Summary quarterly information (unaudited) - Summary of Quarterly Information (Details) - USD ($) $ / shares in Units, $ in Thousands	3 Months Ended																12 Months Ended
	Dec. 31, 2021	[1]	Sep. 30, 2021	[2]	Jun. 30, 2021		Mar. 31, 2021		Dec. 31, 2020	[3]	Sep. 30, 2020	[4]	Jun. 30, 2020		Mar. 31, 2020		Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Quarterly Financial Information Disclosure [Abstract]
Total revenue, net	$ 18,678		$ 25,406		$ 23,001		$ 19,866		$ 22,578		$ 19,342		$ 10,701		$ 12,251		$ 86,951	$ 64,872	$ 49,647
Gross profit	13,941		20,124		18,869		15,179		16,997		16,063		6,301		9,536		68,113	48,897	43,312
Loss from operations	(35,392)		(39,921)		(35,179)		(29,278)		(34,607)		(24,974)		(45,038)		(50,922)		(139,770)	(155,541)	(151,205)
Net loss	$ (42,960)		$ (47,420)		$ (42,652)		$ (39,383)		$ (42,087)		$ (32,612)		$ (51,976)		$ (56,849)		$ (172,415)	$ (183,524)	$ (176,145)
Loss per common share, basic and diluted	$ (0.10)	[5]	$ (0.11)	[5]	$ (0.11)	[5]	$ (0.11)	[5]	$ (0.15)	[5]	$ (0.12)	[5]	$ (0.19)	[5]	$ (0.21)	[5]	$ (0.43)	$ (0.67)	$ (0.72)

[1] Included $5.1 million in senior executive severances, which included our former CEO.

[2] Included $7.3 million in senior executive severances, which included our former EVP of Operations.

[3] Included $0.5 million in write off of certain costs related to trademarks and patents.

[4] Included (i) $2.0 million in license revenue related to the Knight License Agreement, (ii) $5.7 million in inventory charge, primarily related to BIJUVA, and (iii) $0.6 million in write off of certain costs related to trademarks and patents.

[5] Basic and diluted loss per common share are computed independently for each quarter and the full year based upon respective weighted average shares outstanding. Therefore, the sum of the quarterly basic and diluted earnings per share amounts may not equal the annual basic and diluted earnings per share amounts reported.