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value="Sedol"/></identifiers><balance>647775</balance><units>NS</units><curCd>USD</curCd><valUSD>54166945</valUSD><pctVal>1.3105</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>BioCryst Pharmaceuticals Inc</name><lei>549300Z0INP1Z5NP6J59</lei><title>BioCryst Pharmaceuticals Inc</title><cusip>09058V103</cusip><identifiers><isin value="US09058V1035"/><ticker value="BCRX"/><other otherDesc="2100362" value="Sedol"/></identifiers><balance>4007056</balance><units>NS</units><curCd>USD</curCd><valUSD>13824343</valUSD><pctVal>0.3345</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>AstraZeneca PLC</name><lei>PY6ZZQWO2IZFZC3IOL08</lei><title>AstraZeneca PLC</title><cusip>G0593M107</cusip><identifiers><isin value="GB0009895292"/><ticker value="AZN"/><other otherDesc="989529" value="Sedol"/></identifiers><balance>1234917</balance><units>NS</units><currencyConditional curCd="GBP" exchangeRt="0.75506"/><valUSD>124414134</valUSD><pctVal>3.01</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>GB</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Boston Scientific Corp</name><lei>Y6ZDD9FP4P8JSSJMW954</lei><title>Boston Scientific Corp</title><cusip>101137107</cusip><identifiers><isin value="US1011371077"/><ticker value="BSX"/><other otherDesc="2113434" value="Sedol"/></identifiers><balance>2153916</balance><units>NS</units><curCd>USD</curCd><valUSD>97400082</valUSD><pctVal>2.3564</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Bridgebio Pharma Inc</name><lei>54930028YG89VTY2J114</lei><title>Bridgebio Pharma Inc</title><cusip>10806X102</cusip><identifiers><isin value="US10806X1028"/><ticker value="BBIO"/><other otherDesc="BK1KWG8" value="Sedol"/></identifiers><balance>1748288</balance><units>NS</units><curCd>USD</curCd><valUSD>61277494</valUSD><pctVal>1.4825</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><loanByFundCondition isLoanByFund="Y" loanVal="7109264"/></securityLending></invstOrSec><invstOrSec><name>Bristol-Myers Squibb Co</name><lei>HLYYNH7UQUORYSJQCN42</lei><title>Bristol-Myers Squibb Co</title><cusip>110122108</cusip><identifiers><isin value="US1101221083"/><ticker value="BMY"/><other otherDesc="2126335" value="Sedol"/></identifiers><balance>1911652</balance><units>NS</units><curCd>USD</curCd><valUSD>122708942</valUSD><pctVal>2.9688</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Bristol-Myers Squibb Co</name><lei>HLYYNH7UQUORYSJQCN42</lei><title>Bristol-Myers Squibb Company Contingent Value Rights 2019</title><cusip>110122157</cusip><identifiers><isin value="US1101221570"/><ticker value="BMY-R"/><other otherDesc="BKM7ZR0" value="Sedol"/></identifiers><balance>3055358</balance><units>NS</units><curCd>USD</curCd><valUSD>9196628</valUSD><pctVal>0.2225</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Catalent Inc</name><lei>N/A</lei><title>Catalent Inc</title><cusip>148806102</cusip><identifiers><isin value="US1488061029"/><ticker value="CTLT"/><other otherDesc="BP96PQ4" value="Sedol"/></identifiers><balance>1007387</balance><units>NS</units><curCd>USD</curCd><valUSD>56715888</valUSD><pctVal>1.3722</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Centene Corp</name><lei>549300Z7JJ4TQSQGT333</lei><title>Centene Corp</title><cusip>15135B101</cusip><identifiers><isin value="US15135B1017"/><ticker value="CNC"/><other otherDesc="2807061" value="Sedol"/></identifiers><balance>393055</balance><units>NS</units><curCd>USD</curCd><valUSD>24711368</valUSD><pctVal>0.5979</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Aligos Therapeutics Inc</name><lei>N/A</lei><title>ALIGOS THERAPEUTICS INC USD SERIES B-1</title><cusip>N/A</cusip><identifiers><isin value="N/A"/><ticker value="1766593D"/></identifiers><balance>3434645</balance><units>NS</units><curCd>USD</curCd><valUSD>3754239</valUSD><pctVal>0.0908</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Clementia Pharmaceuticals Inc</name><lei>N/A</lei><title>CLEMENTIA PHARMACEUTICALS IN - CVR</title><cusip>N/A</cusip><identifiers><isin value="CA185575CVR1"/><ticker value="CMTA