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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Medtronic PLC</name>
        <lei>549300GX3ZBSQWUXY261</lei>
        <title>Medtronic PLC USD0.0001</title>
        <cusip>G5960L103</cusip>
        <identifiers>
          <isin value="IE00BTN1Y115"/>
          <ticker value="MDT"/>
          <other otherDesc="SEDOL" value="BTN1Y11"/>
        </identifiers>
        <balance>644860</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>61945251.6</valUSD>
        <pctVal>1.1557152730</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Alnylam Pharmaceuticals Inc.</name>
        <lei>529900S3ZI14OWRJII50</lei>
        <title>Alnylam Pharmaceuticals Inc. COM USD0.01</title>
        <cusip>02043Q107</cusip>
        <identifiers>
          <isin value="US02043Q1076"/>
          <ticker value="ALNY"/>
          <other otherDesc="SEDOL" value="B00FWN1"/>
        </identifiers>
        <balance>45828</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>18223504.2</valUSD>
        <pctVal>0.3399967163</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Elevance Health Inc.</name>
        <lei>8MYN82XMYQH89CTMTH67</lei>
        <title>Elevance Health Inc. COM USD0.01</title>
        <cusip>036752103</cusip>
        <identifiers>
          <isin value="US0367521038"/>
          <ticker value="ELV"/>
          <other otherDesc="SEDOL" value="BSPHGL4"/>
        </identifiers>
        <balance>168990</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>59239444.5</valUSD>
        <pctVal>1.1052329114</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Apogee Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>Apogee Therapeutics Inc. COM</title>
        <cusip>03770N101</cusip>
        <identifiers>
          <isin value="US03770N1019"/>
          <ticker value="APGE"/>
          <other otherDesc="SEDOL" value="BM9HHL5"/>
        </identifiers>
        <balance>378258</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>28550913.84</valUSD>
        <pctVal>0.5326756504</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Arcellx Inc</name>
        <lei>N/A</lei>
        <title>Arcellx Inc COMMON STOCK</title>
        <cusip>03940C100</cusip>
        <identifiers>
          <isin value="US03940C1009"/>
          <ticker value="ACLX"/>
          <other otherDesc="SEDOL" value="BPCJ1Q2"/>
        </identifiers>
        <balance>204283</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>13319251.6</valUSD>
        <pctVal>0.2484978606</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Abbott Laboratories</name>
        <lei>HQD377W2YR662HK5JX27</lei>
        <title>Abbott Laboratories COM NPV</title>
        <cusip>002824100</cusip>
        <identifiers>
          <isin value="US0028241000"/>
          <ticker value="ABT"/>
          <other otherDesc="SEDOL" value="2002305"/>
        </identifiers>
        <balance>1130599</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>141652748.71</valUSD>
        <pctVal>2.6428215387</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>AbbVie Inc.</name>
        <lei>FR5LCKFTG8054YNNRU85</lei>
        <title>AbbVie Inc. COM USD0.01</title>
        <cusip>00287Y109</cusip>
        <identifiers>
          <isin value="US00287Y1091"/>
          <ticker value="ABBV"/>
          <other otherDesc="SEDOL" value="B92SR70"/>
        </identifiers>
        <balance>794492</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>181533477.08</valUSD>
        <pctVal>3.3868780351</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Ardelyx Inc</name>
        <lei>549300F542QR4SXHCY32</lei>
        <title>Ardelyx Inc COM USD0.0001</title>
        <cusip>039697107</cusip>
        <identifiers>
          <isin value="US0396971071"/>
          <ticker value="ARDX"/>
          <other otherDesc="SEDOL" value="BN89V40"/>
        </identifiers>
        <balance>3109866</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>18130518.78</valUSD>
        <pctVal>0.3382618832</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Dyne Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>Dyne Therapeutics Inc. COM</title>
        <cusip>26818M108</cusip>
        <identifiers>
          <isin value="US26818M1080"/>
          <ticker value="DYN"/>
          <other otherDesc="SEDOL" value="BN15WD1"/>
        </identifiers>
        <balance>2519217</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>49275884.52</valUSD>
        <pctVal>0.9193423363</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>United Therapeutics Corporation</name>
        <lei>5299005C4HZL4UWROC14</lei>
        <title>United Therapeutics Corporation COM USD0.01</title>
        <cusip>91307C102</cusip>
        <identifiers>
          <isin value="US91307C1027"/>
          <ticker value="UTHR"/>
          <other otherDesc="SEDOL" value="2430412"/>
        </identifiers>
        <balance>106924</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>52098719</valUSD>
        <pctVal>0.9720080829</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Vaxcyte Inc</name>
        <lei>254900M7NMHTGASX8D95</lei>
        <title>Vaxcyte Inc COM</title>
        <cusip>92243G108</cusip>
        <identifiers>
          <isin value="US92243G1085"/>
          <ticker value="PCVX"/>
          <other otherDesc="SEDOL" value="BKPVGH6"/>
        </identifiers>
        <balance>973715</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>44927210.1</valUSD>
        <pctVal>0.8382089272</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Vertex Pharmaceuticals Incorporated</name>
        <lei>54930015RAQRRZ5ZGJ91</lei>
        <title>Vertex Pharmaceuticals Incorporated COM USD0.01</title>
        <cusip>92532F100</cusip>
        <identifiers>
          <isin value="US92532F1003"/>
          <ticker value="VRTX"/>
          <other otherDesc="SEDOL" value="2931034"/>
