<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/schedule13g" xmlns:com="http://www.sec.gov/edgar/common">
  <schemaVersion>X0202</schemaVersion>
<headerData>
    <submissionType>SCHEDULE 13G</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <!-- Field: Pseudo-Tag; ID: Name; Data: HPW Investments Holding Ltd. -->
          <cik>0002141539</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <coverPageHeader>
      <securitiesClassTitle>COMMON SHARES, PAR VALUE $0.0001 PER SHARE</securitiesClassTitle>
      <eventDateRequiresFilingThisStatement>04/23/2026</eventDateRequiresFilingThisStatement>
      <issuerInfo>
        <issuerCik>0002079272</issuerCik>
        <issuerName>LAKEWOOD-AMEDEX BIOTHERAPEUTICS INC.</issuerName>
        <issuerCusips>
          <issuerCusipNumber>51255A201</issuerCusipNumber>
        </issuerCusips>
        <issuerPrincipalExecutiveOfficeAddress>
          <com:street1>8031 Cooper Creek Blvd</com:street1>
          <com:street2>Unit 103</com:street2>
          <com:city>University Park</com:city>
          <com:stateOrCountry>FL</com:stateOrCountry>
          <com:zipCode>34201</com:zipCode>
        </issuerPrincipalExecutiveOfficeAddress>
      </issuerInfo>
      <designateRulesPursuantThisScheduleFiled>
        <designateRulePursuantThisScheduleFiled>Rule 13d-1(d)</designateRulePursuantThisScheduleFiled>
      </designateRulesPursuantThisScheduleFiled>
    </coverPageHeader>
    <coverPageHeaderReportingPersonDetails>


      <reportingPersonName>HPW Investments Holding Ltd.</reportingPersonName>
      <citizenshipOrOrganization>Y9</citizenshipOrOrganization>
      <reportingPersonBeneficiallyOwnedNumberOfShares>
        <soleVotingPower>3435501.00</soleVotingPower>
        <sharedVotingPower>0.00</sharedVotingPower>
        <soleDispositivePower>3435501.00</soleDispositivePower>
        <sharedDispositivePower>0.00</sharedDispositivePower>
      </reportingPersonBeneficiallyOwnedNumberOfShares>
      <reportingPersonBeneficiallyOwnedAggregateNumberOfShares>3435501.00</reportingPersonBeneficiallyOwnedAggregateNumberOfShares>
      <aggregateAmountExcludesCertainSharesFlag>N</aggregateAmountExcludesCertainSharesFlag>
      <classPercent>24.04</classPercent>
      <typeOfReportingPerson>CO</typeOfReportingPerson>
      <comments>(1) Represents 3,435,501 shares held by HPW Investments Holding Ltd.

(2) The beneficial ownership percentage is calculated based on 14,290,892 ordinary shares of the Issuer issued and outstanding as of March 31, 2026.</comments>
    </coverPageHeaderReportingPersonDetails>
    <items>
      <item1>
        <issuerName>LAKEWOOD-AMEDEX BIOTHERAPEUTICS INC.</issuerName>
        <issuerPrincipalExecutiveOfficeAddress>8031 Cooper Creek Blvd., Unit 103, University Park, Florida 34201</issuerPrincipalExecutiveOfficeAddress>
      </item1>
      <item2>
        <filingPersonName>HPW Investments Holding Ltd.</filingPersonName>
        <principalBusinessOfficeOrResidenceAddress>The Principal Business Office of the Reporting Person is:

IFC 5, St. Helier, Jersey, JE1 1ST, Bailiwick of Jersey</principalBusinessOfficeOrResidenceAddress>
        <citizenship>Jersey, Channel Islands</citizenship>
      </item2>
      <item3>
        <notApplicableFlag>Y</notApplicableFlag>
      </item3>
      <item4>
        <amountBeneficiallyOwned>3,435,501</amountBeneficiallyOwned>
        <classPercent>24.04% (1)

(1) The beneficial ownership percentage is calculated based on 14,290,892 shares of the Issuer issued and outstanding as of March 31, 2026.</classPercent>
        <numberOfSharesPersonHas>
          <solePowerOrDirectToVote>3,435,501</solePowerOrDirectToVote>
          <sharedPowerOrDirectToVote>0</sharedPowerOrDirectToVote>
          <solePowerOrDirectToDispose>3,435,501</solePowerOrDirectToDispose>
          <sharedPowerOrDirectToDispose>0</sharedPowerOrDirectToDispose>
        </numberOfSharesPersonHas>
      </item4>
      <item5>
        <notApplicableFlag>Y</notApplicableFlag>
      </item5>
      <item6>
        <notApplicableFlag>Y</notApplicableFlag>
      </item6>
      <item7>
        <notApplicableFlag>Y</notApplicableFlag>
      </item7>
      <item8>
        <notApplicableFlag>Y</notApplicableFlag>
      </item8>
      <item9>
        <notApplicableFlag>Y</notApplicableFlag>
      </item9>
      <item10>
        <notApplicableFlag>Y</notApplicableFlag>
      </item10>
    </items>
    <signatureInformation>
      <reportingPersonName>HPW Investments Holding Ltd.</reportingPersonName>
      <signatureDetails>
        <signature>/s/ Martin Kleppe</signature>
        <title>Dr. Martin Kleppe/Director</title>
        <date>06/23/2026</date>
      </signatureDetails>
    </signatureInformation>
  </formData>
</edgarSubmission>
