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CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY - USD ($)
Common Stock [Member]
Additional Paid-in Capital [Member]
Retained Earnings [Member]
Total
Beginning balance, value at Dec. 31, 2016 $ 196,688 $ 436,995,052 $ (309,702,319) $ 127,489,421
Beginning balance (in shares) at Dec. 31, 2016 196,688,222      
Shares issued in offerings, net of cost $ 12,400 68,560,235 68,572,635
Shares issued in offerings, net of cost (in shares) 12,400,000      
Shares issued for exercise of options, net $ 103 212,512 $ 212,615
Shares issued for exercise of options, net (in shares) 102,546     102,546
Shares issued for exercise of warrants, net $ 7,239 3,791,760 $ 3,798,999
Shares issued for exercise of warrants, net (in shares) 7,238,874      
Share-based compensation 6,760,425 6,760,425
Adoption of ASU 2016-09 at Dec. 31, 2016 31,421 (31,421)
Net loss (76,925,380) (76,925,380)
Ending balance, value at Dec. 31, 2017 $ 216,430 516,351,405 (386,659,120) 129,908,715
Ending balance (in shares) at Dec. 31, 2017 216,429,642      
Shares issued in offerings, net of cost $ 18,578 89,889,219 89,907,797
Shares issued in offerings, net of cost (in shares) 18,578,430      
Shares issued for exercise of options, net $ 5,455 1,660,753 1,666,208
Shares issued for exercise of options, net (in shares) 5,454,367      
Share-based compensation 8,658,561 8,658,561
Net loss (132,617,160) (132,617,160)
Ending balance, value at Dec. 31, 2018 $ 240,463 616,559,938 (519,276,280) $ 97,524,121
Ending balance (in shares) at Dec. 31, 2018 240,462,439     240,462,439
Shares issued in offerings, net of cost $ 29,900 77,001,358 $ 77,031,258
Shares issued in offerings, net of cost (in shares) 29,900,000      
Share-based compensation   10,682,084 10,682,084
Net loss (176,144,999) (176,144,999)
Shares issued for exercise of options and warrants, net $ 814 107,842 108,656
Shares issued for exercise of options and warrants, net (in shares) 814,637      
Ending balance, value at Dec. 31, 2019 $ 271,177 $ 704,351,222 $ (695,421,279) $ 9,201,120
Ending balance (in shares) at Dec. 31, 2019 271,177,076     271,177,076