        </identifiers>
        <balance>240492</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>109029453.12</valUSD>
        <pctVal>2.0341672836</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Xenon Pharmaceuticals Inc</name>
        <lei>549300XV44Q9Z1MIPQ03</lei>
        <title>Xenon Pharmaceuticals Inc COM NPV</title>
        <cusip>98420N105</cusip>
        <identifiers>
          <isin value="CA98420N1050"/>
          <ticker value="XENE"/>
          <other otherDesc="SEDOL" value="BRJ3GY4"/>
        </identifiers>
        <balance>312636</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>14012345.52</valUSD>
        <pctVal>0.2614289443</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Edgewise Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>Edgewise Therapeutics Inc. COM</title>
        <cusip>28036F105</cusip>
        <identifiers>
          <isin value="US28036F1057"/>
          <ticker value="EWTX"/>
          <other otherDesc="SEDOL" value="BKY5JZ8"/>
        </identifiers>
        <balance>617627</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>15326414.01</valUSD>
        <pctVal>0.2859455777</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Eli Lilly &amp; Co.</name>
        <lei>FRDRIPF3EKNDJ2CQJL29</lei>
        <title>Eli Lilly &amp; Co. COM NPV</title>
        <cusip>532457108</cusip>
        <identifiers>
          <isin value="US5324571083"/>
          <ticker value="LLY"/>
          <other otherDesc="SEDOL" value="2516152"/>
        </identifiers>
        <balance>481268</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>517209094.24</valUSD>
        <pctVal>9.6495927309</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Align Technology Inc.</name>
        <lei>549300N5YSE0U3LCP840</lei>
        <title>Align Technology Inc. COM USD0.0001</title>
        <cusip>016255101</cusip>
        <identifiers>
          <isin value="US0162551016"/>
          <ticker value="ALGN"/>
          <other otherDesc="SEDOL" value="2679204"/>
        </identifiers>
        <balance>7287</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1137865.05</valUSD>
        <pctVal>0.0212291981</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Cencora Inc</name>
        <lei>AI8GXW8LG5WK7E9UD086</lei>
        <title>Cencora Inc COM USD0.01</title>
        <cusip>03073E105</cusip>
        <identifiers>
          <isin value="US03073E1055"/>
          <ticker value="COR"/>
          <other otherDesc="SEDOL" value="2795393"/>
        </identifiers>
        <balance>161927</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>54690844.25</valUSD>
        <pctVal>1.0203694773</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Amgen Inc.</name>
        <lei>62QBXGPJ34PQ72Z12S66</lei>
        <title>Amgen Inc. COM USD0.0001</title>
        <cusip>031162100</cusip>
        <identifiers>
          <isin value="US0311621009"/>
          <ticker value="AMGN"/>
          <other otherDesc="SEDOL" value="2023607"/>
        </identifiers>
        <balance>351048</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>114901520.88</valUSD>
        <pctVal>2.1437227090</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Argenx SE</name>
        <lei>7245009C5FZE6G9ODQ71</lei>
        <title>Argenx SE SPON ADR EACH REP 1 ORD SHS</title>
        <cusip>04016X101</cusip>
        <identifiers>
          <isin value="US04016X1019"/>
          <ticker value="ARGX"/>
          <other otherDesc="SEDOL" value="BDVLM39"/>
        </identifiers>
        <balance>167389</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>140765779.55</valUSD>
        <pctVal>2.6262733162</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetConditional assetCat="OTHER" desc="GDR"/>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Ascendis Pharma A/S</name>
        <lei>549300B66JN3W3J8GH73</lei>
        <title>Ascendis Pharma A/S SPON ADR EACH REP 1 ORD SHS</title>
        <cusip>04351P101</cusip>
        <identifiers>
          <isin value="US04351P1012"/>
          <ticker value="ASND"/>
          <other otherDesc="SEDOL" value="BV9G6B8"/>
        </identifiers>
        <balance>375734</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>80121518.16</valUSD>
        <pctVal>1.4948306745</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetConditional assetCat="OTHER" desc="GDR"/>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Avidity Biosciences Inc.</name>
        <lei>N/A</lei>
        <title>Avidity Biosciences Inc. COM</title>
        <cusip>05370A108</cusip>
        <identifiers>
          <isin value="US05370A1088"/>
          <ticker value="RNA"/>
          <other otherDesc="SEDOL" value="BMWHPY1"/>
        </identifiers>
        <balance>733241</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>52888673.33</valUSD>
        <pctVal>0.9867462954</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Zoetis Inc.</name>
        <lei>549300HD9Q1LOC9KLJ48</lei>
        <title>Zoetis Inc. COM USD0.01 CL 'A'</title>
        <cusip>98978V103</cusip>
        <identifiers>
          <isin value="US98978V1035"/>
          <ticker value="ZTS"/>
          <other otherDesc="SEDOL" value="B95WG16"/>
        </identifiers>
        <balance>134911</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>16974502.02</valUSD>
        <pctVal>0.3166940279</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Magnolia Medical Technologies</name>
        <lei>N/A</lei>
        <title>Magnolia Medical Technologies</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="DU0000105108"/>
          <ticker value="1426815D"/>
          <other otherDesc="SEDOL" value="3321777"/>
        </identifiers>
        <balance>37748</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>37.75</valUSD>
        <pctVal>0.0000007043</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>

