Systems Inc</name><lei>TK3LAKL7I0QNTCVWSY07</lei><title>Varian Medical Systems Inc</title><cusip>92220P105</cusip><identifiers><isin value="US92220P1057"/><ticker value="VAR"/><other otherDesc="2927516" value="Sedol"/></identifiers><balance>263697</balance><units>NS</units><curCd>USD</curCd><valUSD>31403676</valUSD><pctVal>0.87</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Vertex Pharmaceuticals Inc</name><lei>54930015RAQRRZ5ZGJ91</lei><title>Vertex Pharmaceuticals Inc</title><cusip>92532F100</cusip><identifiers><isin value="US92532F1003"/><ticker value="VRTX"/><other otherDesc="2931034" 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PP</title><cusip>N/A</cusip><identifiers><isin value="DU0000100943"/><ticker value="ACERTA"/><other otherDesc="B55PZY3" value="Sedol"/></identifiers><balance>143797410</balance><units>NS</units><curCd>USD</curCd><valUSD>12007084</valUSD><pctVal>0.33</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Ipsen SA</name><lei>549300M6SGDPB4Z94P11</lei><title>Ipsen SA</title><cusip>F5362H107</cusip><identifiers><isin value="FR0010259150"/><ticker value="IPN"/><other otherDesc="B0R7JF1" value="Sedol"/></identifiers><balance>171999</balance><units>NS</units><currencyConditional curCd="EUR" exchangeRt="0.9176"/><valUSD>16326409</valUSD><pctVal>0.45</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>FR</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Novo Nordisk A/S</name><lei>549300DAQ1CVT6CXN342</lei><title>Novo Nordisk A/S</title><cusip>K72807132</cusip><identifiers><isin value="DK0060534915"/><ticker value="NOVOB"/><other otherDesc="BHC8X90" value="Sedol"/></identifiers><balance>842568</balance><units>NS</units><currencyConditional curCd="DKK" exchangeRt="6.8487"/><valUSD>43323597</valUSD><pctVal>1.2</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>DK</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Bigfoot Biomedical Inc</name><lei>N/A</lei><title>BIGFOOT BIOMEDICAL INC</title><cusip>N/A</cusip><identifiers><isin value="DU0000100959"/><ticker value="1450137D"/><other otherDesc="B4N0JJ6" value="Sedol"/></identifiers><balance>1035873</balance><units>NS</units><curCd>USD</curCd><valUSD>9808940</valUSD><pctVal>0.27</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>BioNTech AG</name><lei>N/A</lei><title>BIONTECH AG</title><cusip>BIONTECH2</cusip><identifiers><ticker value="3315187Z2 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value="Sedol"/></identifiers><balance>251263</balance><units>NS</units><curCd>USD</curCd><valUSD>32196841</valUSD><pctVal>0.89</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>IE</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Myovant Sciences Ltd</name><lei>N/A</lei><title>Myovant Sciences Ltd</title><cusip>G637AM102</cusip><identifiers><isin value="BMG637AM1024"/><ticker value="MYOV"/><other otherDesc="BD3WG49" value="Sedol"/></identifiers><balance>1495833</balance><units>NS</units><curCd>USD</curCd><valUSD>7778332</valUSD><pctVal>0.22</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>BM</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><loanByFundCondition isLoanByFund="Y" loanVal="315033"/></securityLending></invstOrSec><invstOrSec><name>STERIS PLC</name><lei>N/A</lei><title>STERIS PLC</title><cusip>G8473T100</cusip><identifiers><isin value="IE00BFY8C754"/><ticker value="STE"/><other otherDesc="BFY8C75" value="Sedol"/></identifiers><balance>254718</balance><units>NS</units><curCd>USD</curCd><valUSD>36804204</valUSD><pctVal>1.02</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>GB</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Alcon Inc</name><lei>549300LDT5AP8S0NBM78</lei><title>Alcon Inc</title><cusip>H01301128</cusip><identifiers><isin value="CH0432492467"/><ticker value="ALC"/><other otherDesc="BJXBP41" value="Sedol"/></identifiers><balance>305570</balance><units>NS</units><curCd>USD</curCd><valUSD>17811675</valUSD><pctVal>0.49</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>CH</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>IGM BIO PRIV</name><lei>N/A</lei><title>IGM BIO PRIV USD</title><cusip>IMGBNEW19</cusip><identifiers><ticker value="IGMB PP"/></identifiers><balance>700647</balance><units>NS</units><curCd>USD</curCd><valUSD>11192836</valUSD><pctVal>0.31</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>2</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Wright Medical Group NV</name><lei>549300JGCCQ1HTDOXU32</lei><title>Wright Medical Group NV</title><cusip>N96617118</cusip><identifiers><isin value="NL0011327523"/><ticker value="WMGI"/><other otherDesc="BZ2JCC5" 