CVR"/></identifiers><balance>874311</balance><units>NS</units><curCd>USD</curCd><valUSD>1</valUSD><pctVal>0</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Collegium Pharmaceutical Inc</name><lei>54930049FXZMTLW8D496</lei><title>Collegium Pharmaceutical Inc</title><cusip>19459J104</cusip><identifiers><isin value="US19459J1043"/><ticker value="COLL"/><other otherDesc="BX7RSN3" value="Sedol"/></identifiers><balance>1012140</balance><units>NS</units><curCd>USD</curCd><valUSD>20829841</valUSD><pctVal>0.5039</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Cooper Cos Inc</name><lei>QJKMVPIGLH7530PCUE20</lei><title>Cooper Cos Inc</title><cusip>216648402</cusip><identifiers><isin value="US2166484020"/><ticker value="COO"/><other otherDesc="2222631" value="Sedol"/></identifiers><balance>182891</balance><units>NS</units><curCd>USD</curCd><valUSD>58761049</valUSD><pctVal>1.4216</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Danaher Corp</name><lei>S4BKK9OTCEWQ3YHPFM11</lei><title>Danaher Corp</title><cusip>235851102</cusip><identifiers><isin value="US2358511028"/><ticker value="DHR"/><other otherDesc="2250870" value="Sedol"/></identifiers><balance>436847</balance><units>NS</units><curCd>USD</curCd><valUSD>67047278</valUSD><pctVal>1.6221</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>DENTSPLY SIRONA Inc</name><lei>9NHEHR1SOZCYXDO8HO28</lei><title>DENTSPLY SIRONA Inc</title><cusip>24906P109</cusip><identifiers><isin value="US24906P1093"/><ticker value="XRAY"/><other otherDesc="BYNPPC6" value="Sedol"/></identifiers><balance>254187</balance><units>NS</units><curCd>USD</curCd><valUSD>14384442</valUSD><pctVal>0.348</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>DexCom Inc</name><lei>549300YSK3QDSFR5EU59</lei><title>DexCom Inc</title><cusip>252131107</cusip><identifiers><isin value="US2521311074"/><ticker value="DXCM"/><other otherDesc="B0796X4" value="Sedol"/></identifiers><balance>109417</balance><units>NS</units><curCd>USD</curCd><valUSD>23933875</valUSD><pctVal>0.579</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Edwards Lifesciences Corp</name><lei>YA13X31F3V31L8TMPR58</lei><title>Edwards Lifesciences Corp</title><cusip>28176E108</cusip><identifiers><isin value="US28176E1082"/><ticker value="EW"/><other otherDesc="2567116" value="Sedol"/></identifiers><balance>211388</balance><units>NS</units><curCd>USD</curCd><valUSD>49314707</valUSD><pctVal>1.1931</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Elanco Animal Health Inc</name><lei>549300SHPNDCE059M934</lei><title>Elanco Animal Health Inc</title><cusip>28414H103</cusip><identifiers><isin value="US28414H1032"/><ticker value="ELAN"/><other otherDesc="BF5L3T2" value="Sedol"/></identifiers><balance>1270632</balance><units>NS</units><curCd>USD</curCd><valUSD>37420112</valUSD><pctVal>0.9053</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Enanta Pharmaceuticals Inc</name><lei>529900SSN4DODDQSN594</lei><title>Enanta Pharmaceuticals Inc</title><cusip>29251M106</cusip><identifiers><isin value="US29251M1062"/><ticker value="ENTA"/><other otherDesc="B9L5200" value="Sedol"/></identifiers><balance>196069</balance><units>NS</units><curCd>USD</curCd><valUSD>12113143</valUSD><pctVal>0.2931</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>FibroGen Inc</name><lei>549300Q914ULWWY95822</lei><title>FibroGen Inc</title><cusip>31572Q808</cusip><identifiers><isin value="US31572Q8087"/><ticker value="FGEN"/><other otherDesc="BSDRYR8" value="Sedol"/></identifiers><balance>390915</balance><units>NS</units><curCd>USD</curCd><valUSD>16766344</valUSD><pctVal>0.4056</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Gilead Sciences Inc</name><lei>549300WTZWR07K8MNV44</lei><title>Gilead Sciences Inc</title><cusip>375558103</cusip><identifiers><isin value="US3755581036"/><ticker value="GILD"/><other otherDesc="2369174" value="Sedol"/></identifiers><balance>1083432</balance><units>NS</units><curCd>USD</curCd><valUSD>70401411</valUSD><pctVal>1.7033</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Global Blood Therapeutics Inc</name><lei>549300U4G0QKK99GRT15</lei><title>Global Blood Therapeutics Inc</title><cusip>37890U108</cusip><identifiers><isin value="US37890U1088"/><ticker value="GBT"/><other