        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Becton, Dickinson and Company</name>
        <lei>ICE2EP6D98PQUILVRZ91</lei>
        <title>Becton, Dickinson and Company COM USD1.00</title>
        <cusip>075887109</cusip>
        <identifiers>
          <isin value="US0758871091"/>
          <ticker value="BDX"/>
          <other otherDesc="SEDOL" value="2087807"/>
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        <balance>166928</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>32395716.96</valUSD>
        <pctVal>0.6044083106</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>AstraZeneca PLC</name>
        <lei>PY6ZZQWO2IZFZC3IOL08</lei>
        <title>AstraZeneca PLC ORD USD0.25</title>
        <cusip>G0593M107</cusip>
        <identifiers>
          <isin value="GB0009895292"/>
          <ticker value="AZNCF"/>
          <other otherDesc="SEDOL" value="0989529"/>
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        <balance>1240485</balance>
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        <currencyConditional curCd="GBP" exchangeRt="0.742"/>
        <valUSD>228446409.25</valUSD>
        <pctVal>4.2621346659</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>GB</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
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      <invstOrSec>
        <name>Boston Scientific Corporation</name>
        <lei>Y6ZDD9FP4P8JSSJMW954</lei>
        <title>Boston Scientific Corporation COM USD0.01</title>
        <cusip>101137107</cusip>
        <identifiers>
          <isin value="US1011371077"/>
          <ticker value="BSX"/>
          <other otherDesc="SEDOL" value="2113434"/>
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        <balance>1318073</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>125678260.55</valUSD>
        <pctVal>2.3447848132</pctVal>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Bridgebio Pharma Inc</name>
        <lei>54930028YG89VTY2J114</lei>
        <title>Bridgebio Pharma Inc COM USD0.001</title>
        <cusip>10806X102</cusip>
        <identifiers>
          <isin value="US10806X1028"/>
          <ticker value="BBIO"/>
          <other otherDesc="SEDOL" value="BK1KWG8"/>
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        <balance>1477488</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>113013057.12</valUSD>
        <pctVal>2.1084895579</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Sanofi SA</name>
        <lei>549300E9PC51EN656011</lei>
        <title>Sanofi SA EUR2</title>
        <cusip>F5548N101</cusip>
        <identifiers>
          <isin value="FR0000120578"/>
          <ticker value="SNYNF"/>
          <other otherDesc="SEDOL" value="5671735"/>
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        <balance>1261100</balance>
        <units>NS</units>
        <currencyConditional curCd="EUR" exchangeRt="0.85099"/>
        <valUSD>122338850.44</valUSD>
        <pctVal>2.2824812925</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>FR</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Roche Holding AG</name>
        <lei>549300U41AUUVOAAOB37</lei>
        <title>Roche Holding AG GENUSSCHEINE NPV</title>
        <cusip>H69293217</cusip>
        <identifiers>
          <isin value="CH0012032048"/>
          <ticker value="RHHVF"/>
          <other otherDesc="SEDOL" value="7110388"/>
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        <balance>275465</balance>
        <units>NS</units>
        <currencyConditional curCd="CHF" exchangeRt="0.7919"/>
        <valUSD>113869638.68</valUSD>
        <pctVal>2.1244708376</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EP</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>CH</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>CVS Health Corp</name>
        <lei>549300EJG376EN5NQE29</lei>
        <title>CVS Health Corp COM USD0.01</title>
        <cusip>126650100</cusip>
        <identifiers>
          <isin value="US1266501006"/>
          <ticker value="CVS"/>
          <other otherDesc="SEDOL" value="2577609"/>
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        <balance>1021515</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>81067430.4</valUSD>
        <pctVal>1.5124786006</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Centene Corp.</name>
        <lei>549300Z7JJ4TQSQGT333</lei>
        <title>Centene Corp. COM USD0.001</title>
        <cusip>15135B101</cusip>
        <identifiers>
          <isin value="US15135B1017"/>
          <ticker value="CNC"/>
          <other otherDesc="SEDOL" value="2807061"/>
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        <balance>339642</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>13976268.3</valUSD>
        <pctVal>0.2607558500</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Cogent Biosciences Inc.</name>
        <lei>N/A</lei>
        <title>Cogent Biosciences Inc. COM</title>
        <cusip>19240Q201</cusip>
        <identifiers>
          <isin value="US19240Q2012"/>
          <ticker value="COGT"/>
          <other otherDesc="SEDOL" value="BLR6XK8"/>
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        <balance>408854</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>14522494.08</valUSD>
        <pctVal>0.2709468083</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>The Cooper Companies, Inc.</name>
        <lei>QJKMVPIGLH7530PCUE20</lei>
        <title>The Cooper Companies, Inc. COM</title>
        <cusip>216648501</cusip>
        <identifiers>
          <isin value="US2166485019"/>
          <ticker value="COO"/>
          <other otherDesc="SEDOL" value="BQPDXR3"/>
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        <balance>321068</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>26314733.28</valUSD>
        <pctVal>0.4909551317</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Revolution Medicines Inc</name>
        <lei>549300JU3X0LBCQ65892</lei>
        <title>Revolution Medicines Inc COM</title>
        <cusip>76155X100</cusip>
        <identifiers>
          <isin value="US76155X1000"/>
          <ticker value="RVMD"/>
          <other otherDesc="SEDOL" value="BL71K91"/>
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        <balance>1294495</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>103106526.75</valUSD>
        <pctVal>1.9236629868</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Rhythm Pharmaceuticals Inc</name>
        <lei>529900JPNWXQ8DPLA551</lei>
        <title>Rhythm Pharmaceuticals Inc COM USD0.001</title>
        <cusip>76243J105</cusip>
        <identifiers>
          <isin value="US76243J1051"/>
          <ticker value="RYTM"/>
          <other otherDesc="SEDOL" value="BF2YWG4"/>
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        <balance>191235</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>20469794.4</valUSD>
        <pctVal>0.3819058509</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Crinetics Pharmaceuticals Inc.</name>
        <lei>549300Q1CNFXK5P31D28</lei>
        <title>Crinetics Pharmaceuticals Inc. COM USD0.001</title>
        <cusip>22663K107</cusip>
        <identifiers>
          <isin value="US22663K1079"/>
          <ticker value="CRNX"/>
          <other otherDesc="SEDOL" value="BDD19F8"/>
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        <balance>299801</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>13955736.55</valUSD>
        <pctVal>0.2603727882</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Danaher Corporation</name>
        <lei>S4BKK9OTCEWQ3YHPFM11</lei>
        <title>Danaher Corporation COM USD0.01</title>
        <cusip>235851102</cusip>
        <identifiers>
          <isin value="US2358511028"/>
          <ticker value="DHR"/>
          <other otherDesc="SEDOL" value="2250870"/>
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        <balance>415394</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>95091994.48</valUSD>
        <pctVal>1.7741355071</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>DexCom Inc</name>
        <lei>549300YSK3QDSFR5EU59</lei>
        <title>DexCom Inc COM USD0.001</title>
        <cusip>252131107</cusip>
        <identifiers>
          <isin value="US2521311074"/>
          <ticker value="DXCM"/>
          <other otherDesc="SEDOL" value="B0796X4"/>
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        <balance>423924</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>28135835.88</valUSD>
        <pctVal>0.5249315227</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Edwards Lifesciences Corporation</name>
        <lei>YA13X31F3V31L8TMPR58</lei>
        <title>Edwards Lifesciences Corporation COM USD1</title>
        <cusip>28176E108</cusip>
        <identifiers>
          <isin value="US28176E1082"/>
          <ticker value="EW"/>
          <other otherDesc="SEDOL" value="2567116"/>
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        <balance>462871</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>39459752.75</valUSD>
        <pctVal>0.7362023358</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Element Biosciences Inc</name>
        <lei>N/A</lei>
        <title>Element Biosciences Inc</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="DU0000104465"/>
          <ticker value="1726116D"/>
          <other otherDesc="Internal ID" value="3312013"/>
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        <balance>425023</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2461308.19</valUSD>
        <pctVal>0.0459207347</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EP</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>

