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value="Sedol"/></identifiers><balance>2051583</balance><units>NS</units><curCd>USD</curCd><valUSD>4103166</valUSD><pctVal>0.1198</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><loanByFundCondition isLoanByFund="Y" loanVal="2129897"/></securityLending></invstOrSec><invstOrSec><name>BioMarin Pharmaceutical Inc</name><lei>NSLL8ITTRR0J5HEMR848</lei><title>BioMarin Pharmaceutical Inc</title><cusip>09061G101</cusip><identifiers><isin value="US09061G1013"/><ticker value="BMRN"/><other otherDesc="2437071" value="Sedol"/></identifiers><balance>394754</balance><units>NS</units><curCd>USD</curCd><valUSD>33356713</valUSD><pctVal>0.9741</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>AstraZeneca PLC</name><lei>PY6ZZQWO2IZFZC3IOL08</lei><title>AstraZeneca PLC</title><cusip>G0593M107</cusip><identifiers><isin value="GB0009895292"/><ticker value="AZN"/><other otherDesc="989529" value="Sedol"/></identifiers><balance>1180426</balance><units>NS</units><currencyConditional curCd="GBP" exchangeRt="0.80528"/><valUSD>105420047</valUSD><pctVal>3.0786</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>GB</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>2</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Boston Scientific Corp</name><lei>Y6ZDD9FP4P8JSSJMW954</lei><title>Boston Scientific Corp</title><cusip>101137107</cusip><identifiers><isin value="US1011371077"/><ticker value="BSX"/><other otherDesc="2113434" value="Sedol"/></identifiers><balance>2571722</balance><units>NS</units><curCd>USD</curCd><valUSD>83915289</valUSD><pctVal>2.4506</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Bridgebio Pharma Inc</name><lei>54930028YG89VTY2J114</lei><title>Bridgebio Pharma Inc</title><cusip>10806X102</cusip><identifiers><isin value="US10806X1028"/><ticker value="BBIO"/><other otherDesc="BK1KWG8" value="Sedol"/></identifiers><balance>612999</balance><units>NS</units><curCd>USD</curCd><valUSD>17776971</valUSD><pctVal>0.5191</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><loanByFundCondition isLoanByFund="Y" loanVal="6338338.86"/></securityLending></invstOrSec><invstOrSec><name>Bristol-Myers Squibb Co</name><lei>HLYYNH7UQUORYSJQCN42</lei><title>Bristol-Myers Squibb Co</title><cusip>110122108</cusip><identifiers><isin value="US1101221083"/><ticker value="BMY"/><other otherDesc="2126335" value="Sedol"/></identifiers><balance>1570056</balance><units>NS</units><curCd>USD</curCd><valUSD>87514921</valUSD><pctVal>2.5557</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Catalent Inc</name><lei>N/A</lei><title>Catalent Inc</title><cusip>148806102</cusip><identifiers><isin value="US1488061029"/><ticker value="CTLT"/><other otherDesc="BP96PQ4" value="Sedol"/></identifiers><balance>951573</balance><units>NS</units><curCd>USD</curCd><valUSD>49434217</valUSD><pctVal>1.4436</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Centene Corp</name><lei>549300Z7JJ4TQSQGT333</lei><title>Centene Corp</title><cusip>15135B101</cusip><identifiers><isin value="US15135B1017"/><ticker value="CNC"/><other otherDesc="2807061" value="Sedol"/></identifiers><balance>1055036</balance><units>NS</units><curCd>USD</curCd><valUSD>62679689</valUSD><pctVal>1.8304</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Clementia Pharmaceuticals Inc</name><lei>N/A</lei><title>CLEMENTIA PHARMACEUTICALS IN - CVR</title><cusip>N/A</cusip><identifiers><isin value="CA185575CVR1"/><ticker value="CMTA CVR"/></identifiers><balance>874311</balance><units>NS</units><curCd>USD</curCd><valUSD>1</valUSD><pctVal>0</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Collegium Pharmaceutical Inc</name><lei>54930049FXZMTLW8D496</lei><title>Collegium Pharmaceutical Inc</title><cusip>19459J104</cusip><identifiers><isin value="US19459J1043"/><ticker value="COLL"/><other otherDesc="BX7RSN3" value="Sedol"/></identifiers><balance>1013466</balance><units>NS</units><curCd>USD</curCd><valUSD>16549900</valUSD><pctVal>0.4833</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Cooper Cos Inc</name><lei>QJKMVPIGLH7530PCUE20</lei><title>Cooper