144 0002123546 XXXXXXXX LIVE 0001395064 Takeda Pharmaceutical Company Limited 001-38757 1-1, Nihonbashi-Honcho 2-chome Chuo-ku, Tokyo M0 103-8668 81-3-3278-2111 Nicola Greenway Chief Human Resources Officer American Depositary Shares (ADSs) Interactive Brokers LLC

One Pickwick Plaza Greenwich, CT 06830

34603 578562.16 158131870 08/07/2026 NYSE ADSs 07/28/2023 Restricted Stock Unit Awards - Vested Takeda Pharmaceutical Company Limited N 11912 07/28/2023 Compensation ADSs 07/30/2024 Restricted Stock Unit Awards - Vested Takeda Pharmaceutical Company Limited N 14816 07/30/2024 Compensation ADSs 07/31/2025 Restricted Stock Unit Awards - Vested Takeda Pharmaceutical Company Limited N 18866 07/31/2025 Compensation ADSs 04/13/2023 Employee Stock Purchase Plan Takeda Pharmaceutical Company Limited N 132 04/13/2023 Cash ADSs 10/11/2023 Employee Stock Purchase Plan Takeda Pharmaceutical Company Limited N 142 10/11/2023 Cash ADSs 04/10/2024 Employee Stock Purchase Plan Takeda Pharmaceutical Company Limited N 159 04/10/2024 Cash ADSs 04/10/2025 Employee Stock Purchase Plan Takeda Pharmaceutical Company Limited N 152 04/10/2025 Cash ADSs 10/10/2024 Employee Stock Purchase Plan Takeda Pharmaceutical Company Limited N 165 10/10/2024 Cash ADSs 04/13/2026 Employee Stock Purchase Plan Takeda Pharmaceutical Company Limited N 225 04/13/2026 Cash N Nicola Greenway

500 KENDALL STREET CAMBRIDGE, MA 02142

ADSs 07/13/2026 7348 123072.06 Sale during the past 3 months was conducted in order to satisfy tax obligations in connection with share vesting effective July 13, 2026. Date of such sale reflects the date on which the administrative agent initiated this process, and such sales may not have settled as of the date hereof. 08/06/2026 /s/ Samuel Ntonme, by power of attorney for Nicola Greenway