        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Attralus Inc</name>
        <lei>N/A</lei>
        <title>Attralus Inc</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="DU0000104336"/>
          <ticker value="1829635D"/>
          <other otherDesc="Internal ID" value="3344845"/>
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        <balance>669935</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>415359.7</valUSD>
        <pctVal>0.0077493841</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EP</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>

        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Sonoma Biotherapeutics Inc</name>
        <lei>N/A</lei>
        <title>Sonoma Biotherapeutics Inc - Series B-1</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="DU0000106193"/>
          <ticker value="1783532D"/>
          <other otherDesc="Internal ID" value="3315413"/>
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        <balance>669428</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1051001.96</valUSD>
        <pctVal>0.0196085896</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EP</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>

        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>KARDIUM SERIES 8 CLASS D PREFERRED SHARES USD</name>
        <lei>N/A</lei>
        <title>Kardium Inc - Series 8 Class D Preferred shares</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="DU0US0007846"/>
          <other otherDesc="Internal ID" value="3333615"/>
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        <balance>13234820</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>12237311.62</valUSD>
        <pctVal>0.2283120590</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EP</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>CA</invCountry>

        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>KARDIUM SERIES 8 CLASS D PREFERRED SHARES USD</name>
        <lei>N/A</lei>
        <title>HeartFlow Inc</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="DU0US0008223"/>
          <other otherDesc="Internal ID" value="3348593"/>
        </identifiers>
        <balance>131576</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3835440.4</valUSD>
        <pctVal>0.0715579796</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>

        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Sonoma Biotherapeutics Inc</name>
        <lei>N/A</lei>
        <title>Sonoma Biotherapeutics Inc - Series B</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="DU0000104500"/>
          <ticker value="1783532D"/>
          <other otherDesc="Internal ID" value="3355474"/>
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        <balance>1255200</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1970664</valUSD>
        <pctVal>0.0367667646</pctVal>
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        <assetCat>EP</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>