Cos Inc</title><cusip>216648402</cusip><identifiers><isin value="US2166484020"/><ticker value="COO"/><other otherDesc="2222631" value="Sedol"/></identifiers><balance>94222</balance><units>NS</units><curCd>USD</curCd><valUSD>25974179</valUSD><pctVal>0.7585</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Danaher Corp</name><lei>S4BKK9OTCEWQ3YHPFM11</lei><title>Danaher Corp</title><cusip>235851102</cusip><identifiers><isin value="US2358511028"/><ticker value="DHR"/><other otherDesc="2250870" value="Sedol"/></identifiers><balance>374527</balance><units>NS</units><curCd>USD</curCd><valUSD>51838282</valUSD><pctVal>1.5138</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>DENTSPLY SIRONA Inc</name><lei>9NHEHR1SOZCYXDO8HO28</lei><title>DENTSPLY SIRONA Inc</title><cusip>24906P109</cusip><identifiers><isin value="US24906P1093"/><ticker value="XRAY"/><other otherDesc="BYNPPC6" value="Sedol"/></identifiers><balance>542588</balance><units>NS</units><curCd>USD</curCd><valUSD>21068692</valUSD><pctVal>0.6153</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>DexCom Inc</name><lei>549300YSK3QDSFR5EU59</lei><title>DexCom Inc</title><cusip>252131107</cusip><identifiers><isin value="US2521311074"/><ticker value="DXCM"/><other otherDesc="B0796X4" value="Sedol"/></identifiers><balance>76158</balance><units>NS</units><curCd>USD</curCd><valUSD>20507065</valUSD><pctVal>0.5989</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Edwards Lifesciences Corp</name><lei>YA13X31F3V31L8TMPR58</lei><title>Edwards Lifesciences Corp</title><cusip>28176E108</cusip><identifiers><isin value="US28176E1082"/><ticker value="EW"/><other otherDesc="2567116" value="Sedol"/></identifiers><balance>150583</balance><units>NS</units><curCd>USD</curCd><valUSD>28402965</valUSD><pctVal>0.8295</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Elanco Animal Health Inc</name><lei>549300SHPNDCE059M934</lei><title>Elanco Animal Health Inc</title><cusip>28414H103</cusip><identifiers><isin value="US28414H1032"/><ticker value="ELAN"/><other otherDesc="BF5L3T2" value="Sedol"/></identifiers><balance>2491989</balance><units>NS</units><curCd>USD</curCd><valUSD>55795634</valUSD><pctVal>1.6294</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Exelixis Inc</name><lei>N/A</lei><title>Exelixis Inc</title><cusip>30161Q104</cusip><identifiers><isin value="US30161Q1040"/><ticker value="EXEL"/><other otherDesc="2576941" value="Sedol"/></identifiers><balance>1449685</balance><units>NS</units><curCd>USD</curCd><valUSD>24963576</valUSD><pctVal>0.729</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Fate Therapeutics Inc</name><lei>549300L14Q4UHOODLA90</lei><title>Fate Therapeutics Inc</title><cusip>31189P102</cusip><identifiers><isin value="US31189P1021"/><ticker value="FATE"/><other otherDesc="BCZS820" value="Sedol"/></identifiers><balance>456364</balance><units>NS</units><curCd>USD</curCd><valUSD>10135844</valUSD><pctVal>0.296</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>FibroGen Inc</name><lei>549300Q914ULWWY95822</lei><title>FibroGen Inc</title><cusip>31572Q808</cusip><identifiers><isin value="US31572Q8087"/><ticker value="FGEN"/><other otherDesc="BSDRYR8" value="Sedol"/></identifiers><balance>376919</balance><units>NS</units><curCd>USD</curCd><valUSD>13097935</valUSD><pctVal>0.3825</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Gilead Sciences Inc</name><lei>549300WTZWR07K8MNV44</lei><title>Gilead Sciences Inc</title><cusip>375558103</cusip><identifiers><isin value="US3755581036"/><ticker value="GILD"/><other otherDesc="2369174" value="Sedol"/></identifiers><balance>869796</balance><units>NS</units><curCd>USD</curCd><valUSD>65025949</valUSD><pctVal>1.899</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Glaukos Corp</name><lei>5299004JA1LHE21M6T14</lei><title>Glaukos Corp</title><cusip>377322102</cusip><identifiers><isin value="US3773221029"/><ticker value="GKOS"/><other otherDesc="BYMWL19" value="Sedol"/></identifiers><balance>232700</balance><units>NS</units><curCd>USD</curCd><valUSD>7181122</valUSD><pctVal>0.2097</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Global