otherDesc="BZ05388" value="Sedol"/></identifiers><balance>620555</balance><units>NS</units><curCd>USD</curCd><valUSD>49327917</valUSD><pctVal>1.1934</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Globus Medical Inc</name><lei>5299003M2P4CIK0RF205</lei><title>Globus Medical Inc</title><cusip>379577208</cusip><identifiers><isin value="US3795772082"/><ticker value="GMED"/><other otherDesc="B7D65M0" value="Sedol"/></identifiers><balance>701143</balance><units>NS</units><curCd>USD</curCd><valUSD>41283300</valUSD><pctVal>0.9988</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Heron Therapeutics Inc</name><lei>549300DR2I1DOPD2IX53</lei><title>Heron Therapeutics Inc</title><cusip>427746102</cusip><identifiers><isin value="US4277461020"/><ticker value="HRTX"/><other otherDesc="BJ0XLZ3" value="Sedol"/></identifiers><balance>636001</balance><units>NS</units><curCd>USD</curCd><valUSD>14946023</valUSD><pctVal>0.3616</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Humana Inc</name><lei>529900YLDW34GJAO4J06</lei><title>Humana Inc</title><cusip>444859102</cusip><identifiers><isin value="US4448591028"/><ticker value="HUM"/><other otherDesc="2445063" value="Sedol"/></identifiers><balance>283745</balance><units>NS</units><curCd>USD</curCd><valUSD>103998217</valUSD><pctVal>2.5161</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>ICU Medical Inc</name><lei>5493003NRW7LS2QZRH60</lei><title>ICU Medical Inc</title><cusip>44930G107</cusip><identifiers><isin value="US44930G1076"/><ticker value="ICUI"/><other otherDesc="2451918" value="Sedol"/></identifiers><balance>198540</balance><units>NS</units><curCd>USD</curCd><valUSD>37150805</valUSD><pctVal>0.8988</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Immunomedics Inc</name><lei>5493007ZU7DDO8PSIM59</lei><title>Immunomedics Inc</title><cusip>452907108</cusip><identifiers><isin value="US4529071080"/><ticker value="IMMU"/><other otherDesc="2457961" value="Sedol"/></identifiers><balance>1133856</balance><units>NS</units><curCd>USD</curCd><valUSD>23992393</valUSD><pctVal>0.5805</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Insmed Inc</name><lei>529900Q55QAG41CCAC11</lei><title>Insmed Inc</title><cusip>457669307</cusip><identifiers><isin value="US4576693075"/><ticker value="INSM"/><other otherDesc="2614487" value="Sedol"/></identifiers><balance>2279487</balance><units>NS</units><curCd>USD</curCd><valUSD>54434150</valUSD><pctVal>1.317</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Intuitive Surgical Inc</name><lei>54930052SRG011710797</lei><title>Intuitive Surgical Inc</title><cusip>46120E602</cusip><identifiers><isin value="US46120E6023"/><ticker value="ISRG"/><other otherDesc="2871301" value="Sedol"/></identifiers><balance>74803</balance><units>NS</units><curCd>USD</curCd><valUSD>44219793</valUSD><pctVal>1.0698</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>IQVIA Holdings Inc</name><lei>549300W3R20NM4KQPH86</lei><title>IQVIA Holdings Inc</title><cusip>46266C105</cusip><identifiers><isin value="US46266C1053"/><ticker value="IQV"/><other otherDesc="BDR73G1" value="Sedol"/></identifiers><balance>334675</balance><units>NS</units><curCd>USD</curCd><valUSD>51710634</valUSD><pctVal>1.2511</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Ironwood Pharmaceuticals Inc</name><lei>549300PC8MR6QHH6P296</lei><title>Ironwood Pharmaceuticals Inc</title><cusip>46333X108</cusip><identifiers><isin value="US46333X1081"/><ticker value="IRWD"/><other otherDesc="B3MZ6K5" 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exchangeRt="0.89158"/><valUSD>97524649</valUSD><pctVal>2.3595</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>FR</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Merck &amp; Co Inc</name><lei>4YV9Y5M8S0BRK1RP0397</lei><title>Merck &amp; Co Inc</title><cusip>58933Y105</cusip><identifiers><isin value="US58933Y1055"/><ticker value="MRK"/><other otherDesc="2778844" value="Sedol"/></identifiers><balance>1996418</balance><units>NS</units><curCd>USD</curCd><valUSD>181574217</valUSD><pctVal>4.3929</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Mirati Therapeutics Inc</name><lei>529900GYRW59IDQV6N54</lei><title>Mirati