STOCKHOLDERS' EQUITY (Details Narrative) - USD ($)							12 Months Ended
	Aug. 06, 2018	Sep. 28, 2017	Sep. 25, 2017	Aug. 01, 2017	Jan. 12, 2016	Jan. 06, 2016	Dec. 31, 2018	Dec. 31, 2017	Dec. 31, 2016
Preferred stock, par value (in dollars per share)							$ 0.001	$ 0.001
Preferred stock, authorized							10,000,000	10,000,000
Common stock, authorized							350,000,000	350,000,000
Common stock, issued							240,462,439	216,429,642
Common stock, outstanding							240,462,439	216,429,642
Value of common stock issued during period for stock options exercised							$ 1,666,208	$ 212,615	$ 1,373,000
Proceeds from sale of common stock, net of costs							89,907,797	68,572,635	134,863,475
Underwriting Agreement [Member] | Goldman Sachs & Co. LLC, [Member]
Issue of common stock (in shares)				12,745,098
Issue of common stock (in dollars per shares)				$ 5.10
Common stock exercisable shares				1,911,764
Stock exercisable period				30 days
Net Proceeds				$ 69,908,000
Underwriting Agreement [Member] | J.P. Morgan Securities LLC [Member]
Issue of common stock (in shares)		12,400,000	12,400,000
Issue of common stock (in dollars per shares)			$ 5.55
Net Proceeds			$ 68,573,000
Knight License Agreement [Member] | Knight Therapeutics Inc. [Member]
Issue of common stock (in shares)	3,921,568
Issue of common stock (in dollars per shares)	$ 5.10
Net Proceeds	$ 20,000,000
Underwriting Agreement - Goldman and Cowen [Member]
Number of shares offered in underwriting agreement						15,151,515
Share price (in dollars per share)						$ 8.25
Number of days of the option to purchase shares						30 days
Additional common stock issued under offering						2,272,727
Proceeds from sale of common stock, net of costs						$ 134,864,000
Number of shares issued during the period					17,424,242
Stock Options [Member]
Value of common stock issued during period for stock options exercised							$ 1,666,208	$ 212,615	$ 989,060
Number of stock options exercised (in shares)							5,444,526	102,546	525,362
Number of stock options exercised in cashless exercise (in shares)							10,000		127,109
Number of common stock issued during period for stock options exercised in cashless exercise (in shares)							9,841		87,833