Blood Therapeutics Inc</name><lei>549300U4G0QKK99GRT15</lei><title>Global Blood Therapeutics Inc</title><cusip>37890U108</cusip><identifiers><isin value="US37890U1088"/><ticker value="GBT"/><other otherDesc="BZ05388" value="Sedol"/></identifiers><balance>775569</balance><units>NS</units><curCd>USD</curCd><valUSD>39623820</valUSD><pctVal>1.1571</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Globus Medical Inc</name><lei>5299003M2P4CIK0RF205</lei><title>Globus Medical Inc</title><cusip>379577208</cusip><identifiers><isin value="US3795772082"/><ticker value="GMED"/><other otherDesc="B7D65M0" value="Sedol"/></identifiers><balance>703316</balance><units>NS</units><curCd>USD</curCd><valUSD>29912029</valUSD><pctVal>0.8735</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>SutroVax</name><lei>N/A</lei><title>SutroVax</title><cusip>N/A</cusip><identifiers><isin value="DU0000101028"/></identifiers><balance>387759</balance><units>NS</units><curCd>USD</curCd><valUSD>3075782</valUSD><pctVal>0.0898</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Kymera Therapeutics LLC</name><lei>N/A</lei><title>KYMERA THERAPEUTICS LLC</title><cusip>N/A</cusip><identifiers><ticker value="1552002D"/></identifiers><balance>519175</balance><units>NS</units><curCd>USD</curCd><valUSD>3393639</valUSD><pctVal>0.0991</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Olema Pharmaceuticals, Inc. USD PRIVATE PLACEMENT</name><lei>N/A</lei><title>Olema Pharmaceuticals, Inc. USD PRIVATE PLACEMENT</title><cusip>N/A</cusip><identifiers><other otherDesc="397410" value="Internal ID"/></identifiers><balance>3056701</balance><units>NS</units><curCd>USD</curCd><valUSD>5165825</valUSD><pctVal>0.1509</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Health Catalyst Inc</name><lei>N/A</lei><title>Health Catalyst Inc</title><cusip>42225T107</cusip><identifiers><isin value="US42225T1079"/><ticker value="HCAT"/><other otherDesc="BKLCX50" value="Sedol"/></identifiers><balance>471725</balance><units>NS</units><curCd>USD</curCd><valUSD>12335609</valUSD><pctVal>0.3602</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Humana Inc</name><lei>529900YLDW34GJAO4J06</lei><title>Humana Inc</title><cusip>444859102</cusip><identifiers><isin value="US4448591028"/><ticker value="HUM"/><other otherDesc="2445063" value="Sedol"/></identifiers><balance>278754</balance><units>NS</units><curCd>USD</curCd><valUSD>87534331</valUSD><pctVal>2.5563</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>ICU Medical Inc</name><lei>5493003NRW7LS2QZRH60</lei><title>ICU Medical Inc</title><cusip>44930G107</cusip><identifiers><isin value="US44930G1076"/><ticker value="ICUI"/><other otherDesc="2451918" value="Sedol"/></identifiers><balance>176323</balance><units>NS</units><curCd>USD</curCd><valUSD>35576692</valUSD><pctVal>1.039</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Immunomedics Inc</name><lei>5493007ZU7DDO8PSIM59</lei><title>Immunomedics Inc</title><cusip>452907108</cusip><identifiers><isin value="US4529071080"/><ticker value="IMMU"/><other otherDesc="2457961" value="Sedol"/></identifiers><balance>786954</balance><units>NS</units><curCd>USD</curCd><valUSD>10608140</valUSD><pctVal>0.3098</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Insmed Inc</name><lei>529900Q55QAG41CCAC11</lei><title>Insmed Inc</title><cusip>457669307</cusip><identifiers><isin value="US4576693075"/><ticker value="INSM"/><other otherDesc="2614487" value="Sedol"/></identifiers><balance>1760055</balance><units>NS</units><curCd>USD</curCd><valUSD>28213682</valUSD><pctVal>0.8239</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Intuitive Surgical Inc</name><lei>54930052SRG011710797</lei><title>Intuitive Surgical Inc</title><cusip>46120E602</cusip><identifiers><isin value="US46120E6023"/><ticker value="ISRG"/><other otherDesc="2871301" value="Sedol"/></identifiers><balance>54747</balance><units>NS</units><curCd>USD</curCd><valUSD>27111262</valUSD><pctVal>0.7917</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>IQVIA