X0508 4 2025-05-27 0001124105 GYRE THERAPEUTICS, INC. GYRE 0002050176 Zhang Ping C/O GYRE THERAPEUTICS, INC. 12770 HIGH BLUFF DRIVE, SUITE 150 SAN DIEGO CA 92130 true false Stock Option (Right to Buy) 10.18 2025-05-27 4 A 0 250000 0 A 2035-05-27 Common Stock 250000 250000 D This option represents a right to purchase a total of 250,000 shares of the Issuer's common stock, 25% of which will vest on May 27, 2026, with the remaining vesting in equal monthly installments over the following three years, subject to the Reporting Person's continued service to the Issuer through each vesting date. /s/ Ruoyu Chen, as attorney-in-fact for Ping Zhang 2025-05-28