The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
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COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP FIGI (to the nearest dollar) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABIVAX SA SPONSORED ADS 00370M103   14,836,369 111,334 SH   SOLE   111,334 0 0
ADLAI NORYTE LTD SPONSORED ADS 00704R109   1,301,881 113,207 SH   OTR   0 113,207 0
AGIOS PHARMACEUTICALS INC COM 00847X104   2,111,559 56,900 SH   SOLE   56,900 0 0
ALKERMES PLC SHS G01767105   1,220,018 23,285 SH   SOLE   23,285 0 0
AMYLYX PHARMACEUTICALS INC COM 03237H101   261,138 14,540 SH   SOLE   14,540 0 0
AN2 THERAPEUTICS INC COM 037326105   1,011,299 208,946 SH   SOLE   208,946 0 0
ARRIVENT BIOPHARMA INC COM 04272N102   8,567,092 246,606 SH   SOLE   246,606 0 0
ASCENDIS PHARMA A/S ORD SHS K08588103   3,165,700 11,869 SH   SOLE   11,869 0 0
ASSEMBLY BIOSCIENCES INC COM NEW 045396207   5,680,995 206,732 SH   SOLE   206,732 0 0
ASSEMBLY BIOSCIENCES INC COM NEW 045396207   6,221,884 226,415 SH   OTR   0 226,415 0
ASTRAZENECA PLC ORD G0593M107   265,468 1,400 SH   SOLE   1,400 0 0
AVALO THERAPEUTICS INC COM NEW 05338F306   8,104,441 438,552 SH   SOLE   438,552 0 0
AVALO THERAPEUTICS INC COM NEW 05338F306   6,139,296 332,213 SH   OTR   0 332,213 0
AXSOME THERAPEUTICS INC COM 05464T104   7,055,740 28,826 SH   SOLE   28,826 0 0
BEAM THERAPEUTICS INC COM 07373V105   302,153 8,804 SH   SOLE   8,804 0 0
BIOCRYST PHARMACEUTICALS INC COM 09058V103   510,240 51,024 SH   SOLE   51,024 0 0
BRIGHT MINDS BIOSCIENCES INC COM NEW 10919W405   448,929 6,395 SH   SOLE   6,395 0 0
C4 THERAPEUTICS INC COM STK 12529R107   1,780,059 381,169 SH   SOLE   381,169 0 0
CELCUITY INC COM 15102K100   1,700,284 16,252 SH   SOLE   16,252 0 0
CELLDEX THERAPEUTICS INC NEW COM NEW 15117B202   2,610,802 70,164 SH   SOLE   70,164 0 0
CELLDEX THERAPEUTICS INC NEW COM NEW 15117B202   613,965 16,500 SH   OTR   0 16,500 0
CENTURY THERAPEUTICS INC COM 15673T100   7,222,174 2,947,826 SH   SOLE   2,947,826 0 0
CENTURY THERAPEUTICS INC COM 15673T100   3,430,000 1,400,000 SH   OTR   0 1,400,000 0
CG ONCOLOGY INC COM 156944100   31,748,195 446,843 SH   SOLE   446,843 0 0
CG ONCOLOGY INC COM 156944100   102,268,873 1,439,393 SH   OTR   0 1,439,393 0
COGENT BIOSCIENCES INC COM 19240Q201   5,708,637 147,510 SH   SOLE   147,510 0 0
COMPASS THERAPEUTICS INC COM 20454B104   510,415 233,066 SH   OTR   0 233,066 0
CONTINEUM THERAPEUTICS INC CL A 21217B100   992,267 60,541 SH   SOLE   60,541 0 0
CORBUS PHARMACEUTICALS HLDGS COM NEW 21833P301   201,032 21,432 SH   SOLE   21,432 0 0
CORVUS PHARMACEUTICALS INC COM 221015100   1,238,377 82,890 SH   SOLE   82,890 0 0
CUE BIOPHARMA INC COM 22978P205   337,755 10,702 SH   SOLE   10,702 0 0
CYTOKINETICS INC COM NEW 23282W605   10,072,866 118,240 SH   SOLE   118,240 0 0
CYTOMX THERAPEUTICS INC. COM 23284F105   1,392,743 371,398 SH   SOLE   371,398 0 0
CYTOMX THERAPEUTICS INC. COM 23284F105   2,677,500 714,000 SH   OTR   0 714,000 0
DAMORA THERAPEUTICS INC COM NEW 36322Q206   4,016,724 154,430 SH   SOLE   154,430 0 0