Holdings Inc</name><lei>549300W3R20NM4KQPH86</lei><title>IQVIA Holdings Inc</title><cusip>46266C105</cusip><identifiers><isin value="US46266C1053"/><ticker value="IQV"/><other otherDesc="BDR73G1" value="Sedol"/></identifiers><balance>332744</balance><units>NS</units><curCd>USD</curCd><valUSD>35889768</valUSD><pctVal>1.0481</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Ironwood Pharmaceuticals Inc</name><lei>549300PC8MR6QHH6P296</lei><title>Ironwood Pharmaceuticals Inc</title><cusip>46333X108</cusip><identifiers><isin value="US46333X1081"/><ticker value="IRWD"/><other otherDesc="B3MZ6K5" value="Sedol"/></identifiers><balance>1198139</balance><units>NS</units><curCd>USD</curCd><valUSD>12089223</valUSD><pctVal>0.353</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Johnson &amp; Johnson</name><lei>549300G0CFPGEF6X2043</lei><title>Johnson &amp; Johnson</title><cusip>478160104</cusip><identifiers><isin value="US4781601046"/><ticker value="JNJ"/><other otherDesc="2475833" value="Sedol"/></identifiers><balance>458502</balance><units>NS</units><curCd>USD</curCd><valUSD>60123367</valUSD><pctVal>1.7558</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Karyopharm Therapeutics Inc</name><lei>549300J1VANRCNTYST87</lei><title>Karyopharm Therapeutics, Inc.</title><cusip>48576U106</cusip><identifiers><isin value="US48576U1060"/><ticker value="KPTI"/><other otherDesc="BG3FZW0" value="Sedol"/></identifiers><balance>1178859</balance><units>NS</units><curCd>USD</curCd><valUSD>22645881</valUSD><pctVal>0.6613</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Bayer AG</name><lei>549300J4U55H3WP1XT59</lei><title>Bayer AG</title><cusip>D0712D163</cusip><identifiers><isin value="DE000BAY0017"/><ticker value="BAYN"/><other otherDesc="5069211" value="Sedol"/></identifiers><balance>394511</balance><units>NS</units><currencyConditional curCd="EUR" exchangeRt="0.90695"/><valUSD>23151523</valUSD><pctVal>0.6761</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>DE</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>2</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Eli Lilly &amp; Co</name><lei>FRDRIPF3EKNDJ2CQJL29</lei><title>Eli Lilly &amp; Co</title><cusip>532457108</cusip><identifiers><isin value="US5324571083"/><ticker value="LLY"/><other otherDesc="2516152" value="Sedol"/></identifiers><balance>419772</balance><units>NS</units><curCd>USD</curCd><valUSD>58230772</valUSD><pctVal>1.7005</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Sanofi</name><lei>549300E9PC51EN656011</lei><title>Sanofi</title><cusip>F5548N101</cusip><identifiers><isin value="FR0000120578"/><ticker value="SAN"/><other otherDesc="5671735" value="Sedol"/></identifiers><balance>916067</balance><units>NS</units><currencyConditional curCd="EUR" exchangeRt="0.90695"/><valUSD>80629100</valUSD><pctVal>2.3546</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>FR</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>2</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Merck &amp; Co Inc</name><lei>4YV9Y5M8S0BRK1RP0397</lei><title>Merck &amp; Co Inc</title><cusip>58933Y105</cusip><identifiers><isin value="US58933Y1055"/><ticker value="MRK"/><other otherDesc="2778844" value="Sedol"/></identifiers><balance>1996544</balance><units>NS</units><curCd>USD</curCd><valUSD>153614095</valUSD><pctVal>4.486</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>ITEOS THERAPEUTICS</name><lei>N/A</lei><title>ITEOS THERAPEUTICS</title><cusip>N/A</cusip><identifiers><isin value="DU0000301354"/></identifiers><balance>2740265</balance><units>NS</units><curCd>USD</curCd><valUSD>7727547</valUSD><pctVal>0.2257</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Mirati Therapeutics Inc</name><lei>529900GYRW59IDQV6N54</lei><title>Mirati Therapeutics Inc</title><cusip>60468T105</cusip><identifiers><isin value="US60468T1051"/><ticker value="MRTX"/><other otherDesc="BBPK0J0" value="Sedol"/></identifiers><balance>459543</balance><units>NS</units><curCd>USD</curCd><valUSD>35325070</valUSD><pctVal>1.0316</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>MyoKardia