Therapeutics Inc</title><cusip>60468T105</cusip><identifiers><isin value="US60468T1051"/><ticker value="MRTX"/><other otherDesc="BBPK0J0" value="Sedol"/></identifiers><balance>407378</balance><units>NS</units><curCd>USD</curCd><valUSD>52494729</valUSD><pctVal>1.27</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>MyoKardia Inc</name><lei>549300OLNNNZ1NI9UY54</lei><title>MyoKardia Inc</title><cusip>62857M105</cusip><identifiers><isin value="US62857M1053"/><ticker value="MYOK"/><other otherDesc="BYNZF59" value="Sedol"/></identifiers><balance>232786</balance><units>NS</units><curCd>USD</curCd><valUSD>16966608</valUSD><pctVal>0.4105</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Nektar Therapeutics</name><lei>5299005I24806IOIYE03</lei><title>Nektar Therapeutics</title><cusip>640268108</cusip><identifiers><isin value="US6402681083"/><ticker value="NKTR"/><other otherDesc="2454445" value="Sedol"/></identifiers><balance>483923</balance><units>NS</units><curCd>USD</curCd><valUSD>10445478</valUSD><pctVal>0.2527</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>NeoGenomics Inc</name><lei>549300KN62PPGHBVXB46</lei><title>NeoGenomics Inc</title><cusip>64049M209</cusip><identifiers><isin value="US64049M2098"/><ticker value="NEO"/><other otherDesc="2598246" value="Sedol"/></identifiers><balance>694080</balance><units>NS</units><curCd>USD</curCd><valUSD>20301840</valUSD><pctVal>0.4912</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Neurocrine Biosciences Inc</name><lei>549300FECER0XBN49756</lei><title>Neurocrine Biosciences Inc</title><cusip>64125C109</cusip><identifiers><isin value="US64125C1099"/><ticker value="NBIX"/><other otherDesc="2623911" value="Sedol"/></identifiers><balance>746961</balance><units>NS</units><curCd>USD</curCd><valUSD>80290838</valUSD><pctVal>1.9425</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Odonate Therapeutics Inc</name><lei>549300D50X5LSJ208C14</lei><title>Odonate Therapeutics Inc</title><cusip>676079106</cusip><identifiers><isin value="US6760791060"/><ticker value="ODT"/><other otherDesc="BD1KGM3" value="Sedol"/></identifiers><balance>537308</balance><units>NS</units><curCd>USD</curCd><valUSD>17435645</valUSD><pctVal>0.4218</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Takeda Pharmaceutical Co Ltd</name><lei>549300ZLMVP4X0OGR454</lei><title>Takeda Pharmaceutical Co Ltd</title><cusip>J8129E108</cusip><identifiers><isin value="JP3463000004"/><ticker value="4502"/><other otherDesc="6870445" value="Sedol"/></identifiers><balance>2505036</balance><units>NS</units><currencyConditional curCd="JPY" exchangeRt="108.64"/><valUSD>99887849</valUSD><pctVal>2.4166</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>JP</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>PTC Therapeutics Inc</name><lei>549300UJLWOIWFDGB318</lei><title>PTC Therapeutics Inc</title><cusip>69366J200</cusip><identifiers><isin value="US69366J2006"/><ticker value="PTCT"/><other otherDesc="B17VCN9" value="Sedol"/></identifiers><balance>526342</balance><units>NS</units><curCd>USD</curCd><valUSD>25280206</valUSD><pctVal>0.6116</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Astellas Pharma Inc</name><lei>529900IB708DY2HBBB35</lei><title>Astellas Pharma Inc</title><cusip>J03393105</cusip><identifiers><isin value="JP3942400007"/><ticker value="4503"/><other otherDesc="6985383" value="Sedol"/></identifiers><balance>1425600</balance><units>NS</units><currencyConditional curCd="JPY" exchangeRt="108.64"/><valUSD>24538586</valUSD><pctVal>0.5937</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>JP</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Roche Holding AG</name><lei>549300U41AUUVOAAOB37</lei><title>Roche Holding AG</title><cusip>H69293217</cusip><identifiers><isin value="CH0012032048"/><ticker value="ROG"/><other otherDesc="7110388" value="Sedol"/></identifiers><balance>262955</balance><units>NS</units><currencyConditional curCd="CHF" exchangeRt="0.9676"/><valUSD>85332648</valUSD><pctVal>2.0645</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>CH</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Phathom Pharmaceuticals Inc</name><lei>N/A</lei><title>Phathom