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value="Sedol"/></identifiers><balance>127226</balance><units>NS</units><curCd>USD</curCd><valUSD>20179316</valUSD><pctVal>0.56</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>PH</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>WaVe Life Sciences Ltd</name><lei>54930070006GPKFYZ813</lei><title>WaVe Life Sciences Ltd</title><cusip>Y95308105</cusip><identifiers><isin value="SG9999014716"/><ticker value="WVE"/><other otherDesc="BYZG9R0" value="Sedol"/></identifiers><balance>1318624</balance><units>NS</units><curCd>USD</curCd><valUSD>27071351</valUSD><pctVal>0.75</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>SG</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Bigfoot Biomedical Inc</name><lei>N/A</lei><title>.MKKK 7 08/01/20</title><cusip>BIGFOOTP2</cusip><identifiers><ticker value=".MKKK"/></identifiers><balance>1314000</balance><units>PA</units><curCd>USD</curCd><valUSD>1314000</valUSD><pctVal>0.04</pctVal><payoffProfile>Long</payoffProfile><assetCat>DBT</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>3</fairValLevel><debtSec><maturityDt>2020-08-01</maturityDt><couponKind>Fixed</couponKind><annualizedRt>7</annualizedRt><isDefault>N</isDefault><areIntrstPmntsInArrs>N</areIntrstPmntsInArrs><isPaidKind>N</isPaidKind></debtSec><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>PHATHOM PHARMA INC 6% 22/03/2022 USD CONV</name><lei>N/A</lei><title>PHATHOM PHARMACEUTICALS INC 6% 22/03/2022 USD CONV</title><cusip>N/A</cusip><identifiers><isin value="N/A"/><ticker value="PHATH"/></identifiers><balance>6278000</balance><units>PA</units><curCd>USD</curCd><valUSD>6278000</valUSD><pctVal>0.17</pctVal><payoffProfile>Long</payoffProfile><assetCat>DBT</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>3</fairValLevel><debtSec><maturityDt>2022-03-22</maturityDt><couponKind>Fixed</couponKind><annualizedRt>6</annualizedRt><isDefault>N</isDefault><areIntrstPmntsInArrs>N</areIntrstPmntsInArrs><isPaidKind>N</isPaidKind></debtSec><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Argenx SE</name><lei>7245009C5FZE6G9ODQ71</lei><title>Argenx SE (ADR)</title><cusip>04016X101</cusip><identifiers><isin value="US04016X1019"/><ticker value="ARGX"/><other otherDesc="BDVLM39" value="Sedol"/></identifiers><balance>124680</balance><units>NS</units><curCd>USD</curCd><valUSD>14208533</valUSD><pctVal>0.39</pctVal><payoffProfile>Long</payoffProfile><assetConditional assetCat="OTHER" desc="GDR"/><issuerCat>CORP</issuerCat><invCountry>NL</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Ascendis Pharma A/S</name><lei>549300B66JN3W3J8GH73</lei><title>Ascendis Pharma A/S (ADR)</title><cusip>04351P101</cusip><identifiers><isin value="US04351P1012"/><ticker value="ASND"/><other otherDesc="BV9G6B8" value="Sedol"/></identifiers><balance>138884</balance><units>NS</units><curCd>USD</curCd><valUSD>13377307</valUSD><pctVal>0.37</pctVal><payoffProfile>Long</payoffProfile><assetConditional assetCat="OTHER" desc="GDR"/><issuerCat>CORP</issuerCat><invCountry>DK</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>BeiGene Ltd</name><lei>549300JFUK6FRD5MH739</lei><title>BeiGene Ltd (ADR)</title><cusip>07725L102</cusip><identifiers><isin value="US07725L1026"/><ticker value="BGNE"/><other otherDesc="BYYWPW6" value="Sedol"/></identifiers><balance>135895</balance><units>NS</units><curCd>USD</curCd><valUSD>16641702</valUSD><pctVal>0.46</pctVal><payoffProfile>Long</payoffProfile><assetConditional assetCat="OTHER" desc="GDR"/><issuerCat>CORP</issuerCat><invCountry>KY</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec></invstOrSecs><explntrNotes><explntrNote note="Monthly returns presented in Item B.5.a have been calculated without deducting any applicable sales loads or redemption fees." noteItem="B.5.a"/><explntrNote note="This filing reflects amendments to Item B.5.a. Item B.5.a has been revised to restate the reported figures as percentages. Such figures were inadvertently reported in decimal amounts in the original filing." noteItem="B.5.a"/><explntrNote note="This filing reflects amendments to Item C.2.d. Item C.2.d has been revised to restate the reported figures as percentages. Such figures were inadvertently reported in decimal amounts in the original filing." noteItem="C.2.d"/></explntrNotes><signature><ncom:dateSigned>2019-11-14</ncom:dateSigned><ncom:nameOfApplicant>JESPER NERGAARD</ncom:nameOfApplicant><ncom:signature>JESPER NERGAARD</ncom:signature><ncom:signerName>JESPER NERGAARD</ncom:signerName><ncom:title>VP, CFO, TREASURER, AND PRINCIPAL ACCOUNTING OFFICER</ncom:title></signature></nport:formData></nport:edgarSubmission>