Inc</name><lei>549300OLNNNZ1NI9UY54</lei><title>MyoKardia Inc</title><cusip>62857M105</cusip><identifiers><isin value="US62857M1053"/><ticker value="MYOK"/><other otherDesc="BYNZF59" value="Sedol"/></identifiers><balance>270463</balance><units>NS</units><curCd>USD</curCd><valUSD>12679305</valUSD><pctVal>0.3703</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>NeoGenomics Inc</name><lei>549300KN62PPGHBVXB46</lei><title>NeoGenomics Inc</title><cusip>64049M209</cusip><identifiers><isin value="US64049M2098"/><ticker value="NEO"/><other otherDesc="2598246" value="Sedol"/></identifiers><balance>590234</balance><units>NS</units><curCd>USD</curCd><valUSD>16296361</valUSD><pctVal>0.4759</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Neurocrine Biosciences Inc</name><lei>549300FECER0XBN49756</lei><title>Neurocrine Biosciences Inc</title><cusip>64125C109</cusip><identifiers><isin value="US64125C1099"/><ticker value="NBIX"/><other otherDesc="2623911" value="Sedol"/></identifiers><balance>767132</balance><units>NS</units><curCd>USD</curCd><valUSD>66395275</valUSD><pctVal>1.939</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Odonate Therapeutics Inc</name><lei>549300D50X5LSJ208C14</lei><title>Odonate Therapeutics Inc</title><cusip>676079106</cusip><identifiers><isin value="US6760791060"/><ticker value="ODT"/><other otherDesc="BD1KGM3" value="Sedol"/></identifiers><balance>567168</balance><units>NS</units><curCd>USD</curCd><valUSD>15659508</valUSD><pctVal>0.4573</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Takeda Pharmaceutical Co Ltd</name><lei>549300ZLMVP4X0OGR454</lei><title>Takeda Pharmaceutical Co Ltd</title><cusip>J8129E108</cusip><identifiers><isin value="JP3463000004"/><ticker value="4502"/><other otherDesc="6870445" value="Sedol"/></identifiers><balance>1568036</balance><units>NS</units><currencyConditional curCd="JPY" exchangeRt="107.51"/><valUSD>47992661</valUSD><pctVal>1.4015</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>JP</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>2</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>PTC Therapeutics Inc</name><lei>549300UJLWOIWFDGB318</lei><title>PTC Therapeutics Inc</title><cusip>69366J200</cusip><identifiers><isin value="US69366J2006"/><ticker value="PTCT"/><other otherDesc="B17VCN9" value="Sedol"/></identifiers><balance>518413</balance><units>NS</units><curCd>USD</curCd><valUSD>23126404</valUSD><pctVal>0.6754</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Astellas Pharma Inc</name><lei>529900IB708DY2HBBB35</lei><title>Astellas Pharma Inc</title><cusip>J03393105</cusip><identifiers><isin value="JP3942400007"/><ticker value="4503"/><other otherDesc="6985383" value="Sedol"/></identifiers><balance>1622900</balance><units>NS</units><currencyConditional curCd="JPY" exchangeRt="107.51"/><valUSD>25126266</valUSD><pctVal>0.7338</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>JP</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>2</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Roche Holding AG</name><lei>549300U41AUUVOAAOB37</lei><title>Roche Holding AG</title><cusip>H69293217</cusip><identifiers><isin value="CH0012032048"/><ticker value="ROG"/><other otherDesc="7110388" value="Sedol"/></identifiers><balance>272693</balance><units>NS</units><currencyConditional curCd="CHF" exchangeRt="0.9621"/><valUSD>88693178</valUSD><pctVal>2.5901</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>CH</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>2</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Phathom Pharmaceuticals Inc</name><lei>N/A</lei><title>Phathom Pharmaceuticals Inc</title><cusip>71722W107</cusip><identifiers><isin value="US71722W1071"/><ticker value="PHAT"/><other otherDesc="BJLKVS6" value="Sedol"/></identifiers><balance>169099</balance><units>NS</units><curCd>USD</curCd><valUSD>4366136</valUSD><pctVal>0.1275</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Quest Diagnostics Inc</name><lei>8MCWUBXQ0WE04KMXBX50</lei><title>Quest Diagnostics Inc</title><cusip>74834L100</cusip><identifiers><isin