Pharmaceuticals Inc</title><cusip>71722W107</cusip><identifiers><isin value="US71722W1071"/><ticker value="PHAT"/><other otherDesc="BJLKVS6" 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value="Sedol"/></identifiers><balance>248539</balance><units>NS</units><curCd>USD</curCd><valUSD>26541480</valUSD><pctVal>0.6421</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Rhythm Pharmaceuticals Inc</name><lei>529900JPNWXQ8DPLA551</lei><title>Rhythm Pharmaceuticals Inc</title><cusip>76243J105</cusip><identifiers><isin value="US76243J1051"/><ticker value="RYTM"/><other otherDesc="BF2YWG4" 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value="Sedol"/></identifiers><balance>292456</balance><units>NS</units><curCd>USD</curCd><valUSD>21112399</valUSD><pctVal>0.5108</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Sarepta Therapeutics Inc</name><lei>549300IKDPIED8J8IG21</lei><title>Sarepta Therapeutics Inc</title><cusip>803607100</cusip><identifiers><isin value="US8036071004"/><ticker value="SRPT"/><other otherDesc="B8DPDT7" value="Sedol"/></identifiers><balance>376227</balance><units>NS</units><curCd>USD</curCd><valUSD>48548332</valUSD><pctVal>1.1746</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Silk Road Medical Inc</name><lei>549300VL8KC0ZPDQHE14</lei><title>Silk Road Medical Inc</title><cusip>82710M100</cusip><identifiers><isin value="US82710M1009"/><ticker value="SILK"/><other otherDesc="BGHVXJ7" 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value="Sedol"/></identifiers><balance>391674</balance><units>NS</units><curCd>USD</curCd><valUSD>11092208</valUSD><pctVal>0.2684</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Stryker Corp</name><lei>5493002F0SC4JTBU5137</lei><title>Stryker Corp</title><cusip>863667101</cusip><identifiers><isin value="US8636671013"/><ticker value="SYK"/><other otherDesc="2853688" value="Sedol"/></identifiers><balance>202232</balance><units>NS</units><curCd>USD</curCd><valUSD>42456586</valUSD><pctVal>1.0272</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Teladoc Health Inc</name><lei>549300I2PVFBC9MFAC61</lei><title>Teladoc Health Inc</title><cusip>87918A105</cusip><identifiers><isin value="US87918A1051"/><ticker value="TDOC"/><other otherDesc="BYQRFY1" value="Sedol"/></identifiers><balance>359375</balance><units>NS</units><curCd>USD</curCd><valUSD>30086875</valUSD><pctVal>0.7279</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Teleflex Inc</name><lei>UUL85LWXB4NGSWWXIQ25</lei><title>Teleflex Inc</title><cusip>879369106</cusip><identifiers><isin value="US8793691069"/><ticker value="TFX"/><other otherDesc="2881407" value="Sedol"/></identifiers><balance>62790</balance><units>NS</units><curCd>USD</curCd><valUSD>23636668</valUSD><pctVal>0.5719</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Thermo Fisher Scientific Inc</name><lei>HCHV7422L5HDJZCRFL38</lei><title>Thermo Fisher Scientific Inc</title><cusip>883556102</cusip><identifiers><isin value="US8835561023"/><ticker value="TMO"/><other otherDesc="2886907" value="Sedol"/></identifiers><balance>370501</balance><units>NS</units><curCd>USD</curCd><valUSD>120364660</valUSD><pctVal>2.912</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Janus Henderson Cash Liquidity Fund</name><lei>N/A</lei><title>Janus Henderson Cash Liquidity Fund</title><cusip>N/A</cusip><identifiers><other otherDesc="B1QH830" value="Sedol"/></identifiers><balance>10376255</balance><units>NS</units><curCd>USD</curCd><valUSD>10376255</valUSD><pctVal>0.251</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>PF</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>2</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Janus Henderson Cash Collateral Fund</name><lei>N/A</lei><title>Janus Henderson Cash Collateral Fund</title><cusip>N/A</cusip><identifiers><other otherDesc="B1RYG58" value="Sedol"/></identifiers><balance>12821353</balance><units>NS</units><curCd>USD</curCd><valUSD>12821353</valUSD><pctVal>0.3102</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>PF</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>2</fairValLevel><securityLending><cashCollateralCondition