ABIVAX SA SPONSORED ADS 00370M103 4793840 43052 SH SOLE 43052 0 0 AGIOS PHARMACEUTICALS INC COM 00847X104 7088975 209547 SH SOLE 209547 0 0 ALKERMES PLC SHS G01767105 854651 24170 SH SOLE 24170 0 0 AMYLYX PHARMACEUTICALS INC COM 03237H101 231727 16671 SH SOLE 16671 0 0 AN2 THERAPEUTICS INC COM 037326105 682977 199701 SH SOLE 199701 0 0 APOGEE THERAPEUTICS INC COM 03770N101 165731 1969 SH SOLE 1969 0 0 ARRIVENT BIOPHARMA INC COM 04272N102 1159314 50252 SH SOLE 50252 0 0 ASCENDIS PHARMA A/S SPONSORED ADS 04351P101 2785703 12179 SH SOLE 12179 0 0 ASSEMBLY BIOSCIENCES INC COM NEW 045396207 1558080 56147 SH SOLE 56147 0 0 AVALO THERAPEUTICS INC COM NEW 05338F306 3192318 213819 SH SOLE 213819 0 0 AVALO THERAPEUTICS INC COM NEW 05338F307 5375756 360064 SH OTR 1 0 360064 0 AXSOME THERAPEUTICS INC. COM 05464T104 2375576 14055 SH SOLE 14055 0 0 BEAM THERAPEUTICS INC COM 07373V105 209800 8804 SH SOLE 8804 0 0 BIOCRYST PHARMACEUTICALS INC COM 09058V103 975733 102493 SH SOLE 102493 0 0 BRIGHT MINDS BIOSCIENCES INC COM NEW 10919W405 466644 6395 SH SOLE 6395 0 0 C4 THERAPEUTICS INC COM STK 12529R107 150110 57076 SH SOLE 57076 0 0 CELCUITY INC COM 15102K100 684840 6000 SH SOLE 6000 0 0 CELLDEX THERAPEUTICS INC NEW COM NEW 15117B202 929396 29300 SH SOLE 29300 0 0 CENTURY THERAPEUTICS INC COM 15673T100 6662087 2947826 SH SOLE 2947826 0 0 CG ONCOLOGY INC COM 156944100 5127301 75758 SH SOLE 75758 0 0 CG ONCOLOGY INC COM 156944101 97418118 1439393 SH OTR 1 0 1439393 0 CLIMB BIO INC COM 28658R106 894980 130654 SH SOLE 130654 0 0 COGENT BIOSCIENCES INC COM 19240Q201 5750368 149399 SH SOLE 149399 0 0 COMPASS PATHWAYS PLC SPONSORED ADS 20451W101 873856 158021 SH SOLE 158021 0 0 COMPASS THERAPEUTICS INC COM 20454B104 2734782 516972 SH SOLE 516972 0 0 COMPASS THERAPEUTICS INC COM 20454B105 2240664 423566 SH OTR 1 0 423566 0 CONTEXT THERAPEUTICS INC COM 21077P108 499857 190785 SH SOLE 190785 0 0 CONTINEUM THERAPEUTICS INC CL A 21217B100 353325 27054 SH SOLE 27054 0 0 CORBUS PHARMACEUTICALS HLDGS COM NEW 21833P301 804601 85687 SH SOLE 85687 0 0 CORVUS PHARMACEUTICALS INC COM 221015100 1212681 82890 SH SOLE 82890 0 0 CULLINAN THERAPEUTICS INC COM 230031106 26203 1844 SH SOLE 1844 0 0 CYTOKINETICS INC COM NEW 23282W605 4038240 61269 SH SOLE 61269 0 0 CYTOMX THERAPEUTICS INC. COM 23284F105 1745571 371398 SH SOLE 371398 0 0 CYTOMX THERAPEUTICS INC. COM 23284F106 3355800 714000 SH OTR 1 0 714000 0 DAMORA THERAPEUTICS INC COM NEW 36322Q206 2622323 101248 SH SOLE 101248 0 0 DEFINIUM THERAPEUTICS INC COM SHS 24477V105 1887864 99887 SH SOLE 99887 0 0 DENALI THERAPEUTICS INC COM 24823R105 677491 35286 SH SOLE 35286 0 0 DIANTHUS