        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Lantheus Holdings Inc</name>
        <lei>5299005HUB5IOJGO7S39</lei>
        <title>Lantheus Holdings Inc COM USD0.01</title>
        <cusip>516544103</cusip>
        <identifiers>
          <isin value="US5165441032"/>
          <ticker value="LNTH"/>
          <other otherDesc="SEDOL" value="BP8S8J5"/>
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        <balance>525258</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>34955919.9</valUSD>
        <pctVal>0.6521741290</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Lexeo Therapeutics Inc</name>
        <lei>N/A</lei>
        <title>Lexeo Therapeutics Inc COM</title>
        <cusip>52886X107</cusip>
        <identifiers>
          <isin value="US52886X1072"/>
          <ticker value="LXEO"/>
          <other otherDesc="SEDOL" value="BQ6C357"/>
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        <balance>632552</balance>
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        <curCd>USD</curCd>
        <valUSD>6281241.36</valUSD>
        <pctVal>0.1171893952</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Scholar Rock Holding Corp.</name>
        <lei>549300Z1FLPGL4OWJ459</lei>
        <title>Scholar Rock Holding Corp. COM USD0.001</title>
        <cusip>80706P103</cusip>
        <identifiers>
          <isin value="US80706P1030"/>
          <ticker value="SRRK"/>
          <other otherDesc="SEDOL" value="BFZQ0L8"/>
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        <balance>340484</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>14998320.2</valUSD>
        <pctVal>0.2798243171</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Soleno Therapeutics Inc</name>
        <lei>5493003LCY77N7FXK844</lei>
        <title>Soleno Therapeutics Inc COM</title>
        <cusip>834203309</cusip>
        <identifiers>
          <isin value="US8342033094"/>
          <ticker value="SLNO"/>
          <other otherDesc="SEDOL" value="BL6JK96"/>
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        <balance>1001983</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>46391812.9</valUSD>
        <pctVal>0.8655340858</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Sotera Health Company</name>
        <lei>N/A</lei>
        <title>Sotera Health Company COM</title>
        <cusip>83601L102</cusip>
        <identifiers>
          <isin value="US83601L1026"/>
          <ticker value="SHC"/>
          <other otherDesc="SEDOL" value="BNKVRZ7"/>
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        <balance>1054251</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>18596987.64</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Stryker Corporation</name>
        <lei>5493002F0SC4JTBU5137</lei>
        <title>Stryker Corporation COM USD0.10</title>
        <cusip>863667101</cusip>
        <identifiers>
          <isin value="US8636671013"/>
          <ticker value="SYK"/>
          <other otherDesc="SEDOL" value="2853688"/>
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        <balance>249313</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>87626040.11</valUSD>
        <pctVal>1.6348428693</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Structure Therapeutics Inc</name>
        <lei>N/A</lei>
        <title>Structure Therapeutics Inc SPONSORED ADS</title>
        <cusip>86366E106</cusip>
        <identifiers>
          <isin value="US86366E1064"/>
          <ticker value="GPCR"/>
          <other otherDesc="SEDOL" value="BQS9486"/>
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        <balance>574288</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>39941730.4</valUSD>
        <pctVal>0.7451946140</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetConditional assetCat="OTHER" desc="GDR"/>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Tarsus Pharmaceuticals Inc</name>
        <lei>N/A</lei>
        <title>Tarsus Pharmaceuticals Inc COM</title>
        <cusip>87650L103</cusip>
        <identifiers>
          <isin value="US87650L1035"/>
          <ticker value="TARS"/>
          <other otherDesc="SEDOL" value="BMH5RL1"/>
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        <balance>275745</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>22578000.6</valUSD>
        <pctVal>0.4212387464</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Teleflex Incorporated</name>
        <lei>UUL85LWXB4NGSWWXIQ25</lei>
        <title>Teleflex Incorporated COM USD1</title>
        <cusip>879369106</cusip>
        <identifiers>
          <isin value="US8793691069"/>
          <ticker value="TFX"/>
          <other otherDesc="SEDOL" value="2881407"/>
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        <balance>101052</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>12332386.08</valUSD>
        <pctVal>0.2300858674</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Terns Pharmaceuticals Inc.</name>
        <lei>254900S1ZDQMF4MYP709</lei>
        <title>Terns Pharmaceuticals Inc. COM</title>
        <cusip>880881107</cusip>
        <identifiers>
          <isin value="US8808811074"/>
          <ticker value="TERN"/>
          <other otherDesc="SEDOL" value="BMDJ0C9"/>
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        <balance>339533</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>13717133.2</valUSD>
        <pctVal>0.2559211551</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Teva Pharmaceutical Industries Ltd.</name>
        <lei>549300BAFGM4RC74ZJ94</lei>
        <title>Teva Pharmaceutical Industries Ltd. SPON ADS EACH REP 1 ORD SHS</title>
        <cusip>881624209</cusip>
        <identifiers>
          <isin value="US8816242098"/>
          <ticker value="TEVA"/>
          <other otherDesc="SEDOL" value="2883878"/>
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        <balance>2045096</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>63827446.16</valUSD>
        <pctVal>1.1908314594</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetConditional assetCat="OTHER" desc="GDR"/>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Thermo Fisher Scientific Inc</name>
        <lei>HCHV7422L5HDJZCRFL38</lei>
        <title>Thermo Fisher Scientific Inc COM USD1</title>
        <cusip>883556102</cusip>
        <identifiers>
          <isin value="US8835561023"/>
          <ticker value="TMO"/>
          <other otherDesc="SEDOL" value="2886907"/>
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        <balance>212153</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>122932055.85</valUSD>
        <pctVal>2.2935487518</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Travere Therapeutics Inc</name>
        <lei>N/A</lei>
        <title>Travere Therapeutics Inc COM</title>
        <cusip>89422G107</cusip>
        <identifiers>
          <isin value="US89422G1076"/>
          <ticker value="TVTX"/>
          <other otherDesc="SEDOL" value="BLFGJD5"/>
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        <balance>1437191</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>54915068.11</valUSD>
        <pctVal>1.0245528316</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Steris PLC</name>
        <lei>N/A</lei>
        <title>Steris PLC ORD USD0.001</title>
        <cusip>G8473T100</cusip>
        <identifiers>
          <isin value="IE00BFY8C754"/>
          <ticker value="STE"/>
          <other otherDesc="SEDOL" value="BFY8C75"/>
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        <balance>81625</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>20693570</valUSD>
        <pctVal>0.3860808421</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Freenome Holdings Inc</name>
        <lei>N/A</lei>
        <title>Freenome Holdings Inc - Series D</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="DU0000104596"/>
          <ticker value="1411948D"/>
          <other otherDesc="Internal ID" value="3357975"/>
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        <balance>342803</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1016205.21</valUSD>
        <pctVal>0.0189593851</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EP</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>

