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CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($)
12 Months Ended
Dec. 31, 2017
Dec. 31, 2016
Dec. 31, 2015
CASH FLOWS FROM OPERATING ACTIVITIES      
Net loss $ (76,925,380) $ (89,875,459) $ (85,077,024)
Adjustments to reconcile net loss to net cash flows used in operating activities:      
Depreciation 141,601 77,906 29,959
Amortization of intangible assets 71,516 54,545 32,441
Provision for doubtful accounts 4,206 2,524,909 22,157
Share-based compensation 6,889,323 17,411,021 7,189,699
Changes in operating assets and liabilities:      
Accounts receivable 167,691 (3,975,893) (917,656)
Inventory (409,037) (386,168) 491,960
Other current assets (4,434,130) 709,907 (773,532)
Other assets     (17,442)
Accounts payable (3,260,914) 4,232,340 (3,200,955)
Deferred revenue     (522,613)
Other current liabilities 1,599,510 84,559 3,698,887
Net cash used in operating activities (76,155,614) (69,142,333) (79,044,119)
CASH FLOWS FROM INVESTING ACTIVITIES      
Patent costs (765,291) (845,266) (419,104)
Purchase of fixed assets (61,817) (396,154) (165,257)
Payment of security deposit   (14,036)  
Net cash used in investing activities (827,108) (1,255,456) (584,361)
CASH FLOWS FROM FINANCING ACTIVITIES      
Proceeds from sale of common stock, net of costs 68,572,635 134,863,475 91,374,649
Proceeds from exercise of options 212,615 989,060 1,232,579
Proceeds from exercise of warrants 3,798,999 1,373,000 366,000
Net cash provided by financing activities 72,584,249 137,225,535 92,973,228
(Decrease) increase in cash (4,398,473) 66,827,746 13,344,748
Cash, beginning of period 131,534,101 64,706,355 51,361,607
Cash, end of period $ 127,135,628 $ 131,534,101 $ 64,706,355