X0202 SCHEDULE 13G 0001727388 XXXXXXXX LIVE Voting Common Stock, $0.0001 par value per share 06/30/2026 0002042347 Seaport Therapeutics, Inc. 81221K108 101 Seaport Blvd., Floor 12 Boston MA 02210 Rule 13d-1(d) Zohar Daphne X1 5225497 0 5225497 0 5225497 N 9.1 IN Seaport Therapeutics, Inc. 101 Seaport Blvd., Floor 12, Boston, MA 02210 This statement is filed on behalf of Daphne Zohar (the "Reporting Person"). The address of the principal business office of the Reporting Person is 101 Seaport Blvd., Floor 12, Boston, MA 02210. The Reporting Person is a citizen of the United States. Y The ownership information below represents beneficial ownership of Voting Common Stock, par value $0.0001 per share ("Common Stock") of the Issuer as of June 30, 2026, based upon 53,530,550 shares of Common Stock outstanding as of June 30, 2026, as provided by the Issuer. The Reporting Person is deemed to be the beneficial owner of 5,225,497 shares of Common Stock, consisting of (i) 1,194,001 shares of Common Stock held of record by the Reporting Person and (ii) 4,031,496 shares of Common Stock subject to stock options exercisable within 60 days of June 30, 2026 by the Reporting Person. 9.1 5,225,497 0 5,225,497 0 Y Y Y Y Y Y Zohar Daphne /s/ Daphne Zohar 08/05/2026