        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Asher Biotherapeutics Inc</name>
        <lei>N/A</lei>
        <title>Asher Biotherapeutics - Series C</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="DU0US0006305"/>
          <other otherDesc="Internal ID" value="3372993"/>
        </identifiers>
        <balance>2580733</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>809963.05</valUSD>
        <pctVal>0.0151115161</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EP</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>

        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Twinstrand Biosciences Inc</name>
        <lei>N/A</lei>
        <title>TwinStrand Biosciences Inc</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="DU0000104396"/>
          <ticker value="1724622D"/>
          <other otherDesc="Internal ID" value="3379447"/>
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        <balance>344314</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1380526.98</valUSD>
        <pctVal>0.0257565523</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EP</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>

        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>4D Molecular Therapeutics Inc</name>
        <lei>N/A</lei>
        <title>4D Molecular Therapeutics Inc COM</title>
        <cusip>35104E100</cusip>
        <identifiers>
          <isin value="US35104E1001"/>
          <ticker value="FDMT"/>
          <other otherDesc="SEDOL" value="BKLXFX5"/>
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        <balance>842520</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>6318900</valUSD>
        <pctVal>0.1178919941</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>KARDIUM SERIES 8 CLASS D PREFERRED SHARES USD</name>
        <lei>N/A</lei>
        <title>HeartFlow Inc</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="DU0000106284"/>
          <other otherDesc="Internal ID" value="3301624"/>
        </identifiers>
        <balance>13699</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>399325.85</valUSD>
        <pctVal>0.0074502399</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>

        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Green Cross Holdings Corp</name>
        <lei>N/A</lei>
        <title>Curevo Inc</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="DU0000105594"/>
          <ticker value="CUREVOPP"/>
          <other otherDesc="Internal ID" value="3303679"/>
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        <balance>2031087</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>5330344.1</valUSD>
        <pctVal>0.0994484634</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EP</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>

        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Gilead Sciences Inc.</name>
        <lei>549300WTZWR07K8MNV44</lei>
        <title>Gilead Sciences Inc. COM USD0.001</title>
        <cusip>375558103</cusip>
        <identifiers>
          <isin value="US3755581036"/>
          <ticker value="GILD"/>
          <other otherDesc="SEDOL" value="2369174"/>
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        <balance>478997</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>58792091.78</valUSD>
        <pctVal>1.0968866321</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Asher Biotherapeutics Inc</name>
        <lei>N/A</lei>
        <title>Asher Biotherapeutics Inc</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="DU0000101918"/>
          <ticker value="1741988D"/>
          <other otherDesc="Internal ID" value="3921287"/>
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        <balance>1214301</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>381108.37</valUSD>
        <pctVal>0.0071103556</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EP</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>

        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Hemoshear Therapeutics LLC</name>
        <lei>N/A</lei>
        <title>Magnolia Medical Technologies</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="DU0US0010115"/>
          <other otherDesc="Internal ID" value="3341118"/>
        </identifiers>
        <balance>301933</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>411789.81</valUSD>
        <pctVal>0.0076827805</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EP</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>

        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Green Cross Holdings Corp</name>
        <lei>N/A</lei>
        <title>Curevo Inc - Series B-1</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="DU0US0007429"/>
          <other otherDesc="Internal ID" value="3357506"/>
        </identifiers>
        <balance>886774</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2327231.95</valUSD>
        <pctVal>0.0434192685</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EP</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>

        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Freenome Holdings Inc</name>
        <lei>N/A</lei>
        <title>Freenome Holdings Inc - Series C</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="DU0000103893"/>
          <other otherDesc="Internal ID" value="3927974"/>
        </identifiers>
        <balance>337474</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>997910.62</valUSD>
        <pctVal>0.0186180622</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EP</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>