DAMORA THERAPEUTICS INC COM NEW 36322Q206   3,381,300 130,000 SH   OTR   0 130,000 0
DEFINIUM THERAPEUTICS INC COM SHS 24477V105   6,992,355 148,647 SH   SOLE   148,647 0 0
DIANTHUS THERAPEUTICS INC COM 252828108   4,257,147 43,672 SH   SOLE   43,672 0 0
DIANTHUS THERAPEUTICS INC COM 252828108   2,052,051 21,051 SH   OTR   0 21,051 0
EDITAS MEDICINE INC COM 28106W103   4,310,820 1,330,500 SH   SOLE   1,330,500 0 0
ENGENE THERAPEUTICS INC COM 29286X101   711,142 411,065 SH   SOLE   411,065 0 0
ENLIVEN THERAPEUTICS INC COM 29337E102   14,673,652 289,136 SH   SOLE   289,136 0 0
ENLIVEN THERAPEUTICS INC COM 29337E102   3,869,688 76,250 SH   OTR   0 76,250 0
ENTERA BIO LTD SHS M40527109   338,697 191,354 SH   SOLE   191,354 0 0
ERASCA INC COM 29479A108   3,853,539 210,346 SH   SOLE   210,346 0 0
ERASCA INC COM 29479A108   1,789,150 97,661 SH   OTR   0 97,661 0
EUPRAXIA PHARMACEUTICALS INC COM 29842P105   2,212,929 334,785 SH   SOLE   334,785 0 0
EUPRAXIA PHARMACEUTICALS INC COM 29842P105   1,824,360 276,000 SH   OTR   0 276,000 0
EVOLUS INC COM 30052C107   541,716 78,057 SH   SOLE   78,057 0 0
FULCRUM THERAPEUTICS INC COM 359616109   66,206 18,089 SH   SOLE   18,089 0 0
GERON CORP COM 374163103   1,353,252 1,057,228 SH   SOLE   1,057,228 0 0
IDEAYA BIOSCIENCES INC COM 45166A102   1,411,229 37,865 SH   SOLE   37,865 0 0
INHIBIKASE THERAPEUTICS INC COM NEW 45719W205   704,207 346,900 SH   SOLE   346,900 0 0
INVENTIVA SA ADS 46124U107   756,533 200,141 SH   SOLE   200,141 0 0
ISHARES TR U.S. MED DVC ETF 464288810   681,858 13,800 SH   SOLE   13,800 0 0
KRYSTAL BIOTECH INC COM 501147102   659,343 1,774 SH   SOLE   1,774 0 0
LARIMAR THERAPEUTICS INC COM 517125100   704,309 230,921 SH   SOLE   230,921 0 0
LEONABIO INC COM 04746L203   1,416,666 154,153 SH   SOLE   154,153 0 0
LIPOCINE INC NEW COM NEW 53630X203   201,836 78,842 SH   SOLE   78,842 0 0
LIQUIDIA CORPORATION COM NEW 53635D202   14,519,072 182,103 SH   SOLE   182,103 0 0
LIQUIDIA CORPORATION COM NEW 53635D202   5,939,885 74,500 SH   OTR   0 74,500 0
MADRIGAL PHARMACEUTICALS INC COM 558868105   2,670,252 4,973 SH   SOLE   4,973 0 0
MBX BIOSCIENCES INC COM 55287L101   331,200 6,000 SH   SOLE   6,000 0 0
MILESTONE PHARMACEUTICALS IN COM 59935V107   362,112 270,233 SH   SOLE   270,233 0 0
MINERVA NEUROSCIENCES INC COM NEW 603380205   1,370,717 246,976 SH   SOLE   246,976 0 0
MINERVA NEUROSCIENCES INC COM NEW 603380205   4,186,903 754,397 SH   OTR   0 754,397 0
MIRUM PHARMACEUTICALS INC COM 604749101   12,923,709 110,393 SH   SOLE   110,393 0 0
MONTE ROSA THERAPEUTICS INC COM 61225M102   406,560 16,800 SH   SOLE   16,800 0 0
NEUROGENE INC COM 64135M105   693,787 22,060 SH   SOLE   22,060 0 0
OLEMA PHARMACEUTICALS INC COM 68062P106   393,765 31,476 SH   SOLE   31,476 0 0
ONKURE THERAPEUTICS INC COM CL A 68277Q105   1,098,791 240,963 SH   OTR   0 240,963 0
OPUS GENETICS INC COM 67577R102   588,293 143,137 SH   SOLE   143,137 0 0
PALISADE BIO INC COM 696389402   568,906 272,204 SH   SOLE   272,204 0 0
PERSPECTIVE THERAPEUTICS INC COM NEW 46489V302   1,134,210 332,613 SH   SOLE   332,613 0 0
PHARVARIS N V COM N69605108   10,096,565 291,977 SH   SOLE   291,977 0 0
