<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/schedule13g" xmlns:com="http://www.sec.gov/edgar/common">
  <headerData>
    <submissionType>SCHEDULE 13G</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0002089521</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <coverPageHeader>
      <securitiesClassTitle>Class A Common Stock </securitiesClassTitle>
      <eventDateRequiresFilingThisStatement>09/16/2025</eventDateRequiresFilingThisStatement>
      <issuerInfo>
        <issuerCik>0000318306</issuerCik>
        <issuerName>ABEONA THERAPEUTICS INC.</issuerName>
        <issuerCusip>00289Y206</issuerCusip>
        <issuerPrincipalExecutiveOfficeAddress>
          <com:street1>6555 CARNEGIE AVE, 4TH FLOOR</com:street1>
          <com:city>CLEVELAND</com:city>
          <com:stateOrCountry>OH</com:stateOrCountry>
          <com:zipCode>44103</com:zipCode>
        </issuerPrincipalExecutiveOfficeAddress>
      </issuerInfo>
      <designateRulesPursuantThisScheduleFiled>
        <designateRulePursuantThisScheduleFiled>Rule 13d-1(c)</designateRulePursuantThisScheduleFiled>
      </designateRulesPursuantThisScheduleFiled>
    </coverPageHeader>
    <coverPageHeaderReportingPersonDetails>

      <reportingPersonName>James Russell Revocable Trust</reportingPersonName>
      <citizenshipOrOrganization>NV</citizenshipOrOrganization>
      <reportingPersonBeneficiallyOwnedNumberOfShares>
        <soleVotingPower>2720875.00</soleVotingPower>
        <sharedVotingPower>0.00</sharedVotingPower>
        <soleDispositivePower>2720875.00</soleDispositivePower>
        <sharedDispositivePower>0.00</sharedDispositivePower>
      </reportingPersonBeneficiallyOwnedNumberOfShares>
      <reportingPersonBeneficiallyOwnedAggregateNumberOfShares>2720875.00</reportingPersonBeneficiallyOwnedAggregateNumberOfShares>
      <classPercent>5.3</classPercent>
      <typeOfReportingPerson>OO</typeOfReportingPerson>
      <comments> James Russell Revocable Trust is the reporting entity. James Russell, Trustee, is the control person.</comments>
    </coverPageHeaderReportingPersonDetails>
    <items>
      <item1>
        <issuerName>ABEONA THERAPEUTICS INC.</issuerName>
        <issuerPrincipalExecutiveOfficeAddress>6555 CARNEGIE AVE, 4TH FLOOR, CLEVELAND, OHIO, 44103</issuerPrincipalExecutiveOfficeAddress>
      </item1>
      <item2>
        <filingPersonName>James Russell Revocable Trust</filingPersonName>
        <principalBusinessOfficeOrResidenceAddress>86 Innisbrook Avenue
Las Vegas, Nevada 89113</principalBusinessOfficeOrResidenceAddress>
        <citizenship>Nevada</citizenship>
      </item2>
      <item3>
        <notApplicableFlag>Y</notApplicableFlag>
      </item3>
      <item4>
        <amountBeneficiallyOwned>2,720,875</amountBeneficiallyOwned>
        <classPercent>5.3</classPercent>
        <numberOfSharesPersonHas>
          <solePowerOrDirectToVote>2,720,875</solePowerOrDirectToVote>
          <sharedPowerOrDirectToVote>0</sharedPowerOrDirectToVote>
          <solePowerOrDirectToDispose>2,720,875</solePowerOrDirectToDispose>
          <sharedPowerOrDirectToDispose>0</sharedPowerOrDirectToDispose>
        </numberOfSharesPersonHas>
      </item4>
      <item5>
        <notApplicableFlag>Y</notApplicableFlag>
        <classOwnership5PercentOrLess>N</classOwnership5PercentOrLess>
      </item5>
      <item6>
        <notApplicableFlag>N</notApplicableFlag>
        <ownershipMoreThan5PercentOnBehalfOfAnotherPerson>James Russell Revocable Trust is reporting entity.  James Russell, Trustee, is the control person.</ownershipMoreThan5PercentOnBehalfOfAnotherPerson>
      </item6>
      <item7>
        <notApplicableFlag>Y</notApplicableFlag>
      </item7>
      <item8>
        <notApplicableFlag>Y</notApplicableFlag>
      </item8>
      <item9>
        <notApplicableFlag>Y</notApplicableFlag>
      </item9>
      <item10>
        <notApplicableFlag>N</notApplicableFlag>
        <certifications>By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under &amp;#167; 240.14a-11.

</certifications>
      </item10>
    </items>
    <exhibitInfo>Exhibit 1 is a Power of Attorney from James Russell, Trustee, The James Russell Revocable Trust</exhibitInfo>
    <signatureInformation>
      <reportingPersonName>James Russell Revocable Trust</reportingPersonName>
      <signatureDetails>
        <signature>Michael Volkov</signature>
        <title>By POA from James Russell, Trustee</title>
        <date>09/30/2025</date>
      </signatureDetails>
      <signatureDetails>
        <signature>James Russell</signature>
        <title>Trustee</title>
        <date>09/30/2025</date>
      </signatureDetails>
    </signatureInformation>
  </formData>

</edgarSubmission>