cashCollateralVal="12821353" isCashCollateral="Y"/><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>UnitedHealth Group Inc</name><lei>549300GHBMY8T5GXDE41</lei><title>UnitedHealth Group Inc</title><cusip>91324P102</cusip><identifiers><isin value="US91324P1021"/><ticker value="UNH"/><other otherDesc="2917766" value="Sedol"/></identifiers><balance>452212</balance><units>NS</units><curCd>USD</curCd><valUSD>132941284</valUSD><pctVal>3.2163</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Universal Health Services Inc</name><lei>549300YGMGQDO0NMJD09</lei><title>Universal Health Services Inc</title><cusip>913903100</cusip><identifiers><isin value="US9139031002"/><ticker value="UHS"/><other otherDesc="2923785" value="Sedol"/></identifiers><balance>242851</balance><units>NS</units><curCd>USD</curCd><valUSD>34839404</valUSD><pctVal>0.8429</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Varian Medical Systems Inc</name><lei>TK3LAKL7I0QNTCVWSY07</lei><title>Varian Medical Systems Inc</title><cusip>92220P105</cusip><identifiers><isin value="US92220P1057"/><ticker value="VAR"/><other otherDesc="2927516" value="Sedol"/></identifiers><balance>253688</balance><units>NS</units><curCd>USD</curCd><valUSD>36026233</valUSD><pctVal>0.8716</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Vertex Pharmaceuticals Inc</name><lei>54930015RAQRRZ5ZGJ91</lei><title>Vertex Pharmaceuticals Inc</title><cusip>92532F100</cusip><identifiers><isin value="US92532F1003"/><ticker value="VRTX"/><other otherDesc="2931034" value="Sedol"/></identifiers><balance>366431</balance><units>NS</units><curCd>USD</curCd><valUSD>80230067</valUSD><pctVal>1.941</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>ACERTA PHARMA</name><lei>N/A</lei><title>ACERTA PHARMA B.V. PP</title><cusip>N/A</cusip><identifiers><isin value="DU0000100943"/><ticker value="ACERTA"/><other otherDesc="B55PZY3" value="Sedol"/></identifiers><balance>143797410</balance><units>NS</units><curCd>USD</curCd><valUSD>16134069</valUSD><pctVal>0.3903</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Ipsen SA</name><lei>549300M6SGDPB4Z94P11</lei><title>Ipsen SA</title><cusip>F5362H107</cusip><identifiers><isin value="FR0010259150"/><ticker value="IPN"/><other otherDesc="B0R7JF1" value="Sedol"/></identifiers><balance>142535</balance><units>NS</units><currencyConditional curCd="EUR" exchangeRt="0.89158"/><valUSD>12629562</valUSD><pctVal>0.3056</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>FR</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Novo Nordisk A/S</name><lei>549300DAQ1CVT6CXN342</lei><title>Novo Nordisk A/S</title><cusip>K72807132</cusip><identifiers><isin value="DK0060534915"/><ticker value="NOVOB"/><other otherDesc="BHC8X90" value="Sedol"/></identifiers><balance>821853</balance><units>NS</units><currencyConditional curCd="DKK" exchangeRt="6.6609"/><valUSD>47706686</valUSD><pctVal>1.1542</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>DK</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Bigfoot Biomedical Inc</name><lei>N/A</lei><title>BIGFOOT BIOMEDICAL INC SERIES C-1 USD</title><cusip>BIGFOOTC1</cusip><identifiers><ticker value="BIGFOOTC1"/></identifiers><balance>168418</balance><units>NS</units><curCd>USD</curCd><valUSD>1594792</valUSD><pctVal>0.0386</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Bigfoot Biomedical Inc</name><lei>N/A</lei><title>BIGFOOT BIOMEDICAL INC</title><cusip>N/A</cusip><identifiers><isin value="DU0000100959"/><ticker value="1450137D"/><other otherDesc="B4N0JJ6" value="Sedol"/></identifiers><balance>1035873</balance><units>NS</units><curCd>USD</curCd><valUSD>9808940</valUSD><pctVal>0.2373</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>BioNTech AG</name><lei>N/A</lei><title>BIONTECH AG</title><cusip>BIONTECH2</cusip><identifiers><ticker value="3315187Z2 GR"/></identifiers><balance>1143846</balance><units>NS</units><curCd>USD</curCd><valUSD>34878152</valUSD><pctVal>0.8438</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>DE</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>2</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Allergan PLC</name><lei>635400FWJZQC1IPYUH69</lei><title>Allergan