PHARVARIS N V COM N69605108   16,685,680 482,524 SH   OTR   0 482,524 0
PMV PHARMACEUTICALS INC COM 69353Y103   71,782 53,569 SH   SOLE   53,569 0 0
PRAXIS PRECISION MEDICINES I COM NEW 74006W207   2,524,317 7,540 SH   SOLE   7,540 0 0
PROMIS NEUROSCIENCES INC COM SHS 74346M505   139,496 10,600 SH   SOLE   10,600 0 0
PROTAGONIST THERAPEUTICS INC COM 74366E102   5,565,132 45,400 SH   SOLE   45,400 0 0
PROTHENA CORP PLC SHS G72800108   423,907 43,300 SH   SOLE   43,300 0 0
RELAY THERAPEUTICS INC COM 75943R102   3,334,534 178,222 SH   SOLE   178,222 0 0
RELMADA THERAPEUTICS INC COM 75955J402   2,409,994 348,265 SH   SOLE   348,265 0 0
REVOLUTION MEDICINES INC COM 76155X100   36,400,303 194,363 SH   SOLE   194,363 0 0
REVOLUTION MEDICINES INC COM 76155X100   8,926,888 47,666 SH   OTR   0 47,666 0
ROIVANT SCIENCES LTD SHS G76279101   7,790,259 220,126 SH   SOLE   220,126 0 0
SAB BIOTHERAPEUTICS INC COM NEW 78397T202   1,310,700 336,077 SH   SOLE   336,077 0 0
SAB BIOTHERAPEUTICS INC COM NEW 78397T202   1,560,000 400,000 SH   OTR   0 400,000 0
SAGIMET BIOSCIENCES INC COM SER A 786700104   3,119,403 403,545 SH   SOLE   403,545 0 0
SAVARA INC COM 805111101   1,904,074 309,103 SH   SOLE   309,103 0 0
SILENCE THERAPEUTICS PLC ADS 82686Q101   659,975 60,107 SH   SOLE   60,107 0 0
SPYRE THERAPEUTICS INC COM NEW 00773J202   1,180,774 13,300 SH   SOLE   13,300 0 0
STOKE THERAPEUTICS INC COM 86150R107   255,353 7,745 SH   SOLE   7,745 0 0
STRUCTURE THERAPEUTICS INC SPONSORED ADS 86366E106   1,441,572 26,800 SH   SOLE   26,800 0 0
SUMMIT THERAPEUTICS INC COM 86627T108   1,090,930 73,300 SH   SOLE   73,300 0 0
SUTRO BIOPHARMA INC COM SHS 869367201   3,794,182 159,118 SH   SOLE   159,118 0 0
SYNDAX PHARMACEUTICALS INC COM 87164F105   1,645,046 77,930 SH   SOLE   77,930 0 0
TANGO THERAPEUTICS INC COM 87583X109   54,443,081 1,909,593 SH   SOLE   1,909,593 0 0
TANGO THERAPEUTICS INC COM 87583X109   41,217,904 1,318,551 SH   OTR   0 1,318,551 0
TARSUS PHARMACEUTICALS INC COM 87650L103   7,909,873 117,067 SH   SOLE   117,067 0 0
TAYSHA GENE THERAPIES INC COM SHS 877619106   9,940,323 1,504,400 SH   SOLE   1,504,400 0 0
TREVI THERAPEUTICS INC COM 89532M101   833,430 45,598 SH   SOLE   45,598 0 0
UNICYCIVE THERAPEUTICS INC COM NEW 90466Y202   521,136 103,400 SH   SOLE   103,400 0 0
UNIQURE NV SHS N90064101   15,254 338 SH   SOLE   338 0 0
VAXCYTE INC COM 92243G108   1,777,570 29,800 SH   SOLE   29,800 0 0
VERADERMICS INC COMMON STOCK 922967104   1,229,400 10,000 SH   SOLE   10,000 0 0
VERADERMICS INC COMMON STOCK 922967104   8,605,800 70,000 SH   OTR   0 70,000 0
VIKING THERAPEUTICS INC COM 92686J106   251,884 7,404 SH   SOLE   7,404 0 0
VOYAGER THERAPEUTICS INC COM 92915B106   771,860 230,406 SH   SOLE   230,406 0 0
WAVE LIFE SCIENCES LTD SHS Y95308105   99,812 19,048 SH   SOLE   19,048 0 0
XENCOR INC COM 98401F105   7,828,524 368,305 SH   SOLE   368,305 0 0
XENON PHARMACEUTICALS INC COM 98420N105   2,084,468 33,300 SH   SOLE   33,300 0 0
ZAI LAB LTD ADR 98887Q104   2,924,756 136,016 SH   SOLE   136,016 0 0
ZENTALIS PHARMACEUTICALS INC COM 98943L107   1,451,432 317,600 SH   SOLE   317,600 0 0