144 0002050167 XXXXXXXX LIVE 0001842295 MAZE THERAPEUTICS INC 001-42490 171 Oyster Point Blvd. Suite 300 South San Francisco CA 94080 650-850-5070 ATUL P DANDEKAR Officer Common Morgan Stanley Smith Barney LLC Executive Financial Services

1 New York Plaza 8th Floor New York NY 10004

87500 3683750.00 48119444 12/29/2025 NASDAQ Common 12/29/2025 Exercise of Stock Options Issuer N 87500 12/29/2025 Cash Y The securities to be sold were and will be received upon the exercise of stock options over the next three months. The dates of acquisition and payment were and will be the dates of exercise/sale. 12/29/2025 09/29/2025 /s/ Atul Dandekar