X0609 4 2026-06-08 0 0000318306 ABEONA THERAPEUTICS INC. ABEO 0002106295 Vasanthavada Madhav false 6555 CARNEGIE AVE., 4TH FLOOR CLEVELAND OH 44103 0 1 0 0 Chief Commercial Officer 0 Common Stock 2026-06-08 4 S 0 4170 5.4295 D 308901 D Common Stock 2026-06-09 4 S 0 5450 5.3042 D 303451 D The sale reported in this Form 4 was to cover tax obligations associated with the vesting of restricted stock awards. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $5.345 to $5.54 inclusive. The reporting person undertakes to provide the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth above. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $5.24 to $5.47 inclusive. The reporting person undertakes to provide the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth above. /s/ Joseph Vazzano, Attorney-in-Fact 2026-06-09