PLC</title><cusip>G0177J108</cusip><identifiers><isin value="IE00BY9D5467"/><ticker value="AGN"/><other otherDesc="BY9D546" value="Sedol"/></identifiers><balance>328493</balance><units>NS</units><curCd>USD</curCd><valUSD>62798007</valUSD><pctVal>1.5193</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>IE</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Horizon Therapeutics Plc</name><lei>529900P0GSQ79OOZEV53</lei><title>Horizon Therapeutics Plc</title><cusip>G46188101</cusip><identifiers><isin value="IE00BQPVQZ61"/><ticker value="HZNP"/><other otherDesc="BQPVQZ6" value="Sedol"/></identifiers><balance>859113</balance><units>NS</units><curCd>USD</curCd><valUSD>31099891</valUSD><pctVal>0.7524</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>IE</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Jazz Pharmaceuticals PLC</name><lei>635400GAUMJCLEZRRV50</lei><title>Jazz Pharmaceuticals PLC</title><cusip>G50871105</cusip><identifiers><isin value="IE00B4Q5ZN47"/><ticker value="JAZZ"/><other otherDesc="B4Q5ZN4" value="Sedol"/></identifiers><balance>250336</balance><units>NS</units><curCd>USD</curCd><valUSD>37370158</valUSD><pctVal>0.9041</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>IE</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Myovant Sciences Ltd</name><lei>N/A</lei><title>Myovant Sciences Ltd</title><cusip>G637AM102</cusip><identifiers><isin value="BMG637AM1024"/><ticker value="MYOV"/><other otherDesc="BD3WG49" value="Sedol"/></identifiers><balance>1601473</balance><units>NS</units><curCd>USD</curCd><valUSD>24854861</valUSD><pctVal>0.6013</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>BM</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>STERIS PLC</name><lei>N/A</lei><title>STERIS PLC</title><cusip>G8473T100</cusip><identifiers><isin value="IE00BFY8C754"/><ticker value="STE"/><other otherDesc="BFY8C75" value="Sedol"/></identifiers><balance>248886</balance><units>NS</units><curCd>USD</curCd><valUSD>37935204</valUSD><pctVal>0.9178</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>IE</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Alcon Inc</name><lei>549300LDT5AP8S0NBM78</lei><title>Alcon Inc</title><cusip>H01301128</cusip><identifiers><isin value="CH0432492467"/><ticker value="ALC"/><other otherDesc="BJXBP41" value="Sedol"/></identifiers><balance>298783</balance><units>NS</units><curCd>USD</curCd><valUSD>16902154</valUSD><pctVal>0.4089</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>CH</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>IGM BIO PRIV</name><lei>N/A</lei><title>IGM BIO PRIV USD</title><cusip>IMGBNEW19</cusip><identifiers><ticker value="IGMB PP"/></identifiers><balance>700647</balance><units>NS</units><curCd>USD</curCd><valUSD>25399855</valUSD><pctVal>0.6145</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>2</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Phathom Pharmaceuticals Inc</name><lei>N/A</lei><title>PHATHOM PHARMACEUTICALS INC ORD USD (RESTRICTED LINE)</title><cusip>PHATPRIV1</cusip><identifiers><ticker value="PHATPRIV"/></identifiers><balance>424907</balance><units>NS</units><curCd>USD</curCd><valUSD>11908444</valUSD><pctVal>0.2881</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>2</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Royalty Pharma Finance Trust</name><lei>N/A</lei><title>RPI INTERNATIONAL HOLDINGS, LP</title><cusip>N/A</cusip><identifiers><isin value="DU0000100945"/><ticker value="ROYPHARM"/><other otherDesc="BLRL853" value="Sedol"/></identifiers><balance>127226</balance><units>NS</units><curCd>USD</curCd><valUSD>23469380</valUSD><pctVal>0.5678</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>US</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>3</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>WaVe Life Sciences Ltd</name><lei>54930070006GPKFYZ813</lei><title>WaVe Life Sciences Ltd</title><cusip>Y95308105</cusip><identifiers><isin value="SG9999014716"/><ticker value="WVE"/><other