        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>UCB SA</name>
        <lei>2138008J191VLSGY5A09</lei>
        <title>UCB SA NPV</title>
        <cusip>B93562120</cusip>
        <identifiers>
          <isin value="BE0003739530"/>
          <ticker value="UCBJF"/>
          <other otherDesc="SEDOL" value="5596991"/>
        </identifiers>
        <balance>131102</balance>
        <units>NS</units>
        <currencyConditional curCd="EUR" exchangeRt="0.85099"/>
        <valUSD>36563544.57</valUSD>
        <pctVal>0.6821676529</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>BE</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>HeartFlow Inc</name>
        <lei>N/A</lei>
        <title>HeartFlow Inc - Series F</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="DU0000106398"/>
          <ticker value="0348323Z"/>
          <other otherDesc="Internal ID" value="3373726"/>
        </identifiers>
        <balance>662334</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>19307036.1</valUSD>
        <pctVal>0.3602122184</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>

        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Glaukos Corp.</name>
        <lei>5299004JA1LHE21M6T14</lei>
        <title>Glaukos Corp. COM USD0.001</title>
        <cusip>377322102</cusip>
        <identifiers>
          <isin value="US3773221029"/>
          <ticker value="GKOS"/>
          <other otherDesc="SEDOL" value="BYMWL19"/>
        </identifiers>
        <balance>219939</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>24833312.49</valUSD>
        <pctVal>0.4633161991</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Globus Med Inc</name>
        <lei>5299003M2P4CIK0RF205</lei>
        <title>Globus Med Inc COM USD0.001 CL 'A'</title>
        <cusip>379577208</cusip>
        <identifiers>
          <isin value="US3795772082"/>
          <ticker value="GMED"/>
          <other otherDesc="SEDOL" value="B7D65M0"/>
        </identifiers>
        <balance>753721</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>65807380.51</valUSD>
        <pctVal>1.2277711813</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>HCA Healthcare Inc</name>
        <lei>529900PH4ZGUH2MNEU89</lei>
        <title>HCA Healthcare Inc COM USD0.01</title>
        <cusip>40412C101</cusip>
        <identifiers>
          <isin value="US40412C1018"/>
          <ticker value="HCA"/>
          <other otherDesc="SEDOL" value="B4MGBG6"/>
        </identifiers>
        <balance>224626</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>104868894.36</valUSD>
        <pctVal>1.9565435565</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Humana Inc.</name>
        <lei>529900YLDW34GJAO4J06</lei>
        <title>Humana Inc. COM USD0.166</title>
        <cusip>444859102</cusip>
        <identifiers>
          <isin value="US4448591028"/>
          <ticker value="HUM"/>
          <other otherDesc="SEDOL" value="2445063"/>
        </identifiers>
        <balance>52553</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>13460399.89</valUSD>
        <pctVal>0.2511312705</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>IDEAYA Biosciences Inc.</name>
        <lei>549300ULW08F62IJML11</lei>
        <title>IDEAYA Biosciences Inc. COM USD0.0001</title>
        <cusip>45166A102</cusip>
        <identifiers>
          <isin value="US45166A1025"/>
          <ticker value="IDYA"/>
          <other otherDesc="SEDOL" value="BK0VHF6"/>
        </identifiers>
        <balance>763325</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>26388145.25</valUSD>
        <pctVal>0.4923247820</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Illumina Inc</name>
        <lei>SQ95QG8SR5Q56LSNF682</lei>
        <title>Illumina Inc COM USD0.01</title>
        <cusip>452327109</cusip>
        <identifiers>
          <isin value="US4523271090"/>
          <ticker value="ILMN"/>
          <other otherDesc="SEDOL" value="2613990"/>
        </identifiers>
        <balance>101851</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>13358777.16</valUSD>
        <pctVal>0.2492352907</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Immunome Inc</name>
        <lei>N/A</lei>
        <title>Immunome Inc COM</title>
        <cusip>45257U108</cusip>
        <identifiers>
          <isin value="US45257U1088"/>
          <ticker value="IMNM"/>
          <other otherDesc="SEDOL" value="BM8FWX7"/>
        </identifiers>
        <balance>368171</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>7908313.08</valUSD>
        <pctVal>0.1475457436</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Insmed Inc</name>
        <lei>529900Q55QAG41CCAC11</lei>
        <title>Insmed Inc COM USD0.01</title>
        <cusip>457669307</cusip>
        <identifiers>
          <isin value="US4576693075"/>
          <ticker value="INSM"/>
          <other otherDesc="SEDOL" value="2614487"/>
        </identifiers>
        <balance>80434</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>13998733.36</valUSD>
        <pctVal>0.2611749816</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Inspire Medical Systems Inc</name>
        <lei>549300XQQCQ7HCJKTW25</lei>
        <title>Inspire Medical Systems Inc COM USD0.001</title>
        <cusip>457730109</cusip>
        <identifiers>
          <isin value="US4577301090"/>
          <ticker value="INSP"/>
          <other otherDesc="SEDOL" value="BDT5KT5"/>
        </identifiers>
        <balance>144942</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>13368000.66</valUSD>
        <pctVal>0.2494073740</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Insulet Corporation</name>
        <lei>549300TZTYD2PYN92D43</lei>
        <title>Insulet Corporation COM STK USD0.001</title>
        <cusip>45784P101</cusip>
        <identifiers>
          <isin value="US45784P1012"/>
          <ticker value="PODD"/>
          <other otherDesc="SEDOL" value="B1XGNW4"/>
        </identifiers>