value="US74834L1008"/><ticker value="DGX"/><other otherDesc="2702791" value="Sedol"/></identifiers><balance>239317</balance><units>NS</units><curCd>USD</curCd><valUSD>19217155</valUSD><pctVal>0.5612</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Rhythm Pharmaceuticals Inc</name><lei>529900JPNWXQ8DPLA551</lei><title>Rhythm Pharmaceuticals Inc</title><cusip>76243J105</cusip><identifiers><isin value="US76243J1051"/><ticker value="RYTM"/><other otherDesc="BF2YWG4" value="Sedol"/></identifiers><balance>1342274</balance><units>NS</units><curCd>USD</curCd><valUSD>20429410</valUSD><pctVal>0.5966</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Sage Therapeutics Inc</name><lei>5493000JX4BJS9W6CN35</lei><title>Sage Therapeutics Inc</title><cusip>78667J108</cusip><identifiers><isin value="US78667J1088"/><ticker value="SAGE"/><other otherDesc="BP4GNK9" value="Sedol"/></identifiers><balance>409022</balance><units>NS</units><curCd>USD</curCd><valUSD>11747112</valUSD><pctVal>0.3431</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Sarepta Therapeutics Inc</name><lei>549300IKDPIED8J8IG21</lei><title>Sarepta Therapeutics Inc</title><cusip>803607100</cusip><identifiers><isin value="US8036071004"/><ticker value="SRPT"/><other otherDesc="B8DPDT7" value="Sedol"/></identifiers><balance>430942</balance><units>NS</units><curCd>USD</curCd><valUSD>42154746</valUSD><pctVal>1.2311</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Silk Road Medical Inc</name><lei>549300VL8KC0ZPDQHE14</lei><title>Silk Road Medical Inc</title><cusip>82710M100</cusip><identifiers><isin value="US82710M1009"/><ticker value="SILK"/><other otherDesc="BGHVXJ7" value="Sedol"/></identifiers><balance>614545</balance><units>NS</units><curCd>USD</curCd><valUSD>19345877</valUSD><pctVal>0.565</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Stoke Therapeutics Inc</name><lei>549300RD25SS2DIJHJ67</lei><title>Stoke Therapeutics Inc</title><cusip>86150R107</cusip><identifiers><isin value="US86150R1077"/><ticker value="STOK"/><other otherDesc="BJQ05Z6" value="Sedol"/></identifiers><balance>221018</balance><units>NS</units><curCd>USD</curCd><valUSD>5061312</valUSD><pctVal>0.1478</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Stryker Corp</name><lei>5493002F0SC4JTBU5137</lei><title>Stryker Corp</title><cusip>863667101</cusip><identifiers><isin value="US8636671013"/><ticker value="SYK"/><other otherDesc="2853688" value="Sedol"/></identifiers><balance>168527</balance><units>NS</units><curCd>USD</curCd><valUSD>28058060</valUSD><pctVal>0.8194</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Teladoc Health Inc</name><lei>549300I2PVFBC9MFAC61</lei><title>Teladoc Health Inc</title><cusip>87918A105</cusip><identifiers><isin value="US87918A1051"/><ticker value="TDOC"/><other otherDesc="BYQRFY1" value="Sedol"/></identifiers><balance>139035</balance><units>NS</units><curCd>USD</curCd><valUSD>21551815</valUSD><pctVal>0.6294</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><loanByFundCondition isLoanByFund="Y" loanVal="16580895"/></securityLending></invstOrSec><invstOrSec><name>Teleflex Inc</name><lei>UUL85LWXB4NGSWWXIQ25</lei><title>Teleflex Inc</title><cusip>879369106</cusip><identifiers><isin value="US8793691069"/><ticker value="TFX"/><other otherDesc="2881407" 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value="Sedol"/></identifiers><balance>172957</balance><units>NS</units><curCd>USD</curCd><valUSD>17136580</valUSD><pctVal>0.5004</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Varian Medical Systems Inc</name><lei>TK3LAKL7I0QNTCVWSY07</lei><title>Varian Medical Systems Inc</title><cusip>92220P105</cusip><identifiers><isin value="US92220P1057"/><ticker value="VAR"/><other otherDesc="2927516" value="Sedol"/></identifiers><balance>240694</balance><units>NS</units><curCd>USD</curCd><valUSD>24709646</valUSD><pctVal>0.7216</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Vertex Pharmaceuticals Inc</name><lei>54930015RAQRRZ5ZGJ91</lei><title>Vertex Pharmaceuticals Inc</title><cusip>92532F100</cusip><identifiers><isin