THERAPEUTICS INC COM 252828108 4553331 54258 SH SOLE 54258 0 0 DIANTHUS THERAPEUTICS INC COM 252828109 2228160 26551 SH OTR 1 0 26551 0 DISC MEDICINE INC COM 254604101 206590 3231 SH SOLE 3231 0 0 EDGEWISE THERAPEUTICS INC COM 28036F105 368582 11701 SH SOLE 11701 0 0 ELI LILLY & CO COM 532457108 662234 720 SH SOLE 720 0 0 ENLIVEN THERAPEUTICS INC COM 29337E102 6429976 164030 SH SOLE 164030 0 0 ENLIVEN THERAPEUTICS INC COM 29337E103 3733918 95253 SH OTR 1 0 95253 0 ENTERA BIO LTD SHS M40527109 228152 205542 SH SOLE 205542 0 0 ERASCA INC COM 29479A108 3599532 222468 SH SOLE 222468 0 0 EUPRAXIA PHARMACEUTICALS INC COM 29842P105 3138649 433515 SH SOLE 433515 0 0 EUPRAXIA PHARMACEUTICALS INC COM 29842P106 1998240 276000 SH OTR 1 0 276000 0 EVOLUS INC COM 30052C107 320814 78057 SH SOLE 78057 0 0 FULCRUM THERAPEUTICS INC COM 359616109 292227 38100 SH SOLE 38100 0 0 GERON CORP COM 374163103 632028 424180 SH SOLE 424180 0 0 IDEAYA BIOSCIENCES INC COM 45166A102 2874950 86283 SH SOLE 86283 0 0 INHIBIKASE THERAPEUTICS INC COM NEW 45719W205 547008 325600 SH SOLE 325600 0 0 INHIBRX BIOSCIENCES INC COM 45720N103 166865 2482 SH SOLE 2482 0 0 INTELLIA THERAPEUTICS INC COM 45826J105 403830 31500 SH SOLE 31500 0 0 INVENTIVA SA ADS 46124U107 1110783 200141 SH SOLE 200141 0 0 KALVISTA PHARMACEUTICALS INC COM 483497103 2586443 128487 SH SOLE 128487 0 0 KRYSTAL BIOTECH INC COM 501147102 1114909 4316 SH SOLE 4316 0 0 LARIMAR THERAPEUTICS INC COM 517125100 1154633 256585 SH SOLE 256585 0 0 LEONABIO INC COM 04746L203 1692869 164676 SH SOLE 164676 0 0 LIPOCINE INC NEW COM NEW 53630X203 998287 124942 SH SOLE 124942 0 0 LIQUIDIA CORPORATION COM NEW 53635D202 7090440 187876 SH SOLE 187876 0 0 LIQUIDIA CORPORATION COM NEW 53635D203 641580 17000 SH OTR 1 0 17000 0 MACROGENICS INC COM 556099109 38688 13387 SH SOLE 13387 0 0 MADRIGAL PHARMACEUTICALS INC COM 558868105 1776134 3393 SH SOLE 3393 0 0 MAZE THERAPEUTICS INC COM 578784100 916604 30707 SH SOLE 30707 0 0 MILESTONE PHARMACEUTICALS IN COM 59935V107 396666 333333 SH SOLE 333333 0 0 MINERALYS THERAPEUTICS INC COM 603170101 1884678 69571 SH SOLE 69571 0 0 MINERVA NEUROSCIENCES INC COM NEW 603380205 1497068 248476 SH SOLE 248476 0 0 MINERVA NEUROSCIENCES INC COM NEW 603380206 5357755 889254 SH OTR 1 0 889254 0 MONTE ROSA THERAPEUTICS INC COM 61225M102 370619 22530 SH SOLE 22530 0 0 NEKTAR THERAPEUTICS COM NEW 640268306 309385 4300 SH SOLE 4300 0 0 NUVALENT NC COM 670703107 212276 2072 SH SOLE 2072 0 0 OCULAR THERAPEUTIX INC COM 67576A100 265077 31296 SH SOLE 31296 0 0 OPUS GENETICS INC COM 67577R102 610801 134242 SH SOLE 134242 0 0 PALISADE BIO INC COM 696389402 372925 