otherDesc="BYZG9R0" value="Sedol"/></identifiers><balance>424853</balance><units>NS</units><curCd>USD</curCd><valUSD>3405197</valUSD><pctVal>0.0824</pctVal><payoffProfile>Long</payoffProfile><assetCat>EC</assetCat><issuerCat>CORP</issuerCat><invCountry>SG</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><loanByFundCondition isLoanByFund="Y" loanVal="5165415.15"/></securityLending></invstOrSec><invstOrSec><name>Amarin Corp PLC</name><lei>5493009JFIGUFEVPK217</lei><title>Amarin Corp PLC (ADR)</title><cusip>023111206</cusip><identifiers><isin value="US0231112063"/><ticker value="AMRN"/><other otherDesc="2301938" value="Sedol"/></identifiers><balance>1363264</balance><units>NS</units><curCd>USD</curCd><valUSD>29228380</valUSD><pctVal>0.7071</pctVal><payoffProfile>Long</payoffProfile><assetConditional assetCat="OTHER" desc="GDR"/><issuerCat>CORP</issuerCat><invCountry>GB</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Argenx SE</name><lei>7245009C5FZE6G9ODQ71</lei><title>Argenx SE (ADR)</title><cusip>04016X101</cusip><identifiers><isin value="US04016X1019"/><ticker value="ARGX"/><other otherDesc="BDVLM39" value="Sedol"/></identifiers><balance>140773</balance><units>NS</units><curCd>USD</curCd><valUSD>22596882</valUSD><pctVal>0.5467</pctVal><payoffProfile>Long</payoffProfile><assetConditional assetCat="OTHER" desc="GDR"/><issuerCat>CORP</issuerCat><invCountry>NL</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Ascendis Pharma A/S</name><lei>549300B66JN3W3J8GH73</lei><title>Ascendis Pharma A/S (ADR)</title><cusip>04351P101</cusip><identifiers><isin value="US04351P1012"/><ticker value="ASND"/><other otherDesc="BV9G6B8" value="Sedol"/></identifiers><balance>378632</balance><units>NS</units><curCd>USD</curCd><valUSD>52675284</valUSD><pctVal>1.2744</pctVal><payoffProfile>Long</payoffProfile><assetConditional assetCat="OTHER" desc="GDR"/><issuerCat>CORP</issuerCat><invCountry>DK</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>BeiGene Ltd</name><lei>549300JFUK6FRD5MH739</lei><title>BeiGene Ltd (ADR)</title><cusip>07725L102</cusip><identifiers><isin value="US07725L1026"/><ticker value="BGNE"/><other otherDesc="BYYWPW6" value="Sedol"/></identifiers><balance>112737</balance><units>NS</units><curCd>USD</curCd><valUSD>18687285</valUSD><pctVal>0.4521</pctVal><payoffProfile>Long</payoffProfile><assetConditional assetCat="OTHER" desc="GDR"/><issuerCat>CORP</issuerCat><invCountry>KY</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>GW Pharmaceuticals PLC</name><lei>213800ISBN5CNUZMHZ39</lei><title>GW Pharmaceuticals PLC (ADR)</title><cusip>36197T103</cusip><identifiers><isin value="US36197T1034"/><ticker value="GWPH"/><other otherDesc="B94RPL5" value="Sedol"/></identifiers><balance>255104</balance><units>NS</units><curCd>USD</curCd><valUSD>26673674</valUSD><pctVal>0.6453</pctVal><payoffProfile>Long</payoffProfile><assetConditional assetCat="OTHER" desc="GDR"/><issuerCat>CORP</issuerCat><invCountry>GB</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec><invstOrSec><name>Novartis AG</name><lei>5493007HIVTX6SY6XD66</lei><title>Novartis AG (ADR)</title><cusip>66987V109</cusip><identifiers><isin value="US66987V1098"/><ticker value="NVS"/><other otherDesc="2620105" value="Sedol"/></identifiers><balance>1851104</balance><units>NS</units><curCd>USD</curCd><valUSD>175281038</valUSD><pctVal>4.2407</pctVal><payoffProfile>Long</payoffProfile><assetConditional assetCat="OTHER" desc="GDR"/><issuerCat>CORP</issuerCat><invCountry>CH</invCountry><isRestrictedSec>N</isRestrictedSec><fairValLevel>1</fairValLevel><securityLending><isCashCollateral>N</isCashCollateral><isNonCashCollateral>N</isNonCashCollateral><isLoanByFund>N</isLoanByFund></securityLending></invstOrSec></invstOrSecs><explntrNotes><explntrNote note="Monthly returns presented in Item B.5(a) have been calculated without deducting any applicable sales loads or redemption fees." noteItem="B.5.a"/></explntrNotes><signature><ncom:dateSigned>2020-02-14</ncom:dateSigned><ncom:nameOfApplicant>JESPER NERGAARD</ncom:nameOfApplicant><ncom:signature>JESPER NERGAARD</ncom:signature><ncom:signerName>JESPER NERGAARD</ncom:signerName><ncom:title>VP, CFO, TREASURER, AND PRINCIPAL ACCOUNTING OFFICER</ncom:title></signature></nport:formData><nport:documents>XXXX</nport:documents></nport:edgarSubmission>