value="US92532F1003"/><ticker value="VRTX"/><other otherDesc="2931034" value="Sedol"/></identifiers><balance>314286</balance><units>NS</units><curCd>USD</curCd><valUSD>74784354</valUSD><pctVal>2.1839</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Zogenix Inc</name><lei>54930089H3HF4C32SK78</lei><title>Zogenix Inc</title><cusip>98978L204</cusip><identifiers><isin value="US98978L2043"/><ticker value="ZGNX"/><other otherDesc="BYTJZL1" value="Sedol"/></identifiers><balance>744069</balance><units>NS</units><curCd>USD</curCd><valUSD>18400826</valUSD><pctVal>0.5374</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>RPI International Holdings, LP</name><lei>N/A</lei><title>RPI International Holdings, LP</title><cusip>N/A</cusip><identifiers><isin value="DU0000104087"/></identifiers><balance>3558928</balance><units>NS</units><curCd>USD</curCd><valUSD>5136245</valUSD><pctVal>0.15</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Novo Nordisk A/S</name><lei>549300DAQ1CVT6CXN342</lei><title>Novo Nordisk A/S</title><cusip>K72807132</cusip><identifiers><isin value="DK0060534915"/><ticker value="NOVOB"/><other otherDesc="BHC8X90" value="Sedol"/></identifiers><balance>717096</balance><units>NS</units><currencyConditional curCd="DKK" 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value="Sedol"/></identifiers><balance>931613</balance><units>NS</units><curCd>USD</curCd><valUSD>27594377</valUSD><pctVal>0.8058</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>IE</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Jazz Pharmaceuticals PLC</name><lei>635400GAUMJCLEZRRV50</lei><title>Jazz Pharmaceuticals PLC</title><cusip>G50871105</cusip><identifiers><isin value="IE00B4Q5ZN47"/><ticker value="JAZZ"/><other otherDesc="B4Q5ZN4" 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value="Sedol"/></identifiers><balance>1542059</balance><units>NS</units><curCd>USD</curCd><valUSD>11642545</valUSD><pctVal>0.34</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>BM</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>STERIS PLC</name><lei>N/A</lei><title>STERIS PLC</title><cusip>G8473T100</cusip><identifiers><isin value="IE00BFY8C754"/><ticker value="STE"/><other otherDesc="BFY8C75" value="Sedol"/></identifiers><balance>180020</balance><units>NS</units><curCd>USD</curCd><valUSD>25197399</valUSD><pctVal>0.7358</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>IE</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Alcon Inc</name><lei>549300LDT5AP8S0NBM78</lei><title>Alcon Inc</title><cusip>H01301128</cusip><identifiers><isin value="CH0432492467"/><ticker value="ALC"/><other otherDesc="BJXBP41" 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value="PHATPRIV"/></identifiers><balance>424907</balance><units>NS</units><curCd>USD</curCd><valUSD>10422544</valUSD><pctVal>0.3044</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>2</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Royalty Pharma Finance Trust</name><lei>N/A</lei><title>RPI INTERNATIONAL HOLDINGS, LP</title><cusip>N/A</cusip><identifiers><isin value="DU0000100945"/><ticker value="ROYPHARM"/><other otherDesc="BLRL853" 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value="1766593D"/></identifiers><balance>3434645</balance><units>NS</units><curCd>USD</curCd><valUSD>3754239</valUSD><pctVal>0.1096</pctVal><payoffProfile>Long</payoffProfile><assetCat>EP</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>4D MOLECULAR THERAPEUTICS, INC.</name><lei>N/A</lei><title>4D Molecular Therapeutics, LLC</title><cusip>4DMTPRIV1</cusip><identifiers><isin value="DU0000100942"/><ticker value="4DMT"/><other otherDesc="4DMTPRIV1" value="Internal ID"/></identifiers><balance>373334</balance><units>NS</units><curCd>USD</curCd><valUSD>6518412</valUSD><pctVal>0.1904</pctVal><payoffProfile>Long</payoffProfile><assetCat>EP</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>ACERTA PHARMA</name><lei>N/A</lei><title>ACERTA PHARMA B.V. 