144 0002124509 XXXXXXXX LIVE 0001628171 Revolution Medicines, Inc. 001-39219 700 Saginaw Drive Redwood City CA 94063 6504816801 ANTHONY MANCINI Officer Common Morgan Stanley Smith Barney LLC Executive Financial Services

1 New York Plaza 8th Floor New York NY 10004

9363 1871289.18 214336418 09/25/2026 NASDAQ Common 09/25/2026 Exercise of Stock Options Issuer N 9363 09/25/2026 Cash N 10b5-1 Sales for ANTHONY MANCINI

700 Saginaw Drive Redwood City CA 94063

Common 09/24/2026 587 117400.00 10b5-1 Sales for ANTHONY MANCINI

700 Saginaw Drive Redwood City CA 94063

Common 09/18/2026 1764 347402.16 ANTHONY MANCINI

700 Saginaw Drive Redwood City CA 94063

Common 09/15/2026 1774 353449.03 10b5-1 Sales for ANTHONY MANCINI

700 Saginaw Drive Redwood City CA 94063

Common 09/10/2026 15448 3153807.11 The securities to be sold were and will be received upon the exercise of stock options over the next three months. The dates of acquisition and payment were and will be the dates of exercise/sale. 09/25/2026 06/11/2026 /s/ Anthony Mancini