144 0002050167 XXXXXXXX LIVE 0001842295 MAZE THERAPEUTICS, INC. 001-42490 171 Oyster Point Blvd Suite 300 South San Francisco CA 94080 650-850-5070 ATUL DANDEKAR Officer Common Morgan Stanley Smith Barney LLC Executive Financial Services

1 New York Plaza 8th Floor New York NY 10004

30000 911400.00 49708658 03/30/2026 NASDAQ Common 03/30/2026 Exercise of Stock Options Issuer N 30000 03/30/2026 Cash N 10b5-1 Sales for ATUL DANDEKAR

171 Oyster Point Blvd Suite 300 South San Francisco CA 94080

Common 02/27/2026 7500 340722.75 10b5-1 Sales for ATUL DANDEKAR

171 Oyster Point Blvd Suite 300 South San Francisco CA 94080

Common 01/29/2026 7500 331990.50 The securities to be sold were and will be received upon the exercise of stock options over the next three months. The dates of acquisition and payment were and will be the dates of exercise/sale. 03/30/2026 09/29/2025 /s/ Atul Dandekar