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value="BIGFOOTC1"/></identifiers><balance>168418</balance><units>NS</units><curCd>USD</curCd><valUSD>1594792</valUSD><pctVal>0.0466</pctVal><payoffProfile>Long</payoffProfile><assetCat>EP</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Bigfoot Biomedical Inc</name><lei>N/A</lei><title>BIGFOOT BIOMEDICAL INC</title><cusip>N/A</cusip><identifiers><isin value="DU0000100959"/><ticker value="1450137D"/><other otherDesc="B4N0JJ6" 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GR"/></identifiers><balance>1143846</balance><units>NS</units><curCd>USD</curCd><valUSD>63460576</valUSD><pctVal>1.8533</pctVal><payoffProfile>Long</payoffProfile><assetCat>EP</assetCat><issuerCat>CORP</issuerCat><invCountry>DE</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>2</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Amarin Corp PLC</name><lei>5493009JFIGUFEVPK217</lei><title>Amarin Corp PLC (ADR)</title><cusip>023111206</cusip><identifiers><isin value="US0231112063"/><ticker value="AMRN"/><other otherDesc="2301938" value="Sedol"/></identifiers><balance>1972213</balance><units>NS</units><curCd>USD</curCd><valUSD>7888852</valUSD><pctVal>0.2304</pctVal><payoffProfile>Long</payoffProfile><assetConditional assetCat="OTHER" 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desc="GDR"/><issuerCat>CORP</issuerCat><invCountry>NL</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Ascendis Pharma A/S</name><lei>549300B66JN3W3J8GH73</lei><title>Ascendis Pharma A/S (ADR)</title><cusip>04351P101</cusip><identifiers><isin value="US04351P1012"/><ticker value="ASND"/><other otherDesc="BV9G6B8" value="Sedol"/></identifiers><balance>381566</balance><units>NS</units><curCd>USD</curCd><valUSD>42968147</valUSD><pctVal>1.2548</pctVal><payoffProfile>Long</payoffProfile><assetConditional assetCat="OTHER" desc="GDR"/><issuerCat>CORP</issuerCat><invCountry>DK</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Bristol-Myers Squibb Co</name><lei>HLYYNH7UQUORYSJQCN42</lei><title>Bristol-Myers Squibb Company Contingent Value Rights 2019</title><cusip>110122157</cusip><identifiers><isin value="US1101221570"/><ticker value="BMY-R"/><other otherDesc="BKM7ZR0" value="Sedol"/></identifiers><balance>4004243</balance><units>NS</units><curCd>USD</curCd><valUSD>15216123</valUSD><pctVal>0.4444</pctVal><payoffProfile>Long</payoffProfile><assetConditional assetCat="OTHER" desc="Rights"/><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>GW Pharmaceuticals PLC</name><lei>213800ISBN5CNUZMHZ39</lei><title>GW Pharmaceuticals PLC (ADR)</title><cusip>36197T103</cusip><identifiers><isin value="US36197T1034"/><ticker value="GWPH"/><other otherDesc="B94RPL5" value="Sedol"/></identifiers><balance>360417</balance><units>NS</units><curCd>USD</curCd><valUSD>31561717</valUSD><pctVal>0.9217</pctVal><payoffProfile>Long</payoffProfile><assetConditional assetCat="OTHER" desc="GDR"/><issuerCat>CORP</issuerCat><invCountry>GB</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><loanByFundCondition isLoanByFund="Y" loanVal="11460202.38"/></securityLending></invstOrSec><invstOrSec><name>Novartis AG</name><lei>5493007HIVTX6SY6XD66</lei><title>Novartis AG (ADR)</title><cusip>66987V109</cusip><identifiers><isin value="US66987V1098"/><ticker value="NVS"/><other otherDesc="2620105" value="Sedol"/></identifiers><balance>1681653</balance><units>NS</units><curCd>USD</curCd><valUSD>138652290</valUSD><pctVal>4.0491</pctVal><payoffProfile>Long</payoffProfile><assetConditional assetCat="OTHER" desc="GDR"/><issuerCat>CORP</issuerCat><invCountry>CH</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec></invstOrSecs><explntrNotes><explntrNote note="Monthly returns presented in Item B.5(a) have been calculated without deducting any applicable sales loads or redemption fees." noteItem="B.5.a"/></explntrNotes><signature><ncom:dateSigned>2020-05-15</ncom:dateSigned><ncom:nameOfApplicant>JESPER NERGAARD</ncom:nameOfApplicant><ncom:signature>JESPER NERGAARD</ncom:signature><ncom:signerName>JESPER NERGAARD</ncom:signerName><ncom:title>VP, CFO, TREASURER, AND PRINCIPAL ACCOUNTING OFFICER</ncom:title></signature></nport:formData></nport:edgarSubmission>