        <balance>36426</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>10353726.24</valUSD>
        <pctVal>0.1931699241</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Intuitive Surgical Inc.</name>
        <lei>54930052SRG011710797</lei>
        <title>Intuitive Surgical Inc. COM USD0.001</title>
        <cusip>46120E602</cusip>
        <identifiers>
          <isin value="US46120E6023"/>
          <ticker value="ISRG"/>
          <other otherDesc="SEDOL" value="2871301"/>
        </identifiers>
        <balance>217842</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>123376995.12</valUSD>
        <pctVal>2.3018500033</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>UnitedHealth Group Inc.</name>
        <lei>549300GHBMY8T5GXDE41</lei>
        <title>UnitedHealth Group Inc. COM USD0.01</title>
        <cusip>91324P102</cusip>
        <identifiers>
          <isin value="US91324P1021"/>
          <ticker value="UNH"/>
          <other otherDesc="SEDOL" value="2917766"/>
        </identifiers>
        <balance>557669</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>184092113.59</valUSD>
        <pctVal>3.4346146286</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Daiichi Sankyo Co Ltd.</name>
        <lei>353800XGIU2IHQGC9504</lei>
        <title>Daiichi Sankyo Co Ltd. NPV</title>
        <cusip>J11257102</cusip>
        <identifiers>
          <isin value="JP3475350009"/>
          <ticker value="DSKYF"/>
          <other otherDesc="SEDOL" value="B0J7D91"/>
        </identifiers>
        <balance>1647700</balance>
        <units>NS</units>
        <currencyConditional curCd="JPY" exchangeRt="156.62"/>
        <valUSD>35096624.18</valUSD>
        <pctVal>0.6547992550</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>JP</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Avadel Pharmaceuticals PLC</name>
        <lei>549300E27PTSG2RHC762</lei>
        <title>Avadel Pharmaceuticals PLC COM SHS</title>
        <cusip>G29687103</cusip>
        <identifiers>
          <isin value="IE00BDGMC594"/>
          <ticker value="AVDL"/>
          <other otherDesc="SEDOL" value="BDGMC59"/>
        </identifiers>
        <balance>476744</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>10273833.2</valUSD>
        <pctVal>0.1916793561</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Janux Therapeutics Inc</name>
        <lei>N/A</lei>
        <title>Janux Therapeutics Inc COM</title>
        <cusip>47103J105</cusip>
        <identifiers>
          <isin value="US47103J1051"/>
          <ticker value="JANX"/>
          <other otherDesc="SEDOL" value="BMFX8Y7"/>
        </identifiers>
        <balance>719025</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>9922545</valUSD>
        <pctVal>0.1851253568</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Johnson &amp; Johnson</name>
        <lei>549300G0CFPGEF6X2043</lei>
        <title>Johnson &amp; Johnson COM USD1.00</title>
        <cusip>478160104</cusip>
        <identifiers>
          <isin value="US4781601046"/>
          <ticker value="JNJ"/>
          <other otherDesc="SEDOL" value="2475833"/>
        </identifiers>
        <balance>1444532</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>298945897.4</valUSD>
        <pctVal>5.5774467050</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>JANUS CAPITAL GROUP INC</name>
        <lei>N/A</lei>
        <title>Janus Henderson Cash Liquidity Fund LLC</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal ID" value="895"/>
        </identifiers>
        <balance>40171470.6742</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>40183522.12</valUSD>
        <pctVal>0.7497057327</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>PF</issuerCat>
        <invCountry>US</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Janus Henderson Cash Collateral Fund</name>
        <lei>N/A</lei>
        <title>Janus Henderson Cash Collateral Fund</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal ID" value="896"/>
        </identifiers>
        <balance>18730800</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>18730800</valUSD>
        <pctVal>0.3494613562</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>PF</issuerCat>
        <invCountry>US</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <securityLending>
          <cashCollateralCondition cashCollateralVal="18730800.000000000000" isCashCollateral="Y"/>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>N/A</name>
        <lei>N/A</lei>
        <title>Royal Bank of Canada</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Internal ID" value="RBC SL TD"/>
        </identifiers>
        <balance>4682700</balance>
        <units>PA</units>
        <curCd>USD</curCd>
        <valUSD>4682700</valUSD>
        <pctVal>0.0873653391</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>STIV</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <debtSec>
          <maturityDt>2026-01-02</maturityDt>
          <couponKind>Fixed</couponKind>
          <annualizedRt>3.85</annualizedRt>
          <isDefault>N</isDefault>
          <areIntrstPmntsInArrs>N</areIntrstPmntsInArrs>
          <isPaidKind>N</isPaidKind>
        </debtSec>
        <securityLending>
          <cashCollateralCondition cashCollateralVal="4682700.000000000000" isCashCollateral="Y"/>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
    </invstOrSecs>
    <explntrNotes>
      <explntrNote note="Monthly returns presented in Item B.5(a) have been calculated without deducting any applicable sales loads or redemption fees." noteItem="B.5.a"/>
    </explntrNotes>
    <signature>
      <ncom:dateSigned>2026-02-13</ncom:dateSigned>
      <ncom:nameOfApplicant>JANUS INVESTMENT FUND</ncom:nameOfApplicant>
      <ncom:signature>JESPER NERGAARD</ncom:signature>
      <ncom:signerName>JESPER NERGAARD</ncom:signerName>
      <ncom:title>VP, CFO, TREASURER, AND PRINCIPAL ACCOUNTING OFFICER</ncom:title>
    </signature>
  </formData>
  <documents>XXXX</documents>
</edgarSubmission>