213100 SH SOLE 213100 0 0 PEPGEN INC COM 713317105 105315 59500 SH SOLE 59500 0 0 PERSPECTIVE THERAPEUTICS INC COM NEW 46489V302 1580772 379082 SH SOLE 379082 0 0 PHARVARIS N V COM N69605108 4879651 172731 SH SOLE 172731 0 0 PHARVARIS N V COM N69605109 4067040 143966 SH OTR 1 0 143966 0 PMV PHARMACEUTICALS INC COM 69353Y103 78738 63498 SH SOLE 63498 0 0 PROMIS NEUROSCIENCES INC COM SHS 74346M505 134620 10600 SH SOLE 10600 0 0 PROTAGONIST THERAPEUTICS INC COM 74366E102 421600 4000 SH SOLE 4000 0 0 PROTHENA CORP PLC SHS G72800108 420876 43300 SH SOLE 43300 0 0 RELAY THERAPEUTICS INC COM 75943R102 2564493 257738 SH SOLE 257738 0 0 REPLIMUNE GROUP INC COM 76029N106 921060 120400 SH SOLE 120400 0 0 REVOLUTION MEDICINES INC COM 76155X100 7857022 80792 SH SOLE 80792 0 0 ROIVANT SCIENCES LTD SHS G76279101 3550254 128168 SH SOLE 128168 0 0 SAB BIOTHERAPEUTICS INC COM NEW 78397T202 383000 100000 SH SOLE 100000 0 0 SAB BIOTHERAPEUTICS INC COM NEW 78397T203 1532000 400000 SH OTR 1 0 400000 0 SAVARA INC COM 805111101 1614456 295688 SH SOLE 295688 0 0 SEPTERNA INC COM 81734D104 275023 11445 SH SOLE 11445 0 0 SILENCE THERAPEUTICS PLC ADS 82686Q101 826120 156759 SH SOLE 156759 0 0 SOLENO THERAPEUTICS INC COM 834203309 3875980 115770 SH SOLE 115770 0 0 SOLENO THERAPEUTICS INC COM 834203310 1807920 54000 SH OTR 1 0 54000 0 SPYRE THERAPEUTICS INC COM NEW 00773J202 993164 19690 SH SOLE 19690 0 0 STRUCTURE THERAPEUTICS INC SPONSORED ADS 86366E106 433800 9000 SH SOLE 9000 0 0 TANGO THERAPEUTICS INC COM 87583X109 10502091 502012 SH SOLE 502012 0 0 TANGO THERAPEUTICS INC COM 87583X110 6289556 300648 SH OTR 1 0 300648 0 TARSUS PHARMACEUTICALS INC COM 87650L103 1388970 19800 SH SOLE 19800 0 0 TAYSHA GENE THERAPIES INC COM SHS 877619106 2796915 625708 SH SOLE 625708 0 0 TREVI THERAPEUTICS INC COM 89532M101 323887 27149 SH SOLE 27149 0 0 TYRA BIOSCIENCES INC COM 90240B106 7494736 195685 SH SOLE 195685 0 0 TYRA BIOSCIENCES INC COM 90240B107 111070 2900 SH OTR 1 0 2900 0 UNICYCIVE THERAPEUTICS INC COM NEW 90466Y202 366506 55700 SH SOLE 55700 0 0 UNITED THERAPEUTICS RP DEL COM 91307C102 668881 1128 SH SOLE 1128 0 0 VAXCYTE INC COM 92243G108 6302029 108450 SH SOLE 108450 0 0 VAXCYTE INC COM 92243G109 1162200 20000 SH OTR 1 0 20000 0 VERASTEM INC COM NEW 92337C203 654020 123400 SH SOLE 123400 0 0 VOYAGER THERAPEUTICS INC COM 92915B106 444684 115203 SH SOLE 115203 0 0 WHITEHAWK THERAPEUTICS INC COM 00032Q104 187321 54296 SH SOLE 54296 0 0 XENCOR INC COM 98401F105 964800 80000 SH SOLE 80000 0 0 ZAI LAB LTD ADR 98887Q104 1464509 77858 SH SOLE 77858 0 0 ZENTALIS PHARMACEUTICALS INC COM 98943L107 257400 110000 SH SOLE 110000 0 0