144 0002124755 XXXXXXXX LIVE 0001714899 Denali Therapeutics Inc. 001-38311 161 Oyster Point Blvd South San Francisco CA 94080 6508668547 Chin Peter Scott Officer Common Morgan Stanley Smith Barney LLC Executive Financial Services 1 New York Plaza 38th Fl. New York NY 10004 1654 36867.14 160144391 09/04/2026 NASDAQ Common 09/03/2026 Restricted Stock Lapse - See Remarks Denali Therapeutics Inc. N 1654 09/03/2026 Equity Compensation Y Shares sold to cover tax obligation from settlement of vested Restricted Stock Units. 09/04/2026 /s/Tyler Nielsen, by power of attorney