Loss per common share - Summary of computation of basic and diluted loss per common share (Details) - USD ($) $ / shares in Units, shares in Thousands, $ in Thousands	3 Months Ended																12 Months Ended
	Dec. 31, 2021	[1]	Sep. 30, 2021	[2]	Jun. 30, 2021		Mar. 31, 2021		Dec. 31, 2020	[3]	Sep. 30, 2020	[4]	Jun. 30, 2020		Mar. 31, 2020		Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Numerator:
Net loss	$ (42,960)		$ (47,420)		$ (42,652)		$ (39,383)		$ (42,087)		$ (32,612)		$ (51,976)		$ (56,849)		$ (172,415)	$ (183,524)	$ (176,145)
Denominator:
Weighted average common shares for basic loss per common share																	397,992	275,649	246,353
Effect of dilutive securities																	0	0	0
Weighted average common shares for diluted loss per common share																	397,992	275,649	246,353
Loss per common share, basic and diluted	$ (0.10)	[5]	$ (0.11)	[5]	$ (0.11)	[5]	$ (0.11)	[5]	$ (0.15)	[5]	$ (0.12)	[5]	$ (0.19)	[5]	$ (0.21)	[5]	$ (0.43)	$ (0.67)	$ (0.72)

[1] Included $5.1 million in senior executive severances, which included our former CEO.

[2] Included $7.3 million in senior executive severances, which included our former EVP of Operations.

[3] Included $0.5 million in write off of certain costs related to trademarks and patents.

[4] Included (i) $2.0 million in license revenue related to the Knight License Agreement, (ii) $5.7 million in inventory charge, primarily related to BIJUVA, and (iii) $0.6 million in write off of certain costs related to trademarks and patents.

[5] Basic and diluted loss per common share are computed independently for each quarter and the full year based upon respective weighted average shares outstanding. Therefore, the sum of the quarterly basic and diluted earnings per share amounts may not equal the annual basic and diluted earnings per share amounts reported.